MyMedR

Ng SP, Jamil MA, Nurshaireen A, Zainul MR

Med J Malaysia, 2006 Oct;61(4):499-500.

The empty follicle syndrome (EFS) is a rare complication of in vitro fertilization (IVF) treatment, leading to cycle cancellation. Low human chorionic gonadotropin (hCG) bioavailability and ovarian dysfunction have been implicated with this condition. This case report illustrates a typical case of EFS and several strategies suggested to overcome this problem.

Matched MeSH terms: Infertility, Female/complications; Infertility, Female/therapy*

Fulltext Visual disturbances with clomiphene

Ang CS

Med J Malaysia, 2002 Jun;57(2):215-7.

PMID: 24326655

Clomiphene is a widely prescribed drug for the treatment of infertility. Visual symptoms that occur as a side effect of this drug are uncommon. Some doctors may neglect to mention this side effect when prescribing clomiphene. Thus these visual disturbances can be very alarming to the patient and may also pose a hazard if the patient is doing activities such as driving or operating machinery. The patient should be told to stop taking clomiphene and ophthalmologic evaluation should be performed. Although visual disturbances generally cease on stopping clomiphene, some women may experience persistent visual disturbances.

Matched MeSH terms: Infertility, Female*

Fulltext A retrospective review comparing the use of Gonal-F and Metrodin-HP for in-vitro fertilisation (IVF)

Lee C, Mak FS, Keith J, Welsh D, Yapp P, Chin R

Med J Malaysia, 2003 Mar;58(1):94-8.

PMID: 14556331

All cycles of IVF with pituitary down-regulation (n = 57) done at the Damansara Fertility Centre in the year 2000 were studied. All the 57 patients had controlled ovarian hyperstimulation, either using Metrodin HP (n = 27) or Gonal-F (n = 30). Of these, 53 patients reached oocyte pick-up, 26 patients in Metrodin HP group and 27 patients in Gonal-F group. Gonal-F resulted in a higher clinical pregnancy rate of 66.6% compared to Metrodin HP 38.5% (p < 0.05). The live birth rate tends to be higher in Gonal-F group (40.7%) compared to Metrodin HP (30.8%), (p > 0.05).

Matched MeSH terms: Infertility, Female/therapy*

Fulltext Efficacy of danazol treatment in infertile patients with endometriosis

Kulenthran A

Med J Malaysia, 1992 Mar;47(1):11-4.

PMID: 1387442

The study was done to assess the efficacy of danazol in the treatment of infertile patients with all stages of endometriosis. The cumulative pregnancy rates in 21 patients with Stage I and II endometriosis were compared to 21 patients with Stage III and IV endometriosis. Both groups had danazol treatment for six months. All other fertility related factors were controlled for in both groups. There was a cumulative pregnancy rate of 11% (standard error 7%) at 12 months of follow-up in the group with Stage I and II disease whilst it was 26% (standard error 10%) in the group with moderate or severe disease. These results question the validity of any classification system in prognosticating for fertility in patients with endometriosis.

Matched MeSH terms: Infertility, Female/drug therapy*

Fulltext Clomid induced combined extrauterine and intrauterine pregnancy--a case report

Ng YT, Wong WP, Puraviappan AP

Med J Malaysia, 1983 Jun;38(2):150-2.

PMID: 6621446

A 23 year old Indian lady, gravida 1 para 0, with Clomid induced pregnancy was admitted to the University Hospital on 29 August 1981 with signs and symptoms of pregnancy and intraperitoneal bleed. Period ofamenorrhoea at time of admission was eight weeks. Emergency laparotomy revealed a right leaking ectopic pregnancy and an enlarged gravid uterus. Ultrasound done on the 7th post operative day confirmed concurrent intrauterine pregnancy which progressed normally to term, ending with a normal healthy baby at 39 weeks through an assisted breech delivery.

Matched MeSH terms: Infertility, Female/drug therapy

Fulltext Bromocriptine-induced pregnancies in the amenorrhoea-galactorrhoea syndrome

Mustaffa BE, Khalid BAK, Satgunasingam N, Adeeb N, Tan PL, Chandran S

Med J Malaysia, 1983 Sep;38(3):237-43.

PMID: 6672568

13 patients with the amenorrhoea-galactorrhoea syndrome who conceived during treatment with bromocriptine were reported. Mean period of amenorrhoea was 3.0 years. In ten patients galactorrhoea was noted for a mean period of 4.2 years while in three it was discovered during examination. Seven patients presented with primary infertility. Menses returned in all cases after a mean duration of 2 months of treatment with bromocriptine at an average dose of 5. 86 mg daily. Mean serum prolactin was 4344 mUll (range 750 mU/l to 23,000 mU/l) before treatment and this declined to 186 mU/l with treatment. Seven patients became pregnant 5 to 25 months of treatment while six conceived after first menses. 21 pregnancies resulted from the thirteen patients. There was one spontaneous abortion and one premature delivery in which the baby died. Of the 16 live- births, there were twelve girls and four boys and their mean birth-weight was 2932 g. All were normal at birth and during subsequent developments except one with congenital dislocation of hip. It is concluded that bromocriptine is effective in restoring menstrual cycles and fertility by lowering serum prolactin in patients with the amenorrhoea-galactorrhoea syndrome. Bromocriptine may be safe for use during pregnancy, but it is suggested that the medication should be stopped immediately after conception unless tumour growth is apparent.

