Displaying publications 301 - 320 of 5419 in total

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  1. Ong SG
    Malays Fam Physician, 2013;8(3):31-3.
    PMID: 25893055 MyJurnal
    Tendon rupture is a rare complication that occurs in patients receiving corticosteroid therapy. We report a case of a middle-aged man with mixed connective tissue disease who presented with spontaneous biceps tendon rupture 5 weeks after initiation of high-dose corticosteroid therapy. Musculoskeletal ultrasonography was performed at the clinic and helped to confirm the diagnosis. It is a new imaging modality that is increasingly used in rheumatology clinics in Malaysia as it serves as an extension to physical examination. Musculoskeletal ultrasonography is preferred by patients as it is noninvasive, does not involve ionising radiation, painless, relatively inexpensive and can be performed readily at the clinic.
    KEYWORDS: corticosteroid; musculoskeletal ultrasonography; tendon rupture
    Matched MeSH terms: Mixed Connective Tissue Disease*
  2. MAHONY BJ, MORAN JG
    J R Army Med Corps, 1964;110:13-4.
    PMID: 14125191
    Matched MeSH terms: Disease Outbreaks*
  3. CAMERON JA
    Med J Malaya, 1955 Sep;10(1):48-59.
    PMID: 13287495
    Matched MeSH terms: Disease Management*
  4. Liew SM, Hussein N, Hanafi NS, Pinnock H, Sheikh A, Khoo EM
    Lancet Respir Med, 2018 Aug;6(8):590.
    PMID: 30006073 DOI: 10.1016/S2213-2600(18)30297-2
    Matched MeSH terms: Pulmonary Disease, Chronic Obstructive/prevention & control*
  5. Lim SY, Tan AH, Fox SH, Evans AH, Low SC
    Curr Neurol Neurosci Rep, 2017 01;17(1):3.
    PMID: 28102483 DOI: 10.1007/s11910-017-0717-2
    Parkinson's disease (PD) is a complex motor and non-motor disorder and management is often challenging. In this review, we explore emerging approaches to improve the care of patients, drawing from the literature regarding patient-centred care, patient and caregiver perspectives and priorities, gaps in knowledge among patients and caregivers and the need for accurate information, individual variability in disease manifestations, prognostication of disease course, new developments in health technologies and personalized medicine, specialty care, pharmacological and non-pharmacological management, financial burden, lifestyle and work-related issues, support groups and palliative care.
    Matched MeSH terms: Parkinson Disease/therapy*
  6. Lee ZY, Heyland DK
    Nutr Clin Pract, 2019 Feb;34(1):96-111.
    PMID: 30468264 DOI: 10.1002/ncp.10214
    The stress catabolism state predisposes critically ill patients to a high risk of malnutrition. This, coupled with inadequate or delayed nutrition provision, will lead to further deterioration of nutrition status. Preexisting malnutrition and iatrogenic underfeeding are associated with increased risk of adverse complications. Therefore, accurate detection of patients who are malnourished and/or with high nutrition risk is important for timely and optimal nutrition intervention. Various tools have been developed for nutrition screening and assessment for hospitalized patients, but not all are studied or validated in critically ill populations. In this review article, we consider the pathophysiology of malnutrition in critical illness and the currently available literature to develop recommendations for nutrition screening and assessment. We suggest the use of the (modified) Nutrition Risk in the Critically Ill (mNUTRIC) for nutrition risk screening and the subjective global assessment (SGA) together with other criteria relevant to the critically ill patients, such as gastrointestinal function, risk of aspiration, determination of sarcopenia and frailty, and risk of refeeding syndrome for nutrition assessment. Further research is needed to identify suitable nutrition monitoring indicators to determine the response to the provision of nutrition.
    Matched MeSH terms: Disease Susceptibility; Iatrogenic Disease
  7. Minhat Halimatus Sakdiah, Liyana Najwa Inche Mat, Abdul Syafiq A. Radzis, Ng, Yiet Fai, Nur Syazwany Nasir Khan
    Int J Public Health Res, 2018;8(1):894-898.
    MyJurnal
    Introduction Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD) and the most frequent sub-cortical degenerative disease, characterized by universal progressive disorder of the
    nervous system that affects movement. This cross sectional study aimed to determine the prevalence and correlates of PD among elderly attending the neurology clinic in Serdang Hospital.
    Methods A total of 150 records of patients attended the clinic from January to December 2016 were randomly selected. Data was collected using a proforma form seeking information related to age, gender, race, locality, and presence of comorbidity particularly diabetes mellitus. The data was analysed using the Statistical Package for Social Science (IBM SPSS) version 22.0.
    Results The prevalence of PD among the elderly involved in the study was 34%. Majority of the respondents were aged 60 to 70 years old (54.7%), male (53.3%), Chinese (56.7%), from urban locality (93.0%) and were not diabetic (69.3%). The inferential statistics showed no significant association between all the factors with PD. However, the associations between age and diabetes mellitus with PD were almost significant with p values of 0.07 and 0.08 respectively.
    Conclusions Overall, the prevalence of PD among elderly who attended the neurology clinic in year 2016 was less than half with none of the factors under study were significantly associated with PD. However with bigger sample size, possible significant association may be obtained between age and diabetes mellitus.

