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  1. Hung HY, Azman A, Jamir Singh PS
    JMIR Res Protoc, 2023 Jun 23;12:e45557.
    PMID: 37272062 DOI: 10.2196/45557
    BACKGROUND: Psychological counseling is perceived as a treatment that could significantly improve older individuals' psychological and behavioral functioning. There is a dearth of information on the impact of psychological counseling on preserving dignity and facilitating good aging among older people in Singapore.

    OBJECTIVE: The objectives of this study are as follows: (1) to assess advance care planning among older people and their perception of life and health, end of life, and end-of-life care; (2) to explore older people's accessibility and receptiveness toward counseling; (3) elucidate older people's perspectives on counseling and its impact on emotional management and decision-making; (4) to assess older people's competencies in emotional management; and (5) to propose an intervention model for enhancing older people's well-being and dignity through psychological counseling in Singapore.

    METHODS: A mixed method study design involving quantitative and qualitative methods will be used. Older individuals receiving some form of preventive, primary, or long-term care in the community through voluntary welfare organizations from the senior activity centers located in eastern Singapore participated in the qualitative phase. Six older individuals from each senior activity center have been enrolled for the interview phase to explore 6 components: the Advanced Care Planning (ACP) booklet, Trait Meta Mood Scale (TMMS), accessibility and receptiveness toward counseling, and emotional management and decision-making. The ACP, an instrument designed to assess advanced care planning among older individuals, and the TMMS, an instrument developed to measure meta-mood experience and emotional management, were used in the quantitative phase among 100 participants. The data will be analyzed thematically using NVivo version 12, whereas descriptive statistics and a 2-tailed, 1-sample t test will be conducted in SPSS (version 25; IBM Corp) for empirical data analyses.

    RESULTS: The qualitative phase, which involves a semistructured interview, has been completed among 20 older individuals aged 66-86 years. Thematic analysis of the data is still ongoing. Meanwhile, the quantitative phase commenced on March 22, 2022, with 100 participants providing signed informed consent to participate in the study. The study is expected to be completed by March 2023.

    CONCLUSIONS: The mixed methods study will document the current awareness of ACP, accessibility and receptiveness toward counseling, and the potential use of psychological counseling in enhancing well-being and dignity among older people in Singapore. The research findings will benefit policy makers in their decision-making when attempting to mitigate the potential barriers to seeking counseling assistance among older people.

    INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/45557.

  2. Soundarajan V, Nandakumal G, Dheer Singh PS
    Cureus, 2023 Oct;15(10):e46887.
    PMID: 37841982 DOI: 10.7759/cureus.46887
    In this case report, we present the rare occurrence of supernumerary extraocular muscles (SEOM) in a 35-year-old male with hyperthyroidism. SEOMs are unusual anatomical variations involving extraocular muscles that deviate from the typical muscle arrangement in the eye. While SEOMs are rare, they can have diverse clinical manifestations, including restrictive strabismus and lid abnormalities. In this case, the patient displayed right-sided lid retraction and an asymmetrical palpebral aperture, which raised concerns about a potential association with thyroid eye disease. However, imaging revealed that the SEOM was anatomically connected to the superior rectus muscle, possibly contributing to the observed lid retraction. Understanding the complexities of SEOM and its potential interactions with conditions like thyroid ophthalmopathy is crucial for accurate diagnosis and management. Further research is needed to fully comprehend the development and clinical impact of SEOMs due to their rarity and limited knowledge in the medical literature.
  3. Azman A, Jamir Singh PS, Sulaiman J
    J Ment Health, 2017 Apr;26(2):98-103.
    PMID: 26732363 DOI: 10.3109/09638237.2015.1124395
    BACKGROUND: Mental illness is a disease that affects millions of people every year. It not only causes stress to the mentally ill patients, but also for the family members who provide them the care. The family caregivers, therefore need some form of coping strategies in dealing with their mentally ill family members.

    AIMS: This qualitative study aims at identifying and analysing the coping strategies adopted by the family caregivers in dealing with their mentally ill family members.

    METHOD: A total of 15 family caregivers from the state of Kedah, Malaysia participated in the face-to-face semi structured interview.

