Displaying publications 41 - 60 of 118 in total

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  1. Bakar AA, Lim YL, Wilson SJ, Fuentes M, Bertling K, Taimre T, et al.
    Physiol Meas, 2013 Feb;34(2):281-9.
    PMID: 23363933 DOI: 10.1088/0967-3334/34/2/281
    Optical sensing offers an attractive option for detection of surface biopotentials in human subjects where electromagnetically noisy environments exist or safety requirements dictate a high degree of galvanic isolation. Such circumstances may be found in modern magnetic resonance imaging systems for example. The low signal amplitude and high source impedance of typical biopotentials have made optical transduction an uncommon sensing approach. We propose a solution consisting of an electro-optic phase modulator as a transducer, coupled to a vertical-cavity surface-emitting laser and the self-mixing signal detected via a photodiode. This configuration is physically evaluated with respect to synthesized surface electrocardiographic (EKG) signals of varying amplitudes and using differing optical feedback regimes. Optically detected EKG signals using strong optical feedback show the feasibility of this approach and indicate directions for optimization of the electro-optic transducer for improved signal-to-noise ratios. This may provide a new means of biopotential detection suited for environments characterized by harsh electromagnetic interference.
    Matched MeSH terms: Electronics/instrumentation*
  2. Sidhu P, Shankargouda S, Dicksit DD, Mahdey HM, Muzaffar D, Arora S
    J Endod, 2016 Apr;42(4):622-5.
    PMID: 26850688 DOI: 10.1016/j.joen.2015.12.027
    INTRODUCTION: Use of mobile phone has been prohibited in many hospitals to prevent interference with medical devices. Electromagnetic radiation emitted from cellular phones might interfere with electronic working length determination. The purpose of this in vitro study was to evaluate the effect of a smart phone (Samsung Galaxy Note Edge) on working length determination of electronic apex locators (EALs) Propex II and Rootor.

    METHODS: Fifteen intact, non-carious single-rooted teeth were decoronated at the cementoenamel junction. Visually, working length was determined by using a #15 K-file under stereomicroscope (×20). The effect of cellular phones on electronic working length (EWL) was determined under 2 experimental settings: (1) in a closed room with poor signal strength and (2) in a polyclinic set up with good signal strength and 5 conditions: (1) electronically, without cellular phone in room; (2) electronically, with cellular phone in physical contact with EAL; (3) electronically, with mobile phone in physical contact with EAL and in calling mode for a period of 25 seconds; (4) electronically, mobile phone placed at a distance of 40 cm from the EAL; and (5) electronically, mobile phone placed at a distance of 40 cm and in calling mode for a period of 25 seconds. The EWL was measured 3 times per tooth under each condition. Stability of the readings was scored from 1 to 3: (1) good stability, (2) stable reading after 1 attempt, and (3) stable reading after 2 attempts. The data were compared by using analysis of variance.

    RESULTS: The EWL measurements were not influenced by the presence of cellular phone and could be determined under all experimental conditions.

    CONCLUSIONS: Within the limitations of this study, it can be concluded that mobile phones do not interfere with the EWL determination.

