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Fulltext Gain and isolation enhancement of a wideband MIMO antenna using metasurface for 5G sub-6 GHz communication systems

Hasan MM, Islam MT, Samsuzzaman M, Baharuddin MH, Soliman MS, Alzamil A, et al.

Sci Rep, 2022 Jun 08;12(1):9433.
PMID: 35676407 DOI: 10.1038/s41598-022-13522-5

This work proposes a compact metasurface (MS)-integrated wideband multiple-input multiple-output (MIMO) antenna for fifth generation (5G) sub-6 GHz wireless communication systems. The perceptible novelty of the proposed MIMO system is its wide operating bandwidth, high gain, lower interelement gap, and excellent isolation within the MIMO components. The radiating patch of the antenna is truncated diagonally with a partially ground plane, and a metasurface has been employed for enhancing the antenna performance. The suggested MS integrated single antenna prototype has a miniature dimension of 0.58λ × 0.58λ × 0.02λ. The simulated and measured findings demonstrate a wideband characteristic starting from 3.11 to 7.67 GHz including a high realized gain of 8 dBi. The four-element MIMO system has been designed by rendering each single antenna orthogonally to one another while retaining compact size and wideband properties between 3.2 and 7.6 GHz. The suggested MIMO prototype has been designed and fabricated on a low loss Rogers RT5880 substrate with a miniature dimension of 1.05λ × 1.05λ × 0.02λ and its performance is evaluated using a suggested 10 × 10 array of a square enclosed circular split ring resonators within the same substrate material. The inclusion of the proposed metasurface with a backplane significantly reduces antenna backward radiation and manipulates the electromagnetic field, thus improving the bandwidth, gain and isolation of MIMO components. The suggested 4-port MIMO antenna offers a high realized gain of 8.3 dBi compared to existing MIMO antennas with an excellent average total efficiency of 82% in the 5G sub-6 GHz spectrum and is in good accordance with measured results. Furthermore, the developed MIMO antenna exhibits outstanding diversity characteristics in respect of envelope correlation coefficient (ECC) less than 0.004, diversity gain (DG) close to 10 dB (> 9.98 dB) and high isolation between MIMO components (> 15.5 dB). Therefore, the proposed MS-inspired MIMO antenna substantiates its applicability for 5G sub-6 GHz communication networks.
Fulltext Author Correction: Gain and isolation enhancement of a wideband MIMO antenna using metasurface for 5G sub-6 GHz communication systems

Hasan MM, Islam MT, Samsuzzaman M, Baharuddin MH, Soliman MS, Alzamil A, et al.

Sci Rep, 2023 Feb 16;13(1):2795.
PMID: 36797316 DOI: 10.1038/s41598-023-29750-2
Fulltext A Compact Mu-Near-Zero Metamaterial Integrated Wideband High-Gain MIMO Antenna for 5G New Radio Applications

Hasan MM, Islam MT, Rahim SKA, Alam T, Rmili H, Alzamil A, et al.

Materials (Basel), 2023 Feb 20;16(4).
PMID: 36837381 DOI: 10.3390/ma16041751

This article demonstrates a compact wideband four-port multiple-input-multiple-output (MIMO) antenna system integrated with a wideband metamaterial (MM) to reach high gain for sub-6 GHz new radio (NR) 5G communication. The four antennas of the proposed MIMO system are orthogonally positioned to the adjacent antennas with a short interelement edge-to-edge distance (0.19λmin at 3.25 GHz), confirming compact size and wideband characteristics 55.2% (3.25-5.6 GHz). Each MIMO system component consists of a fractal slotted unique patch with a transmission feed line and a metal post-encased defected ground structure (DGS). The designed MIMO system is realized on a low-cost FR-4 printed material with a miniature size of 0.65λmin × 0.65λmin × 0.02λmin. A 6 × 6 array of double U-shaped resonator-based unique mu-near-zero (MNZ) wideband metamaterial reflector (MMR) is employed below the MIMO antenna with a 0.14λmin air gap, improving the gain by 2.8 dBi and manipulating the MIMO beam direction by 60°. The designed petite MIMO system with a MM reflector proposes a high peak gain of 7.1 dBi in comparison to recent relevant antennas with high isolation of 35 dB in the n77/n78/n79 bands. In addition, the proposed wideband MMR improves the MIMO diversity and radiation characteristics with an average total efficiency of 68% over the desired bands. The stated MIMO antenna system has an outstanding envelope correlation coefficient (ECC) of <0.045, a greater diversity gain (DG) of near 10 dB (>9.96 dB), a low channel capacity loss (CCL) of <0.35 b/s/Hz and excellent multiplexing efficiency (ME) of higher than -1.4 dB. The proposed MIMO concept is confirmed by fabricating and testing the developed MIMO structure. In contrast to the recent relevant works, the proposed antenna is compact in size, while maintaining high gain and wideband characteristics, with strong MIMO performance. Thus, the proposed concept could be a potential approach to the 5G MIMO antenna system.
Fulltext Relationship between High Temperature and Formation of Chalkiness and Their Effects on Quality of Rice

