MyMedR

Fulltext GIFT triplets and management problems--a case report

Wong KK, Lim CT

Med J Malaysia, 1991 Sep;46(3):294-6.

Pregnancies conceived through assisted reproduction can present considerable management problems to the obstetric and paediatric staff. Multiple pregnancies are common. The complication of prematurity increases the morbidity and mortality rates of the neonates.

Matched MeSH terms: Pregnancy; Pregnancy, Multiple*

Thrombotic thrombocytopenic purpura with terminal pancytopenia

Ng SC, Adam BA

Postgrad Med J, 1990 Nov;66(781):955-7.

PMID: 2267212

A 27 year old housewife developed thrombotic thrombocytopenic purpura during the twelfth week of pregnancy. She had partial response to initial plasma infusion and subsequent plasmapheresis. However, her clinical course was complicated by the development of severe pancytopenia the consequence of a hypocellular marrow. She succumbed to septicaemic shock one month after diagnosis. The development of hypocellular marrow in thrombotic thrombocytopenic purpura has not been reported before.

Matched MeSH terms: Pregnancy; Pregnancy Complications, Hematologic*

Epidemiology of persistent hepatitis B virus infection

Lopez CG

Malays J Pathol, 1985 Aug;7:7-10.

PMID: 3843253

Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/epidemiology

Fulltext Primary ovarian pregnancy: a case report

Goh JYL, Rachagan SP, Low EC

Med J Malaysia, 1987 Mar;42(1):70-1.

PMID: 3431507

A case of an ovarian ectopic pregnancy is
presented. The diagnosis was made at laparotomy.
Histology of the surgical specimen confirmed a
primary ovarian pregnancy. The aetiologic factors
and diagnostic criteria are discussed.

Matched MeSH terms: Pregnancy; Pregnancy, Ectopic/pathology*

Fulltext A study of triplet pregnancy--a Malaysian experience

Kulenthran A, Raman S, Sinnathuray TA

Med J Malaysia, 1984 Mar;39(1):73-7.

PMID: 6513844

A retrospective study of nine consecutive cases of triplet pregnancy delivered at the University Hospital showed an incidence of one in 6,349 deliveries. In seven cases the diagnosis was suspected, and confirmed either by radiography or ultrasonography. Pre-eclampsia and polyhydramnios were common ante-natal complications. The perinatal mortality rate was 74 per thousand. Overall, the first triplet had the best outcome in terms of Apgar scores. There were no perinatal deaths in those cases that were delivered by Caesarean section.

Matched MeSH terms: Pregnancy; Pregnancy, Multiple*

Fulltext Towards safe motherhood in Malaysia

Sivanesaratnam V

Med J Malaysia, 1988 Dec;43(4):275-7.

PMID: 3241592

Matched MeSH terms: Pregnancy; Pregnancy Complications/prevention & control*

Fulltext Inadvertent posterior lower segment caesarean section in a sacculated uterus

Choong KH, Sivanesaratnam V, Sinnathuray TA

Med J Malaysia, 1981 Dec;36(4):250-3.

PMID: 7334964

Matched MeSH terms: Pregnancy; Pregnancy Complications/diagnosis*

Blood lead levels in Malaysian urban and rural pregnant women

Lim HH, Ong CN, Domala Z, Phoon WO, Khoo HE

Public Health, 1985 Jan;99(1):23-9.

PMID: 3991872

Matched MeSH terms: Pregnancy; Pregnancy Complications/blood*

Fulltext Bilateral optic neuritis in pregnancy

Suraiya MS, Norazlina B, Carmen C, Muhaya M

Med J Malaysia, 2003 Dec;58(5):771-3.

PMID: 15190668

A 25-year old primigravida at 11-weeks period of amenorrhoea presented with bilateral optic neuritis following Varicella Zoster viral (VZV) infection. She was serologically positive for systemic lupus erythematosus but negative for virus. The exact pathogenesis of the patient's severe optic neuritis, adduction and neurological deficit was unknown. The initiation of high dose steroids for optic neuritis was a big clinical dilemma in a pregnant patient with viral infection. The patient was treated with high dose steroids after three days of commencement of antiviral treatment. At 6 months after presentation, her visual acuity in the right eye was 6/36 with perception to light in the left.

Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/virology*

Anencephalic pregnancies in a Malaysian hospital

Ong HC, Singh H, Ng TK, Chong CH

Med J Malaysia, 1978 Mar;32(3):212-4.

PMID: 683044

Matched MeSH terms: Pregnancy; Pregnancy Complications/epidemiology*

Pattern of toxoplasma antibodies in Malaysian pregnant women

Cheah WC, Fah CS, Fook CW

Med J Malaysia, 1975 Jun;29(4):275-9.

PMID: 1196176

Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/immunology*

Ureteric changes during pregnancy in Asian women

Chan DP

Med J Malaya, 1969 Jun;23(4):235-8.

PMID: 4242165

Matched MeSH terms: Pregnancy; Pregnancy Complications*

Fulltext Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study

Kalok A, Ong MY, Hasrori A, Chiang KS, Yazim F, Baharuddin S, et al.

Int J Environ Res Public Health, 2020 09 24;17(19).

PMID: 32987806 DOI: 10.3390/ijerph17196990

Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period in a Malaysian tertiary center. The diagnosis of GDM was based on the National Institute for Health and Care Excellence (NICE) guideline. The data on patients' demographics, OGTT results, GDM treatment, and pregnancy outcomes were analyzed. A total of 1105 women were included in the final analysis. The percentage of women with isolated abnormal fasting glucose, isolated two-hour abnormality, and both abnormal values were 4.8%, 87.1%, and 8.1%, respectively. Women with both OGTT abnormalities had a higher risk of preeclampsia (odds ratio (OR) 4.73; 95% confidence interval (CI) 1.45-15.41) and neonatal hypoglycemia (OR 8.78; 95% CI 1.93-39.88). Isolated postprandial abnormality was associated with an 80% lesser risk of neonatal hypoglycemia (OR 0.19; 95% CI 0.04-0.87). Both isolated fasting and multiple OGTT abnormalities were associated with insulin therapy. Multiple OGTT abnormalities were a positive predictor of adverse pregnancy outcomes, while isolated postprandial abnormality was associated with a lesser risk of neonatal complication. Further prospective study is essential to validate these findings.

Matched MeSH terms: Pregnancy; Pregnancy Outcome/epidemiology

Transient blindness in pregnancy induced hypertension

Nalliah S, Thavarashah AS

Int J Gynaecol Obstet, 1989 Jul;29(3):249-51.

PMID: 2569423

Transient blindness associated with pregnancy induced hypertension without neurological symptoms is a rare phenomenon. The blindness in these cases is postulated to be of "cortical blindness". Two such cases occurring immediately after childbirth are presented. The ophthalmic manifestations of this complication of pregnancy induced hypertension and the importance of an urgent evaluation are discussed.

Matched MeSH terms: Pregnancy; Pregnancy Complications, Cardiovascular/etiology*

Fulltext The challenge in diagnosing and managing heterotopic interstitial pregnancy in natural conception

Noor Azura Noor Mohamad, Suzanna Daud, Sun Ta Thow, Darminder Singh Chopra, Bahiyah Abdullah

Journal of Clinical and Health Sciences, 2019;4(2):86-90.

MyJurnal

Heterotopic interstitial pregnancy in natural conception is very rare. Definitive diagnosis is
made by systematic pelvic ultrasound. Simultaneous viable conception observed in both intraand extra-uterine is pathognomonic of heterotopic interstitial pregnancy. We report a 34-yearold woman primigravida at 10 weeks’ amenorrhoea who underwent evacuation of retained
product of conception for missed miscarriage. Intraoperatively, minimal product of conception
was retrieved. Bedside pelvic ultrasound showed cystic mass at right superolateral part of
uterine fundus suspicious of interstitial pregnancy. Cornual resection was performed via
laparotomy. Histopathological examination showed presence of product of conception and
interstitial pregnancy. Serum β-human chorionic gonadotropin dropped from 10,027 IU/l on day
one post-ERPC to 210 IU/l at day three post-cornual resection. This case report highlighted
the challenge in diagnosing heterotopic interstitial pregnancy conceived naturally. Timely
diagnosis may avert dire consequences of massive haemorrhage from ruptured uterine cornua