    Matched MeSH terms: Electronics, Medical/instrumentation*
  3. Tan GL
    J Hum Ergol (Tokyo), 1996 Jun;25(1):49-62.
    PMID: 9551132 DOI: 10.11183/jhe1972.25.38
    The analyses of a few tasks were carried out in an electronics factory. The main objectives are to identify the ergonomic and biomechanical hazards of problem work tasks, to analyze each task systematically in order to evaluate the workers' exposures to the risk factors of force, posture pressure and repetition and to make recommendations to reduce the risks and hazards. The methodology includes objective measures--detailed analysis by going through training manuals, job description and production records. Subjective measures include interviewing the operator and supervisors informally, the operators were also required to fill in a structured questionnaire. The paper concludes by making recommendations to reduce the ergonomic hazards by engineering solutions, redesign or administrative controls or the implementation of procedures.
    Matched MeSH terms: Electronics*
  4. Whba R, Su'ait MS, Tian Khoon L, Ibrahim S, Mohamed NS, Ahmad A
    Polymers (Basel), 2021 Feb 23;13(4).
    PMID: 33672185 DOI: 10.3390/polym13040660
    The exploitation of epoxidized natural rubber (ENR) in electrochemical applications is approaching its limits because of its poor thermo-mechanical properties. These properties could be improved by chemical and/or physical modification, including grafting and/or crosslinking techniques. In this work, acrylonitrile (ACN) has been successfully grafted onto ENR- 25 by a radical photopolymerization technique. The effect of (ACN to ENR) mole ratios on chemical structure and interaction, thermo-mechanical behaviour and that related to the viscoelastic properties of the polymer was investigated. The existence of the -C≡N functional group at the end-product of ACN-g-ENR is confirmed by infrared (FT-IR) and nuclear magnetic resonance (NMR) analyses. An enhanced grafting efficiency (~57%) was obtained after ACN was grafted onto the isoprene unit of ENR- 25 and showing a significant improvement in thermal stability and dielectric properties. The viscoelastic behaviour of the sample analysis showed an increase of storage modulus up to 150 × 103 MPa and the temperature of glass transition (Tg) was between -40 and 10 °C. The loss modulus, relaxation process, and tan delta were also described. Overall, the ACN-g-ENR shows a distinctive improvement in characteristics compared to ENR and can be widely used in many applications where natural rubber is used but improved thermal and mechanical properties are required. Likewise, it may also be used in electronic applications, for example, as a polymer electrolyte in batteries or supercapacitor.
    Matched MeSH terms: Electronics
  5. Mohd Pisal MH, Osman AF, Jin TS, Rahman RA, Alrashdi AA, Masa A
    Polymers (Basel), 2021 Feb 17;13(4).
    PMID: 33671304 DOI: 10.3390/polym13040600
    Carbonized natural filler can offer the production of low cost composites with an eco-friendliness value. The evolving field of electronics encourages the exploration of more functions and potential for carbonized natural filler, such as by modifying its surface chemistry. In this work, we have performed surface modification on carbonized wood fiber (CWF) prior to it being used as filler in the ethylene vinyl acetate (EVA) composite system. Zinc chloride (ZnCl2) with various contents (2 to 8 wt%) was used to surface modify the CWF and the effects of ZnCl2 composition on the surface morphology and chemistry of the CWF filler were investigated. Furthermore, the absorptive, mechanical, thermal, and electrical properties of the EVA composites containing CWF-ZnCl2 were also analyzed. SEM images indicated changes in the morphology of the CWF while FTIR analysis proved the presence of ZnCl2 functional groups in the CWF. EVA composites incorporating the CWF-ZnCl2 showed superior mechanical, thermal and electrical properties compared to the ones containing the CWF. The optimum content of ZnCl2 was found to be 6 wt%. Surface modification raised the electrical conductivity of the EVA/CWF composite through the development of conductive deposits in the porous structure of the CWF as a channel for ionic and electronic transfer between the CWF and EVA matrix.
    Matched MeSH terms: Electronics
  6. Wan Faizatul Azirah Ismayatim, Nur Dalila Mohamad Nazri, Ramiaida Darmi, Nursyuhada’ Ab Wahab, Nur Adibah Zamri, Haliza Harun, et al.
    Jurnal Inovasi Malaysia, 2020;4(1):173-192.
    MyJurnal
    This paper presents an innovation of a revolutionized self-directed English learning module entitled My Electronic Visual and Audio (MyEVO), which is designed and developed to assist language learners to conveniently acquire the required listening skills through the combination of current and state-of-the-art technology - Augmented Reality (AR) and mobile applications. Using Video Media method introduced by Gruba (1997, 2004), all listening practices in this module are based on video recording. Feedbacks gained from the users of the module indicate that learners are very excited and happy to use technology assisted module in acquiring listening skills compared to the traditional module. Educators also believe that this module cater the needs of the 21st century learners and is suitable to be used inside the classroom or as a self-directed learning module. Another key feature of this smart module highlighted by the educators is the ability of the mobile application that allows learners to engage with the e-global community known as ‘MyEVO community, where all users can share their answers and exchange opinions regarding the given questions. In addition, listening activities that were designed in this module also cover the Higher Order Thinking Skills (HOTS) needed in learning. Educators also agreed that this interactive feature does not only encourage the learners to be active in their learning but it also helps to reduce their anxiety, learning process becomes more interesting and helps to aid their understanding of the topics covered.
    Matched MeSH terms: Electronics
  7. Hassan H, Jin B, Dai S
    Environ Technol, 2021 Apr 01.
    PMID: 33749543 DOI: 10.1080/09593330.2021.1907451
