Displaying publications 41 - 60 of 128 in total

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  1. Walters SM, Li WP, Saifi R, Azwa I, Syed Omar SF, Collier ZK, et al.
    J Int Assoc Provid AIDS Care, 2022;21:23259582221128512.
    PMID: 36177542 DOI: 10.1177/23259582221128512
    Objective: In Malaysia, HIV is concentrated among key populations who experience barriers to care due to stigma and healthcare discrimination. The COVID-19 pandemic has increased barriers to healthcare. Project ECHO (Extension for Community Healthcare Outcomes) is a transformative tele-education strategy that could improve HIV prevention and treatment. Methods: Practicing physicians who were aged 18 years or older and had internet access participated in asynchronous online focus groups. Results: Barriers to Project ECHO were conflicting priorities, time constraints, and technology. Facilitators included content and format, dedicated time, asynchronized flexible programming, incentives, and ensuring technology was available. Conclusion: Project ECHO is a promising intervention that can increase physicians' knowledge and skill set in specialty medicine during the COVID-19 pandemic. Interventionists in Malaysia in particular, but also in general, should consider these barriers and facilitators when developing Project ECHO as they may aid in developing a more robust program and increase participation.
    Matched MeSH terms: Pandemics/prevention & control
  2. Al-Shareeda MA, Manickam S
    Int J Environ Res Public Health, 2022 Nov 24;19(23).
    PMID: 36497709 DOI: 10.3390/ijerph192315618
    The COVID-19 pandemic is currently having disastrous effects on every part of human life everywhere in the world. There have been terrible losses for the entire human race in all nations and areas. It is crucial to take good precautions and prevent COVID-19 because of its high infectiousness and fatality rate. One of the key spreading routes has been identified to be transportation systems. Therefore, improving infection tracking and healthcare monitoring for high-mobility transportation systems is impractical for pandemic control. In order to enhance driving enjoyment and road safety, 5G-enabled vehicular fog computing may gather and interpret pertinent vehicle data, which open the door to non-contact autonomous healthcare monitoring. Due to the urgent need to contain the automotive pandemic, this paper proposes a COVID-19 vehicle based on an efficient mutual authentication scheme for 5G-enabled vehicular fog computing. The proposed scheme consists of two different aspects of the special flag, SF = 0 and SF = 1, denoting normal and COVID-19 vehicles, respectively. The proposed scheme satisfies privacy and security requirements as well as achieves COVID-19 and healthcare solutions. Finally, the performance evaluation section shows that the proposed scheme is more efficient in terms of communication and computation costs as compared to most recent related works.
    Matched MeSH terms: Pandemics/prevention & control
  3. Al-Mhanna SB, Wan Ghazali WS, Mohamed M, Sheikh AM, Tabnjh AK, Afolabi H, et al.
    PeerJ, 2022;10:e14131.
    PMID: 36248716 DOI: 10.7717/peerj.14131
    BACKGROUND: International restrictions were enacted during the COVID-19 pandemic to limit social interaction and viral transmission. These measures had a negative impact on physical activity (PA), creating changes in students' health and lifestyles. The present study aimed to evaluate the levels of PA among undergraduate students in three different universities in Mogadishu after the relaxation of COVID-19 lockdown using the international physical activity questionnaire-long version (IPAQ-L) and its potential associated factors.

    METHODS: This study is a multicentral study conducted at Somali International University, Horn of Africa University, and Daha International University. A total of 1,189 respondents were asked to answer the online questionnaire provided via a link shared using their social media.

    RESULTS: After COVID-19 restrictions approximately ≥ 150 minutes of PA per week was reported by 500 men (97.3%) and 652 women (96.6%) at work. While 7 (1.4%) of men and 20 (3%) of women participate in < 150 minutes each week, respectively. Furthermore, only seven (1.4%) of males and three (0.4%) of women reported to have not performed any PA at work.

    CONCLUSION: The majority of the undergraduate students at the selected universities in Mogadishu were physically active after the relaxation of COVID-19 rules in Somalia. Such a high level of PA is a significant advantage to public health.