Nevame AYM, Emon RM, Malek MA, Hasan MM, Alam MA, Muharam FM, et al.

Biomed Res Int, 2018;2018:1653721.
PMID: 30065932 DOI: 10.1155/2018/1653721

Occurrence of chalkiness in rice is attributed to genetic and environmental factors, especially high temperature (HT). The HT induces heat stress, which in turn compromises many grain qualities, especially transparency. Chalkiness in rice is commonly studied together with other quality traits such as amylose content, gel consistency, and protein storage. In addition to the fundamental QTLs, some other QTLs have been identified which accelerate chalkiness occurrence under HT condition. In this review, some of the relatively stable chalkiness, amylose content, and gel consistency related QTLs have been presented well. Genetically, HT effect on chalkiness is explained by the location of certain chalkiness gene in the vicinity of high-temperature-responsive genes. With regard to stable QTL distribution and availability of potential material resources, there is still feasibility to find out novel stable QTLs related to chalkiness under HT condition. A better understanding of those achievements is essential to develop new rice varieties with a reduced chalky grain percentage. Therefore, we propose the pyramiding of relatively stable and nonallelic QTLs controlling low chalkiness endosperm into adaptable rice varieties as pragmatic approach to mitigate HT effect.
Fulltext Evaluation of antioxidant compounds, antioxidant activities, and mineral composition of 13 collected purslane (Portulaca oleracea L.) accessions

Alam MA, Juraimi AS, Rafii MY, Abdul Hamid A, Aslani F, Hasan MM, et al.

Biomed Res Int, 2014;2014:296063.
PMID: 24579078 DOI: 10.1155/2014/296063

The methanolic extracts of 13 accessions of purslane were analyzed for their total phenol content (TPC), total flavonoid contents (TFC), and total carotenoid contents (TCC) and antioxidant activity of extracts was screened using FRAP assay and DPPH radical scavenging methods. The TPC, TFC, and TCC ranged from 0.96 ± 0.04 to 9.12 ± 0.29 mg GAE/g DW, 0.13 ± 0.04 to 1.44 ± 0.08 mg RE/g DW, and 0.52 ± 0.06 to 5.64 ± 0.09 mg (β-carotene equivalent) BCE/g DW, respectively. The DPPH scavenging (IC50) activity varied between 2.52 ± 0.03 mg/mL and 3.29 ± 0.01 mg/mL and FRAP ranged from 7.39 ± 0.08 to 104.2 ± 6.34 μmol TE/g DW. Among all the measured micro- and macrominerals K content was the highest followed by N, Na, Ca, Mg, P, Fe, Zn, and Mn. The overall findings proved that ornamental purslane was richer in antioxidant properties, whereas common purslane possesses more mineral contents than ornamental ones.
Fulltext Flavonoids from Tetracera indica Merr. induce adipogenesis and exert glucose uptake activities in 3T3-L1 adipocyte cells

Hasan MM, Ahmed QU, Soad SZM, Latip J, Taher M, Syafiq TMF, et al.