    The interactions within microbial, chemical and electronic elements in microbial fuel cell (MFC) system can be crucial for its bio-electrochemical activities and overall performance. Therefore, this study explored polynomial models by response surface methodology (RSM) to better understand interactions among anode pH, cathode pH and inoculum size for optimising MFC system for generation of electricity and degradation of 2,4-dichlorophenol. A statistical central composite design by RSM was used to develop the quadratic model designs. The optimised parameters were determined and evaluated by statistical results and the best MFC systematic outcomes in terms of current generation and chlorophenol degradation. Statistical results revealed that the optimum current density of 106 mA/m2 could be achieved at anode pH 7.5, cathode pH 6.3-6.6 and 21-28% for inoculum size. Anode-cathode pHs interaction was found to positively influence the current generation through extracellular electron transfer mechanism. The phenolic degradation was found to have lower response using these three parameter interactions. Only inoculum size-cathode pH interaction appeared to be significant where the optimum predicted phenolic degradation could be attained at pH 7.6 for cathode pH and 29.6% for inoculum size.
    Matched MeSH terms: Electronics
  8. Uzir MUH, Jerin I, Al Halbusi H, Hamid ABA, Latiff ASA
    Heliyon, 2020 Dec;6(12):e05710.
    PMID: 33367128 DOI: 10.1016/j.heliyon.2020.e05710
    Customer is considered as the king in the world of business. The issue of customer satisfaction in electronics home appliances has received greater attention from academics and practitioners. In other words, customer satisfaction is a vital consideration in marketing. With the development of technology, new and innovative electronic home appliances are available in the market. Customers purchase and use the costly electronic home appliances where the satisfaction issue is an important concern. In Bangladesh, working families find the electronic home appliance very necessary. Companies offer state-of- the-art appliances for customers' household works. Therefore, the study intends to investigate the effect of product quality (PQ), quality of service (SQ) and perceived value on customer satisfaction (CS). In addition, this study also seeks this relationship shaped by customer's perceived value (CPV) as a key mechanism and interacted by social media usage. A total of 300 households were selected on a judgmental basis from Dhaka city in Bangladesh using a structured questionnaire. Collected data were CB-SEM (AMOS-v24) and SPSS. The findings showed PQ and SQ have positive effects on CS; SQ affects, but PQ does not affect CPV. CPV has a mixing mediating effect on SQ and CS relationship and PQ and CS relationship. Importantly, the positive impact of PQ, SQ and CPV is greater on customers who exhibit higher social media use. The conceptual framework was buttressed by EDT theory. The study contributed to contextual and theoretical knowledge in regards to home appliances. The practicing managers can collect an insight of customer satisfaction for their business.
    Matched MeSH terms: Electronics
  9. Ooi PC, Mohammad Haniff MAS, Mohd Razip Wee MF, Goh BT, Dee CF, Mohamed MA, et al.
    Sci Rep, 2019 May 01;9(1):6761.
    PMID: 31043694 DOI: 10.1038/s41598-019-43279-3
    In the interest of the trend towards miniaturization of electronic gadgets, this study demonstrates a high-density data storage device with a very simple three-stacking layer consisting of only one charge trapping layer. A simple solution-processed technique has been used to fabricate the tristable non-volatile memory. The three-stacking layer was constructed in between two metals to form a two-terminal metal-insulator-metal structure. The fabricated device showed a large multilevel memory hysteresis window with a measured ON/OFF current ratio of 107 that might be attributed to the high charge trapped in molybdenum disulphide (MoS2) flakes-graphene quantum dots (GQDs) heterostructure. Transmission electron microscopy was performed to examine the orientation of MoS2-GQD and mixture dispersion preparation method. The obtained electrical data was used further to speculate the possible transport mechanisms through the fabricated device by a curve fitting technique. Also, endurance cycle and retention tests were performed at room temperature to investigate the stability of the device.
    Matched MeSH terms: Electronics
  10. Chan KG, Pawi S, Ong MF, Kowitlawakul Y, Goy SC
    Nurse Educ Pract, 2020 Oct;48:102864.
    PMID: 32920369 DOI: 10.1016/j.nepr.2020.102864
    The aim of this study was to investigate factors influencing nursing students' intention to use a simulated web-application 'Integrated Nursing Education System' for practicing electronic health documentation. The cross-sectional study was conducted at a Malaysian University that provides undergraduate nursing degree program. A total of 133 undergraduate nursing students in their year 2 to year 4 of the program were recruited. They had accessed the simulated web-application as part of the teaching-learning activities during the academic year 2016/2017. Technology Acceptance Model was used to guide the study. Validated questionnaires were used to measure the students' perceived ease of use, perceived usefulness, attitudes and intention to use the application. Data collection was done at the end of the semester. Data analysis was done using SPSS (19.0) and AMOS (23.0). Perceived usefulness was the most influential factor of the students' intention to use the simulated web-application. Perceived ease of use influenced their perceived usefulness significantly. Nurse educators should explain the usefulness of the simulated web-application before assigning students to access it to practice electronic health documentation. The availability of a stable internet access and IT support is important to influence students' perceived ease of use and intention to use the application.
    Matched MeSH terms: Electronics
  11. Sathian B, Asim M, Banerjee I, Roy B, Pizarro AB, Mancha MA, et al.
    Nepal J Epidemiol, 2021 Mar;11(1):959-982.
    PMID: 33868742 DOI: 10.3126/nje.v11i1.36163
    Background: To date, there is no comprehensive systematic review and meta-analysis to assess the suitability of COVID-19 vaccines for mass immunization. The current systematic review and meta-analysis was conducted to evaluate the safety and immunogenicity of novel COVID-19 vaccine candidates under clinical trial evaluation and present a contemporary update on the development and implementation of a potential vaccines.

