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Cervical cancer prevention

Khoo EM

Family Physician, 1996;8:8-10.

Matched MeSH terms: Physicians, Family
Fulltext General practice consultations

Leong KC, Teng CL

Aust Fam Physician, 2007 Sep;36(9):679; author reply 680.
PMID: 17918303

Comment on: Cannon B, Usherwood TP. General practice consultations - how well do doctors
predict patient satisfaction? Aust Fam Physician. 2007 Mar;36(3):185-6, 192. PubMed PMID: 17339988. https://www.racgp.org.au/afp/200703/15394

Matched MeSH terms: Family Practice/standards*; Physicians, Family/psychology*
Fulltext Malay version of the family satisfaction scale: validity and reliability among Malaysian working women

Aazami S, Shamsuddin K, Akmal S

Int J Public Health Res, 2015;5(2):606-612.
MyJurnal

Introduction Family satisfaction is referred to the extent in which family members feel happy and fulfilled with each other. However, there has been lack of evidences on the family satisfaction scale within the Malaysian context. Therefore, the aim of this study was to assess validity of the Malay version of the Olson’s Family Satisfaction Scale. This is to allow Malaysian researchers to bring family satisfaction in line with the different field of studies.
Methods This study was conducted among 567 Malaysian working women. Data were collected using self-administrated questionnaires. This study conducted exploratory and confirmatory factor analysis, convergent validity and internal consistency using Cronbach’s alpha.
Results The findings of this study support the uni-dimensionality of the Malay version of the family satisfaction scale. The 10 items of the scale account for 68.1% of the total variance and the un-rotated factor loadings ranged from 0.76 to 0.87. Confirmatory factor analysis was run and supported the structure of family satisfaction scale. The results of confirmatory factor analysis using AMOS 21 in the current study reported the following indices: RMSEA= 0.06, CFI= 0.94, NFI= 0.94, TLI= 0.93. The convergent validity (average variance extracted= 0.65) and the internal consistency (Cronbach’s alpha= 0.94) of this construct were adequately supported.
Conclusions The findings support the factor structure, convergent validity and the internal consistency of the examined construct. Therefore, Malay version of the family satisfaction scale is a valid and reliable instrument among Malaysian working women.

Matched MeSH terms: Family
Fulltext Morphological characterization of the progenies of pure and reciprocal crosses of Pangasianodon hypophthalmus (Sauvage, 1878) and Clarias gariepinus (Burchell, 1822)

Okomoda TV, Koh ICC, Hassan A, Amornsakun T, Shahreza SM

Sci Rep, 2018 02 28;8(1):3827.
PMID: 29491444 DOI: 10.1038/s41598-018-22149-4

Twenty-five traditional and thirty-four geometric morphometric comparisons were carried out on pure and reciprocal crosses of Pangasianodon hypophthalmus (Sauvage, 1878) and Clarias gariepinus (Burchell, 1822). Thirty fish samples each of the C. gariepinus (CH), P. hypophthalmus (PH), Pangapinus (♀PH × ♂CG) and the two distinct morphotypes of the Clariothalmus (♀CG × ♂PH) (Clarias-like and Panga-like) between the ages of four and six months were used for this study. Phenotypically, the Clarias-like Clariothalmus and the Pangapinus progenies were indistinguishable from their maternal parents while the Panga-like Clariothalmus was a phenotypic intermediary of the putative parents but looks more closely to the paternal parent. Hence, both univariate proportion and multivariate analysis of the collected data successfully separated the different fishes into three multivariate spaces. The analysis of the dendrogram with complete linkage and Euclidean distance further showed the close relationship of the isolated Panga-like Clariothalmus progenies to the paternal parent, however, Clarias-like Clariothalmus and the Pangapinus were completely intermingled with their maternal parents. The most important index of discrimination of these fishes into different multivariate spaces was the fin characteristic which showed 100% exclusive ranges for the individual groups in many cases.

Matched MeSH terms: Family
Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective long-chain omega-3 fatty acids as the metastatic antagonists

Morshed AKMH, Al Azad S, Mia MAR, Uddin MF, Ema TI, Yeasin RB, et al.