    Study site: neurology clinic in Hospital Serdang
    Matched MeSH terms: Parkinson Disease*
  8. Maresova P, Javanmardi E, Barakovic S, Barakovic Husic J, Tomsone S, Krejcar O, et al.
    BMC Public Health, 2019 Nov 01;19(1):1431.
    PMID: 31675997 DOI: 10.1186/s12889-019-7762-5
    BACKGROUND: The phenomenon of the increasing number of ageing people in the world is arguably the most significant economic, health and social challenge that we face today. Additionally, one of the major epidemiologic trends of current times is the increase in chronic and degenerative diseases. This paper tries to deliver a more up to date overview of chronic diseases and other limitations associated with old age and provide a more detailed outlook on the research that has gone into this field.

    METHODS: First, challenges for seniors, including chronic diseases and other limitations associated with old age, are specified. Second, a review of seniors' needs and concerns is performed. Finally, solutions that can improve seniors' quality of life are discussed. Publications obtained from the following databases are used in this scoping review: Web of Science, PubMed, and Science Direct. Four independent reviewers screened the identified records and selected relevant publications published from 2010 to 2017. A total of 1916 publications were selected. In all, 52 papers were selected based on abstract content. For further processing, 21 full papers were screened."

    RESULTS: The results indicate disabilities as a major problem associated with seniors' activities of daily living dependence. We founded seven categories of different conditions - psychological problems, difficulties in mobility, poor cognitive function, falls and incidents, wounds and injuries, undernutrition, and communication problems. In order to minimize ageing consequences, some areas require more attention, such as education and training; technological tools; government support and welfare systems; early diagnosis of undernutrition, cognitive impairment, and other diseases; communication solutions; mobility solutions; and social contributions.

    CONCLUSIONS: This scoping review supports the view on chronic diseases in old age as a complex issue. To prevent the consequences of chronic diseases and other limitations associated with old age related problems demands multicomponent interventions. Early recognition of problems leading to disability and activities of daily living (ADL) dependence should be one of essential components of such interventions.