    Matched MeSH terms: Pandemics/prevention & control
  4. Vohra SB, Kumar CM
    Eye (Lond), 2023 Feb;37(3):548-553.
    PMID: 35220400 DOI: 10.1038/s41433-022-01979-7
    AIMS: This international survey was conducted to study the impact of Covid-19 pandemic on the provision and practices of ophthalmic anaesthesia, evaluate the methods employed by parent ophthalmic units for safeguarding their anaesthesia providers and patients during lockdown, and to assess pandemic's effect on anaesthesia providers as individuals. The study was done with the hope that the results will help in protecting patients and safeguarding precious human resource by better management if this pandemic was to continue or there was to be another pandemic.

    METHODS: An anonymous questionnaire survey was distributed electronically between December 2020-January 2021 to the practicing ophthalmic anaesthesia providers in different parts of the world.

    RESULTS: The survey identified that apart from reducing elective operating services, the ophthalmic units were ill prepared for the pandemic and the overall management was lacklustre. There was a definite lack of effective peri-operative patient screening, and, streaming processes. Measures for personal protection of staff were not optimal especially during regional/local ophthalmic anaesthesia. Severity of the pandemic, sudden job plan changes, and redeployment to intensive care units/acute covid wards had an adverse psychological impact on the affected staff.

    CONCLUSION: Ophthalmic anaesthesia services worldwide have had poor attentiveness to the life-threatening menace and reality of Covid-19 pandemic. A review of the institutional practices to address correctible deficiencies is urgently required. Robust, mandatory, elective, timely preventative strategies need to be implemented to protect patients, and, the precious ophthalmic workforce from potential adverse physical and psychological injuries.

    Matched MeSH terms: Pandemics/prevention & control
  5. Pahrol MA, Ismail R, Mohamad N, Lim YC, Muhamad Robat R, Rajendiran S, et al.
    Front Public Health, 2023;11:1028443.
    PMID: 36935685 DOI: 10.3389/fpubh.2023.1028443
    INTRODUCTION: Healthcare workers (HCWs) have been continually exposed to patients with COVID-19 and are at higher risk of contracting the disease. Their psychological health is important for overall wellbeing and productivity, which could lead to a reduction in human errors during the pandemic crisis. This study aimed to measure the level of concerns, work practices, adequacy of preventive measures among HCWs, and the impacts on their life and work, including mental health status during the second wave of the COVID-19 pandemic in Malaysia.

    METHODS: An online questionnaire was distributed randomly to 1,050 HCWs from the Ministry of Health facilities in the Klang Valley who were involved directly in managing or screening COVID-19 cases from May to August 2020. The questionnaire was divided into five domains, which were concerns, impact on life and work, practice, perceived adequacy of preventive measures, and Revised Impact of Event Scale (IES-R). Logistic regression was used to identify sociodemographic predictors of the five domains.

    RESULTS: A total of 907 respondents (86.4%) participated in this survey. Approximately half of the respondents had a low concern (50.5%), most of them had a good practice (85.1%), with 67.5% perceiving there were adequate preventive measures, and they perceived the outbreak had a low impact (92%) on their life and work. From the IES-R domain, 18.6% of respondents potentially suffered from post-traumatic stress disorder (PTSD).

    CONCLUSION: During the second wave of the COVID-19 outbreak in Malaysia, HCWs practiced high levels of precautions and preventive measures because they were aware of the risk of infection as an occupational hazard. With the adequate implementation of policy and control measures, the psychological wellbeing of the majority HCWs remained well and adequately supported.

