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Fulltext Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review

Md Lazin Md Lazim MR, Aminuddin A, Chellappan K, Ugusman A, Hamid AA, Wan Ahmad WAN, et al.

Int J Environ Res Public Health, 2020 04 10;17(7).
PMID: 32290168 DOI: 10.3390/ijerph17072591

Finger photoplethysmography (PPG) waveform is blood volume change of finger microcirculation that reflects vascular function. Reflection index (RI), stiffness index (SI) and second derivative of photoplethysmogram (SDPPG) are derived from PPG waveforms proposed as cardiovascular disease (CVD) markers. Heart rate (HR) is a known factor that affects vascular function. Individual resting HR variation may affect RI, SI and SDPPG. This review aims to identify studies about the relationship between HR with RI, SI and SDPPG among humans. A literature search was conducted in Medline via the Ebscohost and Scopus databases to find relevant articles published within 11 years. The main inclusion criteria were articles in the English language that discuss the relationship between HR with RI, SI and SDPPG using PPG among humans. The search found 1960 relevant articles but only six articles that met the inclusion criteria. SI and RI showed an association with HR. SDPPG (SDPPG-b/SDPPG-a ratio, SDPPG-d/SDPPG-a ratio, aging index (AGI) and revised aging index (RAGI)) also had an association with HR. Only RI had a considerable association with HR, the association between SI and HR was non-considerable and the association between HR and SDPPG was inconclusive. Further interventional studies should be conducted to investigate this issue, as a variation in resting HR may challenge the validity of PPG-based CVD markers.

Matched MeSH terms: Fingers/blood supply*
Synchronous glomus tumors in a distal digit: a case report

Noor MA, Masbah O, Lumpur K

J Hand Surg Am, 1997 May;22(3):508-10.
PMID: 9195463

Glomus tumors occurring synchronously in the subungual region and the pulp of a fingertip are extremely uncommon. Awareness of this will lead to early diagnosis and treatment.

Matched MeSH terms: Fingers*
Distribution of hair on the dorsum of the phalanges of the hand in a Chinese population from Malaysia

Dharap AS, Lim BC, Ong LB

Anthropol Anz, 1996 Dec;54(4):311-6.
PMID: 9008788

Hair distribution on the dorsum of phalanges of the hand was studied on 302 Chinese subjects (134 males and 168 females) randomly selected from the residents of Kota Bharu, Malaysia. Proximal phalangeal hair was seen on the dorsum of both hands in 99.3% of male subjects but in only 85.1% of female subjects. Chinese females showed a significantly lower (p < 0.05) incidence of proximal phalangeal hair on the hands than Chinese males. Comparison with other racial groups showed that Chinese females had significantly less (p < 0.05) hair on the proximal phalanges of the hands than Malay and African (Nigerian) females. The least common digital combination of proximal phalangeal hair in female subjects was the presence of proximal phalangeal hair only on the fourth digit (ring finger) and was noted in 0.6% of subjects. This has not been reported before. The frequency of middle phalangeal hair (MPH) distribution in Chinese falls between that in Malays and in Japanese which is probably explained by the fact that all these three racial groups originate from Asia. A study of digital combination of MPH in Chinese showed that the most common and the least common combinations in the Chinese differ considerably from those in other races. A total of 16 patterns of hair distribution was noted on the dorsum of the phalanges of the hands in Chinese subjects. Our study showed that though Chinese females had less digital hair on the hands than Chinese males, they showed a much larger variety of patterns of digital hair distribution than males.

Matched MeSH terms: Fingers/anatomy & histology*
Hair distribution on the phalanges of the hands in Malays

Dharap AS, Varma SL, Chary TV

Anthropol Anz, 1994 Dec;52(4):315-20.
PMID: 7840537

618 Malay subjects were selected randomly to find out the frequency and patterns of hair distribution on the phalanges of their hands. Hair on the proximal phalanx was absent in 2% of the males and in 3.3% of the females. The middle phalangeal hair (MPH) was absent in 78% of the females and in 64.9% of the males. The frequency in order of MPH was found to be 4 > 3 > 5 > 2. Fifteen patterns of hair distribution on the phalanges of the hand were found. Such a large number of patterns has not been reported yet. No subject had hair on the distal phalanges. These observations when compared with earlier studies show that the Malays are similar to other Asiatic populations such as the Japanese and Nepalis.