Matched MeSH terms: Pregnancy; Pregnancy, Heterotopic; Pregnancy, Interstitial

Testosterone, dehydroepiandrosterone and 4-androstene-3, 17-dione concentrations in maternal and fetal plasma in the last days of ovine gestation

Colás AE, Curet LB

Biol Reprod, 1978 Apr;18(3):434-40.

PMID: 149570

Matched MeSH terms: Pregnancy; Pregnancy, Animal*

Relationship between early marriage and teenager pregnancy to stunting in toddler at Bangun Rejo Village, Tanjung Morawa District, Tanjung Morawa, Deli Serdang 2019

Pangaribuan IK, Sari I, Simbolon M, Manurung B, Ramuni K

Enferm Clin, 2020 06;30 Suppl 5:88-91.

PMID: 32713593 DOI: 10.1016/j.enfcli.2019.11.028

The brain undergoes very rapid growth and development among toddler below 5 year of age. The fault in their upbringing during this period of time will cause them to undergo growth and development disorder, and parents who get married too young early have lack of knowledge of raising their young children. As a result, the latter become vulnerable during their growth and development. The objective of the research was to analyze the correlation between early marriage and teenager pregnancy to stunting in growth among toddlers. The research used descriptive analytic method with cross-sectional design. It was conducted at Bangun Rejo Village, Tanjung Morawa District, Deli Serdang regency from June to September 2019. The population consisted of 645 toddler aged between 0 and 59 months. The sample was chosen by using systematic random sampling technique. The data were gathered by using questionnaires in order to get the information about early marriage and by conducting observation in order to find out toddler stunting. The result of univariate analysis showed that 87 (82.1%) infants had normal growth. The result of bivariate analysis, using chi-square test, showed that there was correlation between early marriage and toddler stunting, teenager pregnancy (p=0.000) and marriage age (p=0.001). The conclusion of the research was that there was correlation between early marriage and teenager pregnancy to stunting in toddler. The study showed that toddlers in case of parent with early marriage was more vulnerable to growth and development disorder. It is recommended that health service of care for adolescents and integrated monitoring of toddler be established in order to decrease the risk of incidence of early marriage and toddler stunting.

Matched MeSH terms: Pregnancy; Pregnancy in Adolescence*

Fulltext High physical activity and high sedentary behavior increased the risk of gestational diabetes mellitus among women with excessive gestational weight gain: a prospective study

Yong HY, Mohd Shariff Z, Mohd Yusof BN, Rejali Z, Bindels J, Tee YYS, et al.

BMC Pregnancy Childbirth, 2020 Oct 07;20(1):597.

PMID: 33028258 DOI: 10.1186/s12884-020-03299-8

BACKGROUND: Although physical activity (PA) in pregnancy benefits most women, not much is known about pregnancy-related changes in PA and its association with gestational diabetes mellitus (GDM) risk. The aim of this study was to identify the trajectory of PA during pregnancy and possible associations with the risk of GDM.

METHODS: This was a prospective cohort study of 452 pregnant women recruited from 3 health clinics in a southern state of Peninsular Malaysia. PA levels at the first, second, and third trimester were assessed using the Pregnancy Physical Activity Questionnaire. GDM was diagnosed at 24-28 weeks of gestation following the Ministry of Health Malaysia criteria. Group-based trajectory modeling was used to identify PA trajectories. Three multivariate logistic models were used to estimate the odds of trajectory group membership and GDM.

