Affiliations 

  • 1 Beijing Advanced Innovation Center for Materials Genome Engineering and School of Materials Science and Engineering, Peking University, Beijing 100871, China
  • 2 National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Lifetech Scientific (Shenzhen) Co. Ltd., Shenzhen 518110, China
  • 3 Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
  • 4 BioMed-X Center, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
  • 5 AIM Lab, Maryland NanoCenter, University of Maryland, College Park, MD 20742, USA
  • 6 Paediatric Cardiology, Institut Jantung Negara (National Heart Institute), 145, Jalan Tun Razak, Kuala Lumpur 50400, Malaysia
  • 7 Shen Zhen Testing Center of Medical Devices, Shenzhen 518057, China
  • 8 Beijing Advanced Innovation Center for Materials Genome Engineering and School of Materials Science and Engineering, Peking University, Beijing 100871, China. yfzheng@pku.edu.cn zhangdeyuan@lifetechmed.com gaorunlin@citmd.com
  • 9 National and Local Joint Engineering Laboratory of Interventional Medical Biotechnology and System, Lifetech Scientific (Shenzhen) Co. Ltd., Shenzhen 518110, China. yfzheng@pku.edu.cn zhangdeyuan@lifetechmed.com gaorunlin@citmd.com
  • 10 Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. yfzheng@pku.edu.cn zhangdeyuan@lifetechmed.com gaorunlin@citmd.com
Sci Adv, 2021 Jun;7(23).
PMID: 34088662 DOI: 10.1126/sciadv.abf0614

Abstract

Balancing the biodegradability and mechanical integrity of a bioresorbable scaffold (BRS) with time after implantation to match the remodeling of the scaffolded blood vessel is important, but a key challenge in doing so remains. This study presents a novel intercalated structure of a metallic BRS by introducing a nanoscale Zn sacrificial layer between the nitrided Fe platform and the sirolimus-carrying poly(d,l-lactide) drug coating. The PDLLA-Zn-FeN BRS shows a multistage biodegradation behavior, maintaining mechanical integrity at the initial stage and exhibiting accelerated biodegradation at the subsequent stage in both rabbit abdominal aortas and human coronary arteries, where complete biodegradation was observed about 2 years after implantation. The presence of the nanoscale Zn sacrificial layer with an adjustable thickness also contributes to the tunable biodegradation of BRS and allows the reduction of the metallic strut thickness to 53 μm, with radial strength as strong as that of the current permanent drug-eluting stents.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.