MyMedR

Influenza HI antibodies in dengue-positive and negative sera of febrile patients

Tan DS, Omar M, Chew V

Med J Malaysia, 1979 Jun;33(4):355-6.

PMID: 522749

Infectious mononucleosis or toxoplasmosis?

Tan DS, Zaman V, Lopes M

Med J Malaysia, 1978 Sep;33(1):23-5.

PMID: 750891

The role of toxoplasmosis in congenital disease in Malaysia

Tan DS, Mak JW

Southeast Asian J Trop Med Public Health, 1985 Mar;16(1):88-92.

PMID: 4023821

Toxoplasmosis was found not to be an important cause of intrauterine infection in Malaysia as the rate of toxoplasma-specific IgM in 1,060 congenitally defective Malaysian children, 0 to 4 months old (0.4%) was lower than that in 405 normal children of the same age group (2.0%). A total of 8.2 intra-uterine toxoplasmic infections per 1,000 live births was detected of which one-third (2.7 per 1,000 live births) was overt, manifesting symptoms more of liver damage, than eye or brain damage. A comparison was made with the rates in U.S.A. and Europe. The role of toxoplasmosis in abortion needs to be studied.

Enterovirus survey before and after poliomyelitis vaccination in Kuala Lumpur, Malaysia

Tan DS, Lam SK

Southeast Asian J Trop Med Public Health, 1978 Sep;9(3):301-7.

PMID: 219550

Stool samples from healthy children mainly of the low income group aged 0 to 7 years of age from five Maternal and Child Health Centres in Kuala Lumpur were obtained for isolation of enteroviruses. The specimens were collected before and after the mass vaccination given in the face of polio type 1 epidemic which started in October, 1971. The prevelance rate of enteroviruses was 11.9% (3.0% polioviruses, 8.9% non-polio enteroviruses) before the vaccination and essentially the same after. Coxsackie A viruses predominated over the other enteroviruses in the pre- and post-vaccination phases. The highest isolation rate of enteroviruses was observed in children 0 to 2 years age. No significant differences in distribution by sex, race and month were noted. A sharp fall in the prevalence rates of total enteroviruses and polioviruses was noted shortly after the mass vaccination campaign However, the rates reverted to the pre-vaccination state during the next successive years.

An outbreak of acute conjunctivitis caused by coxsackievirus A24 in Kuala-Lumpur, Malaysia, 1978

Tan DS, Yin-Murphy M, Kandiah S

Southeast Asian J Trop Med Public Health, 1980 Mar;11(1):24-7.

PMID: 6250226

An investigation of an outbreak of acute conjunctivitis in Kuala Lumpur from May to August 1978 was made. A total of 2,133 cases was involved, most of whom were adult Malay males of low income status from the surrounding villages and low-cost flats. The majority of cases had bilateral conjunctivitis with clear discharge. Pain and subconjunctival haemorrhage were not common and recovery, mostly without complications, occurred within 1 week. Eye scrapings and paired sera specimens were examined and the causal agent was found to be Coxsackievirus A24 (CA24).

Evaluation of Leptospira biflexa antigens for screening human sera by the microscopic agglutination (MA) test in comparison with the sensitized-erythrocyte-lysis (SEL) test

Tan DS, Welch QB

Southeast Asian J Trop Med Public Health, 1974 Mar;5(1):12-6.

PMID: 4839075

A preliminary study of the status of leptospirosis in the Malaysian Armed forces

Tan DS, Lopes DA

Southeast Asian J Trop Med Public Health, 1972 Jun;3(2):208-11.

PMID: 5082848

Assay of 3-hydroxy-3-methylglutaryl CoA reductase activity using anionic-exchange column chromatography

Ong KK, Khor HT, Tan DT

Anal Biochem, 1991 Aug 01;196(2):211-4.

PMID: 1776669

A rapid, easy, and sensitive method is described in this paper for the assay of 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase, a key enzyme in cholesterol biosynthesis. [14C]HMG CoA was used as the substrate and the product formed, i.e., [14C]mevalonate, was allowed to be converted to its lactone form (mevalonolactone) in the presence of HCl. The reaction mixture was applied to a column containing an anionic exchanger. The column was made up of QAE-Sephadex (A25, formate form) packed to a height of 4 cm in Pasteur pipets. Under these conditions, mevalonolactone was not retained by the column and was eluted with ammonium formate solution while HMG CoA, being negatively charged, was retained by the gel and eluted by HCl above 0.05 M. Determination of the amount of radioactivity in mevalonolactone was then used to quantitate the activity of HMG CoA reductase. This assay has been successfully used for determining the activity of this enzyme in a microsomal fraction prepared from the liver of the rat.

An outbreak of rabies in West malaysia in 1970 with unusual laboratory observations

Tan DS, Ariff AW, Mohamed Noordin Keling

Med J Malaya, 1972 Dec;27(2):107-14.