    Methods: For this study PubMed, MEDLINE, and Embase electronic databases were used to search for eligible studies on the interface between novel coronavirus and vaccine design until December 31, 2020.

    Results: We have included fourteen non-randomized and randomized controlled phase I-III trials. Implementation of a universal vaccination program with proven safety and efficacy through robust clinical evaluation is the long-term goal for preventing COVID-19. The immunization program must be cost-effective for mass production and accessibility. Despite pioneering techniques for the fast-track development of the vaccine in the current global emergency, mass production and availability of an effective COVID-19 vaccine could take some more time.

    Conclusion: Our findings suggest a revisiting of the reported solicited and unsolicited systemic adverse events for COVID-19 candidate vaccines. Hence, it is alarming to judiciously expose thousands of participants to COVID-19 candidate vaccines at Phase-3 trials that have adverse events and insufficient evidence on safety and effectiveness that necessitates further justification.

    Matched MeSH terms: Electronics
  12. Junaid HM, Batool M, Harun FW, Akhter MS, Shabbir N
    Crit Rev Anal Chem, 2020 Sep 08.
    PMID: 32897731 DOI: 10.1080/10408347.2020.1806703
    Spectacular color change during a chemical reaction is always fascinating. A variety of chemosensors including Schiff bases have been reported for selective as well as sensitive recognition of ions. This review explains the use of Schiff bases as color changing agents in the detection of anions. This magic of colors is attributed to change in the electronic structure of the system during reaction. Schiff base chemosensors are easy to synthesize, inexpensive and can be used for visual sensing of different ions. Development of Schiff base chemosensors is commonly based on the interactions between polar groups of Schiff bases and ionic species and the process of charge transfer, electron transfer and hydrogen bonding between Schiff bases and ionic species cause the color of the resultant to be changed. Therefore, designing of simple Schiff base chemosensors which are capable of selective sensing of different anions has attracted considerable interest. In particular, naked eye sensing through color change is important and useful since it allows sensing of ions through color changes without using any instrumental technique.HighlightsNaked eye sensors are of much interest these days due to their visual detection properties rather employing complex instrumentation.Optical sensors are sensitive, selective, cost effective and robust.The magic of color change is fascinating factor in detection by these sensors.The color change may be attributed by interaction between anion and Schiff base by different mechanism i.e. electron transfer, charge transfer, hydrogen bonding, ICT etc.LOD data is an evidence of their great efficiency.
    Matched MeSH terms: Electronics
  13. Kow CS, Hasan SS
    J Asthma, 2021 Feb 08.
    PMID: 33461348 DOI: 10.1080/02770903.2021.1878531
    Objective: With emerging of observational evidence, we aimed to perform a meta-analysis to summarize the overall effect of the chronic use of inhaled corticosteroids on the clinical outcomes in patients with coronavirus disease 2019 (COVID-19). Methods:Systematic literature search in electronic databases was performed to identify observational studies that investigated the preadmission use of inhaled corticosteroids on the risk of a fatal or severe course of illness in patients with COVID-19 and reported adjusted measures of association. Adjusted odds ratios or relative risks and the corresponding 95% confidence intervals from each study were pooled to produce pooled odds ratio and 95% confidence interval. Results: The meta-analysis revealed no significant difference in the risk for the development of a fatal course of COVID-19 with preadmission use of inhaled corticosteroids in patients with COVID-19 relative to non-use of inhaled corticosteroids (pooled odds ratio=1.28; 95% confidence interval 0.73-2.26). Similarly, the meta-analysis observed no significant difference in the risk for the development of a severe course of COVID-19 with preadmission use of inhaled corticosteroids in patients with COVID-19 relative to non-use of inhaled corticosteroids (pooled odds ratio=1.45; 95% confidence interval 0.96-2.20).Conclusions: Our findings assured the safety of continued use of inhaled corticosteroids during the COVID-19 pandemic.
    Matched MeSH terms: Electronics
  14. Kumar S, Foroozesh J
    Carbohydr Polym, 2021 Apr 01;257:117619.
    PMID: 33541647 DOI: 10.1016/j.carbpol.2021.117619