    Matched MeSH terms: Pandemics/prevention & control
  6. Lee VH, Adham M, Ben Kridis W, Bossi P, Chen MY, Chitapanarux I, et al.
    Lancet Oncol, 2022 Dec;23(12):e544-e551.
    PMID: 36455583 DOI: 10.1016/S1470-2045(22)00505-8
    The effects of the COVID-19 pandemic continue to constrain health-care staff and resources worldwide, despite the availability of effective vaccines. Aerosol-generating procedures such as endoscopy, a common investigation tool for nasopharyngeal carcinoma, are recognised as a likely cause of SARS-CoV-2 spread in hospitals. Plasma Epstein-Barr virus (EBV) DNA is considered the most accurate biomarker for the routine management of nasopharyngeal carcinoma. A consensus statement on whether plasma EBV DNA can minimise the need for or replace aerosol-generating procedures, imaging methods, and face-to-face consultations in managing nasopharyngeal carcinoma is urgently needed amid the current pandemic and potentially for future highly contagious airborne diseases or natural disasters. We completed a modified Delphi consensus process of three rounds with 33 international experts in otorhinolaryngology or head and neck surgery, radiation oncology, medical oncology, and clinical oncology with vast experience in managing nasopharyngeal carcinoma, representing 51 international professional societies and national clinical trial groups. These consensus recommendations aim to enhance consistency in clinical practice, reduce ambiguity in delivering care, and offer advice for clinicians worldwide who work in endemic and non-endemic regions of nasopharyngeal carcinoma, in the context of COVID-19 and other airborne pandemics, and in future unexpected settings of severe resource constraints and insufficiency of personal protective equipment.
    Matched MeSH terms: Pandemics/prevention & control
  7. Rani MDM, Mohamed NA, Solehan HM, Ithnin M, Ariffien AR, Isahak I
    PLoS One, 2022;17(6):e0269059.
    PMID: 35700197 DOI: 10.1371/journal.pone.0269059
    INTRODUCTION: Several countries have started mass vaccination programs to halt the spread of the COVID-19 pandemic. With an R naught value of 2 to 3, about 70% of the population needs to be immunized to achieve herd immunity. This study aimed to investigate the reasons for acceptance or refusal of COVID-19 vaccines among the Malaysian population.

    METHODOLOGY: An exploratory, descriptive qualitative design was performed. The cross-sectional survey used a non-probability convenient sampling technique to recruit the respondents, who were required to answer an open-ended question: Either "If you are willing to get the vaccine, please state your reason" or "If you are not willing to get vaccinated, please state your reason." The survey also included questions on demography such as age, gender, and place of residence. According to the Health Belief Model, the data was transcribed, translated, and analyzed: perceived susceptibility, perceived severity, perceived barrier, and cues for action.

    RESULTS: A total of 1091 respondents who completed the online survey comprised 685 (62.8%) females, 406 (37.2%) males, with a mean age of 38.16 (SD = 16.44). The majority (81.1%) were willing to get vaccinated. Thematic analysis showed that most respondents perceived that the vaccine is safe, effective, protective and will provide herd immunity. Barriers to vaccination include unknown long-term side effects, rapid vaccine production, inadequate information and concerns regarding halal status. Cues to vaccination included individual desire, social responsibility, economic concerns and wait-and-see behavior.

    CONCLUSIONS: The public should be well informed about the vaccine, its efficacy, side effects, and halal status to increase vaccine acceptability and achieve herd immunity.

