Displaying publications 41 - 60 of 1525 in total

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  1. Thermal distribution analysis of three-dimensional tumor-embedded breast models with different breast density compositions
    Wahab AA, Salim MI, Ahamat MA, Manaf NA, Yunus J, Lai KW
    Med Biol Eng Comput, 2016 Sep;54(9):1363-73.
    PMID: 26463520 DOI: 10.1007/s11517-015-1403-7
    Breast cancer is the most common cancer among women globally, and the number of young women diagnosed with this disease is gradually increasing over the years. Mammography is the current gold-standard technique although it is known to be less sensitive in detecting tumors in woman with dense breast tissue. Detecting an early-stage tumor in young women is very crucial for better survival chance and treatment. The thermography technique has the capability to provide an additional functional information on physiological changes to mammography by describing thermal and vascular properties of the tissues. Studies on breast thermography have been carried out to improve the accuracy level of the thermography technique in various perspectives. However, the limitation of gathering women affected by cancer in different age groups had necessitated this comprehensive study which is aimed to investigate the effect of different density levels on the surface temperature distribution profile of the breast models. These models, namely extremely dense (ED), heterogeneously dense (HD), scattered fibroglandular (SF), and predominantly fatty (PF), with embedded tumors were developed using the finite element method. A conventional Pennes' bioheat model was used to perform the numerical simulation on different case studies, and the results obtained were then compared using a hypothesis statistical analysis method to the reference breast model developed previously. The results obtained show that ED, SF, and PF breast models had significant mean differences in surface temperature profile with a p value <0.025, while HD breast model data pair agreed with the null hypothesis formulated due to the comparable tissue composition percentage to the reference model. The findings suggested that various breast density levels should be considered as a contributing factor to the surface thermal distribution profile alteration in both breast cancer detection and analysis when using the thermography technique.
    Matched MeSH terms: Breast Neoplasms/pathology; Breast Density*
  2. Fine needle aspiration cytology of secretory carcinoma of breast: a case report
    Jayaram G, Looi LM, Yip CH
    Malays J Pathol, 1997 Jun;19(1):69-73.
    PMID: 10879245
    A 39-year-old female presented with a mobile 1.5 cm nodule in the right breast. Fine needle aspiration cytology smears stained with May Grunwald Giemsa were highly cellular with a monotonous population of dissociated and clustered tumour cells that showed a bland cytological appearance with cytoplasmic vacuolation and occasional signet ring forms. Intracellular and extracellular mucus was present. Histological study of the excised breast mass showed a secretory carcinoma. This is a rare breast neoplasm in which cytological features are characteristic enough to permit a specific diagnosis on needle aspirates.
    Matched MeSH terms: Breast Neoplasms/pathology*; Breast Neoplasms/secretion; Breast Neoplasms/therapy
  3. Fulltext Prebiopsy localization of nonpalpable breast lesions
    Zulfiqar A, Param V, Meah FA, Nair S, Siti-Aishah MA, Norizan A
    Med J Malaysia, 1993 Sep;48(3):317-24.
    PMID: 8183145
    Radiologically guided localization procedures are indicated pre-operatively when breast lesions are nonpalpable. The results of 42 percutaneous hookwire localizations over a period of 3 years are described. Of the total, 7 (17%) were found to be malignant. Biopsy was indicated by mammographically detected mass in 48%, by microcalcifications in 40% and by microcalcifications with an associated mass in 12%.
    Matched MeSH terms: Breast/pathology*; Breast Neoplasms/diagnosis*
  4. Impact of adjuvant chemotherapy on survival of women with T1N0M0, hormone receptor negative breast cancer
    Bhoo-Pathy NT, Inaida S, Tanaka S, Taib NA, Yip CH, Saad M, et al.
    Cancer Epidemiol, 2017 06;48:56-61.
    PMID: 28371729 DOI: 10.1016/j.canep.2017.03.007
    BACKGROUND: The benefit of adjuvant chemotherapy in women with T1N0M0 breast cancers is unclear. While gene expression-based prognostic assays may aid management of women with early estrogen receptor (ER) positive tumors, therapeutic decision-making in women with early stage ER negative tumors remains fraught with difficulties. We investigated the association between adjuvant chemotherapy and overall survival in women with T1N0M0, hormone receptor negative breast cancers.