Matched MeSH terms: Fingers*
Incidence, density and direction of hair on the dorsum of phalanges of the hands in Malays

Dharap AS, Varma SL, Chary TV

Anthropol Anz, 1995 Sep;53(3):269-76.
PMID: 7486886

In this study 200 Malay subjects (100 males and 100 females) were randomly selected from patients attending outpatient clinics of Hospital USM, Kelantan, Malaysia, to find out the incidence, density and direction of hair on the dorsum of phalanges of the hand. These features have not been studied so far in females nor has such a study been conducted in Malays. The probability of density of hair distribution among the digits of both hands showed significant correlation on proximal phalanges (p < 0.05) in both sexes. Significant correlation was not observed, however, in the middle phalangeal hair (MPH) of the hands. The direction of proximal phalangeal hair, from little finger to the thumb, showed significant changes from ulnar to radial in both sexes (p < 0.05). Identification of isolated digits, which is of medicolegal importance, would be more accurate if the direction and the density of hair on the digits are both considered together. MPH was present in 48% of males and in 33% of females studied. Comparisons with presence of MPH in other populations show that Malays are ethnically similar to other Asiatic populations.

Study site: utpatient clinics of Hospital USM, Kelantan, Malaysi

Matched MeSH terms: Fingers/anatomy & histology*
Trigger finger, a report on a series of cases

An HK

Med J Malaysia, 1978 Sep;33(1):7-9.
PMID: 750899
Matched MeSH terms: Fingers*; Trigger Finger Disorder*
Normal values for total hand length, palm length and middle finger length in Malaysian newborns from 34-42 weeks of gestation

Halder D, Dharap AS, Than M

Anthropol Anz, 1999 Mar;57(1):69-75.
PMID: 10320927

Early identification of a syndrome at birth is of paramount importance for genetic counselling and possible prevention. Often malformation of the hands and fingers are cardinal manifestations of recognizable syndromes. As there are no published standards for hand and finger size for Malay newborn infants, this study was undertaken to establish normal values for hand, middle finger and palmar lengths, and their indices. A cross-sectional study was done on 509 consecutive newborn Malay babies between 34 and 42 weeks of gestation. Measurements were made on the right hand according to the recommended guidelines of Bergsma & Feingold (1975). The mean values for the measurements did not differ significantly between boys and girls, or change with gestation. For the whole group the mean value for total hand length was 64.4 +/- 3.42 mm, middle finger length 37.1 +/- 2.91 mm, palmar length 27.4 +/- 2.15 mm, finger index 0.425 +/- 0.03 and palmar index 0.58 +/- 0.03. A comparison with published measurements for newborns of different racial origin shows significant differences for the total hand length, middle finger length and palm length from Indian and Jewish infants, but not from Japanese infants. The indices were similar in Malay, Indian, Jewish and Japanese newborn infants.

Matched MeSH terms: Fingers/physiology*
Fulltext Dynamic traction and passive mobilization for the rehabilitation of zone II flexor tendon injuries: a modified regime

Chai SC, Wong CW

Med J Malaysia, 2005 Jul;60 Suppl C:59-65.
PMID: 16381286

This retrospective study aims to evaluate the effectiveness of the modified regime for rehabilitation of Zone II flexor tendon injuries in Sibu Hospital. From January to December 2003, 8 patients with 15 injured digits were treated by using the combined method of dynamic traction and passive mobilization. According to Strickland's criteria, 14 (93.3%) digits achieved good to excellent outcomes and only 1 (6.7%) was rated as poor. No occurrence of tendon rupture was noted. The overall grip strength of the injured hand was 50.1% of the uninjured hand at 3 months after the repair. Our results compare favorably with the other published studies. We believed that this modified regime is as effective as other established regimes and suitable to be adopted in our setting. Further study with larger sample group will be required to consolidate our findings.

