MyMedR

Fulltext Single dose oral amoxycillin and clavulanic acid in the treatment of gonococcal urethritis in males

Lim VKE, Bakar R, Hussin Z

Med J Malaysia, 1982 Sep;37(3):235-8.

Forty-two previously untreated male patients with uncomplicated gonococcal urethritis were treated with a single dose oral regimen comprising 3 gm ofamoxycillin and 125 mg of clavulanic acid. Thirty-five patients returned for follow-up and the cure rate among them was 89 percent. The cure rate for patients infected with penicillinase producing Neisseria gonorrhoeae (PPNG) was 73 percent. Further work is required to establish the optimum dosage for this particular regimen.

Study site: Sexually Transmitted Diseases (STD) clinic at the Faculty of Medicine,
Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)

Fulltext Meningitis due to Listeria monocytogenes

Halim AJ, Lim VKE

Med J Malaysia, 1982 Jun;37(2):191-3.

PMID: 6813660

To our knowledge, meningitis due to Listeria monocytogenes has not previously been reported in Malaysia. We describe here two infants with meningitis due to Listeria monocytogenes occurring within a month of each other in the Universiti Kebangsaan Malaysia Paediatric Unit. The incidence of listeriosis in Malaysia is unknown and it is possible that this infection may have been missed in the past.

Fulltext Knowledge and attitude on infant oral health among graduating medical students in kulasekaram

Chellaih P, Sivadas G, Vaishnavi Vedam VK

J Educ Health Promot, 2020;9:207.

PMID: 33062740 DOI: 10.4103/jehp.jehp_194_20

AIM: This study was intended to evaluate the knowledge and attitudes regarding infant's oral health care among graduating medical students from Kulasekaram, Tamil Nadu.

MATERIALS AND METHODS: A cross-sectional survey research design was employed in this study. Self-administered questionnaire of the validated "Graduating medical students' Knowledge and Attitudes Survey Regarding Infant's oral health care" were utilized to ascertain the baseline levels of knowledge and attitudes of graduating medical students' in Kulasekaram hospital. In this regard, a preliminary study with a convenience sample of 100 medical students was conducted so as to assess the knowledge of infant oral health care among graduating medical students in Kulasekaram. This study, while limited in sample size, benefits the general practitioners as target readers to assess the abnormalities in children at early stages of life.

RESULTS: The results of the study revealed that the mean percentage score overall was 65.7%. Only 3.2% of participants obtained a passing score of 80% or greater. Widespread knowledge deficits and poor attitudes among graduating medical students were noted in this study, particularly in the domain of pharmacological management of pain. Positive correlations were observed between the respondents' score and level of education. Further analysis revealed respondents had an inaccurate self-evaluation of their pain management knowledge.

CONCLUSION: The results of this study reveal that there is dearth of knowledge and attitudes of graduating medical students' regarding infant oral health care. Educational and quality improvement initiatives in oral health care of infants could enhance medical student's knowledge baseline in the area of oral health care and possibly improve practices.

Fulltext Prevalence of torus palatinus and torus mandibularis among Malay population

Hiremath VK, Husein A, Mishra N

J Int Soc Prev Community Dent, 2011 Jul;1(2):60-4.

PMID: 24478956 DOI: 10.4103/2231-0762.97704

The aims of this study were to determine the prevalence, size, shape, and location of torus palatinus (TP) and torus mandibularis (TM), and to assess their sex-related and age-related differences in the Malay population. Sixty-five subjects were assessed for the presence of both tori at the School of Dental Sciences University Sains Malaysia. The prevalence of TP was 38-63% and that of TM was 1-10%. TP was frequently more common in females than males (90.9% versus 9.1%; P < 0.05) and was frequently found in medium sizes, spindle shaped, and was often located at the combined premolar to molar areas. The prevalence of TM was not significantly different in males and females (33.3% versus 66.7%; P = 0.523), occurred most commonly in bilateral multiple form, and was often located at the canine to premolar area.

Serum immunoglobulin levels in the Semai

Lim VK, Moosdeen F, Nagappan N

Med J Malaysia, 1977 Jun;31(4):288-91.

PMID: 927234

Fulltext Methicillin resistant Staphylococcus aureus in a Malaysian neonatal unit

Lim VKE, Zulkifli HI

Singapore Med J, 1987 Apr;28(2):176-9.

