Displaying publications 21 - 40 of 373 in total

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  1. Immunophenotyping pediatric leukemias in Kelantan, Malaysia
    Menon BS, Dasgupta A, Jackson N
    Pediatr Hematol Oncol, 1998 Mar-Apr;15(2):175-8.
    PMID: 9592844
    This study reviewed the immunophenotyping results of children with acute leukemia in Kelantan, Malaysia. In the 3.5-year period (January 1994 to June 1997), 45 cases were identified. All children were under the age of 12 years and the predominant ethnic group was Malay. Thirty-six cases (80%) were acute lymphoblastic leukemia (ALL) and 9 cases (20%) were acute myeloblastic leukemia (AML). Of the ALL cases, 3% were of B-cell and 22% of T-cell origin, and 96% of the B-lineage ALL were CD10 positive. All the AML cases expressed CD33 and 78% were positive for CD13. The incidence of mixed-lineage leukemias was 13.8% for My+ ALL and 11.1% for Ly+ AML.
    Matched MeSH terms: Burkitt Lymphoma/immunology; Leukemia-Lymphoma, Adult T-Cell/immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/ethnology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology*
  2. Fulltext Cold agglutinins in low-grade B-cell lymphoma
    Fadilah SA, Hamidah AB, Cheong SK
    Med J Malaysia, 1999 Sep;54(3):383-5.
    PMID: 11045070
    The presence of serum cold agglutinin can be the initial presentation of lymphoproliferative diseases. Conditions with persistent cold agglutinins are a spectrum of diseases that vary from benign lymphoproliferation of the "autoimmune-like chronic cold agglutinin disease" to malignant lymphoma. We report a case of a 72-year-old woman who presented with severe anaemia, hepatosplenomegaly and episodes of peripheral haemagglutination precipitated by cold exposure. The haemoglobin was 5.6 g/dL with a cold agglutinin titer of 1:256 at 4 degrees C and 1:8 at room temperature (30 degrees C). The cold agglutinin showed anti-I specificity and kappa light chain restriction. Peripheral blood showed atypical lymphoid cells with a B-cell immunophenotype. Immunoglobulin gene rearrangement study by polymerase chain reaction (PCR) showed an amplified band at 100 bp, consistent with a clonal proliferation of B-lymphocytes. We believe that our patient had cold antibody haemolytic anaemia as the initial presentation of a low-grade non-Hodgkin's lymphoma. The association of cold antibody haemolytic anaemia with low-grade B-cell lymphoma is unusual.
    Matched MeSH terms: Lymphoma, B-Cell/blood*; Lymphoma, B-Cell/complications; Lymphoma, B-Cell/genetics; Lymphoma, B-Cell/pathology
  3. Fulltext Diffuse peritoneal lymphomatosis simulating peritoneal carcinomatosis
    Sharifah MI, Zamzami NA, Rafeah TN
    Med J Malaysia, 2011 Aug;66(3):270-2.
    PMID: 22111459 MyJurnal
    Burkitt's lymphoma is a form of Non-Hodgkin's B-cell lymphoma. We report a case of Burkitt's lymphoma mimicking peritoneal carcinomatosis. We will discuss the imaging and clinical findings that differentiate between peritoneal carcinomatosis and Burkitt's lymphoma. A 26-year-old man presented with nonspecific abdominal pain, vomiting and diarrhea associated with significant amount of loss of weight. Computed tomography images showed extensive peritoneal and mesenteric mass associated generalized lymphadenopathy. Core biopsy of the mass confirmed Burkitt's lymphoma. CT scan features are helpful indicator to differentiate Burkitt's lymphoma and peritoneal carcinomatosis. Focal or diffuse nodular thickening of the bowel wall with extensive lymphadenopathy are likely to be lymphomatosis over carcinomatosis. However, final and confirmatory diagnosis is histopathology examination.
    Matched MeSH terms: Burkitt Lymphoma/diagnosis*; Burkitt Lymphoma/therapy
  4. Fulltext An unusual presentation of lymphoma of the head and neck region
    Teh CS, Chong SY
    Med J Malaysia, 2011 Aug;66(3):264-5.
    PMID: 22111456 MyJurnal
    A 33-year-old Malay lady presented to us with 1-month history of globus sensation in the throat. Clinically, she had a 3cmx2cmx1cm sessile soft mass arising from the right tongue base and was treated as hypertrophied lingual tonsil. Biopsy of the mass was done when the patient developed bleeding and was reported as diffuse non-Hodgkin's B-cell lymphoma. Globus sensation is a common complaint in the ORL clinic. It is important to be able to decide if further investigation is warranted to differentiate a malignant from a benign lesion as at times, a malignant lesion can masquerade as a harmless lesion.
