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Three-dimensional image analysis of developing mandibular third molars apices for age estimation: A study using CBCT data enhanced with Mimics & 3-Matics software

Asif MK, Nambiar P, Ibrahim N, Al-Amery SM, Khan IM

Leg Med (Tokyo), 2019 Jul;39:9-14.
PMID: 31158731 DOI: 10.1016/j.legalmed.2019.05.003

Three-dimensional imaging has improved the method of analysis in many forensic science investigations. The study aimed to derive regression equation for age estimation by investigating the relationship between chronological age and surface area of the developing mandibular 3rd molars apices. Furthermore, other predictor variables: ethnicity (Malay and Chinese), gender and status of the root development completion (open/closed apices) were also investigated in terms of fit to the age estimation model. One hundred and twenty eight training and 55 validation samples of intact mandibular 3rd molars were selected from 183 CBCT scans. The samples comprised of 93 Malays and 90 Chinese, ranging in age from 13 to 24 years. Three-dimensional image modeling and surface area analysis of the developing mandibular 3rd molars apices were performed using Mimics and 3-Matics software. Multiple linear regression analysis was used to derive age estimation model using chronological age as a dependent variable and surface area of the apices, ethnicity, gender and status of the root development completion (open/closed apices) as predictor variables. A strong inverse correlation (r = 0.95, SD = 1.144) was observed between chronological age and all the predictor variables. The results showed that 89.6% of the variation in age can be explained by the predictor variables. Mean absolute error (MAE) value of 0.8223 was observed when the derived regression equation was tested on the independent validation sample. In conclusion, three-dimensional surface area analysis of the developing mandibular 3rd molars apices can be used as a reliable method for age estimation.

Matched MeSH terms: Forensic Medicine/methods*
Establishment of Reference Ranges for Normal Organ Weights in Malaysian Adults at Autopsy

Jothee S, Shafie MS, Vijayaretnam SV, Nor FM

Am J Forensic Med Pathol, 2020 Jun;41(2):110-114.
PMID: 32205487 DOI: 10.1097/PAF.0000000000000539

Organ weights are routinely measured during autopsies as a crude screening tool to detect possible organ pathology. In several centers, inclusion of major organ weights indicates whether an autopsy report has achieved its standard of practice, which in turn should be subjected to an audit. Previous studies show statistical variation in organ weights across different populations. Malaysian pathologists have relied on Western data and crude subjective determination in the interpretation of normal organ weights. Hence, the need for a reference range as a guide for pathologists is acute. Organ weights from traumatic deaths between 2004 and 2017 were analyzed in the UKM Medical Centre. Statistical analysis was performed to form reference ranges for normal weights of the brain, heart, lung, liver, spleen, and kidneys. In addition, the data were compared between sexes, races, and body mass index values to determine whether organ weights were affected by these parameters. In this study, reference ranges for organ weights are presented for Malaysian adult men and women.

Matched MeSH terms: Forensic Medicine*
Decoding death by unknown causes using post mortem image-guided virtopsy: A review of recent literature and the Malaysian experience

Tawfiq Zyoud TY, Abdul Rashid SN, Suppiah S, Abdul Rahim E, Mahmud R

Med J Malaysia, 2020 07;75(4):411-418.
PMID: 32724006

INTRODUCTION: Autopsy is one of the most important approaches to identify clearly the exact cause of death, whether it was due to natural causes, sudden death, or traumatic. Various studies have been done in different countries regarding ways to improve the diagnosis during autopsy. The imaging approach is one of the methods that has been used to complement autopsy findings and to enhance the diagnosis for achieving the most accurate post-mortem diagnosis. The aim of this study is to identify the role of imaging modalities that complement routine autopsy and correlate the findings of diagnostic imaging that can help improve the accuracy of diagnosing the cause of death.
METHODS: We sourced articles from Scopus, Ovid and PubMed databases for journal publications related to post-mortem diagnostic imaging. We highlight the most relevant full articles in English that explain the type of modality that was utilised and the added value it provided for diagnosing the cause of death.
RESULTS: Minimally invasive autopsies assisted by imaging modalities added a great benefit to forensic medicine, and supported conventional autopsy. In particular the role of post mortem computed tomography (PMCT), post mortem computed tomography angiography (PMMR) and positron emission tomography computed tomography (PMCTA) that have incremental benefits in diagnosing traumatic death, fractures, tissue injuries, as well as the assessment of body height or weight for corpse identification.
CONCLUSION: PMCT and PMMR, with particular emphasis on PMCTA, can provide higher accuracy than the other modalities. They can be regarded as indispensable methods that should be applied to the routine autopsy protocol, thus improving the findings and accuracy of diagnosing the cause of death.