Mol Divers, 2023 Dec;27(6):2651-2672.
PMID: 36445532 DOI: 10.1007/s11030-022-10573-8

The HER2-positive patients occupy ~ 30% of the total breast cancer patients globally where no prevalent drugs are available to mitigate the frequent metastasis clinically except lapatinib and neratinib. This scarcity reinforced researchers' quest for new medications where natural substances are significantly considered. Valuing the aforementioned issues, this research aimed to study the ERBB2-mediated string networks that work behind the HER2-positive breast cancer formation regarding co-expression, gene regulation, GAMA-receptor-signaling pathway, cellular polarization, and signal inhibition. Following the overexpression, promotor methylation, and survivability profiles of ERBB2, the super docking position of HER2 was identified using the quantum tunneling algorithm. Supramolecular docking was conducted to study the target specificity of EPA and DHA fatty acids followed by a comprehensive molecular dynamic simulation (100 ns) to reveal the RMSD, RMSF, Rg, SASA, H-bonds, and MM/GBSA values. Finally, potential drug targets for EPA and DHA in breast cancer were constructed to determine the drug-protein interactions (DPI) at metabolic stages. Considering the values resulting from the combinational models of the oncoinformatic, pharmacodynamic, and metabolic parameters, long-chain omega-3 fatty acids like EPA and DHA can be considered as potential-targeted therapeutics for HER2-positive breast cancer treatment.

Matched MeSH terms: Multigene Family
Fulltext A qualitative study of lived experiences and needs of advanced cancer patients in Malaysia: Gaps and steps forward

Yong ASJ, Cheong MWL, Hamzah E, Teoh SL

Qual Life Res, 2023 Aug;32(8):2391-2402.
PMID: 36964453 DOI: 10.1007/s11136-023-03401-5

PURPOSE: Due to the high burden of cancer-related suffering, it is paramount to understand the gaps in cancer care that lead to suffering. Advanced cancer patients have unmet needs and challenges that differ from those with early-stage cancer due to the rapid disease progression. By exploring advanced cancer patients' lived experiences and needs from the physical, psychological, social, and spiritual aspects, this study aims to identify gaps in the Malaysian health system and propose contextualised measures to improve cancer care.
METHODS: Semi-structured, in-depth interviews were conducted to explore advanced cancer patients' lived experiences and needs from the physical, psychological, social, and spiritual aspects. The interviews were then transcribed and coded. Themes were developed from the codes using iterative thematic approach.
RESULTS: The lived experiences and needs of nineteen patients converged into four major themes: disruption to daily lives, psychosocial and spiritual support system, information needs, and financial needs. This study described predominantly how cancer impacted patients' lives and livelihood, how patients coped with their psychological conditions after diagnosis, the need for effective communication and trust in a multicultural society, and how finance affected access to and experience of cancer care.
CONCLUSION: Advanced cancer patients had different needs beyond receiving medical treatments. A concerted effort is required from clinicians, allied health professionals, social workers, support groups, and family members to understand and fulfil these needs.

Matched MeSH terms: Family
Marital conflict, trauma exposure, posttraumatic stress disorder, and depressive symptoms among Malaysian firefighters

Majani AF, Ghazali SR, Yoke Yong C, Pauzi N, Adenan F, Manogaran K

Psychol Rep, 2023 Aug;126(4):1605-1619.
PMID: 35084251 DOI: 10.1177/00332941221075246

Multiple exposures to life-threatening events may lead to various mental health issues and indirectly affect the marriage of those affected. Very few studies have investigated trauma exposure, posttraumatic stress disorder (PTSD), depressive symptoms, and marital conflicts among firefighters, a group that faces such exposure occupationally. The present study explores the relationship between trauma exposure, PTSD, and depression in relation to marital conflicts among firefighters in Sarawak, adopting a cross-sectional research design. Different marital status reported significant PTSD and depressive symptoms. The widowed scored higher PTSD and depressive symptoms than the married and single groups. Firefighters with PTSD and depressive symptoms reported having more problems in aggression family history of distress, sexual dissatisfaction, and problem solving communication than those without. Regression analysis showed that problem solving communication (t (212) = 2.59, p = .01) and global distress scores (t (212) = 2.17, p < .05) in type of marital conflicts served as a significant predictor for depressive symptoms. The present study suggests that proper planning for treatment and intervention is needed to improve psychological well-being among firefighters and other high-risk professions following multiple exposures to traumatic events in carrying their job duty. Proper intervention programs also should be initiated for spouses of firefighters dealing with traumatized partners.

Matched MeSH terms: Family Conflict
Fulltext How to make the best of NLRP3 inhibitors in patients with COVID-19?