    Matched MeSH terms: Pandemics/prevention & control
  8. Asawapaithulsert P, Flaherty GT, Piyaphanee W
    Am J Trop Med Hyg, 2022 Aug 17;107(2):492-494.
    PMID: 35895400 DOI: 10.4269/ajtmh.22-0177
    Prior to the COVID-19 pandemic, there was a rapid increase in international travel. Travel medicine is a branch of preventive medicine focusing on risk assessment pre-travel, during travel and post-travel with the aim of promoting health and preventing adverse health outcomes. Travel medicine specialists inform travelers about potential health risks and mitigate infectious disease risks such as travelers' diarrhea, yellow fever, and malaria. Travel medicine topics were popular in the American Society of Tropical Medicine and Hygiene conferences between 2016 and 2020, and now comprise approximately 2% of all presentations. Most topics related to the post-travel assessment (50%), followed by diseases contracted during travel (26%), and pre-travel assessment and consultation (24%). Our analysis of the 10 sub-domains of travel medicine issues found that malaria (26%) and immunization (12%) were represented to the greatest extent. We anticipate that both travel and tropical medicine fields will regain their popularity after recovery from the pandemic.
    Matched MeSH terms: Pandemics/prevention & control
  9. Feizollah A, Anuar NB, Mehdi R, Firdaus A, Sulaiman A
    Int J Environ Res Public Health, 2022 May 21;19(10).
    PMID: 35627806 DOI: 10.3390/ijerph19106269
    The COVID-19 pandemic introduced unprecedented challenges for people and governments. Vaccines are an available solution to this pandemic. Recipients of the vaccines are of different ages, gender, and religion. Muslims follow specific Islamic guidelines that prohibit them from taking a vaccine with certain ingredients. This study aims at analyzing Facebook and Twitter data to understand the discourse related to halal vaccines using aspect-based sentiment analysis and text emotion analysis. We searched for the term "halal vaccine" and limited the timeline to the period between 1 January 2020, and 30 April 2021, and collected 6037 tweets and 3918 Facebook posts. We performed data preprocessing on tweets and Facebook posts and built the Latent Dirichlet Allocation (LDA) model to identify topics. Calculating the sentiment analysis for each topic was the next step. Finally, this study further investigates emotions in the data using the National Research Council of Canada Emotion Lexicon. Our analysis identified four topics in each of the Twitter dataset and Facebook dataset. Two topics of "COVID-19 vaccine" and "halal vaccine" are shared between the two datasets. The other two topics in tweets are "halal certificate" and "must halal", while "sinovac vaccine" and "ulema council" are two other topics in the Facebook dataset. The sentiment analysis shows that the sentiment toward halal vaccine is mostly neutral in Twitter data, whereas it is positive in Facebook data. The emotion analysis indicates that trust is the most present emotion among the top three emotions in both datasets, followed by anticipation and fear.
    Matched MeSH terms: Pandemics/prevention & control
  10. Verghis S
    Global Health, 2023 Nov 27;19(1):92.
    PMID: 38012736 DOI: 10.1186/s12992-023-00988-9
    BACKGROUND: Aligning with global evidence related to migrants and COVID-19, the pandemic highlighted and exposed long-standing structural inequities in the context of migrant populations in Malaysia who experienced a disproportionate level of exposure to SARS-CoV-2 and COVID-19 morbidity, as well as exacerbated precarity during COVID-19 owing to disruptions to their livelihoods, health, and life.

    MAIN BODY: Focusing on COVID-19 and migrant workers in Malaysia, this review addresses two research queries: (i) what are the policy responses of the government toward migrants with regard to COVID-19? (ii) what are the lessons learned from the Malaysian experience of COVID-19 and migrants that can inform pandemic preparedness, especially regarding migrant health policy? The review used Arksey and O'Malley's methodological framework refined by Levac, Colquhoun, and O'Brien. In addition to the PubMed, Web of Science, Scopus, and EBSCO databases, and Malaysian English language newspapers, including the Malay Mail, Malaysiakini, and the New Straits Times, the search also included reports from the websites of government ministries and departments, such as the Immigration Department, Ministry of Human Resources, Ministry of Health, and the International Trade and Industry Ministry.

    CONCLUSION: Using the case example of Malaysia and the policy approach toward migrant populations in Malaysia during the height of the COVID pandemic in 2020 and 2021, this paper unravels complex pathways and inter-linkages between the contexts of migration and health which coalesced to engender and exacerbate vulnerability to disease and ill-health for the migrant workers. The lack of coordination and coherence in policies addressing migrant workers during the pandemic, the normalization of cheap and disposable labor in neoliberal economic regimes, and the securitization of migration were key factors contributing to the failure of migration policies to provide protection to migrant workers during COVID-19. The review suggests that policy approaches embodying the principles of Health in All Policies, a whole-of-society approach, and the promotion of safe, just, and regular migration, predicated on equity and inclusion, are integral to a comprehensive and effective response to pandemics such as COVID-19.

