MyMedR

Intracranial calcifications. II. Pathologic anatomy

Arumugasamy N

Med J Malaya, 1966 Dec;21(2):149-60.

PMID: 4227386

Matched MeSH terms: Brain Neoplasms/pathology*

Letter to the Editor: The Coronavirus Disease 2019 Impact on Oncofertility Services in Malaysia

Ahmad MF, Abu MA, Abdul Karim AK

J Adolesc Young Adult Oncol, 2020 12;9(6):693-694.

PMID: 33090942 DOI: 10.1089/jayao.2020.0105

Matched MeSH terms: Neoplasms/pathology

Fulltext Lymphangioma of the Dorsal Tongue

Nelson BL, Bischoff EL, Nathan A, Ma L

Head Neck Pathol, 2020 Jun;14(2):512-515.

PMID: 31823215 DOI: 10.1007/s12105-019-01108-z

Lymphangiomas are rare, congenital malformations of the lymphatic system which have a marked predilection for the head and neck. In this region, they most commonly occur on the dorsum of the tongue, followed by the lips, buccal mucosa, soft palate, and floor of the mouth. Lymphangiomas of the tongue are commonly present at birth; however, they may go unnoticed until after eruption of the dentition or even puberty. They may present as a defined mass or as macroglossia with impaired speech, difficulty in mastication, and, in extreme cases, airway obstruction. Clinically, lymphagiomas of the tongue are characterized by clusters of pebbly, vesicle-like nodules. A benign proliferation of lymphatic vessels is identified histologically. A classic case of a lymphangioma of the dorsal tongue is presented.

Matched MeSH terms: Tongue Neoplasms/pathology*

Some neuropathologic aspects of intracranial sarcomas

Arumugasamy N

Med J Malaya, 1969 Mar;23(3):169-73.

PMID: 4240068

Matched MeSH terms: Brain Neoplasms/pathology*

Primary uterine angiosarcoma with "rhabdoid morphology": A case report

Gandhi JS, Kamboj M, Gupta G, Seth N

Malays J Pathol, 2018 Aug;40(2):203-207.

PMID: 30173240

INTRODUCTION: Primary uterine angiosarcoma is a very rare tumour, with only 23 cases described till now. It is a malignant tumour with cells variably recapitulating the morphologic features of an endothelium and expressing immunohistochemical markers of endothelial cells. In general, it is a bulky neoplasm and frequently is at advance stage of disease at presentation. In general, patients with uterine angiosarcoma tend to have a poorer prognosis, mostly related to the aggressive nature and the metastatic potential of these tumours.

CASE REPORT: We report a rare case of primary uterine angiosarcoma with unusual rhabdoid morphology in a 41-year-old female, who underwent radical hysterectomy and died of disease after 4 months of treatment.

DISCUSSION: We described the differential diagnosis of primary angiosarcoma of the uterus that can pose a diagnostic challenge.

Matched MeSH terms: Uterine Neoplasms/pathology*

Orbitofacial dermatofibrosarcoma protuberans with intranasal extension

Sharudin SN, Tan SW, Mohamad NF, Vasudevan SK, Khairan H, Mun YC, et al.

Orbit, 2018 Jun;37(3):196-200.

PMID: 29058523 DOI: 10.1080/01676830.2017.1383474

A 25-year-old Chinese woman presented with recurrent painless swelling over the left medial canthus region for 3 months and intranasal mass for an indeterminate duration. Initial incision biopsy of the mass was reported as nodular fasciitis but the lesion recurred 3 weeks later. Intraoperative findings during repeat biopsy showed a mass extending from the deep dermal tissue into the anterior orbit and polyp-like nasal mass. Histopathology findings were that of dermatofibrosarcoma protuberans (DFSP). The mass recurred 4 months later without orbital or intranasal recurrence. Wide excision biopsy under frozen section guidance was attempted however; clear surgical margins could not be achieved despite extensive resection. She was subsequently referred for adjuvant radiotherapy. We report an exceptionally rare case of local recurrence of DFSP in an unusual anatomic location. This case was surgically challenging in achieving negative margins, and thus neoadjuvant therapy may improve overall outcome to prevent local relapse.

Matched MeSH terms: Facial Neoplasms/pathology*; Nose Neoplasms/pathology*; Orbital Neoplasms/pathology*; Skin Neoplasms/pathology*

Fulltext A rare case of middle mediastinal thymoma mimicking left lower lobe lung tumor

Venayaga K, Ooi JSM, Shabir B

Med J Malaysia, 2005 Oct;60(4):508-10.

PMID: 16570719

Matched MeSH terms: Lung Neoplasms/pathology; Mediastinal Neoplasms/pathology; Thymus Neoplasms/pathology

Malays J Pathol, 2018 Apr;40(1):79-82.

PMID: 29704389

No abstract available.

Matched MeSH terms: Intestinal Neoplasms/pathology*; Pancreatic Neoplasms/pathology*; Stomach Neoplasms/pathology*

Composite mucinous and granulosa-theca-cell tumour of the ovary: an unusual neoplasm

Chandran R, Rahman H, Gebbie D

Aust N Z J Obstet Gynaecol, 1993 Nov;33(4):437-9.