PMID: 4268035

Pathogenicity and molecular analysis of an infectious bursal disease virus isolated from Malaysian village chickens

Tan DY, Hair-Bejo M, Omar AR, Aini I

Avian Dis, 2004 Apr-Jun;48(2):410-6.

PMID: 15283430

The characteristics of the pathogenic infectious bursal disease virus (IBDV) that infected avian species other than commercial chickens were largely unknown. In this study, by using in vivo and molecular methods, we had characterized an IBDV isolate (named 94268) isolated from an infectious bursal disease (IBD) outbreak in Malaysian village chickens--the adulterated descendant of the Southeast Asian jungle fowl (Gallus bankiva) that were commonly reared in the backyard. The 94268 isolate was grouped as the very virulent IBDV (vvIBDV) strain because it caused severe lesions and a high mortality rate in village chickens (>88%) and experimentally infected specific-pathogen-free chickens (>66%). In addition, it possessed all of the vvIBDV molecular markers in its VP2 gene. Phylogenetic analysis using distance, maximum parsimony, and maximum likelihood methods revealed that 94268 was monophyletic with other vvIBDV isolates and closely related to the Malaysian vvIBDV isolates. Given that the VP2 gene of 94268 isolate was almost identical and evolutionarily closely related to other field IBDV isolates that affected the commercial chickens, we therefore concluded that IBD infections had spread across the farm boundary. IBD infection in the village chicken may represent an important part of the IBD epidemiology because these birds could harbor the vvIBDV strain and should not be overlooked in the control and prevention of the disease.

Influenza HI antibodies in pig and man in Malaysia (with special reference to swine influenza)

Tan DS, Omar M, Yap TC

Med J Malaysia, 1979 Dec;34(2):159-62.

PMID: 548720

The importance of Malaysian bats in the transmission of oral disease

Tan DS, Peck AJ, Omar M

Med J Malaya, 1969 Sep;24(1):32-5.

PMID: 4243840

A seroepidemiologic study of hepatitis A in Malaysia

Tan DS, Fang R, Collett D, Ooi BG

Southeast Asian J Trop Med Public Health, 1986 Jun;17(2):201-4.

PMID: 3538434

Sera from 494 non-icteric patients admitted with illnesses other than overt hepatitis into the various hospitals in rural and urban Malaysia were tested for IgG antibody to hepatitis A virus. The overall antibody prevalence rate was 67.0% with rates increasing steadily from childhood 10 years old and under (39.4%) to middle-age and above (96.0%). No significant differences were noted between males (68.4%) and females (65.3%). The highest rate was in the Indians (80.6%), the lowest in the Chinese (55.9%) with Malays occupying intermediate position (70.3%). The rate in the rural patients (74.7%) was higher than that in the urban patients (65.5%) especially in the 21 to 40 year age-group where the rural patients had a rate of 96.7% compared with that in urban patients (61.1%). A comparison of antibody prevalence rates in different countries was made.

Markers of hepatitis B virus infection in asymptomatic drug abusers in Malaysia

Mangalam S, Tan DS, Vijayamalar B, Collett D, Fang R

Southeast Asian J Trop Med Public Health, 1986 Jun;17(2):209-13.

PMID: 3787308

Sera from 200 Malaysian male drug abusers were tested for markers of Hepatitis B virus (HBV) infection, viz. HBsAg, HBeAg, anti-HBs and anti-HBc using commercially available enzyme immunoassay (EIA) kits supplied by Abbot Laboratories, Chicago. Of these, 103 (51.5%) were positive for at least one HBV marker, 11 (5.5%) were positive for HBsAg; 4 (2%) for HBeAg, 74 (37%) for anti-HBs and 85 (42.5%) for anti-HBc. The HBsAg carrier rate was roughly the same as the carrier rate in the general population of Malaysia. The majority of drug abusers (95%) have had subclinical, asymptomatic HBV infection. Racially the Malay drug abusers had the highest exposure rate (54.2%). The HBsAg carrier rate was highest in the Chinese drug abusers (15.3%) and lowest in the Indians (0%). The mean age for the HBsAg carriers was found to be 26 years with a mean duration of drug abuse of 72 months. The Malaysian Anti-Narcotics Task Force of the National Security Council reported in the Malay Mail (July 13, 1985) that there were about 106,000 identified drug abusers in Malaysia and that 63% of these were in the 20-29 age groups. It appears from our study that this age group also coincides with the period of high HBsAg carrier rate. Age wise, those less than 21 years old had the highest HBsAg (11%) and HBeAg (5.6%) prevalence rates indicating high infectivity. After the age of 30 years, nearly 50% of the drug abusers appear to be immune with the HBe prevalence of 0%.(ABSTRACT TRUNCATED AT 250 WORDS)

Prediction of toxicity outcomes following radiotherapy using deep learning-based models: A systematic review

Tan D, Mohd Nasir NF, Abdul Manan H, Yahya N

Cancer Radiother, 2023 Sep;27(5):398-406.