    Matched MeSH terms: Lymphoma, Large B-Cell, Diffuse/diagnosis*; Lymphoma, Large B-Cell, Diffuse/therapy
  5. Primary lymphoma of the cecum: a case report
    Al Hendal A, Al Zamil A, Al Mishaan M
    Gulf J Oncolog, 2008 Jul.
    PMID: 20084779
    We report here a case of primary colorectal T-cell lymphoma of the cecum in a 30-year-old man. Patient presented with a history of abdominal pain, fever, vomiting and hematochezia. Clinical examination was unremarkable and colonoscopy showed an ulcerating mass in the colon. A right hemicolectomy with dissection of the paracolic lymph nodes was performed. The final histopathological examination showed a primary T- cell lymphoma of the cecum. Staging didn't show any involvement in any other sites of the body. Primary colon lymphoma is a rare gastrointestinal tumor that represents less than 1% of the gastrointestinal lymphomas. Peripheral T-cell lymphoma represents a relatively small proportion of lymphomas and has a lower prevalence in Western countries. The risk factors, clinical presentation, staging, prognostic factors and treatment modalities of extra-nodal lymphoma are discussed.
    Matched MeSH terms: Lymphoma, T-Cell/pathology*; Lymphoma, T-Cell/surgery
  6. Rapidly progressing tetraparesis in a young male patient with pyrexia
    Fadilah SA, Cheong SK, Raymond AA
    Postgrad Med J, 2000 Mar;76(893):170-3.
    PMID: 10684332
    Matched MeSH terms: Burkitt Lymphoma/complications*; Burkitt Lymphoma/diagnosis*
  7. Fulltext Malignant lymphoma of nasal septum--a case report
    Amin JM, Merican S, Nazarina AR
    Med J Malaysia, 1992 Jun;47(2):147-9.
    PMID: 1494335
    Malignant lymphoma of nasal septum is uncommon. It presents a problem in diagnosis to both otorhinolaryngologist and pathologist. This case report is about one such patient in whom the local disease has been controlled with the treatment of radiotherapy alone. However it is suggested that combined treatment of radiotherapy and cytotoxic therapy might improve the survival rate.
    Matched MeSH terms: Lymphoma, T-Cell/diagnosis; Lymphoma, T-Cell/pathology*
  8. Fulltext A rare cause of acute appendicitis: Burkitt's lymphoma of the appendix
    Abdul Ghani S, Noori S, Tan PE
    Med J Malaysia, 1984 Dec;39(4):311-3.
    PMID: 6544940
    This paper presents a case report of a primary lymphoma of the appendix as the underlying cause of acute appendicitis. As in previous reported cases, diagnosis can only be made intraoperatively followed by a proven histopathological picture as they present with an acute surgical abdomen.
    Matched MeSH terms: Burkitt Lymphoma/complications*; Burkitt Lymphoma/pathology
  9. A Diagnostic Dilemma of Sinonasal T Cell Lymphoma: Report of A Unique Case and Literature Review
    V S, Thamby SP, Al-Hatamleh MAI, Mohamud R, Abdullah B
    Gulf J Oncolog, 2019 Sep;1(31):83-89.
    PMID: 31591996
    BACKGROUND: Natural Killer/T-cell non-Hodgkin lymphomas are rare and aggressive disease of non-Hodgkin lymphoma characterized by angioinvasion, angiodestruction and necrosis. It has a strong association with Epstein-Barr virus (EBV) as the lymphoma cells are almost invariably infected with the clonal episomal form of EBV. Because of their rarity, it is a challenge to diagnose and treat them even to the experienced pathologists.

    CASE PRESENTATION: The featured case describes a 40-year-old male who presented with symptoms suggestive for sinusitis. Further diagnostic investigation by the functional endoscopic sinus surgery (FESS) revealed a chronic sinusitis with multiple biopsies showing negative for malignancy, viral and bacterial infections and therefore undiagnosed for sinonasal NK/T-cell lymphoma. Subsequently after a month of surgery, he developed multiple lymph nodes in inguinal where biopsy revealed extranodal NK/T-cell non-Hodgkin lymphoma, high grade but in no time for treatment, he finally succumbed to the illness.