Matched MeSH terms: Fingers*
Fulltext Macrodactyly and poliosis in tuberous sclerosis complex

Sasongko TH, Ismail NF, Nik Mohd Ariff NA, Zabidi-Hussin ZA

Jpn J Clin Oncol, 2014 Nov;44(11):1130.
PMID: 25320338 DOI: 10.1093/jjco/hyu157
Matched MeSH terms: Fingers/abnormalities*
Multisensory distortions of the hand have differential effects on tactile perception

Treshi-marie Perera A, Newport R, McKenzie KJ

Exp Brain Res, 2015 Nov;233(11):3153-61.
PMID: 26195170 DOI: 10.1007/s00221-015-4384-8

Research has suggested that altering the perceived shape and size of the body image significantly affects perception of somatic events. The current study investigated how multisensory illusions applied to the body altered tactile perception using the somatic signal detection task. Thirty-one healthy volunteers were asked to report the presence or absence of near-threshold tactile stimuli delivered to the index finger under three multisensory illusion conditions: stretched finger, shrunken finger and detached finger, as well as a veridical baseline condition. Both stretching and shrinking the stimulated finger enhanced correct touch detections; however, the mechanisms underlying this increase were found to be different. In contrast, the detached appearance reduced false touch reports-possibly due to reduced tactile noise, as a result of attention being directed to the tip of the finger only. These findings suggest that distorted representations of the body could have different modulatory effects on attention to touch and provide a link between perceived body representation and somatosensory decision-making.

Matched MeSH terms: Fingers/innervation*
Fulltext Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after stroke

Jahangir AW, Tan HJ, Norlinah MI, Nafisah WY, Ramesh S, Hamidon BB, et al.

Med J Malaysia, 2007 Oct;62(4):319-22.
PMID: 18551937 MyJurnal

Botulinum toxin is effective in reducing spasticity post stroke. As there are limited data on post stroke spasticity in Asia, we undertake this study to determine the effectiveness and safety of intramuscular injection of botulinum toxin type-A (BTX-A), in the treatment of chronic focal post-stroke hand spasticity, and the impact of BTX-A on the activities of daily living and quality of life, in comparison to placebo, in Malaysian stroke patients. This was a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of BTX-A in 27 subjects with wrist and finger spasticity after a stroke. The outcome measures were assessed with the Modified Ashworth Scale (MAS) to assess spasticity of the flexor muscles, Barthel Index (BI) for activities of daily living and EQ-5D and EQ VAS for quality of life. Assessments were performed at baseline and 1 and 3 months after injection. Compared to placebo, the BTX-A group had greater improvement in the flexor tone of the wrist and fingers (p = 0.001 and p < 0.001, respectively), at first month follow-up visit and sustained the improvement through to three months. Although there was an improvement in the measures of global function and quality of life in the BTX-A group, there was no significant improvement in between the two groups. No serious BTX-A related adverse effects were reported. The results of this study demonstrate that intramuscular injection of botulinum toxin A is safe and effective in the treatment of chronic focal post-stroke spasticity of the hand.

Matched MeSH terms: Fingers/innervation; Fingers/physiopathology*
Handedness, sexual orientation, and somatic markers for prenatal androgens: Are southpaws really that gay?