    Matched MeSH terms: Chronic Disease/epidemiology*
  9. Nor Azah Samat, Syafiqah Husna Mohd Imam Ma’arof
    Sains Malaysiana, 2016;45:1741-1745.
    Disease frequency is used to measure the situation of the disease with reference to the population size and time period
    which is in a fractional form. The lower part of the fraction, known as denominator is the important part as it was used
    to calculate a rate or ratio. Since the disease frequency is based on a ratio estimator, the results are highly dependent
    upon the value of denominator. Therefore, the main aim of this paper was to propose a new method in calculating the
    denominator for the relative risk equation with the application to chikungunya disease data from Malaysia. The new
    method of calculating the denominator of the relative risk equation includes the use of discrete time-space stochastic
    SIR-SI (susceptible-infective-recovered for human population and susceptible-infective for vector population) disease
    transmission model instead of the total disease counts. The results of the analysis showed that the estimation of expected
    disease counts based on total posterior means can overcome the problem of expected counts estimation based on the total
    number of disease especially when there is no observed disease count in certain regions. The proposed new approach to
    calculate the denominator for the relative risk equation is suitable for the case of rare disease in which it offers a better
    method of expected disease counts estimation.
    Matched MeSH terms: Disease Susceptibility; Disease Vectors
  10. Mohammed KI, Zaidan AA, Zaidan BB, Albahri OS, Alsalem MA, Albahri AS, et al.
    J Med Syst, 2019 Jun 11;43(7):223.
    PMID: 31187288 DOI: 10.1007/s10916-019-1362-x
    Remotely monitoring a patient's condition is a serious issue and must be addressed. Remote health monitoring systems (RHMS) in telemedicine refers to resources, strategies, methods and installations that enable doctors or other medical professionals to work remotely to consult, diagnose and treat patients. The goal of RHMS is to provide timely medical services at remote areas through telecommunication technologies. Through major advancements in technology, particularly in wireless networking, cloud computing and data storage, RHMS is becoming a feasible aspect of modern medicine. RHMS for the prioritisation of patients with multiple chronic diseases (MCDs) plays an important role in sustainably providing high-quality healthcare services. Further investigations are required to highlight the limitations of the prioritisation of patients with MCDs over a telemedicine environment. This study introduces a comprehensive and inclusive review on the prioritisation of patients with MCDs in telemedicine applications. Furthermore, it presents the challenges and open issues regarding patient prioritisation in telemedicine. The findings of this study are as follows: (1) The limitations and problems of existing patients' prioritisation with MCDs are presented and emphasised. (2) Based on the analysis of the academic literature, an accurate solution for remote prioritisation in a large scale of patients with MCDs was not presented. (3) There is an essential need to produce a new multiple-criteria decision-making theory to address the current problems in the prioritisation of patients with MCDs.
    Matched MeSH terms: Chronic Disease*
  11. Lim SY, Tan AH, Ahmad-Annuar A, Klein C, Tan LCS, Rosales RL, et al.
    Lancet Neurol, 2019 09;18(9):865-879.
    PMID: 31175000 DOI: 10.1016/S1474-4422(19)30195-4
    1·8 billion people of diverse ethnicities and cultures live in the Western Pacific Region. The increasing longevity of populations in this region is a major contributor to the exponential increase in Parkinson's disease prevalence worldwide. Differences exist between Parkinson's disease in the Western Pacific Region and in Europe and North America that might provide important insights into our understanding of the disease and approaches to management. For example, some genetic factors (such as LRRK2 mutations or variants) differ, environmental exposures might play differential roles in modulating the risk of Parkinson's disease, and fewer dyskinesias are reported, with some differences in the profile of non-motor symptoms and comorbidities. Gaps in awareness of the disease and inequitable access to treatments pose challenges. Further improvements in infrastructure, clinical governance, and services, and concerted collaborative efforts in training and research, including greater representation of the Western Pacific Region in clinical trials, will improve care of patients with Parkinson's disease in this region and beyond.