PMID: 8179566

This case represents a unique primary ovarian tumour consisting of malignant mucinous elements and granulosa-theca-cell elements, the histogenesis of which remains uncertain. It also underscores the need for thorough sampling of mucinous tumours in order to discover a possible coexisting, different neoplastic component.

Matched MeSH terms: Liver Neoplasms/pathology; Ovarian Neoplasms/pathology*; Peritoneal Neoplasms/pathology

Malignant melanoma of the choroid in a naevus of Ota

Singh M, Kaur B, Annuar NM

Br J Ophthalmol, 1988 Feb;72(2):131-3.

PMID: 3349013

A rare case of choroidal malignant melanoma in a naevus of Ota is described. This is the first reported case from Asia outside the Japanese population. This case illustrates the need for close observation of all pigmented lesions of the eye.

Matched MeSH terms: Choroid Neoplasms/pathology*; Eye Neoplasms/pathology; Skin Neoplasms/pathology*

The Will Rogers phenomenon in the staging of breast cancer - does it matter?

Tan GH, Bhoo-Pathy N, Taib NA, See MH, Jamaris S, Yip CH

Cancer Epidemiol, 2015 Feb;39(1):115-7.

PMID: 25475062 DOI: 10.1016/j.canep.2014.11.005

Changes in the American Joint Commission on Cancer staging for breast cancer occurred when the 5th Edition was updated to the 6th Edition.

Matched MeSH terms: Breast Neoplasms/pathology*

Fulltext Evidence in support of potential applications of lipid peroxidation products in cancer treatment

Erejuwa OO, Sulaiman SA, Ab Wahab MS

Oxid Med Cell Longev, 2013;2013:931251.

PMID: 24369491 DOI: 10.1155/2013/931251

Cancer cells generate reactive oxygen species (ROS) resulting from mitochondrial dysfunction, stimulation of oncogenes, abnormal metabolism, and aggravated inflammatory activities. Available evidence also suggests that cancer cells depend on intrinsic ROS level for proliferation and survival. Both physiological and pathophysiological roles have been ascribed to ROS which cause lipid peroxidation. In spite of their injurious effects, the ROS and the resulting lipid peroxidation products could be beneficial in cancer treatment. This review presents research findings suggesting that ROS and the resulting lipid peroxidation products could be utilized to inhibit cancer growth or induce cancer cell death. It also underscores the potential of lipid peroxidation products to potentiate the antitumor effect of other anticancer agents. The review also highlights evidence demonstrating other potential applications of lipid peroxidation products in cancer treatment. These include the prospect of lipid peroxidation products as a diagnostic tool to predict the chances of cancer recurrence, to monitor treatment progress or how well cancer patients respond to therapy. Further and detailed research is required on how best to successfully, effectively, and selectively target cancer cells in humans using lipid peroxidation products. This may prove to be an important strategy to complement current treatment regimens for cancer patients.

Matched MeSH terms: Neoplasms/pathology

Fulltext Surgical management of a massive facial hemangioma

Baharudin A, Samsudin AR, Halim AS, Shafie MA

Med J Malaysia, 2007 Aug;62(3):254-5.

PMID: 18246921 MyJurnal

Hemangiomas are the most common congenital lesions in man and occur predominantly in the head and neck region. Massive hemangioma especially near vital organs or structures pose a challenge to surgeons. With the availability of expertise in embolization of feeding vessel of the hemangioma and reconstructive techniques we were able to manage successfully a complicated case of massive facial hemangioma.

Matched MeSH terms: Facial Neoplasms/pathology

Fulltext Primary Burkitt lymphoma of the ovary

Ng SP, Leong CF, Nurismah MI, Shahila T, Jamil MA

Med J Malaysia, 2006 Aug;61(3):363-5.

PMID: 17240592 MyJurnal

A 20 year-old woman presented with features of a twisted ovarian cyst and had an emergency laparotomy Intraoperative findings revealed bilateral, solid ovarian tumors and a left oophorectomy with biopsy of the contralateral ovary performed. Histopathology report confirmed Burkitt lymphoma of ovary. There was no other evidence of lymphoma elsewhere. The primary Burkitt lymphoma of the ovaries was successfully managed with six courses of highly toxic chemotherapy (Berlin-Frankfurt- Munster 1986 protocol). The patient has remained disease free for the last 36 months.

Matched MeSH terms: Ovarian Neoplasms/pathology*

An interesting case of isolated pancreatic teratoma: lessons to learn

Razman J, Azlanudin A, Eyad AJ, Zahiah M, Das S

Clin Ter, 2012 Nov;163(6):495-7.