    Matched MeSH terms: Pandemics/prevention & control
  11. Osabohien RA, Jaaffar AH, Ibrahim J, Usman O, Igharo AE, Oyekanmi AA
    PLoS One, 2024;19(1):e0293563.
    PMID: 38252674 DOI: 10.1371/journal.pone.0293563
    Africa has been known to experience series of problems among which are poverty, food insecurity, lack of access to energy, lack of infrastructure among others. These problems were exacerbated by the COVID-19 pandemic, which has had a severe impact on the socioeconomic status of households in Africa. This paper examines the relationship between socioeconomic shocks, social protection, and household food security during the pandemic in Nigeria, the Africa's largest economy. Using the World Bank's COVID-19 national longitudinal baseline phone survey (2020) for the analysis and applied the multinomial logit regression, the study finds that socioeconomic shocks resulting from the pandemic have led to an increased level of food insecurity. Social protection programmes have played a crucial role in mitigating the impact of these shocks on households. However, the study also highlights the need for more targeted and effective social protection policies to ensure that vulnerable households are adequately protected from the adverse effects of the pandemic. The findings of this study have important implications for policymakers and stakeholders in Africa's largest economy, as they seek to address the challenges posed by the pandemic and promote household food security for the actualisation the United Nations (UN) Sustainable Development Goal (SDG) of food and nutrition security (SDG2). The study, therefore, recommends that efforts be made to preserve food supply chains by mitigating the pandemic's effect on food systems, increasing food production, and looking forward beyond the pandemic by building resilient food systems with the use of social protection interventions.
    Matched MeSH terms: Pandemics/prevention & control
  12. Andrighetto G, Szekely A, Guido A, Gelfand M, Abernathy J, Arikan G, et al.
    Nat Commun, 2024 Feb 16;15(1):1436.
    PMID: 38365869 DOI: 10.1038/s41467-024-44999-5
    The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures. We find evidence that, after the emergence of the COVID-19 pandemic, hand washing norms increased while tightness and punishing frequency slightly decreased but observe no evidence for a robust change in most other norms. Thus, at least in the short term, our findings suggest that cultures are largely stable to pandemic threats except in those norms, hand washing in this case, that are perceived to be directly relevant to dealing with the collective threat.
    Matched MeSH terms: Pandemics/prevention & control
  13. Prameela KK
    Med J Malaysia, 2011 Jun;66(2):166-9; quiz 170.
    PMID: 22106709
    Essential nutritive and immunological ingredients abundantly present in breastmilk make it the choice infant nutrition. The uniqueness of mother's milk, in contrast to most therapeutics and immunizations, lies in its potential to adapt itself to the requirements of the infant so that timely immune defenses are tapped from its constituents by immune regulation, modulation and immune acceleration to stimulate novel substances; these render it pertinent as defense when faced with challenging organisms. While it is appreciated that immunity can be transferred from mother to infant through breastmilk following maternal influenza vaccination, the immense benefits conferred by breastfeeding per se during influenza pandemics may not be fully valued. This is substantiated by debates and ambiguities for continued breastfeeding in the face of maternal influenza infections. This article emphasises the utmost importance of breastfeeding in viral pandemics in the light of the changing immunological strategies used by viruses at different times and the urgent need for such opportune defenses. The prolific interaction of its constituents is frequently understated as enormous advantages to the suckling infant.
    Matched MeSH terms: Pandemics/prevention & control*
  14. Mukhsam MH, Jeffree MS, Pang NTP, Syed Abdul Rahim SS, Omar A, Abdullah MS, et al.
    Am J Trop Med Hyg, 2020 Sep;103(3):1201-1203.
    PMID: 32705977 DOI: 10.4269/ajtmh.20-0458