    Matched MeSH terms: Parkinson Disease/epidemiology*
  12. Cheow PS, Tan TK, Song AA, Yusoff K, Chia SL
    Biotechniques, 2020 02;68(2):96-100.
    PMID: 31937115 DOI: 10.2144/btn-2019-0110
    Reverse genetics has been used to generate recombinant Newcastle disease virus with enhanced immunogenic properties for vaccine development. The system, which involves co-transfecting the viral antigenomic plasmid with three helper plasmids into a T7 RNA polymerase-expressing cell to produce viral progenies, poses a great challenge. We have modified the standard transfection method to improve the transfection efficiency of the plasmids, resulting in a higher titer of virus progeny production. Two transfection reagents (i.e., lipofectamine and polyethylenimine) were used to compare the transfection efficiency of the four plasmids. The virus progenies produced were quantitated with flow cytometry analysis of the infectious virus unit. The modified transfection method increased the titer of virus progenies compared with that of the standard transfection method.
    Matched MeSH terms: Newcastle disease virus*
  13. Sayuti KA, Azizi MYSB
    BMJ Case Rep, 2020 Apr 22;13(4).
    PMID: 32327461 DOI: 10.1136/bcr-2019-234225
    We report a case of a 46-year-old woman who has presented to a peripheral hospital with progressive exertional dyspnoea and chest discomfort. The resting ECG showed features of left-sided ventricular hypertrophy. The initial chest radiograph was reported as cardiomegaly. Initial echocardiography revealed left atrial dilatation and 'left ventricular' hypertrophy with normal ejection fraction. She was treated as possible coronary artery disease and was subsequently referred to our centre for CT coronary angiography. Findings from the CT scan were consistent with congenitally corrected transposition of the great arteries (ccTGA). This report describes the radiological features of ccTGA, its associated cardiovascular anomalies, pathophysiology and potential complications.
    Matched MeSH terms: Coronary Artery Disease/complications*
  14. Chuah KH, Chan WK
    Aliment Pharmacol Ther, 2020 06;51(12):1429-1430.
    PMID: 32445522 DOI: 10.1111/apt.15700
    Matched MeSH terms: Non-alcoholic Fatty Liver Disease*
  15. Minhat HS, Kadir Shahar H
    Curr Med Res Opin, 2020 08;36(8):1309-1311.
    PMID: 32569488 DOI: 10.1080/03007995.2020.1786680
    Background: Like other affected countries around the globe, Malaysia is shocked by the Coronavirus disease 2019, which is also known as COVID-19.Aims: This commentary article discusses the COVID-19 scenario in Malaysia, particularly in relation to the sudden increase in the number of new cases related to an international mass gathering.Findings: Projection through modelling helps the relevant authorities to act quickly and effectively, including enforcement of physical and social distancing. Modelling also assists in understanding the link between the biological processes that underpin transmission events and the population-level dynamics of the disease.Conclusion: There is no one-size-fits-all approach in managing disease outbreak. The fight against COVID-19 very much depends on their attitude during the 14-day Movement Control Order (MCO) which has been extended recently.
    Matched MeSH terms: Disease Transmission, Infectious/prevention & control
  16. Huan NC, Sidhu C, Thomas R
    Clin Chest Med, 2021 12;42(4):711-727.
    PMID: 34774177 DOI: 10.1016/j.ccm.2021.08.007
    Pneumothorax is a common problem worldwide. Pneumothorax develops secondary to diverse aetiologies; in many cases, there may be no recognizable lung abnormality. The pathogenetic mechanism(s) causing spontaneous pneumothorax may be related to an interplay between lung-related abnormalities and environmental factors such as smoking. Tobacco smoking is a major risk factor for primary spontaneous pneumothorax; chronic obstructive pulmonary disease is most frequently associated with secondary spontaneous pneumothorax. This review article provides an overview of the historical perspective, epidemiology, classification, and aetiology of pneumothorax. It also aims to highlight current knowledge and understanding of underlying risks and pathophysiological mechanisms in pneumothorax development.
    Matched MeSH terms: Pulmonary Disease, Chronic Obstructive*
  17. Joshi C, Bapat R, Anderson W, Dawson D, Cherukara G, Hijazi K
    J Clin Periodontol, 2021 12;48(12):1570-1586.
    PMID: 34545592 DOI: 10.1111/jcpe.13550
    AIM: The present systematic review and meta-analysis assessed the strength of a reported association between elevated serum anti-periodontal bacterial antibody responses and coronary heart disease (CHD).