Ellis L, Skorska MN, Bogaert AF

Laterality, 2017 Mar;22(2):157-180.
PMID: 26932806 DOI: 10.1080/1357650X.2016.1151024

BACKGROUND: Some evidence suggests that prenatal androgens influence both handedness and sexual orientation. This study sought to clarify how androgens, handedness, and sexual orientation are interrelated.
METHODS: Data were obtained from large samples of students enrolled at universities in Malaysia and the US, including self-reported information on handedness, sexual orientation, and five somatic markers of prenatal androgen exposure (2D:4D, height, strength, muscularity, and athletic ability). Factor analysis of these somatic markers yielded two factors: a muscular coordination and a bone growth factor.
RESULTS: In women, but not in men, ambidextrousness was more prevalent among those with homosexual tendencies. Modest and often complex associations were found between the androgen factors and handedness. Clear links between the androgen factors and sexual orientation were found, especially for muscular coordination. For males and females, intermediate sex-typical androgen exposure was associated with heterosexual preferences.
CONCLUSIONS: Ambidextrousness appears to be somewhat more common among females with homosexual tendencies, but left-handedness is nearly as strongly associated with heterosexual preferences, particularly in males, as is right-handedness. Factors indicative of prenatal androgen exposure are associated with sexual orientation in theoretically predictable ways, especially for muscular coordination, but associations between prenatal androgens and handedness are complex.

Matched MeSH terms: Fingers/anatomy & histology; Fingers/physiology
Fulltext A Diabetic Elderly Man with Finger Ulcer

Mohamad N, Badrin S, Wan Abdullah WNH

Korean J Fam Med, 2018 Mar;39(2):126-129.
PMID: 29629046 DOI: 10.4082/kjfm.2018.39.2.126

Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. He experienced a cat bite over his left middle finger 1 month prior to the appearance of the lesion. A skin biopsy revealed the presence of Sporothrix schenckii. Oral itraconazole 200 mg twice daily was started empirically and the patient showed marked improvement in the skin lesion after 2 months of therapy.

Matched MeSH terms: Fingers
Fulltext Outcome of Tendon Transfers for Radial Nerve Palsy in a Malaysian Tertiary Centre

Richford J, Abdullah S, Norhafizah M, Juliana I, Rashdeen F, Razana A

Malays Orthop J, 2018 Mar;12(1):1-6.
PMID: 29725505 MyJurnal DOI: 10.5704/MOJ.1803.001

Tendon transfers for radial nerve palsy is a common operation with good results. We did a retrospective study on twenty patients with radial nerve palsy who underwent tendon transfer surgery and recovered between January 2008 and December 2012. Outcomes measured were motor power of wrist extension, finger extension, grip strength and DASH scores. There was significant improvement of motor power of wrist and finger extension between the preoperative period and three months post-operatively, between the pre operative period and six months post operatively and between three and six months postoperatively (p = 0.0005). Grip strength improved significantly as well between preoperative, three and six months postoperatively (p = 0.0005). DASH scores reflecting patient satisfaction at six months postoperatively showed only mild or moderate difficulty of function.

Matched MeSH terms: Fingers
2D:4D digit ratio and religiosity in university student and general population samples

Richards G, Davies W, Stewart-Williams S, Bellin W, Reed P

Transpers Psychol Rev, 2018;20(1):23-36.
PMID: 30283240

The ratio of index to ring finger length (2D:4D) is used as a proxy for prenatal sex hormone exposure. It has been hypothesised to correlate with religiosity, though no published research has explored this possibility. Here, we initially examined 2D:4D in relation to self-reported religious affiliation and questionnaire measures of general religiosity, spirituality, religious fundamentalism, and religious commitment in male (N = 106) and female (N = 105) university students (Study 1). Although no significant correlations were observed between 2D:4D and the questionnaire measures, females who affiliated with organised religions had higher digit ratios compared to agnostic or atheist females. Study 2 attempted to replicate these findings in an adult general population sample (N = 172 males, N = 257 females), but did not observe significant effects in either sex. Overall, these findings suggest that high 2D:4D may be relatively-specifically associated with religious affiliation in young, highly-educated, females.