Matched MeSH terms: Infertility, Female/drug therapy

Fulltext Reproduction research and health: part III: fertility health

Sinnathuray TA

Med J Malaysia, 1980 Mar;34(3):307-13.

PMID: 7412671

The tremendous research advances in recent decades in the three widely used methods of fertility regulation (family planning), namely hormonal steroidal contraception, sterilisation and legal abortion, have been presented and discussed. The considerable health benefits accruing to the woman, in particular, and to the society, in general, from the practice of these fertility regulation methods. especially in the context of developing countries, have been reviewed. Recent research advances in the area of fertility augmentation (infertility management) have been presented and discussed. The manner in which some of the future trends in fertility regulation are likely to develop has been briefly stated.

Matched MeSH terms: Infertility, Female

Fulltext Chlamydial infection in asymptomatic infertile women

Rachagan SP, Ngeow YF

Med J Malaysia, 1990 Dec;45(4):298-303.

PMID: 2152050

Thirty-six asymptomatic infertile women undergoing laparoscopic examination as part of their infertility investigations, were included in this study on chlamydial infection. Patients were tested for chlamydial antigen in the cervix and peritoneal fluid. The serum of twenty-five of these patients was titrated for evidence of chlamydial antibodies. Fifty women attending a family planning clinic were used as a control group. The study showed a strong relationship between chlamydial infection and infertility due to tubal pathology. The incidence of chlamydial infection in asymptomatic infertile women was 33.3%. The results indicate that Chlamydia trachomatis should be sought in patients presenting with infertility and, if detected, appropriate medical treatment be given.

Matched MeSH terms: Infertility, Female/microbiology*

Fulltext Inhibition of progesterone secretion by oestradiol administered in the luteal phase of assisted conception cycles

Tay PYS, Lenton EA

Med J Malaysia, 2003 Jun;58(2):187-95.

PMID: 14569738

A prospective randomised study was done to assess the effect of supplemental oestradiol in addition to progesterone on the luteal steroid profiles and pregnancy outcome in stimulated cycles with and without pituitary down regulation. Women undergoing stimulated cycle IVF with GnRH-a and FSH (Group A, n = 63) or stimulated intrauterine insemination using CC and FSH (Group B, n = 55) were studied. These subjects were randomly allocated to receive either 400 mg daily of vaginally administrated Cyclogest (progesterone) alone or in combination with 2 mg daily of oral Oestradiol Valerate (E2V) during the luteal phase. Significant lower concentrations of plasma progesterone were observed in those subjects supplemented with both E2V and progesterone compared to those in whom progesterone only was given during the luteal phase (P < 0.05). Exogenous E2V had a minimal impact on plasma oestradiol concentrations and did not disguise the characterised mid luteal decline in oestradiol secretion. The suppressive effect of E2V on plasma progesterone was lost if implantation occurred normally because any small change in steroid concentrations was reversed by the rapidly increasing concentrations of HCG. Similar pregnancy rates were observed among subjects supplemented with or without oestradiol. The addition of oestradiol to the luteal supplement suppresses endogenous corpus luteum progesterone secretion irrespective of the type of assisted conception cycle and that its use is unlikely to be beneficial to the process of implantation.

Matched MeSH terms: Infertility, Female/blood; Infertility, Female/drug therapy*

Treatment of tubal occlusion by hydrotubation

Thambu JA

Med J Malaysia, 1978 Sep;33(1):4-6.

PMID: 750894

Matched MeSH terms: Infertility, Female/drug therapy

Certain aspects of hystero-salpingography

Peng LT, Fong TN

Med J Malaysia, 1975 Dec;30(2):121-6.

PMID: 1228377

Matched MeSH terms: Infertility, Female/diagnosis

SOME USES OF HYPNOSIS IN GYNECOLOGY

MUN CT

Med J Malaysia, 1964 Jun;18:223-5.

PMID: 14199437

Matched MeSH terms: Infertility, Female*

The use of clomiphene citrate in the treatment of infertility

Chan DP

Med J Malaya, 1970 Mar;24(3):190-3.

PMID: 4246799

Matched MeSH terms: Infertility, Female/drug therapy*

Clomiphene citrate in Asian women

Ken TP, Khin TS

Med J Malaya, 1970 Jun;24(4):297-9.

PMID: 4248351

Matched MeSH terms: Infertility, Female/drug therapy*

Endometriosis and social class

Arumugam K, Templeton AA

Med J Aust, 1990 Nov 05;153(9):567.

PMID: 2233493

Matched MeSH terms: Infertility, Female/complications

Serum prolactin levels in infertile patients with endometriosis

Arumugam K

Malays J Pathol, 1991 Jun;13(1):43-5.