    Chitin biopolymer has received significant attention recently by many industries as a green technology. Nanotechnology has been used to make chitin nanocrystals (ChiNCs) that are rod-shaped natural nanomaterials with nanoscale size. Owing to the unique features such as biodegradability, biocompatibility, renewability, rod-shape, and excellent surface and interfacial, physiochemical, and thermo-mechanical properties; ChiNCs have been green and attractive products with wide applications specifically in medical and pharmaceutical, food and packaging, cosmetic, electrical, and electronic, and also in the oil and gas industry. This review aims to give a comprehensive and applied insight into ChiNCs technology. It starts with reviewing different sources of chitin and their extraction methods followed by the characterization of ChiNCs. Furthermore, a detailed investigation into various complex fluids (dispersions, emulsions, foams, and gels) stabilized by ChiNCs and their characterisation have been thoroughly deliberated. Finally, the current status including ground-breaking applications, untapped investigations, and future prospective have been presented.
    Matched MeSH terms: Electronics
  15. Bin Rafiq MKS, Amin N, Alharbi HF, Luqman M, Ayob A, Alharthi YS, et al.
    Sci Rep, 2020 Jan 21;10(1):771.
    PMID: 31964954 DOI: 10.1038/s41598-020-57596-5
    Radio frequency (RF) magnetron sputtering was used to deposit tungsten disulfide (WS2) thin films on top of soda lime glass substrates. The deposition power of RF magnetron sputtering varied at 50, 100, 150, 200, and 250 W to investigate the impact on film characteristics and determine the optimized conditions for suitable application in thin-film solar cells. Morphological, structural, and opto-electronic properties of as-grown films were investigated and analyzed for different deposition powers. All the WS2 films exhibited granular morphology and consisted of a rhombohedral phase with a strong preferential orientation toward the (101) crystal plane. Polycrystalline ultra-thin WS2 films with bandgap of 2.2 eV, carrier concentration of 1.01 × 1019 cm-3, and resistivity of 0.135 Ω-cm were successfully achieved at RF deposition power of 200 W. The optimized WS2 thin film was successfully incorporated as a window layer for the first time in CdTe/WS2 solar cell. Initial investigations revealed that the newly incorporated WS2 window layer in CdTe solar cell demonstrated photovoltaic conversion efficiency of 1.2% with Voc of 379 mV, Jsc of 11.5 mA/cm2, and FF of 27.1%. This study paves the way for WS2 thin film as a potential window layer to be used in thin-film solar cells.
    Matched MeSH terms: Electronics
  16. Ying Qian Ong, Sakinah Harith, Mohd Razif Shahril, Norshazila Shahidan
    MyJurnal
    Treatment effectiveness depends on the knowledge, attitude, and practice (KAP) of osteoarthritis (OA) patients to- wards their assigned treatment. This study aimed to explore the KAP towards non-surgical intervention among OA patients. A methodological framework proposed by Arksey and O’Malley (2005) was implemented. An electronic database search of English-language academic articles was conducted using PubMed and ScienceDirect databases encompassing 1998 to 2018 period of time, resulting in a total of 26 studies. OA patients were knowledgeable about the disease and exercise management. However, they were lack of knowledge on drug therapy and complementary strategies. The attitude towards non-surgical interventions was ambivalence. Lastly, the practice section mainly fo- cused on patients’ compliance and behaviour towards different conservative managements, namely physiotherapy, medications, and complementary and alternative medicines (CAMs) which influenced by both knowledge level and attitudes. In conclusion, a higher knowledge level and positive attitude will result in good practice.
    Matched MeSH terms: Electronics
  17. Ahmad Badruddin Ghazali, Nur Imanina Abdullah Thaidi
    MyJurnal
    The purpose of this study was to integrate the available data published to date on susuk or charm needles into a com- prehensive analysis of their clinical/radiological features. An electronic search was undertaken in September 2019. Eligibility criteria included publications having enough clinical and radiological to confirm a definite diagnosis. The initial literature search resulted in 48 publications. Ten publications were excluded for duplicates, and another 17 excluded after a screening of the abstract. Besides, the screening of the abstract shows that five publications were not meeting the inclusion criteria, resulting in a total of 14 publications of susuk that were included in the systematic review. Bias analysis was conducted according to Oxford Center for Evidence-Based Medicine. The resulting total of 78 cases from the selected publications were analysed, showing a wide age range with different distribution among gender and ethnicity. Three cases reported in the literature having symptoms related to susuk. Susuk can be seen as an incidental finding during a routine radiographic assessment, and clinicians should be able to differentiate it from other radiopaque foreign bodies. The practice is not limited to South East Asian population and can be seen in wide racial profiles.
    Matched MeSH terms: Electronics
  18. Venkiteswaran A, Tandon S
    J Int Soc Prev Community Dent, 2021 04 15;11(2):115-124.
    PMID: 34036071 DOI: 10.4103/jispcd.JISPCD_320_20
    Aim: This narrative aims to outline the use of hypnosis in managing dental anxiety in during dental treatment. The PICO used to answer the objectives are (P) dental patients, (I) hypnosis, (C) conventional behaviour management techniques & (O) reduced pain/anxiety.