    CONCLUSION: The case presented here was initially diagnosed as a chronic sinusitis, not as sinonasal NK/Tcell lymphoma which later developed into extranodal NK/T-cell lymphoma. The prognosis showed improvement for nasal lymphomas but remains poor for disseminated and extranasal lymphomas which are more aggressive with lower survival rate. It is clinically important to differentiate diseases for proper staging and monitoring as they require completely different treatment strategies.

    Matched MeSH terms: Lymphoma, Extranodal NK-T-Cell/diagnosis*; Lymphoma, Extranodal NK-T-Cell/pathology
  10. Hypercalcaemia: an unusual presenting feature of childhood acute lymphoblastic leukaemia
    Rajagopal R, Lum SH, Jalaludin MY, Krishnan S, Abdullah WA, Ariffin H
    Br J Haematol, 2013 Oct;163(2):147.
    PMID: 23961807 DOI: 10.1111/bjh.12500
    Matched MeSH terms: Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications*; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis*
  11. Fulltext Atypical Ocular Presentation of Non-Hodgkin Lymphoma- A Case Report
    Khairidzan, M.K., Normalina, M., Ismail, M.A., Siraj, H., Nor Azlin, I.M., Zainol, R., et al.
    International Medical Journal Malaysia, 2006;5(1):1-7.
    MyJurnal
    We present a case of a 45-year-old female who presented with blurring of right vision associated with constitutional symptoms. Examinations revealed right optic disc swelling with inferior exudative retinal detachment and hepatomegaly. Gynaecological examination showed a fungating cervical mass. Histopathological reports of cone biopsy confirmed the presence of large B cell non-Hodgkin lymphoma. HIV screening was positive. A diagnosis of HIV related lymphoma was made. Chemotherapy and antiretroviral treatment were instituted. The ocular signs resolved. However, the patient could not tolerate the side effects of medical therapy and opted for palliative treatment.
    Matched MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma, AIDS-Related
  12. Severe asymptomatic hypophosphataemia in a child with T-acute lymphoblastic leukaemia
    Zakaria NH, Sthaneshwar P, Shanmugam H
    Malays J Pathol, 2017 Dec;39(3):317-320.
    PMID: 29279597 MyJurnal
    Hypophosphataemia is a metabolic disorder that is commonly encountered in critically ill patients. Phosphate has many roles in physiological functions, thus the depletion of serum phosphate could lead to impairment in multiple organ systems, which include the respiratory, cardiovascular, neurological and muscular systems and haematological and metabolic functions. Hypophosphataemia is defined as plasma phosphate level below 0.80 mmol per litre (mmol/L) and can be further divided into subgroups of mild (plasma phosphate of 0.66 to 0.79 mmol/L), moderate (plasma phosphate of 0.32 to 0.65 mmol/L) and severe (plasma phosphate of less than 0.32 mmol/L). The causes of hypophosphataemia include inadequate phosphate intake, decreased intestinal absorption, gastrointestinal or renal phosphate loss, and redistribution of phosphate into cells. Symptomatic hypophosphataemia associated with haematological malignancies has been reported infrequently. We report here a case of asymptomatic severe hypophosphataemia in a child with acute T-cell lymphoblastic leukaemia. A 14-year-old Chinese boy was diagnosed to have acute T cell lymphoblastic leukaemia (ALL). His serum biochemistry results were normal except inorganic phosphate and lactate dehydrogenase levels. The serum inorganic phosphate level was 0.1mmol/L and the level was low on repeated analysis. The child had no symptoms related to low phosphate levels. The possible causes of low phosphate were ruled out and urine Tmp/GFR was normal. Chemotherapy regime was started and the serum phosphate levels started to increase. Hypophosphataemia in leukaemia was attributed to shift of phosphorus into leukemic cells and excessive cellular phosphate consumption by rapidly proliferating cells. Several reports of symptomatic hypophosphataemia in myelogenous and lymphoblastic leukaemia in adults have been reported. To our knowledge this is the first case of severe asymptomatic hypophosphataemia in a child with ALL.
    Matched MeSH terms: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/blood; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/complications*
  13. Simultaneous non-Hodgkin lymphoma of the external auditory canal and thyroid gland: A case report
    Khaw B, Sivalingam S, Pathamanathan SS, Tan TS, Naicker M
    Ear Nose Throat J, 2014 12;93(12):508-11.