BMC Complement Altern Med, 2017 Aug 30;17(1):431.
PMID: 28854906 DOI: 10.1186/s12906-017-1929-3

BACKGROUND: Tetracera indica Merr. (Family: Dilleniaceae), known to the Malay as 'Mempelas paya', is one of the medicinal plants used in the treatment of diabetes in Malaysia. However, no proper scientific study has been carried out to verify the traditional claim of T. indica as an antidiabetic agent. Hence, the aims of the present study were to determine the in vitro antidiabetic potential of the T. indica stems ethanol extract, subfractions and isolated compounds.
METHODS: The ethanol extract and its subfractions, and isolated compounds from T. indica stems were subjected to cytotoxicity test using MTT viability assay on 3T3-L1 pre-adipocytes. Then, the test groups were subjected to the in vitro antidiabetic investigation using 3T3-L1 pre-adipocytes and differentiated adipocytes to determine the insulin-like and insulin sensitizing activities. Rosiglitazone was used as a standard antidiabetic agent. All compounds were also subjected to fluorescence glucose (2-NBDG) uptake test on differentiated adipocytes. Test solutions were introduced to the cells in different safe concentrations as well as in different adipogenic cocktails, which were modified by the addition of compounds to be investigated and in the presence or absence of insulin. Isolation of bioactive compounds from the most effective subfraction (ethyl acetate) was performed through repeated silica gel and sephadex LH-20 column chromatographies and their structures were elucidated through (1)H-and (13)C-NMR spectroscopy.
RESULTS: Four monoflavonoids, namely, wogonin, norwogonin, quercetin and techtochrysin were isolated from the T. indica stems ethanol extract. Wogonin, norwogonin and techtochrysin induced significant (P
Fulltext Global and local mutations in Bangladeshi SARS-CoV-2 genomes

Hasan MM, Das R, Rasheduzzaman M, Hussain MH, Muzahid NH, Salauddin A, et al.

Virus Res, 2021 May;297:198390.
PMID: 33737154 DOI: 10.1016/j.virusres.2021.198390

Coronavirus Disease 2019 (COVID-19) warrants comprehensive investigations of publicly available Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genomes to gain new insight about their epidemiology, mutations, and pathogenesis. Nearly 0.4 million mutations have been identified so far among the ∼60,000 SARS-CoV-2 genomic sequences. In this study, we compared a total of 371 SARS-CoV-2 published whole genomes reported from different parts of Bangladesh with 467 sequences reported globally to understand the origin of viruses, possible patterns of mutations, and availability of unique mutations. Phylogenetic analyses indicated that SARS-CoV-2 viruses might have transmitted through infected travelers from European countries, and the GR clade was found as predominant in Bangladesh. Our analyses revealed 4604 mutations at the RNA level including 2862 missense mutations, 1192 synonymous mutations, 25 insertions and deletions and 525 other types of mutation. In line with the global trend, D614G mutation in spike glycoprotein was predominantly high (98 %) in Bangladeshi isolates. Interestingly, we found the average number of mutations in ORF1ab, S, ORF3a, M, and N were significantly higher (p < 0.001) for sequences containing the G614 variant compared to those having D614. Previously reported frequent mutations, such as R203K, D614G, G204R, P4715L and I300F at protein levels were also prevalent in Bangladeshi isolates. Additionally, 34 unique amino acid changes were revealed and categorized as originating from different cities. These analyses may increase our understanding of variations in SARS-CoV-2 virus genomes, circulating in Bangladesh and elsewhere.
Multilevel Pharmacological Effects of Antipsychotics in Potential Glioblastoma Treatment

Awuah WA, Kalmanovich J, Mehta A, Huang H, Abdul-Rahman T, Cheng Ng J, et al.