    Materials and Methods: An electronic search of three databases; PubMed, Scopus and EBSCOhost was conducted using the keywords "hypnosis or hypnotherapy" AND "dentistry or dental" between the year 2000 and 2020. A total of 19 studies were selected based on eligibility. Data extracted were study subject, design of study, parameters used to assess, type of hypnosis script used and the study outcome.

    Results: The studies show that hypnosis is effective in pain management and dental anxiety. It can also be used for improving compliance in patients who are wearing orthodontic appliances (Trakyali et al, 2008) and reducing salivary flow during dental treatment (Satlz et al, 2014).

    Conclusion: Hypnosis has the potential to be a useful tool in the management of children and adults.

    Matched MeSH terms: Electronics
  19. Tawfik EA, Cartwright MS, Grimm A, Boon AJ, Kerasnoudis A, Preston DC, et al.
    Muscle Nerve, 2021 05;63(5):651-656.
    PMID: 33382094 DOI: 10.1002/mus.27163
    Neuromuscular ultrasound is a rapidly evolving specialty with direct application for patient care. Competency assessment is an essential standard needed to ensure quality for practitioners, particularly for those newly acquiring skills with the technique. Our aim was to survey experts' opinions regarding physician competency assessment of neuromuscular ultrasound and to identify minimal competency of knowledge and skills. The opinions of 18 experts were obtained through the Delphi method using two consecutive electronic surveys. A high degree of consensus was achieved on items regarding framework and the conduct of neuromuscular ultrasound assessment and the knowledge and skills that a candidate needs to attain minimal competency in neuromuscular ultrasound. In this study, a group of neuromuscular ultrasound experts developed a general framework for neuromuscular ultrasound competency assessment and recommended testable areas of knowledge and skills suitable for establishing minimal competency.
    Matched MeSH terms: Electronics
  20. Nadia Ahmad NF, Nik Ghazali NN, Wong YH
    Biosens Bioelectron, 2021 May 30;189:113384.
    PMID: 34090154 DOI: 10.1016/j.bios.2021.113384
    The advanced stimuli-responsive approaches for on-demand drug delivery systems have received tremendous attention as they have great potential to be integrated with sensing and multi-functional electronics on a flexible and stretchable single platform (all-in-one concept) in order to develop skin-integration with close-loop sensation for personalized diagnostic and therapeutic application. The wearable patch pumps have evolved from reservoir-based to matrix patch and drug-in-adhesive (single-layer or multi-layer) type. In this review, we presented the basic requirements of an artificial pancreas, surveyed the design and technologies used in commercial patch pumps available on the market and provided general information about the latest wearable patch pump. We summarized the various advanced delivery strategies with their mechanisms that have been developed to date and representative examples. Mechanical, electrical, light, thermal, acoustic and glucose-responsive approaches on patch form have been successfully utilized in the controllable transdermal drug delivery manner. We highlighted key challenges associated with wearable transdermal delivery systems, their research direction and future development trends.
    Matched MeSH terms: Electronics
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