    PMID: 25531844
    Approximately 25% of all cases of extranodal non-Hodgkin lymphoma (NHL) occur in the head and neck region; NHL of the external auditory canal (EAC) and thyroid gland are rare. Specific immunohistochemical staining of the excised tissue is required to confirm the final pathologic diagnosis. We report the case of a 53-year-old woman with underlying systemic lupus erythematosus and autoimmune hemolytic anemia that were in remission. She presented with chronic left ear pain, a mass in the left EAC, and rapid growth of an anterior neck swelling that had led to left vocal fold palsy. High-resolution computed tomography (CT) of the temporal bone and CT of the neck detected a mass lateral to the left tympanic membrane and another mass in the anterior neck that had infiltrated the thyroid gland. The patient was diagnosed with simultaneous B-cell lymphoma of the left EAC and thyroid gland. She was treated with chemotherapy. She responded well to treatment and was lost to follow-up after 1 year. To the best of our knowledge, the simultaneous occurrence of a lymphoma in the EAC and the thyroid has not been previously described in the literature.
    Matched MeSH terms: Lymphoma, B-Cell/diagnosis*; Lymphoma, B-Cell/therapy; Lymphoma, B-Cell, Marginal Zone/diagnosis*; Lymphoma, B-Cell, Marginal Zone/therapy
  14. Use of Indomethacin as an anti-pyretic agent in malignant reticulosis
    Banerjee AK
    Med J Malaya, 1972 Mar;26(3):173-8.
    PMID: 4555503
    Matched MeSH terms: Lymphoma/complications*; Lymphoma, Non-Hodgkin/complications; Lymphoma, Large B-Cell, Diffuse/complications
  15. Fulltext Bone marrow and peripheral blood changes in non-Hodgkin's lymphoma
    Lim EJ, Peh SC
    Singapore Med J, 2000 Jun;41(6):279-85.
    PMID: 11109344
    47 patients with non-Hodgkin's lymphoma (NHL) were studied retrospectively to determine their marrow and blood changes at diagnosis.
    Matched MeSH terms: Lymphoma, Non-Hodgkin/blood*; Lymphoma, Non-Hodgkin/complications; Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/epidemiology; Lymphoma, Non-Hodgkin/pathology*
  16. 18q21 Rearrangement and trisomy 3 in extranodal B-cell lymphomas: a study using a fluorescent in situ hybridisation technique
    Tai YC, Tan JA, Peh SC
    Virchows Arch, 2004 Nov;445(5):506-14.
    PMID: 15365830
    t(11;18)(q21;q21) Translocation and trisomy 3 are the most common chromosomal aberrations reported in low-grade mucosa-associated lymphoid tissue (MALT) lymphoma. The current study aims to investigate the frequency of these chromosomal aberrations in a series of 52 extranodal B-cell lymphomas. The tumours were categorised into three histological grades: grade 1 (low-grade lymphoma of MALT type), grade 2 [diffuse large B-cell lymphoma (DLBCL) with MALT component] and grade 3 (DLBCL without MALT component). Fluorescence in situ hybridisation analyses on paraffin tissue sections were performed using a locus-specific probe for the 18q21 region and a centromeric probe for chromosome 3. The 18q21 rearrangement was detected in 9 of 40 (23%) cases, including 7 of 23 (30%) grade-1 and 2 of 11 (18%) grade-3 tumours. Amplification of the 18q21 region was detected in 10 of 40 (25%) cases, and trisomy 3 was detected in 9 of 34 (26%) cases. Amplification of the 18q21 region may be an important alternative pathogenetic pathway in MALT lymphoma and was found almost exclusively in tumours without 18q21 rearrangement. Our study showed that tumours with 18q21 rearrangement and 18q21 amplification develop along two distinct pathways, and the latter was more likely to transform into high-grade tumours upon acquisition of additional genetic alterations, such as trisomy 3. Trisomy 3 was more frequently found in coexistence with 18q21 abnormalities, suggesting that it was more likely to be a secondary aberration.
    Matched MeSH terms: Lymphoma, B-Cell/genetics*; Lymphoma, B-Cell/immunology; Lymphoma, B-Cell/pathology; Lymphoma, B-Cell, Marginal Zone/genetics
  17. Fulltext Globus sensation in throat, the lymphoid and non-lymphoid origin of tongue base lesions
    Irfan M
    Med J Malaysia, 2011 Dec;66(5):525.
    PMID: 22390121
    Matched MeSH terms: Lymphoma, Large B-Cell, Diffuse/diagnosis*
  18. Higher frequency of p53 gene mutations in diffuse large B-cell lymphoma with MALT component
    Tai YC, Tan JA, Peh SC
    Pathol. Int., 2004 Nov;54(11):811-8.