Curr Top Med Chem, 2023;23(5):389-402.
PMID: 36593538 DOI: 10.2174/1568026623666230102095836

Glioblastoma Multiforme (GBM) is a debilitating type of brain cancer with a high mortality rate. Despite current treatment options such as surgery, radiotherapy, and the use of temozolomide and bevacizumab, it is considered incurable. Various methods, such as drug repositioning, have been used to increase the number of available treatments. Drug repositioning is the use of FDA-approved drugs to treat other diseases. This is possible because the drugs used for this purpose have polypharmacological effects. This means that these medications can bind to multiple targets, resulting in multiple mechanisms of action. Antipsychotics are one type of drug used to treat GBM. Antipsychotics are a broad class of drugs that can be further subdivided into typical and atypical classes. Typical antipsychotics include chlorpromazine, trifluoperazine, and pimozide. This class of antipsychotics was developed early on and primarily works on dopamine D2 receptors, though it can also work on others. Olanzapine and Quetiapine are examples of atypical antipsychotics, a category that was created later. These medications have a high affinity for serotonin receptors such as 5- HT2, but they can also act on dopamine and H1 receptors. Antipsychotic medications, in the case of GBM, also have other effects that can affect multiple pathways due to their polypharmacological effects. These include NF-B suppression, cyclin deregulation, and -catenin phosphorylation, among others. This review will delve deeper into the polypharmacological, the multiple effects of antipsychotics in the treatment of GBM, and an outlook for the field's future progression.
Fulltext Green Metallic Nanoparticles: Biosynthesis to Applications

Chopra H, Bibi S, Singh I, Hasan MM, Khan MS, Yousafi Q, et al.

Front Bioeng Biotechnol, 2022;10:874742.
PMID: 35464722 DOI: 10.3389/fbioe.2022.874742

Current advancements in nanotechnology and nanoscience have resulted in new nanomaterials, which may pose health and environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal and metal oxide nanoparticles. The primary goal is to decrease the adverse effects of synthetic processes, their accompanying chemicals, and the resulting complexes. Utilizing various biomaterials for nanoparticle preparation is a beneficial approach in green nanotechnology. Furthermore, using the biological qualities of nature through a variety of activities is an excellent way to achieve this goal. Algae, plants, bacteria, and fungus have been employed to make energy-efficient, low-cost, and nontoxic metallic nanoparticles in the last few decades. Despite the environmental advantages of using green chemistry-based biological synthesis over traditional methods as discussed in this article, there are some unresolved issues such as particle size and shape consistency, reproducibility of the synthesis process, and understanding of the mechanisms involved in producing metallic nanoparticles via biological entities. Consequently, there is a need for further research to analyze and comprehend the real biological synthesis-dependent processes. This is currently an untapped hot research topic that required more investment to properly leverage the green manufacturing of metallic nanoparticles through living entities. The review covers such green methods of synthesizing nanoparticles and their utilization in the scientific world.
Fulltext Development of a New Molecular Marker for the Resistance to Tomato Yellow Leaf Curl Virus

Nevame AYM, Xia L, Nchongboh CG, Hasan MM, Alam MA, Yongbo L, et al.

Biomed Res Int, 2018;2018:8120281.
PMID: 30105248 DOI: 10.1155/2018/8120281

Tomato yellow leaf curl virus (TYLCV) responsible for tomato yellow leaf curl disease (TYLCD) causes a substantial decrease in tomato (Solanum lycopersicum L.) yield worldwide. The use of resistant variety as a sustainable management strategy has been advocated. Tremendous progress has been made in genetically characterizing the resistance genes (R gene) in tomato. Breeding tomato for TYLCV resistance has been based mostly on Ty-3 as a race-specific resistance gene by introgression originating from wild tomato species relatives. Improvement or development of a cultivar is achievable through the use of marker-assisted selection (MAS). Therefore, precise and easy use of gene-targeted markers would be of significant importance for selection in breeding programs. The present study was undertaken to develop a new marker based on Ty-3 gene sequence that can be used for MAS in TYLCV resistant tomato breeding program. The new developed marker was named ACY. The reliability and accuracy of ACY were evaluated against those of Ty-3 linked marker P6-25 through screening of commercial resistant and susceptible tomato hybrids, and genetic segregation using F2 population derived from a commercial resistant hybrid AG208. With the use of bioinformatics and DNA sequencing analysis tools, deletion of 10 nucleotides was observed in Ty-3 gene sequence for susceptible tomato variety. ACY is a co-dominant indel-based marker that produced clear and strong polymorphic band patterns for resistant plant distinguishing it from its susceptible counterpart. The obtained result correlates with 3:1 segregation ratio of single resistant dominant gene inheritance, which depicted ACY as gene-tag functional marker. This marker is currently in use for screening 968 hybrids varieties and one thousand breeding lines of tomato varieties stocked in Jiangsu Green Port Modern Agriculture Development Company (Green Port). So far, ACY has been used to identify 56 hybrids and 51 breeding lines. These newly detected breeding lines were regarded as potential source of resistance for tomato breeding. This work exploited the sequence of Ty-3 and subsequently contributed to the development of molecular marker ACY to aid phenotypic selection. We thus recommend this marker to breeders, which is suitable for marker-assisted selection in tomato.
Fulltext Development and Validation of an Early Scoring System for Prediction of Disease Severity in COVID-19 Using Complete Blood Count Parameters