PMID: 3629274

Methicillin resistant Siaphylococcus aureus Is a common isolate from clinical specimens obtained from babies at the special care nursery of the Kuala Lumpur Maternity Hospital. Major Infections due to this organism were, however uncommon and the organism had in the majority of cases been present as a coloniser or as a cause of superficial infection. Netilmicin is a valuable antibiotic in the treatment of the severe infections.

Changes in global NO2 pollution by shipping during the COVID-19 lockdown: Implication for sustainable marine operations

Athul S, Kuttippurath J, Patel VK

J Hazard Mater, 2025 Jan 05;481:136482.

PMID: 39556909 DOI: 10.1016/j.jhazmat.2024.136482

Severe restrictions on human travel and consumption during the lockdown (LD) have affected global marine traffic and operations. The LD period is ideal for studying the emissions as there were restricted human activities. Although several pollutants are emitted by ships, the most important is nitrogen dioxide (NO2), and can be considered an indicator of shipping emissions. Therefore, we examine the changes in NO2 pollution over the shipping lanes, ports and coasts across the globe during LD. Here, we find a significant decline in NO2 during LD over the major lanes, including the USA-Europe trade routes through the North Atlantic Ocean, Asia-Middle East through the Arabian Sea, Interasia, and Intereuropean through the North Sea and Baltic Sea, about 10-20%, as analysed form the TROPOMI satellite measurements. A similar reduction over the sea straight pass, such as the Cape of Good Hope and the Strait of Malacca is also estimated. Furthermore, the major global ports of Callao, Santos, Antwerp, Rotterdam, Busan, Tubarao, Richards Bay, Barcelona, Durban and Chennai exhibit a significant decrease in NO2 during LD, about 30%. The decline in NO2 over the shipping routes and ports can be attributed to reduced cargo, passenger, fishing and tanker vessel density due to the LD restrictions; consistent with the emission inventory analysis. Henceforth, this study suggests strict environmental policies in the shipping sector to curb emissions, as pollution is a great concern for public health in the port cities and coastal regions.

Fulltext A case of tuberculosis of the thyroid gland

Puri MM, Dougall P, Arora VK

Med J Malaysia, 2002 Jun;57(2):237-9.

PMID: 24326661

We report a case of tuberculosis of the thyroid gland associated with mediastinal lymphadenitis in a 30 years-old male, who presented with dysphagia and a mid line anterior neck swelling. Fine needle aspiration was positive for acid fast bacilli. He made an uneventful recovery with antituberculous drugs. Although seldom observed, tuberculosis should be kept in mind in te differential diagnisis of nodular lesions of the thyroid.

Fulltext DNA fingerprinting of methicillin-resistant Staphylococcus aureus (MRSA) by pulsed-field gel electrophoresis (PFGE) in a teaching hospital in Malaysia

Alfizah H, Norazah A, Nordiah AJ, Lim VKE

Med J Malaysia, 2002 Sep;57(3):319-28.

PMID: 12440272 MyJurnal

Methicillin-resistant Staphylococcus aureus (MRSA) has been prevalent in our hospital over the last three years. Differentiation among MRSA strains by DNA typing in addition to antibiotic resistance pattern surveillance is crucial in order to implement infection control measures. The aim of this study was to characterize MRSA isolates from patients admitted to Hospital Universiti Kebangsaan Malaysia (HUKM) by phenotypic (analyses of antibiotic susceptibility pattern) and genotypic (PFGE) techniques to determine the genetic relatedness of the MRSA involved and to identify endemic clonal profiles of MRSA circulating in HUKM. Seventy one MRSA strains collected between January to March 2000 from patients from various wards in HUKM were tested for antimicrobial resistance and typed by pulsed-field gel electrophoresis (PFGE). Four major types of PFGE patterns were identified (A, B, C and D) among MRSA strains. Two predominant PFGE types were recognised, Type A (59.2%) and Type B (33.8%). Most of these strains were isolated from ICU, Surgical wards and Medical wards. MRSA strains with different PFGE patterns appeared to be widespread among wards. Strains with the same antibiotype could be of different PFGE types. Most of isolates were resistant to ciprofloxacin, erythromycin, gentamicin and penicillin. One isolate with a unique PFGE pattern Type D and susceptible to gentamicin was identified as a different clone. Some isolates obtained from the same patient showed different PFGE subtypes suggesting that these patients were infected/colonized with multiple MRSA strains. PFGE analysis suggests that MRSA strains with different PFGE types was propagated within our hospital. The relationship between antibiotic susceptibility and PFGE patterns was independent. The ability of PFGE technique in differentiating our MRSA strains make it a method of choice for investigating the source, transmission and spread of nosocomial MRSA infection, and thus an appropriate control programme can be implemented to prevent the spread of MRSA infection.