PMID: 1795561

Raised prolactin levels have been implicated as a cause for infertility in patients with endometriosis. This study was done to investigate if serum prolactin levels were significantly raised in infertile patients with endometriosis. Serum prolactin levels were studied in 43 infertile patients with endometriosis. For controls, 36 infertile patients with normal pelvic findings were used. For standardization, blood samples were drawn on day 21 of the menstrual cycle. Analysis was done by radioimmunoassay using reagent kits. The mean prolactin level in the endometriotic group was 372 mIU/l (range 187-752) while that in the controls was 333 mIU/l.(range 124-767). There was no statistical difference (t = 1.12). Furthermore the accepted normal level for serum prolactin in our population is less than 540 mIU/l. These results show that there is no evidence to implicate raised prolactin levels as a cause for infertility in patients with endometriosis.

Matched MeSH terms: Infertility, Female/blood*

Fulltext Electrophoretic Techniques for the Detection of Human Microsatellite D19S884

Mansor F, Zamri L, Hamzah SS

Malays J Med Sci, 2015 Mar-Apr;22(2):18-24.

PMID: 26023291 MyJurnal

The detection and analysis of microsatellites is very important for the mapping of genetic diseases because they are commonly used as genetic markers. Microsatellite marker D19S884 has been associated with polycystic ovary syndrome (PCOS), the most common reproductive endocrine disease of women in their childbearing years. It is responsible for an estimated 70% of cases of anovulatory infertility. In this work, we detected microsatellites in DNA extracted from the blood of PCOS patients.

Matched MeSH terms: Infertility, Female

Genital tuberculosis: a new challenge in an old disease

Nissapatorn V

South. Med. J., 2008 Dec;101(12):1201.

PMID: 19005453 DOI: 10.1097/SMJ.0b013e318185a090

Matched MeSH terms: Infertility, Female/etiology*

Fulltext Salpingitis isthmica nodosa: review of four cases from the General Hospital, Kota Bharu

Sathyamoorthy P

Singapore Med J, 1994 Feb;35(1):65-6.

PMID: 8009284

Four cases of salpingitis isthmica nodosa diagnosed from a total of 82 hysterosalpingograms, over a period of three years at the General Hospital, Kota Bharu, were reviewed. The diagnosis was made based on the radiographic appearance of globules of contrast medium in the periluminal tissues which were in continuity with the lumen of the fallopian tubes. Three of these patients had ectopic pregnancy. Diagnosis of salpingitis isthmica nodosa which is readily demonstrated by hysterosalpingogram, is extremely important because of its impact on ectopic pregnancy rates. Hysterosalpingography is indicated following ectopic pregnancy to show whether there is diverticulosis of the contralateral tube. By such knowledge, optimal treatment can be offered to patients wishing to attempt further conception. As the disease is relatively localised it is amenable to resection with reimplantation of the distal portion of the tube.

Matched MeSH terms: Infertility, Female/radiography; Infertility, Female/surgery

Fulltext Cost-effectiveness of assisted reproductive technologies in Saudi Arabia: Comparing in vitro fertilization with intrauterine insemination

Almaslami F, Aljunid SM

SAGE Open Med, 2020;8:2050312120931988.

PMID: 32587695 DOI: 10.1177/2050312120931988

Objectives: The aim of this study was to compare the cost-effectiveness of in vitro fertilization and intrauterine insemination for the management of unexplained, mild male and mild female factor infertility in Saudi Arabia.

Methods: A cost-effectiveness analysis from a societal perspective was conducted for couples seeking assisted reproductive technology services between January and December 2016 in one of the largest private hospitals in Saudi Arabia. Activity-Based Costing and Step-Down Costing methodologies with expert interviews were used to compute the costs of in vitro fertilization and intrauterine insemination. A total of 710 assisted reproductive technology procedures were observed by the embryologist in charge. The costs calculated included direct and indirect costs. A cost-effectiveness analysis and a Monte Carlo simulation probabilistic sensitivity analysis were conducted.

Results: The average cost per in vitro fertilization and intrauterine insemination cycle was SR 27,360 (range: SR 19,541-29,618) and SR 10,143 (range: SR 7568-11,976), respectively, and the live birth rate per initiated in vitro fertilization and intrauterine insemination cycle was 20.7% and 7.9%, respectively, resulting in an average cost per live birth per in vitro fertilization and intrauterine insemination treatment cycle of SR 132,174 (95% confidence interval: 120,802-143,546) and SR 128,392 (95% confidence interval: 124,468-132,316), respectively. The incremental cost-effectiveness ratio was SR 134,508 per extra live birth implicit in a decision to treat with in vitro fertilization. Probabilistic sensitivity analysis confirms the robustness of the cost-effectiveness results.

Conclusion: This study found that from a societal perspective, one in vitro fertilization treatment cycle was more cost-effective than intrauterine insemination in Saudi Arabia.

Matched MeSH terms: Infertility, Female

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