Matched MeSH terms: Forensic Medicine
Morphological patterns of the palatal rugae: A review

Chong JA, Mohamed AMFS, Pau A

J Oral Biosci, 2020 09;62(3):249-259.
PMID: 32619633 DOI: 10.1016/j.job.2020.06.003

BACKGROUND: Palatal rugae are asymmetric ridges of connective tissue located behind the incisive papilla over the anterior hard palate. They serve as stable superimposition landmarks to assess tooth movement in orthodontics and as identification aids in forensic odontology. However, the stability of palatal rugae remains controversial. This review aimed to describe the genetic, growth, and environmental factors that may influence the palatal rugae patterns. A broad search of PubMed and ScienceDirect databases was conducted. A total of 193 articles were identified, of which 73 met the selection criteria. Data were extracted into a table that presented the details of the study, sample description, and changes in the palatal rugae patterns.
HIGHLIGHT: There were conflicting results regarding sexual dimorphism and population characterization of the palatal rugae patterns. All rugae showed positional changes, increased lengths, and lower numbers, but no significant shape changes with growth. The lengths, numbers, and positions of the rugae were affected by orthodontic treatment, especially their lateral points, but their individual characteristics did not change.
CONCLUSION: The diversity in rugae patterns and their potential for sex discrimination among different populations showed differing results due to individual variations and the complex influence of genetic, growth, and environmental factors on their morphology.

Matched MeSH terms: Forensic Medicine
A 15-year study of death in custody in Tuanku Ja'afar Hospital Seremban

Mahamad Arif ANF, Syed Alwee Al'aidrus SS, Shafee MS, Mohd Nor F

Malays J Pathol, 2021 Aug;43(2):303-310.
PMID: 34448794

Death-in-custody refers to the occurrence of death, while a person is under the custody of any enforcement agency. Their incidence often creates overwhelming public and media attention. Currently, there is no standardised definition of 'death-in-custody' in Malaysia and internationally. A crosssectional descriptive study was performed in the Department of Forensic Medicine Hospital Tuanku Ja'afar Seremban (HTJS) for a period of 24 months. Information on all custodial deaths registered at HTJS from January 2001 till December 2015 was selected from the in-house hospital death registration system. The definition of 'death-in-custody' used was guided by the recommendation by the 'Australian Royal Commission into Aboriginal Deaths in Custody' 1991 with few adjustments. Four custodial settings of interest (the police, prison, immigration depot for the illegal immigrant, and army custody) were studied. A total of 172 deaths-in-custody were collected, in which the majority of cases were natural deaths (84.88%), predominantly infective in nature (65.07%). Less than 1/6th of cases were unnatural deaths with more than 80% died from legal intervention. All custodial deaths were dominated by males (96.51%) with a mean and median age of 37 years. In terms of nationality, 52.91% of the deaths involved Malaysian citizens in which the 'Malay/Bumi' race outnumbered the other two main races. The most documented custodial deaths occurred in prison (44.19%) followed by immigration depots (38.37%) and police lock-ups (17.44%). This study provides a general overview of the pattern including the causes and the demographic profile involving death in custody in the Seremban district registered at HTJS.

Matched MeSH terms: Forensic Medicine*
Fulltext Preliminary forensic assessment of the visualised fingerprints on nonporous substrates immersed in water using the green and optimised novel nanobio-based reagent

Azman AR, Mahat NA, Abdul Wahab R, Ahmad WA, Ismail D

Sci Rep, 2022 08 30;12(1):14780.
PMID: 36042359 DOI: 10.1038/s41598-022-18929-8

The discovery of forensic evidence (e.g. weapons) during forensic underwater investigations has seen an increasing trend. To date, small particle reagent (SPR) has been one of the routinely used methods for visualising fingerprints on wet, non-porous substrates. However, the long term use of SPR is detrimental to humans and environment due to the use of toxic chemicals. Although previously we have successfully developed and optimised a greener nanobio-based reagent (NBR), its suitable practical use in a more realistic scene (e.g. outdoor pond) was not evaluated. Therefore, this present research is aimed at (1) investigating the performance of NBR against the benchmark SPR in visualising fingerprints immersed in a natural outdoor pond and (2) evaluating the greenness of NBR against the analytical Eco-Scale. Results showed that the performance of the optimised NBR was mostly comparable (University of Canberra (UC) comparative scale: 0) with SPR at visualising fingerprints on three different non-porous substrates immersed in a natural outdoor pond. Observably, the NBR had higher preference towards aged fingerprints (up to 4 weeks of immersion). In addition, its greenness assessment revealed 76 points, indicating 'excellent green analysis'. The findings gathered here further supported the practical use of the NBR in forensic investigations.

Matched MeSH terms: Forensic Medicine/methods
Abstracts of the International Convention of Forensic Medicine & Science, Langkawi 2023: Towards Quality and Accountability in Forensic Practice, co-organised by Ministry of Health, Malaysia, Malaysian Society of Forensic Medicine and Science and Hospital Sultanah Bahiyah, Kedah and held on 25th - 27th July 2023

Malays J Pathol, 2024 Apr;46(1):199-230.
PMID: 38682856

No abstract available.

Matched MeSH terms: Forensic Medicine*