    METHOD: All newly diagnosed breast cancer patients with node-negative and hormone receptor negative tumors measuring≤2cm at the University Malaya Medical Centre (Malaysia) from 1993 to 2013 were included. Mortality of patients with and without adjuvant chemotherapy were compared and adjusted for possible confounders using propensity score.

    RESULTS: Of 6732 breast cancer patients, 341 (5.1%) had small (≤2cm), node-negative and hormone receptor negative tumors at diagnosis. Among them, only 214 (62.8%) received adjuvant chemotherapy. Five-year overall survival was 88.1% (95% confidence interval (CI): 82.0%-94.2%) for patients receiving chemotherapy and 89.6% (95% CI: 85.1%-94.1%) for patients without chemotherapy. Chemotherapy was not associated with survival following adjustment for age, ethnicity, tumor size, tumor grade, HER2 status, lympho-vascular invasion, type of surgery and radiotherapy administration. However, chemotherapy was associated with a significant survival advantage (adjusted hazard ratio: 0.35, 95%CI: 0.14-0.91) in a subgroup of women with high-grade tumors.

    CONCLUSION: Adjuvant chemotherapy does not appear to be associated with a survival benefit in women with T1N0M0, hormone receptor negative breast cancer except in those with high-grade tumors.

    Matched MeSH terms: Breast Neoplasms/drug therapy*; Breast Neoplasms/mortality; Breast Neoplasms/pathology
  5. Difficulty of Achieving Clear Margins in Nonpalpable Ductal Carcinoma of the Breast
    Yip CH
    JAMA Surg, 2017 04 01;152(4):385.
    PMID: 28002571 DOI: 10.1001/jamasurg.2016.4752
    Matched MeSH terms: Breast Neoplasms/surgery; Carcinoma, Ductal, Breast/surgery*
  6. Malaysian initiatives towards successful breastfeeding
    Awin N
    Malaysian Journal of Child Health, 1997;9(1):24-31.
    MyJurnal
    The advantages and benefits of breastfeeding and the scientific basis for them are already well-documented and made known to the health and related professions, policy makers as well as the lay public. The role of breastfeeding in child survival, protection, growth and development has been the focus of several international deliberations, including the Convention of the Protection, Promotion and Support of Breastfeeding (August 1990) and The World Summit for Children (October 1990). Follow-ing the World Summit, our Prime Minister, on 18 July 1991, signed the World Declaration for Child Survival, Protection and Development. (Copied from article).
    Matched MeSH terms: Breast Feeding
  7. Fulltext Breast Cancer Detection Using Infrared Thermal Imaging and a Deep Learning Model
    Mambou SJ, Maresova P, Krejcar O, Selamat A, Kuca K
    Sensors (Basel), 2018 Aug 25;18(9).
    PMID: 30149621 DOI: 10.3390/s18092799
    Women's breasts are susceptible to developing cancer; this is supported by a recent study from 2016 showing that 2.8 million women worldwide had already been diagnosed with breast cancer that year. The medical care of a patient with breast cancer is costly and, given the cost and value of the preservation of the health of the citizen, the prevention of breast cancer has become a priority in public health. Over the past 20 years several techniques have been proposed for this purpose, such as mammography, which is frequently used for breast cancer diagnosis. However, false positives of mammography can occur in which the patient is diagnosed positive by another technique. Additionally, the potential side effects of using mammography may encourage patients and physicians to look for other diagnostic techniques. Our review of the literature first explored infrared digital imaging, which assumes that a basic thermal comparison between a healthy breast and a breast with cancer always shows an increase in thermal activity in the precancerous tissues and the areas surrounding developing breast cancer. Furthermore, through our research, we realized that a Computer-Aided Diagnostic (CAD) undertaken through infrared image processing could not be achieved without a model such as the well-known hemispheric model. The novel contribution of this paper is the production of a comparative study of several breast cancer detection techniques using powerful computer vision techniques and deep learning models.
    Matched MeSH terms: Breast/pathology; Breast Neoplasms/pathology
  8. Modulation of oncogenic transcription factors by bioactive natural products in breast cancer
    Hasanpourghadi M, Pandurangan AK, Mustafa MR
    Pharmacol Res, 2018 02;128:376-388.