    MATERIALS AND METHODS: Twenty original studies were identified after systematically searching five databases. The majority (n = 11) compared serum anti-Porphyromonas gingivalis (Pg) and/or anti-Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti-Pg antibodies and CHD (n = 10) and serum anti-Aa antibodies and CHD (n = 6) was investigated using a meta-analysis approach separately.

    RESULTS: Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta-analyses showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD, with pooled odds ratios of 1.23 [95% confidence interval (CI): 1.09-1.38, p = .001] and 1.25 (95% CI: 1.04-1.47, p = .0004), respectively.

    CONCLUSIONS: A modest increase of CHD events in individuals with higher serum anti-Pg and anti-Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at-risk populations. However, the observed inconsistencies with the design and interpretation of immunoassays warrant standardization of the immunoassays assessing antibody responses against periodontal bacteria.

    Matched MeSH terms: Coronary Disease*
  18. Lim SY, Tan AH
    Parkinsonism Relat Disord, 2018 Jan;46 Suppl 1:S47-S52.
    PMID: 28793970 DOI: 10.1016/j.parkreldis.2017.07.029
    BACKGROUND: Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment.

    METHODS: It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital technologies - to review the strengths and weaknesses of these outcome measures.

    RESULTS: This paper discusses advances (including an enhanced understanding of PD itself, and the development of clinimetrics as a field) that have led to improvements in the COMs used in PD; their strengths and limitations; and factors to consider when selecting and using a measuring instrument.

    CONCLUSIONS: It is envisaged that in the future, a combination of COMs and technology-based objective measures will be utilized, with different methods having their own strengths and weaknesses. Judgement is required on the part of the clinician and researcher in terms of which instrument(s) are appropriate to use, depending on the particular clinical or research setting or question.

    Matched MeSH terms: Parkinson Disease/diagnosis*
  19. Narwani Hussin, Wong, Mabelle, Liew, Houng Bang, Liau, Siow Yen
    Int J Public Health Res, 2016;6(2):736-740.
    MyJurnal
    Introduction: Rheumatic Heart Disease (RHD) has been thought as a disease of poor socioeconomic status. It is more prevalent in underdeveloped and developing countries than in developed countries. It is also common among the population with multiple social issues such as overcrowded dwellings, undernutrition, poor sanitation and suboptimal medical care. This study was done to review the socio demographic profiles of RHD patients in Hospital Queen Elizabeth (HQE) II, Kota Kinabalu, Sabah.
    Methods: A secondary data review of all patients registered under the RHD registry in HQE II for one- year starting from July 2013 to June 2014.
    Results: 204 RHD patients were included. Nearly three quarter (74.0%) were female. The mean age was 40.43 (14.75) years old. 61.1% has completed secondary
    education. 42.7% were housewives. The mean monthly income was RM 1363.83 (1297.05) which was categorized under the vulnerable income group. When they were categorized under the poverty level and the vulnerable income group, 42.6% and 76.5% of them fell under those categories respectively. The nearest health facilities to their houses were district hospitals (33.3%) with the mean distance of 9.17 km and health clinics (30.8%) with the mean distance of 4.27 km. Only 11.5% of them lived near the specialist hospitals with the mean distance of 21.32 km.
    Conclusions: Results from this review suggested that majority of RHD patients were in the low socioeconomic group with less access to health care facilities with specialist care. They are the most vulnerable groups and need to be prioritized in the specialized care program. .
    Matched MeSH terms: Rheumatic Heart Disease*
  20. Abolnik C, Mubamba C, Wandrag DBR, Horner R, Gummow B, Dautu G, et al.
    Transbound Emerg Dis, 2018 Apr;65(2):e393-e403.
    PMID: 29178267 DOI: 10.1111/tbed.12771
    It is widely accepted that Newcastle disease is endemic in most African countries, but little attention has been afforded to establishing the sources and frequency of the introductions of exotic strains. Newcastle disease outbreaks have a high cost in Africa, particularly on rural livelihoods. Genotype VIIh emerged in South-East Asia and has since caused serious outbreaks in poultry in Malaysia, Indonesia, southern China, Vietnam and Cambodia. Genotype VIIh reached the African continent in 2011, with the first outbreaks reported in Mozambique. Here, we used a combination of phylogenetic evidence, molecular dating and epidemiological reports to trace the origins and spread of subgenotype VIIh Newcastle disease in southern Africa. We determined that the infection spread northwards through Mozambique, and then into the poultry of the north-eastern provinces of Zimbabwe. From Mozambique, it also reached neighbouring Malawi and Zambia. In Zimbabwe, the disease spread southward towards South Africa and Botswana, causing outbreaks in backyard chickens in early-to-mid 2013. In August 2013, the disease entered South Africa's large commercial industry, and the entire country was infected within a year, likely through fomites and the movements of cull chickens. Illegal poultry trading or infected waste from ships and not wild migratory birds was the likely source of the introduction to Mozambique in 2011.
    Matched MeSH terms: Disease Outbreaks/veterinary*; Newcastle Disease/epidemiology*; Newcastle Disease/virology; Newcastle disease virus/genetics; Newcastle disease virus/isolation & purification*
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