    The COVID-19 pandemic caught the world by surprise, causing millions of confirmed cases and hundreds of thousands of deaths. Hence, the Malaysian government announced a Movement Control Order at the start of the containment phase to flatten the epidemiological curve. Universiti Malaysia Sabah (UMS), a public university in Borneo, was accelerated into alert phase because of high risk of case importation from more than 400 China incoming undergraduates. Measures to mitigate the potential COVID-19 outbreaks in its population were taken by using conventional public health measures with special attention to task-shifting and widespread community mental health interventions. A Preparedness and Response Centre was established to overseer the mitigating measures happening inside the university. Measures taken included empowerment of frontline staff, strengthening of restrictions, strengthening university health center, vigorous contact tracing, widespread health education, maintaining cultural sensitivity, and establishment of early standard operating procedures and university continuity plans. Hence, UMS was able to ensure no importation of cases into its campus during both acute and containment phases at the nationwide level.
    Matched MeSH terms: Pandemics/prevention & control*
  15. Apuke OD, Omar B
    Health Educ Res, 2020 10 01;35(5):471-480.
    PMID: 33090216 DOI: 10.1093/her/cyaa031
    This study examined media coverage of COVID-19 in Nigeria with attention to the frequency and depth of coverage, story format, news sources, media tone and themes. Four widely read newspapers were content analysed between February 2020 and April 2020. Focus was on Daily Sun, Vanguard, Daily Trust and Leadership. Results indicated that the Nigerian media performed well in terms of covering the pandemic, which in turn created awareness. However, the coverage was not in-depth as most of the reported stories were short and were predominantly straight news. It was also observed that the media cited more of the Nigeria Centre for Disease Control (NCDC) and government officials. Further findings disclosed that most of the stories were alarming and induced panic. Most common topics were coverage of cases in Nigeria, death rates and concerns about Nigeria's preparedness. Public sensitization and education were sparingly covered. Ethics healthcare workers could adhere to received minimal attention. The media should focus more on sensitizing and educating the public on the necessary steps to take in curbing the virus. They should refrain from over usage of alarming and panic tone in presenting the stories of COVID-19 pandemic in Nigeria.
    Matched MeSH terms: Pandemics/prevention & control*
  16. Ng CFS, Seposo XT, Moi ML, Tajudin MABA, Madaniyazi L, Sahani M
    Int J Infect Dis, 2020 Dec;101:409-411.
    PMID: 33075527 DOI: 10.1016/j.ijid.2020.10.027
    The first wave of COVID-19 epidemic began in late January in Malaysia and ended with a very small final size. The second wave of infections broke out in late February and grew rapidly in the first 3 weeks. Authorities in the country responded quickly with a series of control strategies collectively known as the Movement Control Order (MCO) with different levels of intensity matching the progression of the epidemic. We examined the characteristics of the second wave and discussed the key control strategies implemented in the country. In the second wave, the epidemic doubled in size every 3.8 days (95% confidence interval [CI]: 3.3, 4.5) in the first month and decayed slowly after that with a halving time of approximately 3 weeks. The time-varying reproduction number Rt peaked at 3.1 (95% credible interval: 2.7, 3.5) in the 3rd week, declined sharply thereafter and stayed below 1 in the last 3 weeks of April, indicating low transmissibility approximately 3 weeks after the MCO. Experience of the country suggests that adaptive triggering of distancing policies combined with a population-wide movement control measure can be effective in suppressing transmission and preventing a rebound.
    Matched MeSH terms: Pandemics/prevention & control
  17. Md Hamzah N, Yu MM, See KF
    Health Care Manag Sci, 2021 Jun;24(2):273-285.
    PMID: 33651316 DOI: 10.1007/s10729-020-09539-9
    Malaysia was faced with a life-threatening crisis in combating COVID-19 with a number of positive cases reaching 5305 and 88 deaths by 18th April 2020 (the first detected case was on 25th January 2020). The government rapidly initiated a public health response and provided adequate medical care to manage the public health crisis during the implementation of movement restrictions, starting 18th March 2020, throughout the country. The objective of this study was to investigate the relative efficiency level of managing COVID-19 in Malaysia using network data envelopment analysis. Malaysia state-level data were extracted from secondary data sources which include variables such as total number of confirmed cases, death cases and recovered cases. These variables were used as inputs and outputs in