    PMID: 28923544 DOI: 10.1016/j.phrs.2017.09.009
    Carcinogenesis, a multi-step phenomenon, characterized by alterations at genetic level and affecting the main intracellular pathways controlling cell growth and development. There are growing number of evidences linking oncogenes to the induction of malignancies, especially breast cancer. Modulations of oncogenes lead to gain-of-function signals in the cells and contribute to the tumorigenic phenotype. These signals yield a large number of proteins that cause cell growth and inhibit apoptosis. Transcription factors such as STAT, p53, NF-κB, c-JUN and FOXM1, are proteins that are conserved among species, accumulate in the nucleus, bind to DNA and regulate the specific genes targets. Oncogenic transcription factors resulting from the mutation or overexpression following aberrant gene expression relay the signals in the nucleus and disrupt the transcription pattern. Activation of oncogenic transcription factors is associated with control of cell cycle, apoptosis, migration and cell differentiation. Among different cancer types, breast cancer is one of top ten cancers worldwide. There are different subtypes of breast cancer cell-lines such as non-aggressive MCF-7 and aggressive and metastatic MDA-MB-231 cells, which are identified with distinct molecular profile and different levels of oncogenic transcription factor. For instance, MDA-MB-231 carries mutated and overexpressed p53 with its abnormal, uncontrolled downstream signalling pathway that account for resistance to several anticancer drugs compared to MCF-7 cells with wild-type p53. Appropriate enough, inhibition of oncogenic transcription factors has become a potential target in discovery and development of anti-tumour drugs against breast cancer. Plants produce diverse amount of organic metabolites. Universally, these metabolites with biological activities are known as "natural products". The chemical structure and function of natural products have been studied since 1850s. Investigating these properties leaded to recognition of their molecular effects as anticancer drugs. Numerous natural products extracted from plants, fruits, mushrooms and mycelia, show potential inhibitory effects against several oncogenic transcription factors in breast cancer. Natural compounds that target oncogenic transcription factors have increased the number of candidate therapeutic agents. This review summarizes the current findings of natural products in targeting specific oncogenic transcription factors in breast cancer.
    Matched MeSH terms: Breast Neoplasms/drug therapy; Breast Neoplasms/genetics; Breast Neoplasms/metabolism*
  9. Fulltext Ultrasonographic Evaluation of Skin Toxicity Following Radiotherapy of Breast Cancer: A Systematic Review
    Hussein FA, Manan HA, Mustapha AWMM, Sidek K, Yahya N
    Int J Environ Res Public Health, 2022 Oct 18;19(20).
    PMID: 36294025 DOI: 10.3390/ijerph192013439
    The present review aimed to systematically review skin toxicity changes following breast cancer radiotherapy (RT) using ultrasound (US). PubMed and Scopus databases were searched according to PRISMA guidelines. The characteristics of the selected studies, measured parameters, US skin findings, and their association with clinical assessments were extracted. Seventeen studies were included with a median sample size of 29 (range 11-166). There were significant US skin changes in the irradiated skin compared to the nonirradiated skin or baseline measurements. The most observed change is skin thickening secondary to radiation-induced oedema, except one study found skin thinning after pure postmastectomy RT. However, eight studies reported skin thickening predated RT attributed to axillary surgery. Four studies used US radiofrequency (RF) signals and found a decrease in the hypodermis's Pearson correlation coefficient (PCC). Three studies reported decreased dermal echogenicity and poor visibility of the dermis-subcutaneous fat boundary (statistically analysed by one report). The present review revealed significant ultrasonographic skin toxicity changes in the irradiated skin most commonly skin thickening. However, further studies with large cohorts, appropriate US protocol, and baseline evaluation are needed. Measuring other US skin parameters and statistically evaluating the degree of the association with clinical assessments are also encouraged.
    Matched MeSH terms: Breast
  10. Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women
    Looi LM, Cheah PL, Ng MH, Yip CH, Mun KS, Rahman NA
    Asian Pac J Cancer Prev, 2010;11(3):713-6.
