• 1 1Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia
  • 2 2Biomedical Science Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand
  • 3 3Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • 4 4Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand
Am J Trop Med Hyg, 2021 07 08;105(3):688-691.
PMID: 34237022 DOI: 10.4269/ajtmh.21-0317


Strongyloides stercoralis affects more than half a billion people worldwide, and hyperinfection in immunocompromised patients can be fatal. Elimination of this neglected tropical disease requires field-applicable diagnostic tools. We conducted a laboratory evaluation of a lateral flow rapid dipstick test (SsRapid™) using sera samples from a Strongyloides-endemic area in northeast Thailand. Group 1 was S. stercoralis-positive and larvae- and/or antibody-positive (according to the IgG ELISA) (N = 100). Group 2 had negative fecal examination and IgG ELISA results (N = 25). Group 3 had other parasitic infections and negative IgG ELISA results (N = 25). The results showed good diagnostic sensitivity (82%) and excellent specificity (96%). Suggested improvements in the SsRapid™ test include increased diagnostic sensitivity and conversion to the more robust cassette format. Field studies should be performed as well.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.