Congenital lobar emphysema: a case with bronchial septum

Saim L, Mohamad AS, Ambu VK

Int J Pediatr Otorhinolaryngol, 1994 Jan;28(2-3):241-6.

PMID: 8157425

Congenital lobar emphysema has been described under various designations. Although the etiology is not clear, some form of bronchial obstruction has been documented in about 50% of the patients. A rare case of congenital lobar emphysema with a membranous septum in the left main bronchus is described. Although prompt lobectomy has been the treatment of choice in most cases, this case demonstrates the importance of early bronchoscopy to exclude treatable intra luminal abnormalities.

Fulltext Chemotherapy in nasopharyngeal carcinoma: review of results at University Hospital, Kuala Lumpur

Khanijow VK, Prasad U, Chang CM

Med J Malaysia, 1989 Dec;44(4):329-33.

PMID: 2520043

Nasopharyngeal carcinoma (NPC) is one of the commonest presentation of head and neck cancers in Malaysia, especially in the Chinese. The standard treatment is radical radiotherapy to the post-nasal space and the neck. Chemotherapy is given to patients with primary advanced disease and to patients with recurrence. The study reviews results of chemotherapy given to 33 patients at the University Hospital, Kuala Lumpur, over the last four years.

Fulltext Bacterial peritonitis in peritoneal dialysis

Cheong IKS, Lim VKE, Ujang K

Med J Malaysia, 1981 Mar;36(1):17-9.

PMID: 7321932

38 episodes of peritonitis in 28 patients were recorded among 97 patients undergoing a total of 159 peritoneal dialysis at the Nephrology Unit, General Hospital, Kuala Lumpur between November 1979 to June 1980. Of these only 14 episodes were associated with a positive bacterial culture. Organism of the Moraxella-Acinetobacter group were responsible in 8 episodes. There were 16 positive cultures in patients who had no clinical evidence of peritonitis. The interpretation of bacterial peritonitis in patients undergoing peritoneal dialysis must be made on the basis of clinical findings and bacteriological reports.

Fulltext Congenital ossicular abnormality. A case report

Khanijow VK, Phang WK, Kerr AI

Med J Malaysia, 1987 Dec;42(4):314-6.

PMID: 3454405

In children, congenital deafness presents not infrequently. The majority of cases are sensorineural in nature and congenital conductive deafness is far less common. The causes range from abnormalties and fixation of ossicles, ankylosed malleo-incudal joint and absence of one or more ossicles. We describe a case of congenital ossicular abnormality, presenting with conductive deafness.

Fulltext Pattern of neonatal septicemia in a Malaysian maternity hospital

Boo NY, Wong YH, Lim VK

Med J Malaysia, 1989 Sep;44(3):189-93.

PMID: 2626133

Over a 12 months period, out of 25,411 livebirths, 155 neonates (6.1 per 1000 livebirths) had proven septicemia by blood culture. The mortality rate was 26.5%. Septicemia was more common among the very low birthweight and preterm neonates of gestation of 30 weeks or less. 45.8% of the septicemia occurred during the first 48 hours of life. Staphylococcus epidermidis was the most common causative organism. However, mortality was highest among neonates who acquired multiresistant nosocomial infection during the later part of neonatal life.

Fulltext The bacteriology of perforated appendix

Lim VKE, Hussin Z, Abdul Wahab Y

Med J Malaysia, 1983 Dec;38(4):275-8.

PMID: 6599982

Perforated appendix is a serious surgical condition that carries a high morbidity. Antibiotic treatment is often started before the availability of bacteriological reports. The choice of antibiotics would depend on the bacteriology associated with perforated appendix. In a retrospective survey of the bacteriology of peritoneal pus obtained from cases of perforated appendix at the General Hospital, Kuala Lumpur, E. coli was found to be the most commonly encountered organism. This was followed in order of decreasing frequency by streptococci, Bacteroides species, Klebsiella-Enterobacter group and Pseudomonas aeruginosa. From the results of the antibiotic sensitivities an antibiotic regimen comprising of a combination of gentamicin, metronidazole and penicillin is recommended as appropriate chemotherapy in perforated appendix.

Acinic cell carcinoma of the parotid gland: A diagnostic dilemma on cytology

Sharma A, Ahuja S, Diwaker P, Wadhwa N, Arora VK

Malays J Pathol, 2019 Aug;41(2):191-194.