    PMID: 21039041
    A study was initiated to explore possible differences in handling telomere attrition in the most common lignant and benign tumours of the breast in Malaysian women. Infiltrating ductal carcinoma (IDC) and fibroadenoma (FA) represented the malignant and benign prototypes respectively. 29 IDC, 28 FA and 22 benign non-lesional control (BNL) breast tissue samples were analysed for telomerase activation using a Telomerase PCR ELISA kit (Boehringer Mannheim). In addition, 23 IDC, 12 FA and 14 BNL were subjected to telomere length determination with a TeloTAGGG Telomere Length Assay Kit (Roche Diagnostic GmbH, Germany), following digestion of genomic DNA by frequently cutting restriction enzymes RsaI and HinfI. Mean telomerase activity in IDC (A450nm=0.3338), but not FA (A450nm=0.0003) was significantly raised (p<0.05) compared with BNL (A450nm=0.0031). Similarly IDC (1.2 kb), but not FA (2.2 kb), showed significant telomere shortening (p<0.05) relative to BNL (2.9 kb). The findings imply that telomere attrition and telomerase activation differ between malignant and benign tumours of the breast and may be important for targeted therapy.
    Matched MeSH terms: Breast/metabolism; Breast/pathology*; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology*; Carcinoma, Ductal, Breast/genetics; Carcinoma, Ductal, Breast/metabolism; Carcinoma, Ductal, Breast/pathology*
  11. Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters
    Naidu R, Yip CH, Taib NA
    Med Oncol, 2012 Jun;29(2):411-7.
    PMID: 21301999 DOI: 10.1007/s12032-011-9837-8
    The purpose of the present study was to evaluate the association between TCF7L2 rs12255372(G/T) or rs7903146(C/T) polymorphism and breast cancer risk, and clinico-pathologic characteristics of the patients. Genotyping of these polymorphisms was performed on 387 breast cancer patients and 252 normal and healthy women who had no history of any malignancy using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Malaysian population. The allele (P = 0.033) frequency of rs7903146 (T) polymorphism was significantly higher in the cancer patients than normal individuals. No significant association was demonstrated between CT (OR(adj) = 1.386; 95% CI, 0.985-1.949) or TT (OR(adj) = 1.579; 95% CI, 0.869-2.870) genotype and breast cancer risk. However, women who were carriers of T allele (OR(adj) = 1.316; 95% CI, 1.022-1.695) or T allele genotype (OR(adj) = 1.419; 95% CI, 1.027-1.960) showed significant increased risk of breast cancer. Women who were GT heterozygotes (OR(adj) = 1.329; 95% CI, 0.948-1.862) or TT homozygotes (OR(adj) = 1.574; 95% CI, 0.829-2.987), and carriers of T allele genotype (OR(adj) = 1.365; 95% CI, 0.989-1.883) or T allele (OR(adj) = 1.284; 95% CI, 0.995-1.657) were not associated with breast cancer risk. The rs7903146(T) allele genotype was significantly associated with nodal involvement (P = 0.003) but rs12255372 (T) allele genotype was not associated with the clinico-pathologic characteristics. In conclusion, our findings suggest that rs7903146 (T) variant may elevate the risk of breast cancer, thus could be a potential candidate for breast cancer susceptibility. The variant may also increase the metastatic potential of the tumor.
    Matched MeSH terms: Breast/metabolism*; Breast/pathology; Breast Neoplasms/genetics*; Breast Neoplasms/metabolism; Breast Neoplasms/pathology*; Carcinoma, Ductal, Breast/genetics*; Carcinoma, Ductal, Breast/metabolism; Carcinoma, Ductal, Breast/pathology*
  12. Fulltext Barriers to breast self examination practice among Malaysian female students: a cross sectional study
    Akhtari-Zavare M, Juni MH, Ismail IZ, Said SM, Latiff LA
    Springerplus, 2015;4:692.
    PMID: 26587360 DOI: 10.1186/s40064-015-1491-8
    Breast cancer is the most frequent cancer and the second reason of cancer deaths among woman worldwide, including Malaysia. The objective of this paper is to assess the practice of breast self-examination (BSE) and identify the barriers of BSE practice among undergraduate female students in Malaysia.
    Matched MeSH terms: Breast Neoplasms; Breast Self-Examination
  13. Potential hydrophobic protein markers of breast cancer in Malaysian Chinese, Malay and Indian patients
    Liang S, Singh M, Gam LH
    Cancer Biomark, 2010;8(6):319-30.