Matched MeSH terms: Fingers
Fulltext Hair Thread Tourniquet Syndrome in an Infant: Emergency Exploration Saves Limbs

Kesu Belani L, Leong JF, Narin Singh PSG, Abdullah S

Cureus, 2019 Dec 13;11(12):e6377.
PMID: 31938655 DOI: 10.7759/cureus.6377

Hair thread tourniquet syndrome (HTTS) is a rare condition where fibres constrict around appendages causing ischaemia and necrosis. It is a sporadically reported condition, where almost all reported cases showed involvement of fingers, toes or genitalia. A significant number of the cases are infants aged two weeks to six months where it is attributed to the mother's excessive hair fall due to hormonal changes after delivery. We present a two-month-old infant who was irritable for the past two days with her left ring finger exhibiting an ischaemic constriction with no apparent insulting agent. She successfully treated surgically after we suspected an incomplete removal of hair thread in the emergency department. We would like to highlight the importance of a high index of suspicion in cases as such as early intervention saves the appendage.

Matched MeSH terms: Fingers
Fulltext Wide Awake Local Anesthesia No Tourniquet Forearm Triple Tendon Transfer in Radial Nerve Palsy

Abdullah S, Ahmad AA, Lalonde D

Plast Reconstr Surg Glob Open, 2020 Aug;8(8):e3023.
PMID: 32983779 DOI: 10.1097/GOX.0000000000003023

Tendon transfer for radial nerve palsy is a common procedure done under general anesthesia. We describe a surgical technique of triple tendon transfer with wide awake local anesthesia no tourniquet (WALANT). We transfer flexor carpi radialis to extensor digitorum communis, palmaris longus to extensor pollicis longus, and pronator teres to extensor carpi radialis brevis. This is commonly known as the Brand transfer. Our anesthetic or WALANT solution consists of up to 200 mL of 1:400,000 epinephrine, 0.25% lidocaine buffered with sodium bicarbonate. This technique overcomes the problem of judging the appropriate amount of transfer tension by observing awake patients actively extend their fingers, thumb, and wrist during the surgery and making adjustments before we close the wound. In our experience, there is no need of brain retraining because a patient is able to immediately use the flexor muscles to perform extension movements. WALANT is a safe and viable option for radial nerve tendon transfers.

Matched MeSH terms: Fingers
Fulltext Dermatoglyphic pattern among Kadazandusun and Bajau ethnic groups in Sabah

M. Tanveer Hossain Parash, Zainal Arifin Mustapha, Urban John Arnold D’Souza, Sadia Choudhury Shimmi

Malaysian Journal of Medicine and Health Sciences, 2019;15(106):81-81.
MyJurnal

Introduction:Dermatoglyphics have been used extensively to characterize populations, analyse the nature and origin of human variation and population structure and evaluate the micro-differentiation of populations. Dermato-glyphics is considered as a sensitive indicator of intrauterine anomalies and known to be one of the best available diagnostic tools in genetic disorders. KadazanDusun and Bajau are the major ethnic groups of Sabah. The aim of the study was to study the distribution of fingerprint patterns on different digits in these two ethnicities of Sabah and to find if any variation occurs in fingerprint pattern qualitatively between these ethnicities. Methods: This cross-section-al study was conducted from March’ 2016 to February’ 2018 at different villages of Kudat, Ranau, Kota Belud, Kota Kinabalu and Papar, Sabah. After obtaining informed consent 400 persons (KadazanDusun 250, Bajau 150) were included in this study by stratified random sampling. Demographic data and history of present and past illness were obtained from each subject through a valid questionnaire. Finger and palm prints were photographed using Nikon D5200 camera and later were grouped into different types manually. Results: There were 205 female and 195 male participants in the study. Among the three types of fingerprints, whorls were more abundant (>50%) in the thumbs, index, ring and little fingers whereas loops were observed more (>55%) in the middle fingers. The arches were the least (0-3%) observed pattern in all the fingers. The dermatoglyphic pattern of right and left index fingers were only significantly different (p0.05) difference in respect of left and right hands and gender. Conclusion: The study findings would serve as a baseline data for further studies to develop data base of the dermatoglyphic pattern of major ethnic groups of Sabah which would facilitate non-invasive diagnosis of congenital anomalies and various genetic disorders.