Rahman T, Khandakar A, Hoque ME, Ibtehaz N, Kashem SB, Masud R, et al.

IEEE Access, 2021;9:120422-120441.
PMID: 34786318 DOI: 10.1109/ACCESS.2021.3105321

The coronavirus disease 2019 (COVID-19) after outbreaking in Wuhan increasingly spread throughout the world. Fast, reliable, and easily accessible clinical assessment of the severity of the disease can help in allocating and prioritizing resources to reduce mortality. The objective of the study was to develop and validate an early scoring tool to stratify the risk of death using readily available complete blood count (CBC) biomarkers. A retrospective study was conducted on twenty-three CBC blood biomarkers for predicting disease mortality for 375 COVID-19 patients admitted to Tongji Hospital, China from January 10 to February 18, 2020. Machine learning based key biomarkers among the CBC parameters as the mortality predictors were identified. A multivariate logistic regression-based nomogram and a scoring system was developed to categorize the patients in three risk groups (low, moderate, and high) for predicting the mortality risk among COVID-19 patients. Lymphocyte count, neutrophils count, age, white blood cell count, monocytes (%), platelet count, red blood cell distribution width parameters collected at hospital admission were selected as important biomarkers for death prediction using random forest feature selection technique. A CBC score was devised for calculating the death probability of the patients and was used to categorize the patients into three sub-risk groups: low (<=5%), moderate (>5% and <=50%), and high (>50%), respectively. The area under the curve (AUC) of the model for the development and internal validation cohort were 0.961 and 0.88, respectively. The proposed model was further validated with an external cohort of 103 patients of Dhaka Medical College, Bangladesh, which exhibits in an AUC of 0.963. The proposed CBC parameter-based prognostic model and the associated web-application, can help the medical doctors to improve the management by early prediction of mortality risk of the COVID-19 patients in the low-resource countries.
Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Morshed AKMH, Paul S, Hossain A, Basak T, Hossain MS, Hasan MM, et al.

Cancers (Basel), 2023 Apr 03;15(7).
PMID: 37046789 DOI: 10.3390/cancers15072128

Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and their use in cancer treatment alone, or in combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein in combination with conventional medicines have been reported, and some of them have also undergone clinical trials in later stages. As a result, we investigated the prospects of Baicalein, a naturally occurring substance extracted from the stems of Scutellaria baicalensis Georgi and Oroxylum indicum Kurz, which targets a wide range of molecular changes that are involved in cancer development. In other words, this review is primarily driven by the findings from studies of Baicalein therapy in several cancer cell populations based on promising pre-clinical research. The modifications of numerous signal transduction mechanisms and transcriptional agents have been highlighted as the major players for Baicalein's anti-malignant properties at the micro level. These include AKT serine/threonine protein kinase B (AKT) as well as PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 & 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated protein kinase (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated protein kinase (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, and Sonic hedgehog (Shh) signaling cascades. The promise of Baicalein as an anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element for treating various malignancies and its capability to inhibit malignant stem cells, evidence of synergistic effects, and design of nanomedicine-based drugs are altogether well supported by the data presented in this review study.
Fulltext Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017

James SL, Castle CD, Dingels ZV, Fox JT, Hamilton EB, Liu Z, et al.

Inj Prev, 2020 10;26(Supp 1):i96-i114.
PMID: 32332142 DOI: 10.1136/injuryprev-2019-043494

BACKGROUND: Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries.
METHODS: We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs).
FINDINGS: In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505).
INTERPRETATION: Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.

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