a network process that consists of 3 sub processes i) community surveillance, ii) medical care I and iii) medical care II. A state-level analysis was performed according to low, medium and high population density categories. The efficiency level of community surveillance was highest compared to medical care processes, indicating that the overall inefficiency is greatly influenced by the inefficiency of the medical care processes rather than the community surveillance process. Results showed that high-density category performed well in both community surveillance and medical care II processes. Meanwhile, low-density category performed better in medical care I process. There was a good overall performance of the health system in Malaysia reflecting a strong preparedness and response level to this pandemic. Furthermore, resource allocation for rapid response was distributed effectively during this challenging period.
    Matched MeSH terms: Pandemics/prevention & control
  18. BasheeruddinAsdaq SM, Naveen NR, Gunturu LN, Pamayyagari K, Abdullah I, Sreeharsha N, et al.
    Biomed Res Int, 2021;2021:9195965.
    PMID: 34977249 DOI: 10.1155/2021/9195965
    Since its outbreak, the coronavirus (COVID-19) pandemic has caused havoc on people's lives. All activities were paused due to the virus's spread across the continents. Researchers have been working hard to find new medication treatments for the COVID-19 pandemic. The World Health Organization (WHO) recommends that safety and self-measures play a major role in preventing the virus from spreading from one person to another. Wireless technology is playing a critical role in avoiding viral propagation. This technology mainly comprises of portable devices that assist self-isolated patients in adhering to safe precautionary measures. Government officials are currently using wireless technologies to identify infected people at large gatherings. In this research, we gave an overview of wireless technologies that assisted the general public and healthcare professionals in maintaining effective healthcare services during COVID-19. We also discussed the possible challenges faced by them for effective implementation in day-to-day life. In conclusion, wireless technologies are one of the best techniques in today's age to effectively combat the pandemic.
    Matched MeSH terms: Pandemics/prevention & control
  19. Campos DMO, Silva MKD, Barbosa ED, Leow CY, Fulco UL, Oliveira JIN
    Comput Biol Chem, 2022 Dec;101:107754.
    PMID: 36037724 DOI: 10.1016/j.compbiolchem.2022.107754
    The current COVID-19 pandemic, an infectious disease caused by the novel coronavirus (SARS-CoV-2), poses a threat to global health because of its high rate of spread and death. Currently, vaccination is the most effective method to prevent the spread of this disease. In the present study, we developed a novel multiepitope vaccine against SARS-CoV-2 containing Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (BA.1) variants. To this end, we performed a robust immunoinformatics approach based on multiple epitopes of the four structural proteins of SARS-CoV-2 (S, M, N, and E) from 475 SARS-CoV-2 genomes sequenced from the regions with the highest number of registered cases, namely the United States, India, Brazil, France, Germany, and the United Kingdom. To investigate the best immunogenic epitopes for linear B cells, cytotoxic T lymphocytes (CTL), and helper T lymphocytes (HTL), we evaluated antigenicity, allergenicity, conservation, immunogenicity, toxicity, human population coverage, IFN-inducing, post-translational modifications, and physicochemical properties. The tertiary structure of a vaccine prototype was predicted, refined, and validated. Through docking experiments, we evaluated its molecular coupling to the key immune receptor Toll-Like Receptor 3 (TLR3). To improve the quality of docking calculations, quantum mechanics/molecular mechanics calculations (QM/MM) were used, with the QM part of the simulations performed using the density functional theory formalism (DFT). Cloning and codon optimization were performed for the successful expression of the vaccine in E. coli. Finally, we investigated the immunogenic properties and immune response of our SARS-CoV-2 multiepitope vaccine. The results of the simulations show that administering our prototype three times significantly increases the antibody response and decreases the amount of antigens. The proposed vaccine candidate should therefore be tested in clinical trials for its efficacy in neutralizing SARS-CoV-2.
    Matched MeSH terms: Pandemics/prevention & control
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