Matched MeSH terms: Fingers
Construction of A Preliminary Three-Dimensional Structure Simian betaretrovirus Serotype-2 (SRV-2) Reverse Transcriptase Isolated from Indonesian Cynomolgus Monkey

Saepuloh U, Iskandriati D, Pamungkas J, Solihin DD, Mariya SS, Sajuthi D

Trop Life Sci Res, 2020 Oct;31(3):47-61.
PMID: 33214855 DOI: 10.21315/tlsr2020.31.3.4

Simian betaretrovirus serotype-2 (SRV-2) is an important pathogenic agent in Asian macaques. It is a potential confounding variable in biomedical research. SRV-2 also provides a valuable viral model compared to other retroviruses which can be used for understanding many aspects of retroviral-host interactions and immunosuppression, infection mechanism, retroviral structure, antiretroviral and vaccine development. In this study, we isolated the gene encoding reverse transcriptase enzyme (RT) of SRV-2 that infected Indonesian cynomolgus monkey (Mf ET1006) and predicted the three dimensional structure model using the iterative threading assembly refinement (I-TASSER) computational programme. This SRV-2 RT Mf ET1006 consisted of 547 amino acids at nucleotide position 3284-4925 of whole genome SRV-2. The polymerase active site located in the finger/palm subdomain characterised by three conserved catalytic aspartates (Asp90, Asp165, Asp166), and has a highly conserved YMDD motif as Tyr163, Met164, Asp165 and Asp166. We estimated that this SRV-2 RT Mf ET1006 structure has the accuracy of template modelling score (TM-score 0.90 ± 0.06) and root mean square deviation (RMSD) 4.7 ± 3.1Å, indicating that this model can be trusted and the accuracy can be seen from the appearance of protein folding in tertiary structure. The superpositionings between SRV-2 RT Mf ET1006 and Human Immunodeficiency Virus-1 (HIV-1) RT were performed to predict the structural in details and to optimise the best fits for illustrations. This SRV-2 RT Mf ET1006 structure model has the highest homology to HIV-1 RT (2B6A.pdb) with estimated accuracy at TM-score 0.911, RMSD 1.85 Å, and coverage of 0.953. This preliminary study of SRV-2 RT Mf ET1006 structure modelling is intriguing and provide some information to explore the molecular characteristic and biochemical mechanism of this enzyme.

Matched MeSH terms: Fingers
Fulltext Changing hands: persistent alterations to body image following brief exposure to multisensory distortions

Perera AT, Newport R, McKenzie KJ

Exp Brain Res, 2017 06;235(6):1809-1821.
PMID: 28293693 DOI: 10.1007/s00221-017-4935-2

The dynamic flexibility of body representation has been highlighted through numerous lines of research that range from clinical studies reporting disorders of body ownership, to experimentally induced somatic illusions that have provided evidence for the embodiment of manipulated representations and even fake limbs. While most studies have reported that enlargement of body parts alters somatic perception, and that these can be more readily embodied, shrunken body parts have not been found to consistently alter somatic experiences, perhaps due to reduced feelings of ownership over smaller body parts. Over two experiments, we aimed to investigate the mechanisms responsible for altered somatic representations following exposure to both enlarged and shrunken body parts. Participants were given the impression that their hand and index finger were either longer or shorter than veridical length and asked to judge veridical finger length using online and offline size estimation tasks, as well as to report the degree of ownership towards the distorted finger and hand representations. Ownership was claimed over all distorted representations of the hand and finger and no differences were seen across ownership ratings, while the online and offline measurements of perceived size demonstrated differing response patterns. These findings suggest that ownership towards manipulated body representations is more bidirectional than previously thought and also suggest differences in perceived body representation with respect to the method of measurement suggesting that online and offline tasks may tap into different aspects of body representation.

Matched MeSH terms: Fingers

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