Cholinesterase activity as a potential biomarker for neurotoxicity induced by pesticides in vivo exposed Oreochromis niloticus (Nile tilapia): assessment tool for organophosphates and synthetic pyrethroids

Amin M 1 , Yousuf M 1 , Attaullah M 2 , Ahmad N 3 , Azra MN 4 , Lateef M 5 Show all authors , Buneri ID 1 , Zekker I 6 , El-Saber Batiha G 7 , Aboelenin SM 8 , Zahoor M 9 , Ikram M 10 , Naeem M 10

Affiliations 

  • 1 Department of Zoology, University of Karachi, Karachi, Pakistan
  • 2 Department of Zoology, University of Malakand, Chakdara, Pakistan
  • 3 Department of Maritime Science, Bahria University, Karachi, Pakistan
  • 4 Institute of Tropical Aquaculture and Fisheries, Universiti Malaysia Terengganu, Terengganu, Malaysia
  • 5 Biochemistry Department, Bahria University Medical and Dental College, Karachi, Pakistan
  • 6 Institute of Chemistry, University of Tartu, Tartu, Estonia
  • 7 Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicines, Damanhour University, Damanhour, Egypt
  • 8 Biology Department, Turabah University College, Taif University, Taif, Saudi Arabia
  • 9 Department of Bio-Chemistry, University of Malakand, Khyber Pakhtunkhwa, Pakistan
  • 10 Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan
Environ Technol, 2023 Jun;44(14):2148-2156.
PMID: 34962184 DOI: 10.1080/09593330.2021.2024276

Abstract

Organophosphates (OPs) and synthetic pyrethroids (SPs) are the most popular broad spectrum pesticides, used in agriculture as they have a strong pesticidal activity while also being biodegradable in the environment. The present study aimed to demonstrate the effects of these pesticides on the Acetylcholinesterase (AChE) activity in brain, gills and body muscles of Oreochromis niloticus - an important enzyme for the assessment and biomonitoring pollution caused by neurotoxins in the environment. The fish were exposed for 24 and 48 h to the LC0 concentrations of the malathion (1.425 mg/L), the chlorpyrifos (0.125 mg/L) and the λ-cyhalothrin (0.0039 mg/L), respectively. The activity of the AChE was significantly increased (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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