PMID: 31427555

INTRODUCTION: Acinic cell carcinoma (ACC) represents 1-6% of parotid gland neoplasms.

CASE REPORT: We report cytomorphological features of two uncommon variants of acinic cell carcinoma. The first case was an eleven-year-old female with a nodular mass in parotid and the FNA smears demonstrated a lymphoepithelial lesion composed of epithelial tumour cells with features of acinar cells in a lymphoid background. The second case was a 62-year-old male with a large parotid mass. The FNA smears revealed presence of extracellular, acellular amyloid-like material with tumour cells arranged in follicles.

DISCUSSION: Awareness of cytomorphological features of these unusual variants of acinic cell carcinoma may help to avoid diagnostic pitfall.

Fulltext Avulsion Fracture of Brachioradialis Muscle Origin: An Exceedingly Rare Entity: A Case Report

Behera G, Balaji G, Menon J, Sharma D, Komuravalli VK

Malays Orthop J, 2016 Jul;10(2):50-52.

PMID: 28435562 DOI: 10.5704/MOJ.1607.010

Avulsion fracture of the brachioradialis origin at its proximal attachment on the lateral supracondylar ridge of the distal humerus is exceedingly rare, and only two cases have been reported in the literature so far. In this article, we present a 38 years old patient who sustained a closed avulsion fracture of the lateral supracondylar ridge of left humerus at the proximal attachment of brachioradialis following a fall backwards on outstretched hand after being struck by a lorry from behind while riding on a two-wheeler (motorcycle). He was managed with above elbow plaster for four weeks followed by elbow and wrist mobilization. At final followup, the patient had painless full range elbow motion with good elbow flexion strength. The unique mechanism by which this avulasion fracture occurred is explained on the basis of the mode of injury, position of the limb and structure and function of the brachioradialis muscle.

Fulltext Post-operative Hypertension following Correction of Flexion Deformity of the Knees in a Spastic Diplegic Child: A Case Report

Vipin M, Sujendra DM, Imthiaz VK, Hitesh-Shah

Malays Orthop J, 2016 Nov;10(3):46-48.

PMID: 28553449 DOI: 10.5704/MOJ.1611.006

An adolescent boy with spastic diplegic cerebral palsy presented with crouch gait. He had bilateral severe flexion deformities of knees and hips. He was treated with single event multilevel surgery for the correction of deformities. Surgical procedures included bilateral adductor release, iliopsoas lengthening, bilateral femoral shortening and patella plication. Persistent hypertension was noted in the post-operative period. All causes of secondary hypertension were ruled out. Having persistent hypertension following the femoral shortening procedure is unusual. Antihypertensive medication controlled his blood pressure 15 months after surgery. Hypertension following correction of knee flexion deformity and limb lengthening is well known. Hypertension has not been described with the shortening osteotomy of the femur. Hypertension is a rare complication following the corrective surgery for the treatment of crouch gait. Blood pressure should be monitored during the post-operative period to detect such a rare complication.

Role of protein kinase C in hydroxyapatite- induced phagocytosis by a murine macrophage cell line (RAW264.7)

Gopinath VK, Musa M, Samsudin AR, Sosroseno W

Immunopharmacol Immunotoxicol, 2006;28(3):485-9.

PMID: 16997796

The role of protein kinase C (PKC) in hydroxyapatite (HA)-induced phagocytosis by RAW 264.7 cells was investigated. The cells were incubated with HA particles at various incubation time and the levels of PKC activity were determined from the cell lysate. To determine the role of PKC, particles were incubated with the cells pretreated with the various concentrations of bisindolylmaleimide, a PKC inhibitor, and phagocytosis was then assessed at 60 min. Latex beads were used as a control. Our results showed that following incubation with HA particles, the levels of PKC activity in RAW264.7 cells was highest at 7 min and then decreased to reach the baseline levels of the controls at 30 min. Pretreatment of the cells with bisindolylmaleimide significantly reduced phagocytosis of HA particles in a dose-dependent pattern. The results of our present study suggest therefore that ingestion of HA by RAW264.7 cells may depend on PKC activity that may act in the early stages of phagocytosis.

Role of interleukin-1beta and tumour necrosis factor-alpha on hydroxyapatite-induced phagocytosis by murine macrophages (RAW264.7 cells)

Gopinath VK, Musa M, Samsudin AR, Sosroseno W

Br J Biomed Sci, 2006;63(4):176-8.

PMID: 17201208

Displaying publications 41 - 60 of 192 in total