Kow CS, Ramachandram DS, Hasan SS

Eur J Clin Pharmacol, 2023 Aug;79(8):1143-1144.
PMID: 37294339 DOI: 10.1007/s00228-023-03518-z
Matched MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein
Nurse-led family-based approach in primary health care for patients with type 2 diabetes mellitus: a qualitative study

Matrook KA, Cowman S, Pertl M, Whitford D

Int J Qual Stud Health Well-being, 2024 Dec;19(1):2323060.
PMID: 38446054 DOI: 10.1080/17482631.2024.2323060

PURPOSE: The prevalence of Type 2 diabetes is rapidly increasing, with 537 million people estimated to have diabetes in 2021. The literature suggests that nurses can deliver effective person-centred diabetes care and that families can be essential in supporting patients. Thus, a Nurse-led Family-based (NLFB) approach may be particularly effective. This study aims to explore the perceptions of nurses, adults with type 2 diabetes, and family members regarding the NLFB intervention.
METHODS: Guided by the UK Medical Research Council Framework, this seminal study adopted a qualitative, descriptive approach with content analysis. Data were obtained through 16 semi-structured, in-depth interviews. Themes emerged based on an inductive process using constant comparison (Graneheim and Lundman 2004). The COREQ checklist was used in ensuring rigour.
RESULTS: Three main themes emerged includes: (1) nurses' experiences with current diabetes care practices, (2) stakeholders' views on the development of a NLFB approach, and (3) merging the nurse-led family aspects into the diabetes care. The key challenges are the dominant medical model, lack of specialist nurses, and time. The key facilitators are knowledge and social support.
CONCLUSION: The study recommends stakeholders embrace nursing empowerment strategies and involve families to enhance the nurses' advanced roles and family inclusion in healthcare.

Matched MeSH terms: Family
Fulltext Individual aspiration or family survival: rural-urban female migration in Malaysia

Kusago T

Asian Pac Migr J, 1998;7(4):483-523.
PMID: 12295220 DOI: 10.1177/011719689800700404

"This paper analyzes the determinants of female migration to export processing zones (EPZs) in Malaysia. A comparison of the individual and household migration models reveals interesting and important contrasting results. First, the role played by the expected net income gains is opposite in the two models: negative in the individual model, positive in the household model. Second, family migration experience is significant in the individual model but not in the household model. Third, attitudes matter to the household decision on a daughter's migration but not in the individual model. These contrasting results suggest that explaining the daughter's migration decision may require more than separation of the individual motives and familial needs."

Matched MeSH terms: Family Characteristics*; Family Relations; Nuclear Family*
Emotional regulation as a mediator between the filial behaviour of the oldest son and subjective well-being of older parents in Pakistan

Hassan SMU, Hamid TA, Haron SA, Ibrahim R

Psychogeriatrics, 2020 Jan;20(1):59-69.
PMID: 31016831 DOI: 10.1111/psyg.12458

BACKGROUND: The link between the filial behaviour of an adult child and older parents' well-being is well entrenched, and theoretical evidence has indicated that it may be mediated by emotional regulation. Therefore, the current study aimed to examine whether emotional regulation (i.e. cognitive reappraisal and suppression) mediates the association between filial behaviour of the oldest son (i.e. the filial behaviour of respect and filial behaviour of daily maintenance) and subjective well-being in older parents.
METHODS: This correlational study recruited 400 community-dwelling older parents in Rawalpindi Pakistan through a multistage cluster random sampling technique. Subjective well-being was measured by Concise Measure of Subjective Well-being; filial behaviour was examined through receipt of 12 domains; emotional regulation was assessed by using the Emotional Regulation Questionnaire. The structural equation modelling was employed to test the mediation effects.
RESULTS: Cognitive reappraisal was found to partially mediate the relationship between filial behaviour of respect and subjective well-being (β in direct model = 0.661, P

Matched MeSH terms: Family Characteristics/ethnology*; Family Relations/ethnology*; Family Relations/psychology*
Fulltext Family planning and contraception in Islamic countries: a critical review of the literature

Shaikh BT, Azmat SK, Mazhar A

J Pak Med Assoc, 2013 Apr;63(4 Suppl 3):S67-72.
PMID: 24386733

The population of the world reached seven billion in 2012. Pakistan's population stands at more than 180 million, is growing rapidly, and has the highest unmet need for family planning (FP) in isolated rural areas. The low usage of contraception in the rural areas of Pakistan correlates with the level of isolation, poverty, illiteracy, and to a large extent, religious misinterpretations/misconceptions. Almost 25% of couples who desired FP services were not receiving them for a variety of reasons of which religion could be one, especially in the rural remote areas where the media is still not reaching and influencing mind-sets. In this scenario, the role of social marketing in bringing about attitudinal and behavioural change among users in underserved areas and gatekeepers and opinion makers in society must not be neglected. The work in promoting FP, contraception and birth spacing requires authentic evidence from similar sociocultural contexts and this endeavour of compiling case studies from various Islamic countries on their FP initiatives is a good step. Governments around the world, including many in the Islamic world, support FP programmes to enable individuals and couples to choose the number and timing of their children.

