Multisystem inflammatory syndrome in children (MIS-C) occurring in temporal proximity between siblings

Lim L 1 , Lim SJ 2 , Loy JS 2 , Ng DC 3

Affiliations 

  • 1 Department of Paediatric Intensive Care, Hospital Melaka, Melaka, Malaysia
  • 2 Department of Paediatrics, Hospital Melaka, Melaka, Malaysia
  • 3 Department of Paediatrics, Hospital Tuanku Ja'afar Seremban, Seremban, Malaysia davidngce@gmail.com
BMJ Case Rep, 2021 Sep 16;14(9).
PMID: 34531241 DOI: 10.1136/bcr-2021-246066

Abstract

We report a pair of siblings who developed multisystem inflammatory syndrome in children (MIS-C) in close temporal proximity after recent exposure to SARS-CoV-2. Both siblings presented with Kawasaki disease-like features and haemodynamic instability, with the onset of symptoms within 6 days of each other. Remarkably, one of the siblings was the elder of a pair of monozygotic twins. The younger monozygotic twin, however, did not develop MIS-C.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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