RESULTS: Two distinct PA trajectories were identified: low PA levels in all intensity of PA and sedentary behavior (Group 1: 61.1%, n = 276) and high PA levels in all intensity of PA as well as sedentary behavior (Group 2: 38.9%, n = 176). Moderate and high intensity PA decreased over the course of pregnancy in both groups. Women in group 2 had significantly higher risk of GDM in two of the estimated logistic models. In all models, significant associations between PA trajectories and GDM were only observed among women with excessive gestational weight gain in the second trimester.

CONCLUSIONS: Women with high sedentary behavior were significantly at higher risk of GDM despite high PA levels by intensity and this association was significant only among women with excessive GWG in the second trimester. Participation in high sedentary behavior may outweigh the benefit of engaging in high PA to mitigate the risk of GDM.

Matched MeSH terms: Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third

Fulltext A Qualitative Study to Explore the Barriers for Nonadherence to Referral to Hospital Births by Women with High-Risk Pregnancies in Nepal

Rajbanshi S, Norhayati MN, Nik Hazlina NH

Int J Environ Res Public Health, 2021 05 28;18(11).

PMID: 34071394 DOI: 10.3390/ijerph18115801

Maternal and neonatal morbidity and mortality tend to decrease if referral advice during pregnancy is utilized appropriately. This study explores the reasons for nonadherence to referral advice among high-risk pregnant women. A qualitative study was conducted in Morang District, Nepal. A phenomenological inquiry was used. Fourteen participants were interviewed in-depth. High-risk women who did not comply with the referral to have a hospital birth were the study participants. Participants were chosen purposively until data saturation was achieved. The data were generated using thematic analysis. Preference of homebirth, women's diminished autonomy and financial dependence, conditional factors, and sociocultural factors were the four major themes that hindered hospital births. Women used antenatal check-ups to reaffirm normalcy in their current pregnancies to practice homebirth. For newly-wed young women, information barriers such as not knowing where to seek healthcare existed. The poorest segments and marginalized women did not adhere to referral hospital birth advice even when present with high-risk factors in pregnancy. Multiple factors, including socioeconomic and sociocultural factors, affect women's decision to give birth in the referral hospital. Targeted interventions for underprivileged communities and policies to increase facility-based birth rates are recommended.

Matched MeSH terms: Pregnancy; Pregnancy, High-Risk*

Fulltext Tubal Ectopic Pregnancy: Do Our Women Benefit From Laparoscopic Surgery?

Lim, K.J., Omar, M.H., Jamil, M.A., Ng, S.P.

International Medical Journal Malaysia, 2006;5(2):1-8.

MyJurnal

Introduction: Operative laparoscopy is the gold standard approach for treatment of tubal pregnancy. Although benefits of this approach are well established, data on its uptake trend in Malaysia is largely unknown. Objective: This study aims to determine the operative laparoscopy uptake in management of tubal pregnancy at a busy tertiary hospital and whether the benefits associated with laparoscopic surgery was achieved. Materials and Methods: This prospective observational study was conducted on all women admitted for tubal pregnancy at Hospital Sultanah Aminah, Johor Bahru, a public tertiary hospital over a period of 12 months. The on-call team was responsible for the surgical approach. Patient’s clinical presentation, operative laparoscopic uptake, factors affecting the choice of approach and duration of hospitalization were analyzed. Results: The tubal pregnancy rate was 7.6 per 1000 deliveries. Twenty- seven of the 138 cases (20%) had hypovolemic shock, requiring urgent laparotomy and were excluded from study. The operative laparoscopy rate for stable tubal pregnancy was only 42.3% (47 of 111 cases). Women managed laparoscopically were associated with a significantly higher pre-operative hemoglobin level, mostly nullipara and had surgery performed during office hours. They waited longer for their surgery but were discharged earlier compared to the laparotomy group. There was no difference in the duration of hospitalization. Conclusions: Less than half of all hemodynamically stable tubal pregnancies in our hospital had operative laparoscopy. The current laparoscopy uptake rate can be further improved.

Matched MeSH terms: Pregnancy; Pregnancy, Tubal; Pregnancy Rate

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