Matched MeSH terms: Family Planning Services/organization & administration*
Pediatric palliative care: using miniature chairs to facilitate communication

Chin LE, Loong LC, Ngen CC, Beng TS, Shireen C, Kuan WS, et al.

Am J Hosp Palliat Care, 2014 Dec;31(8):833-5.
PMID: 24150973 DOI: 10.1177/1049909113509001

Good communication is essential but sometimes challenging in pediatric palliative care. We describe 3 cases whereby miniature chairs made of various materials and colors were used successfully to encourage communication among pediatric patients, family, and health care professionals. This chair-inspired model may serve as a simple tool to facilitate complex discussions and to enable self-expression by children in the pediatric palliative care setting.

Matched MeSH terms: Family/psychology
Caring for families of the terminally ill in Malaysia from palliative care nurses' perspectives

Namasivayam P, Lee S, O'Connor M, Barnett T

J Clin Nurs, 2014 Jan;23(1-2):173-80.
PMID: 23651099 DOI: 10.1111/jocn.12242

AIMS AND OBJECTIVES: To describe the process that nurses experienced in engaging with families in Malaysian palliative care settings and the challenges they faced.
BACKGROUND: In palliative care settings, nurses and the terminally ill person's family members interact very closely with each other. It is important for nurses to work with families to ensure that the care of the terminally ill person is optimised.
RESEARCH DESIGN: A qualitative design using grounded theory methods was used to describe how nurses engaged with families and the challenges they faced.
METHODS: Twenty-two nurses from home care and inpatient palliative care settings across Malaysia participated in this study. Data were collected through seven interviews and eight focus group discussions conducted between 2007-2009.
RESULTS: The main problem identified by nurses was the different expectations to patient care with families. The participants used the core process of Engaging with families to resolve these differences and implemented strategies described as Preparing families for palliative care, Modifying care and Staying engaged to promote greater consistency and quality of care. When participants were able to resolve their different expectations with families, these resulted in positive outcomes, described as Harmony. However, negative outcomes of participants not being able to resolve their different expectations with families were Disharmony.
CONCLUSIONS: This study highlights the importance of engaging and supporting families of the terminally ill as well as providing a guide that may be used by nurses and carers to better respond to families' needs and concerns.
RELEVANCE TO CLINICAL PRACTICE: The study draws attention to the need for formal palliative care education, inclusive of family care, to enable nurses to provide the terminally ill person and their family effective and appropriate care.
KEYWORDS: Malaysia; beliefs; families; grounded theory; multicultural; nurses; nursing care; palliative care; terminally ill

Matched MeSH terms: Family/psychology*
Fulltext A hybrid distance measure for clustering expressed sequence tags originating from the same gene family

Ng KH, Ho CK, Phon-Amnuaisuk S

PLoS One, 2012;7(10):e47216.
PMID: 23071763 DOI: 10.1371/journal.pone.0047216

Clustering is a key step in the processing of Expressed Sequence Tags (ESTs). The primary goal of clustering is to put ESTs from the same transcript of a single gene into a unique cluster. Recent EST clustering algorithms mostly adopt the alignment-free distance measures, where they tend to yield acceptable clustering accuracies with reasonable computational time. Despite the fact that these clustering methods work satisfactorily on a majority of the EST datasets, they have a common weakness. They are prone to deliver unsatisfactory clustering results when dealing with ESTs from the genes derived from the same family. The root cause is the distance measures applied on them are not sensitive enough to separate these closely related genes.

