Biological insights into the piericidin family of microbial metabolites

Azad SM 1 , Jin Y 2 , Ser HL 3 , Goh BH 4 , Lee LH 3 , Thawai C 5 Show all authors , He YW 1

Affiliations 

  • 1 State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China
  • 2 School of Biotechnology, East China Science and Technology University, Shanghai, China
  • 3 Novel Bacteria and Drug Discovery Research Group (NBDD), Jeffrey Cheah School of Medicine and Health Science, Monash University Malaysia, Malaysia
  • 4 Biofunctional Molecule Exploratory Research Group (BMEX),, School of Pharmacy, Monash University Malaysia, Malaysia
  • 5 Department of Biology, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand
J Appl Microbiol, 2022 Feb;132(2):772-784.
PMID: 34260807 DOI: 10.1111/jam.15222

Abstract

Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumour cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumour agents.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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