    PMID: 15533223
    p53 gene mutation is not a frequent event in the tumorigenesis of lymphomas and the expression of p53 protein is independent of p53 gene mutations. The present study aimed to investigate mutations in the p53 gene in a series of extranodal B-cell lymphomas, and its association with p53 protein expression. A total of 52 cases were graded histologically into Grade 1, Grade 2 and Grade 3 tumors and p53 protein expression was detected using immunohistochemistry. Mutations in the p53 gene were analyzed using polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and mobility shifts were confirmed by direct sequencing. The tumors comprised 26 (50%) Grade 1, 9 (17%) Grade 2 and 15 (29%) Grade 3. A high proportion of Grade 2 (25%) tumors expressed p53 protein (P = 0.051) and carried p53 gene mutation (33%) (P = 0.218). However, p53 protein expression was not associated with p53 gene mutations (P = 0.057). Transversion mutations (88%) were more frequently detected than transition mutations (12%). The present study revealed that p53 gene mutations and p53 protein expression occurred in higher frequencies in Grade 2 tumors, which may be of pathogenetic importance. The high frequency of transversion mutations may reflect the influence of an etiological agent in the tumorigenesis of mucosa-associated lymphoid tissue (MALT lymphoma).
    Matched MeSH terms: Lymphoma, Large B-Cell, Diffuse/genetics*; Lymphoma, Large B-Cell, Diffuse/metabolism; Lymphoma, Large B-Cell, Diffuse/pathology*; Lymphoma, B-Cell, Marginal Zone/genetics*; Lymphoma, B-Cell, Marginal Zone/metabolism; Lymphoma, B-Cell, Marginal Zone/pathology*
  19. TARC, a CC chemokine, is frequently expressed in classic Hodgkin's lymphoma but not in NLP Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and most cases of anaplastic large cell lymphoma
    Peh SC, Kim LH, Poppema S
    Am. J. Surg. Pathol., 2001 Jul;25(7):925-9.
    PMID: 11420464
    Thymus and activation-regulated chemokine (TARC) has been identified as a lymphocyte-directed CC chemokine that attracts activated T-helper type 2 (Th2) cells in humans. Recent studies showed that the T cells surrounding Reed-Sternberg cells in Hodgkin's lymphomas (HL) are Th2 type. Anaplastic large cell lymphomas (ALCL), T-cell-rich B-cell lymphoma (TCRBCL) can mimic HL in some instances. This study aimed to establish the pattern of TARC expression in these diseases. Immunohistochemical stain using a polyclonal goat anti-human antibody to TARC was performed on 119 cases of confirmed HL; 99 were classical type (43 mixed cellularity, 43 nodular sclerosis, 5 lymphocyte depleted, 4 lymphocyte rich, 4 unclassifiable) and 20 lymphocyte predominant HL. Additional 27 ALCL (9 T-, 18 null-cell phenotype), 16 T-cell and 8 B-cell non-Hodgkin's lymphoma (NHL) were studied. A total of 85.8% of the classical HL, one case of ALCL, and one case of large cell B-cell lymphoma with anaplastic morphology showed positive TARC expression in the tumor cells. The expression was paranuclear and/or diffuse in the cell cytoplasm. The tumor cells in all cases of lymphocyte predominant HL, TCRBCL, null ALCL, and T-NHL did not express TARC. The high frequency of TARC expression in the Reed-Sternberg cells of classical HL may explain the characteristic T-cell infiltrate in this disease. The absence in other types that may be morphologically similar indicates that staining for TARC may aid in differential diagnosis.
    Matched MeSH terms: Lymphoma, B-Cell/metabolism*; Lymphoma, B-Cell/pathology; Lymphoma, B-Cell/virology; Lymphoma, Large B-Cell, Diffuse/metabolism*; Lymphoma, Large B-Cell, Diffuse/pathology; Lymphoma, Large B-Cell, Diffuse/virology
  20. Fulltext Primary non-Hodgkin's lymphoma of the cranial vault mimicking a meningioma: a case report
    Muin IA, Saffari HM, Hasimah YN
    Med J Malaysia, 1997 Mar;52(1):86-8.
    PMID: 10968060
    Primary non-Hodgkin's lymphoma of the brain is rare. Majority of the lesions are intraaxial, multicentric and involve the leptomeninges. We report a case of malignant primary non-Hodgkin's lymphoma arising from the cranial vault. Computed tomography of the brain showed an extraaxial lesion in the right parietal region mimicking a meningioma.
    Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis*
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