Matched MeSH terms: Multigene Family*
Fulltext Family support in cancer survivorship

Muhamad M, Afshari M, Kazilan F

Asian Pac J Cancer Prev, 2011;12(6):1389-97.
PMID: 22126470

This paper raises issues about the role of family members in providing support for breast cancer survivors. Data were collected from 400 breast cancer survivors in Peninsular Malaysia through a custom-designed questionnaire fielded at hospitals and support group meetings. The data were analyzed using descriptive statistics. The analyses show that all family members could be supportive, especially in decision making and help with emotional issues. The spouse was the main support provider among the family members (others were children, parents, siblings and more distant relatives). The results also indicated that a significant percentage practiced collaborative decision-making. Breast cancer survivors needed their family members' support for information on survivorship strategies such as managing emotions, health, life style and dietary practice. The family members' supportive role may be linked to the Malaysian strong family relationship culture. For family members to contribute more adequately to cancer survivorship, it is suggested that appropriate educational intervention also be provided to them.

Matched MeSH terms: Family/psychology*
Nurse-family interaction in Malaysian palliative care settings: a focused literature review

Namasivayam P, O Connor M, Barnett T, Lee S, Peters L

Int J Palliat Nurs, 2011 Oct;17(10):507-13.
PMID: 22068121 DOI: 10.12968/ijpn.2011.17.10.507

Palliative care in Malaysia developed in the 1990s to improve the quality of life of people with advanced cancer. Like many other countries, Malaysia faces its own challenges in providing palliative care to patients and their families. In Malaysian culture, families play a significant part in providing care to the dying. Connecting with families in patient care is therefore important. This paper reports a focused literature review evaluating studies on the care of the families of terminally ill people in palliative care environments in Malaysia.

Matched MeSH terms: Professional-Family Relations*
Fulltext To Share or Not to Share: Malaysian Healthcare Professionals' Views on Localized Prostate Cancer Treatment Decision Making Roles

Lee YK, Lee PY, Cheong AT, Ng CJ, Abdullah KL, Ong TA, et al.

PLoS One, 2015;10(11):e0142812.
PMID: 26559947 DOI: 10.1371/journal.pone.0142812

AIM: To explore the views of Malaysian healthcare professionals (HCPs) on stakeholders' decision making roles in localized prostate cancer (PCa) treatment.
METHODS: Qualitative interviews and focus groups were conducted with HCPs treating PCa. Data was analysed using a thematic approach. Four in-depth interviews and three focus group discussions were conducted between December 2012 and March 2013 using a topic guide. Interviews were audio-recorded, transcribed verbatim, and analysed thematically.
FINDINGS: The participants comprised private urologists (n = 4), government urologists (n = 6), urology trainees (n = 6), government policy maker (n = 1) and oncologists (n = 3). HCP perceptions of the roles of the three parties involved (HCPs, patients, family) included: HCP as the main decision maker, HCP as a guide to patients' decision making, HCP as a facilitator to family involvement, patients as main decision maker and patient prefers HCP to decide. HCPs preferred to share the decision with patients due to equipoise between prostate treatment options. Family culture was important as family members often decided on the patient's treatment due to Malaysia's close-knit family culture.
CONCLUSIONS: A range of decision making roles were reported by HCPs. It is thus important that stakeholder roles are clarified during PCa treatment decisions. HCPs need to cultivate an awareness of sociocultural norms and family dynamics when supporting non-Western patients in making decisions about PCa.

Matched MeSH terms: Family; Family Relations
Gay and lesbian couples in Malaysia

Baba I

J Homosex, 2001;40(3-4):143-63.
PMID: 11386331 DOI: 10.1300/J082v40n03_08
Matched MeSH terms: Family Characteristics*
Fulltext A comparative study on family, social supports and mental health of rural and urban Malay women

Mubarak AR

Med J Malaysia, 1997 Sep;52(3):274-84.
PMID: 10968098

The present study aims to compare the family's social environment, social supports and mental health of Malay women from rural and urban areas. Equal number (n-184) of Malay women from similar socio-economic back grounds were chosen from the rural areas of Kedah and urban areas of Pulau Pinang using the stratified random sampling method. The results indicated significantly higher level of mental health problems among the rural respondents when compared with the urban subjects. Among the family related variables included in the present study, cohesiveness, moral religious emphasis and organization and intellectual and cultural orientation were found to be significantly associated with the mental health problems of rural respondents. Whereas, only one variable, namely, active recreational orientation was found to be having an impact on the mental health of urban respondents. Similarly, deficiencies in the social support perceived from family and other members of the community were found to be significantly associated with the mental health problems of rural samples when compared to the social support perceived from the others for the urban subjects. The implications of these observations are discussed.

Matched MeSH terms: Family*

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