    PMID: 22072120 DOI: 10.3233/CBM-2011-0221
    Breast cancer is a leading cause of worldwide mortality in females. In Malaysia, breast cancer is the most commonly diagnosed cancer in women. Of these, the Chinese had the most number of breast cancer cases, followed by the Indian and the Malay. The most common type of breast cancer is infiltrating ductal carcinoma (IDC). A proteomic approach was used to identify protein profile changes in cancerous tissues compared with the normal tissues, the tissues were collected from patients of three different ethnicities, i.e. Chinese, Malay and Indian. Ten differentially expressed hydrophobic proteins were identified. We had evaluated the potential of these proteins as biomarker for infiltrating ducal carcinoma (IDC) and the ethnic-specific expression of these proteins was also determined. The data showed that peroxiredoxin-2, heat shock protein 60, protein disulfide isomerase and calreticulin may serve as ethnic-related potential markers for either one or combination of Chinese, Malay and Indian cohorts as their expression levels were significantly high in the cancerous tissues compared to the normal tissues in the ethnic group tested.
    Publication year=2010-2011
    Matched MeSH terms: Breast Neoplasms/ethnology; Breast Neoplasms/genetics; Breast Neoplasms/metabolism*; Carcinoma, Ductal, Breast/ethnology; Carcinoma, Ductal, Breast/genetics; Carcinoma, Ductal, Breast/metabolism*
  14. Nucleolar organizer regions distribution in fine needle aspiration cytological smears from breast lesions
    Hasnan J, Jayaram G
    Malays J Pathol, 1996 Jun;18(1):35-41.
    PMID: 10879223
    Fine needle aspiration (FNA) cytology is now an integral part of the pre-operative investigation of breast lesions and the therapeutic protocol is today often planned on the basis of cytodiagnosis. However, from time to time the cytological picture may be equivocal or inconclusive. In recent years, nucleolar organizer region (NOR) scores have been explored for potential value in the diagnosis of malignancy as the scores in malignant nuclei are seen to be higher than in benign or reactive nuclei. With a view to applying NOR scoring in the evaluation of cytologically equivocal cases, we adopted the argyrophil technique for staining NOR s (AgNOR) in FNA cytological smears of 56 breast lesions, comprising 31 benign and 25 malignant lesions. Histological correlation was possible in 26 of these cases (17 malignant and 9 benign) and AgNOR scoring was done on paraffin sections of these as well. There was a significant difference between mean AgNOR scores in benign and malignant lesions in the cytological smears (P < 0.001). The AgNOR scores ranged from 2.5 to 5.0 per cell in benign lesions and 5.8 to 17.2 per cell in malignant lesions. None of the cases fell into the gray zone of overlap. One malignant lesion that was cytologically equivocal showed a mean AgNOR score of 6.08. The AgNOR scores on histological sections also showed a statistically significant difference (P < 0.001) between benign and malignant lesions with mean scores ranging from 1.34 to 2.58 dots per cell in benign lesions and scores of 2.42 to 5.28 dots per cell in malignant lesions. However, the scores overlapped in four cases and therefore it was considered unsuitable for routine diagnostic work. From this preliminary study, we conclude that an FNA AgNOR score of 5.0 and less strongly favours a benign lesion whereas a score above 5.0 would be in favour of a malignant lesion. A larger study would be needed to verify our impression that AgNOR scoring can be useful in cytologically equivocal cases.
    Matched MeSH terms: Breast/pathology; Breast Neoplasms/pathology*; Fibrocystic Breast Disease/pathology; Carcinoma, Ductal, Breast/pathology
  15. Discriminant analysis of normal and malignant breast tissue based upon INAA investigation of elemental concentration
    Ng KH, Ong SH, Bradley DA, Looi LM
    Appl Radiat Isot, 1997 Jan;48(1):105-9.
    PMID: 9022216
    Discriminant analysis of six trace element concentrations measured by instrumental neutron activation analysis (INAA) in 26 paired-samples of malignant and histologically normal human breast tissues shows the technique to be a potentially valuable clinical tool for making malignant-normal classification. Nonparametric discriminant analysis is performed for the data obtained. Linear and quadratic discriminant analyses are also carried out for comparison. For this data set a formal analysis shows that the elements which may be useful in distinguishing between malignant and normal tissues are Ca, Rb and Br, providing correct classification for 24 out of 26 normal samples and 22 out of 26 malignant samples.