PMID: 23306744

Mature cystic teratomas of the pancreas are extremely rare tumours encountered in day-to-day clinical practice. Only few cases have been reported to date involving all age groups. The management, diagnosis and evaluation of this tumor are questionable, with definitive diagnosis taking place intra-operatively. We hereby report the case in a 30 year-old-male who presented with newly diagnosed diabetes mellitus and during the follow up he was noted to have elevated liver enzymes clinically, he was asymptomatic. The computerized tomography revealed a retropancreatic mass and pushing the mesenteric veins anteriorly. The mass was hypodense in nature and there was presence of calcification. Although the patient was asymptomatic, the decision for resecting the mass was made in view of the size and possibility of malignancy. In conclusion, considering the size and approximity of the mass to the pancreas, Whipple procedure's is the most appropriate approach although the histological diagnosis has not been established preoperatively.

Matched MeSH terms: Pancreatic Neoplasms/pathology*

Fulltext Images in clinical medicine. Nevus comedonicus

Bhullar A, Shamsudin N

N Engl J Med, 2015 Jun 25;372(26):2541.

PMID: 26107054 DOI: 10.1056/NEJMicm1406555

Matched MeSH terms: Skin Neoplasms/pathology*

Malignant teratoma of the thyroid with predominantly neuroepithelial differentiation. Fine needle aspiration cytologic, histologic and immunocytochemical features of a case

Jayaram G, Cheah PL, Yip CH

Acta Cytol., 2000 May-Jun;44(3):375-9.

PMID: 10833994

BACKGROUND: Teratoma of the thyroid in adults is extremely rare, and most are malignant. Only nine cases have been adequately documented in the English-language literature, and there are no reports detailing the fine needle aspiration (FNA) cytologic characteristics.

CASE: A 32-year-old female presented with a left-sided nodular thyroid mass with left cervical lymphadenopathy. FNA cytology of the thyroid and lymph nodes was done. The cytologic and immunocytochemical features were that of a small round cell tumor with neuroepithelial (NE) differentiation, metastasizing to the cervical nodes. Microscopic study of the thyroidectomy specimen showed a tumor showing an NE pattern with occasional islands of squamous and cuboidal epithelium, leading to a diagnosis of malignant teratoma.

CONCLUSION: Knowledge of FNA cytologic features of rare but highly malignant lesions like thyroid teratomas allow early recognition so that suitable and possibly aggressive treatment protocols can be adopted in the hope of prolonging survival.

Matched MeSH terms: Thyroid Neoplasms/pathology*

Excision biopsy of lymph node--needle fixing technique

Arumainathan U, Kumar M, Raman R

Trop Doct, 2003 Jan;33(1):31.

PMID: 12568517

Matched MeSH terms: Otorhinolaryngologic Neoplasms/pathology*

Mucoepidermoid carcinoma of the thyroid: a case report

Jayaram G, Wong KT, Jalaludin MA

Malays J Pathol, 1998 Jun;20(1):45-8.

PMID: 10879264

Primary mucoepidermoid carcinoma (MEC) of thyroid is an uncommon tumour and reports on its' cytology are consequently scanty. A 46-year-old male presented with a thyroid nodule of nine months duration. Fine needle aspiration (FNA) cytology of the nodule showed features of a malignant tumor that was different from the usual types of thyroid carcinoma. Monolayers and syncytial clusters of round and spindle tumour cells with large vesicular nuclei and single macronucleoli were present. A diagnosis of carcinoma was given with the comment that this was unlike any of the usual types of thyroid cancer and that a metastatic malignancy should be ruled out. The cytological picture of MEC may not always be distinctive enough for accurate tumour typing. Nevertheless the cytological features are usually sufficiently different to rule out all of the usual types of thyroid carcinoma. This distinction may be important from the point of view of differing prognosis in MEC of thyroid (as compared to differentiated thyroid cancers) and the need to exclude a metastatic carcinoma, especially from a primary in one of the salivary glands.

Matched MeSH terms: Thyroid Neoplasms/pathology*

Fulltext The experience with fine needle aspiration cytology in the management of palpable breast lumps in the University Hospital Kuala Lumpur

Yip CH, Jayaram G, Alhady SF

Med J Malaysia, 2000 Sep;55(3):363-7.

PMID: 11200718

A total of 676 palpable breast lumps seen in the Breast Clinic, University Hospital, Kuala Lumpur from August 1993 to August 1994 were subjected to fine needle aspiration cytology. Fifty-four were reported as inadequate, 501 benign, 95 malignant and 26 suspicious. One hundred and eighty-seven aspirates had histological correlation, while 34 of the malignant aspirates had clinical correlation. The majority of the other 455 patients were followed up for a period of 60 to 72 months without any malignancies becoming apparent. For analysis, only the 221 cases with histological or clinical correlation were included, (the suspicious category was included into the positive group and the inadequate cases were excluded), giving a sensitivity of 91.7%, a specificity of 91.7% and a diagnostic accuracy of 91.7%. Breast cytology was an accurate and rapid method of diagnosis of breast diseases, and in a busy surgical unit with limited operating time, it allowed for the triage of patients with breast complaints in deciding which cases needed early open biopsy. A negative cytology does not exclude the possibility of cancer, as there was a false negative rate of 11%. However by utilising a diagnostic triad of clinical examination, radiological assessment and fine needle aspiration cytology, the risk of missing a malignancy is small.

Matched MeSH terms: Breast Neoplasms/pathology*

Displaying publications 21 - 40 of 1598 in total