    RESULTS: The study findings identified an array of coping strategies used by the family caregivers, including religious coping, emotional coping, acceptance, becoming engaged in leisure activities, and the use of traditional healing to help them cope with their mentally ill members. Suggestions and conclusions: Study suggests that the family caregivers should engage themselves in social support groups to learn about and obtain the positive coping strategies used by other caregivers who have similar experiences in caring for the mentally ill. Study also suggests that they should get appropriate training from the mental health professionals in order to enhance the caregivers' coping skills.

  4. Numan A, Singh PS, Alam A, Khalid M, Li L, Singh S
    ACS Omega, 2022 Aug 09;7(31):27079-27089.
    PMID: 35967060 DOI: 10.1021/acsomega.2c03645
    Efficient and simple detection of chemical warfare agents (CWAs) is an essential step in minimizing the potentially lethal consequences of chemical weapons. CWAs are a family of organic chemicals that are used as chemical weapons because of their enormous severity and lethal effects when faced with unforeseen challenges. To stop the spread of CWAs, it is critical to develop a platform that detects them in a sensitive, timely, selective, and minimally invasive manner. Rapid advances in the demand for on-site sensors, metal nanoparticles, and biomarker identification for CWAs have made it possible to use fluorescence as a precise real-time and point-of-care (POCT) testing technique. For POCT-based applications, the new capabilities of micro- and nanomotors offer enormous prospects. In recent decades, significant progress has been made in the design of fluorescent sensors and the further development of noble metal nanoparticles for the detection of organophosphorus CWAs, as described in this review. Through this work, recent attempts to fabricate sensors that can detect organophosphorus CWAs through changes in their fluorescence properties have been summarized. Finally, an integrated outlook on how noble metal nanoparticles could be used to develop smart sensors for organophosphorus CWAs that communicate with and control electronic devices to monitor and improve the health of individuals.
  5. Syasyila K, Kamaluddin MR, Abdullah Mohd Nor H, Jamir Singh PS
    PLoS One, 2025;20(7):e0327810.
    PMID: 40644474 DOI: 10.1371/journal.pone.0327810
    The prevalence of recidivism among individuals with a history of substance use and incarceration remains a significant concern for criminal justice systems worldwide. With significant social and economic ramifications, preventing people with a history of substance use from reoffending is a substantial issue. It is imperative to comprehend the complex connections between psychological and social factors to continue developing successful therapies. To better understand this complexity, this review provides a comprehensive analysis of how psychological vulnerabilities and social barriers combine to influence reoffending. Our search strategies in major databases, including Scopus, Web of Science (WoS), ScienceDirect, PubMed, and PubMed Central (PMC), yielded 34,766 results, which decreased to 858 articles after eliminating ineligible records, duplicates, and records unrelated to the language. Finally, 30 articles qualified to be included in the systematic review following PRISMA guidelines. In addition to social determinants, including family support, community impact, stigma, and peer influence, the review concentrated on psychological issues like drug abuse, dual diagnoses, and early-life adversity. The review highlights the importance of social support, with strong family and community relationships associated with reduced recidivism risk. Mental health issues, particularly those co-occurring with substance use, impede reintegration, with emotional dysregulation and poor decision-making contributing to continued criminal conduct. Other significant risk factors include involvement in a gang, trauma exposure, and a lack of rehabilitative assistance. The results highlight that recidivism is a fundamentally psychological and societal problem rather than just an individual one. Breaking reoffending cycles requires addressing these elements through comprehensive, long-term interventions. Given possible gender disparities in recidivism pathways, future systematic reviews should consider doing separate syntheses for men and women to provide more focused insights.
  6. Bai R, Dong W, Wang X, Zhang A, Santomauro DF, GBD Eating Disorders Collaborators, et al.
    JAMA Psychiatry, 2026 Oct 28.
    PMID: 42949727 DOI: 10.1001/jamapsychiatry.2026.3457
    IMPORTANCE: Eating disorders are a major cause of nonfatal mental health burden, yet global evidence on their long-term trends, geographic distribution, and future trajectories remains limited.

    OBJECTIVE: To estimate the global, regional, and national prevalence and disability burden of anorexia nervosa and bulimia nervosa-and mortality attributable to anorexia nervosa-from 1990 to 2023, and to forecast prevalence to 2050.

    DESIGN, SETTING, AND PARTICIPANTS: Using Global Burden of Disease (GBD) 2023 methods, data were synthesized from systematic literature reviews, population surveys, and vital registration systems. Estimates were produced for 204 countries and territories from 1990 to 2023, with forecasts through 2050. These data were analyzed from October 2025 to August 2026.