PMID: 37482464 DOI: 10.1016/j.canrad.2023.05.001

PURPOSE: This study aims to perform a comprehensive systematic review of deep learning (DL) models in predicting RT-induced toxicity.

MATERIALS AND METHODS: A literature review was performed following the PRISMA guidelines. Systematic searches were performed in PubMed, Scopus, Cochrane and Embase databases from the earliest record up to September 2022. Related studies on deep learning models for radiotherapy toxicity prediction were selected based on predefined PICOS criteria.

RESULTS: Fourteen studies of radiotherapy-treated patients on different types of cancer [prostate (n=2), HNC (n=4), liver (n=2), lung (n=4), cervical (n=1), and oesophagus (n=1)] were eligible for inclusion in the systematic review. Information regarding patient characteristics and model development was summarized. Several approaches, such as ensemble learning, data augmentation, and transfer learning, that were utilized by selected studies were discussed.

CONCLUSION: Deep learning techniques are able to produce a consistent performance for toxicity prediction. Future research using large and diverse datasets and standardization of the study methodologies are required to improve the consistency of the research output.

Fulltext Genetic characterization of porcine circovirus 2 found in Malaysia

Jaganathan S, Toung OP, Yee PL, Yew TD, Yoon CP, Keong LB

Virol J, 2011;8:437.

PMID: 21914166 DOI: 10.1186/1743-422X-8-437

Porcine circovirus type 2 is the primary etiological agent associated with a group of complex multi-factorial diseases classified as Porcine Circovirus Associated Diseases (PCVAD). Sporadic cases reported in Malaysia in 2007 caused major economic losses to the 2.2 billion Malaysian ringgit (MYR) (approximately 0.7 billion US dollar) swine industry. The objective of the present study was to determine the association between the presence of PCV2 and occurrences of PCVAD.

Vermicomposting of cattle and goat manures by Eisenia foetida and their growth and reproduction performance

Loh TC, Lee YC, Liang JB, Tan D

Bioresour Technol, 2005 Jan;96(1):111-4.

PMID: 15364088

Vermicomposting is commonly adopted for the treatment of livestock organic wastes. In the present study, two types of livestock manure were used for culturing of the earthworm, Eisenia foetida. Each treatment group consisted of six replicates and worm vermicasts were examined after 5 weeks. The concentrations of total C, P and K in goat manure vermicasts were higher than those in cattle manure vermicasts. Cattle vermicasts had a higher N content than goat vermicasts but the C:N ratio of fresh manure was higher than that of vermicasts for both materials. Earthworm biomass and reproductive performance, in terms of number of worms after 5 weeks of experiment, were higher in cattle manure than in goat manure. The cocoon production per worm in cattle manure was higher than in goat manure. However, the hatchability of cocoons was not affected by manure treatments. In conclusion, cattle manure provided a more nutritious and friendly environment to the earthworms than goat manure.

Fulltext The role of cytomegalovirus (CMV) infection in congenital diseases in Malaysia

Balasubramaniam V, Sinniah M, Tan DS, Redzwan G, Lo'man SG

Med J Malaysia, 1994 Jun;49(2):113-6.

PMID: 8090088

A previous cross-sectional serological survey of various age groups (0-55 years) of the Malaysian normal population showed that cytomegalovirus (CMV) infection is highly endemic in Malaysia. A total of 1,688 infants (0-4 months) with congenital abnormalities were screened for evidence of congenital CMV infection and the rest of the TORCHES (TOxoplasmosis, Rubella, Cytomegalovirus, HErpes simplex, Syphilis) group of congenital infections. Congenital CMV infection was detected in 193 (11.4%) infants which is significantly higher than the prevalence of congenital syphilis (4%), congenital rubella infection (3.7%), congenital toxoplasma (1.0%) and congenital herpes simplex virus infection (0%). Of the 193 cases, 10.4 per cent had CNS defects. We concluded that 1) congenital CMV appears to be the most important cause of congenital infections among the TORCHES diseases in Malaysia; and 2) secondary rather than primary infections or reactivation is responsible for most of the intrauterine CMV infection in Malaysia, as primary infection is usually associated with neurological involvement.

An outbreak of Hongkong influenza in a youth camp in West Malaysia

Tan DS, Dhillon GS, Omar M, Eapen JS

Med J Malaya, 1971 Jun;25(4):263-8.

PMID: 4261297

Poliomyelitis antibody studies in Kuala Lumpur children

Tan DS, Lim TW, Ahluwalia P, Lee GC

Med J Malaya, 1968 Jun;23(4):269-75.

PMID: 4235589

Displaying publications 21 - 40 of 71 in total