    Matched MeSH terms: Breast/chemistry*; Breast Neoplasms/diagnosis; Breast Neoplasms/chemistry*; Carcinoma, Ductal, Breast/diagnosis; Carcinoma, Ductal, Breast/chemistry
  16. Fulltext The role of ductography in patients with nipple discharge
    Zulfiqar MA, Nair S, Lily M, Norizan MA, Samad SA
    Med J Malaysia, 1996 Dec;51(4):457-61.
    PMID: 10968034
    The main objective of this study is to illustrate the role of ductography in the management of nipple discharge. Thirty-six patients had ductography for the investigation of blood-stained or serous nipple discharge. The ductogram findings were reviewed. Ductography showed an intraductal lesion in 13 patients, duct ectasia in 16 and normal ducts in 7. Fourteen patients had surgery. Eight had preoperative ductography using a mixture of methylene blue and contrast media. Histology revealed 5 cases of duct papilloma, 2 cases of epithelial hyperplasia, 4 cases of fibrocystic change and 3 cases of duct ectasia. Twenty had follow-up without surgery and of these, the nipple discharge ceased in 11 patients. Two patients did not come for follow-up. Ductography has a significant role in the management of nipple discharge. Firstly, surgery might be averted in patients with normal ducts or duct ectasia on ductography. Secondly, intraductal methylene blue will demonstrate the abnormal ductal system to the surgeon and allow for a less radical surgery.
    Matched MeSH terms: Breast Diseases/radiography*
  17. Fulltext Programmes to promote breastfeeding
    Jelliffe EF
    Med J Malaysia, 1986 Mar;41(1):64-71.
    PMID: 3796353
    Modern concepts concerning the development of breastfeeding programmes are given, with special reference to maternal reflexes, the need for information and the health and nutrition of mothers. Motivation and education are needed for health professionals, families and administrators. Some successful programmes are mentioned including small-scale hospital activities and national programmes, notably the one developed in Brazil.
    Matched MeSH terms: Breast Feeding*
  18. Abstracts of the 5th International Academy of Pathology Malaysian Division, Annual Scientific Meeting 2018: Mediastinal and Breast Pathology
    Malays J Pathol, 2018 Dec;40(3):373-387.
    PMID: 30580371
    No abstract available.
    Matched MeSH terms: Breast Neoplasms/pathology*
  19. Fulltext Primary breast tuberculosis (TB) in a patient with known invasive breast carcinoma: A case report
    Lee CH, Sharif SZ
    Med J Malaysia, 2016 Jun;71(3):149-51.
    PMID: 27495893 MyJurnal
    Breast tuberculosis (TB) is rare even in endemic countries. Most of these cases occur as secondary TB due to a concurrent infection. Primary breast TB is diagnosed when it is the only site of disease without other foci of infection. The presentation of primary breast TB may often mimic carcinoma of the breast. While imaging is not specific, histopathology provides a definitive diagnosis. Here, we present a case of primary breast TB in a breast cancer patient and review the literature.
    Matched MeSH terms: Breast; Breast Neoplasms
  20. Fulltext Invasive Lobular Carcinoma of Breast Presenting with Left Sterno-chondral Junction Swelling. A Case Report
    Amran, A.R., Azlin Saat, Cheung, H.S.
    International Medical Journal Malaysia, 2007;6(2):1-8.
    MyJurnal
    Invasive Lobular Carcinoma of the breast is less common than Invasive Ductal Carcinoma and the presentation can be different from other types of breast carcinomas. It can present as diffuse swelling or thickening of breast rather than a mass. Sometimes, it can present as metastatic deposits from a very small primary breast lesion. These make the diagnosis of this type of breast carcinoma difficult and challenging for the radiologist and surgeon. We describe a case of Invasive Lobular Carcinoma of the breast, which presented with a left sterno-chondral metastasis and discuss the imaging findings and treatment of this condition.
    Matched MeSH terms: Breast; Breast Neoplasms
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