    EXPOSURE: Anorexia nervosa or bulimia nervosa diagnosis.

    MAIN OUTCOMES AND MEASURES: Counts and age-standardized rates with 95% uncertainty intervals (UIs) for anorexia nervosa and bulimia nervosa prevalence, years lived with disability (YLDs), and disability-adjusted life-years (DALYs), and anorexia nervosa mortality, reported by age, sex, and location.

    RESULTS: In 2023, an estimated 18.1 million people (95% UI, 13.9-24.0) globally were living with anorexia nervosa or bulimia nervosa, of whom 12.6 million (69.4%) were female, 5.5 million were male (30.6%), and 41.2% were aged 10 to 24 years. These cases accounted for 3.83 million DALYs (95% UI, 2.23-5.69). Since 1990, the global number of prevalent cases increased by 71.0%, while age-standardized prevalence and DALY rates rose by about 21%. Females experienced substantially higher prevalence and DALY rates than males. The highest age-standardized prevalence rates were observed in high-income regions, particularly Australasia and Western Europe, whereas the largest relative increases in age-standardized prevalence occurred in East Asia, South Asia, and Southeast Asia. Forecasts indicate continued increases in prevalent cases through 2050.

    CONCLUSIONS AND RELEVANCE: This GBD 2023 analysis found that anorexia nervosa and bulimia nervosa contribute substantially to global nonfatal health loss. These findings support the integration of eating disorders into mental health surveillance, prevention, and service planning worldwide.

  7. GBD 2023 LDL Cholesterol Collaborators, Razo C, DeCleene NK, Johnson CO, Stark BA, LeGrand K, et al.
    JAMA, 2026 Aug 25;336(8):673-698.
    PMID: 42525403 DOI: 10.1001/jama.2026.8628
    IMPORTANCE: Elevated low-density lipoprotein cholesterol (LDL-C) is a modifiable risk factor for cardiovascular disease, the leading cause of premature death worldwide. Assessing the LDL-C-related burden is critical for guiding prevention and treatment strategies.

    OBJECTIVES: To estimate the global, regional, and national burden of ischemic heart disease and ischemic stroke attributable to elevated LDL-C (relative to 35-54 mg/dL) from 1990 to 2023 and to quantify the contributions of population growth, aging, risk-deleted burden, and exposure changes to burden trends.

    DESIGN, SETTING, AND POPULATION: This comparative risk assessment, part of the Global Burden of Disease Study 2023, estimated population-level LDL-C exposure and associated health loss in 204 countries and territories. Mean LDL-C levels were estimated using spatiotemporal gaussian process regression based on 806 studies across 161 countries. Relative risks were derived from meta-analyses of 38 randomized clinical trials. Population-attributable fractions for deaths and disability-adjusted life-years (DALYs) were estimated by age and sex for adults aged 25 years or older from 1990 to 2023, with 95% uncertainty intervals.

    EXPOSURE: Population-level LDL-C concentrations.

    MAIN OUTCOMES AND MEASURES: Population-attributable fractions, counts, and rates (all ages and age standardized per 100 000) of LDL-C-attributable deaths and DALYs from ischemic heart disease and ischemic stroke, with uncertainty intervals.

    RESULTS: In 2023, elevated LDL-C accounted for 3.6 million deaths (95% uncertainty interval, 2.2-5.4 million; 6.0% of global mortality) and 90.7 million DALYs (95% uncertainty interval, 58.9-123.3 million; 3.2% of DALYs). Although global all-ages rates remained stable, age-standardized death and DALY rates decreased by 45.6% and 39.5%, respectively, since 1990. In 2023, age-standardized LDL-C-attributable DALY rates were highest in Eastern Europe and lowest in high-income Asia-Pacific. One-third of the global LDL-C burden occurred in India and China. Population growth and aging drove the increasing burden, with notable regional disparities in LDL-C exposure and risk-deleted DALY rates shifting toward middle-sociodemographic settings.

    CONCLUSIONS AND RELEVANCE: Despite declining age-standardized rates, the absolute LDL-C burden has increased since 1990 due to demographic changes and has shifted toward middle-sociodemographic countries. Measurement and surveillance gaps persist. Strengthened prevention, diagnosis, and treatment access strategies are essential to mitigate the health burden of LDL-C.

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