Affiliations 

  • 1 Biotechnology Centre of Ho Chi Minh City, 176 Hai Ba Trung Street, Ho Chi Minh City, Viet Nam. Electronic address: lenacns83@yahoo.com
  • 2 PPSK, Health Campus, Universiti Sains Malaysia, Malaysia. Electronic address: sarmari14@gmail.com
  • 3 Finlay Institute, Cuba. Electronic address: rcalero@finlay.edu.cu
  • 4 Universidad de Concepcion, Chile. Electronic address: frank.camacho@gmail.com
  • 5 Universidad de Concepcion, Chile. Electronic address: fatima8526@gmail.com
  • 6 PPSK, Health Campus, Universiti Sains Malaysia, Malaysia. Electronic address: mmhossaink140@yahoo.com
  • 7 Finlay Institute, Cuba. Electronic address: gsierra@finlay.edu.cu
  • 8 PPSK, Health Campus, Universiti Sains Malaysia, Malaysia; INFORMM, Health Campus, Universiti Sains Malaysia, Malaysia. Electronic address: norazmimn@usm.my
  • 9 INFORMM, Health Campus, Universiti Sains Malaysia, Malaysia. Electronic address: ducmar13@gmail.com
Tuberculosis (Edinb), 2014 Sep;94(5):475-81.
PMID: 25034135 DOI: 10.1016/j.tube.2014.06.004

Abstract

The most important targets for vaccine development are the proteins that are highly expressed by the microorganisms during infection in-vivo. A number of Mycobacterium tuberculosis (Mtb) proteins are also reported to be expressed in-vivo at different phases of infection. In the present study, we analyzed multiple published databases of gene expression profiles of Mtb in-vivo at different phases of infection in animals and humans and selected 38 proteins that are highly expressed in the active, latent and reactivation phases. We predicted T- and B-cell epitopes from the selected proteins using HLAPred for T-cell epitope prediction and BCEPred combined with ABCPred for B-cell epitope prediction. For each selected proteins, regions containing both T- and B-cell epitopes were identified which might be considered as important candidates for vaccine design against tuberculosis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.