METHODS: This study aims to resolve the gut microbiome composition of S. syndactylus by using a fecal sample as DNA source, adapting high-throughput sequencing, and 16S rRNA as the targeted region.
RESULTS: A total of 1 272 903 operational taxonomic units (OTUs) reads were assigned to 22 phyla, 139 families, and 210 genera of microbes. The {Unknown Phylum} Bacteria-2 is the dominant phyla found across all samples. Meanwhile, {Unknown Phylum} Bacteria-2 and Firmicutes are genera that have the highest relative abundance found in the Siamang gut.
CONCLUSIONS: This study yields nonsignificance relationship between Siamang gut microbiome composition with these three factors: group, sex, and age.
METHODS: This is a prospective cohort study, where cognitive assessments were done 1-day before surgery, at discharge, and during 6 weeks of follow-up. Sample size calculation, accounting for an estimated 20% dropout rate, determined a minimum of 170 subjects were required for the study. Reduction of MMSE score of more than 2.5 was considered as having POCD. Score differences between groups were analysed using T-test and analysis of variance (ANOVA), while consistency between tools was analysed using correlation and regression.
RESULTS: A total of 188 patients completed the study, with a POCD prevalence of 20.2% and 6.9% at discharge and at the 6 week follow up, respectively. All cognitive tools show a significant difference between preoperative and postoperative scores. All tests show a significant moderate correlation with MMSE.
CONCLUSIONS: In conclusion, it is imperative to employ a battery of cognitive assessments to evaluate cognitive changes comprehensively.
METHODS: A total of 102 school-aged children with obesity (54 girls and 48 boys) aged 8-16 years completed a 16-week school-based lifestyle modification intervention program, MyBFF@school Phase I. The intervention consisted of physical activity, healthy eating promotion, and psychological empowerment. MHO and MUO statuses were defined based on the 2018 consensus-based criteria. Fasting venous blood collection, body composition measurement, clinical assessment and physical fitness testing were conducted at baseline and at the end of week 16.
RESULTS: After the intervention, the CRFs of the children with MUO improved with significant decreases in systolic (p
AIM: This study evaluates the local and systemic biocompatibility of IVD in five non-pregnant female cats.
METHODS: The IVD was successfully inserted into the vaginal lumen after estrogen administration. Radiographic imaging confirmed the IVD's position, which lasted up to two days post-insertion.
RESULTS: Systemic response, assessed through hematological examinations on days 0, 1, and 3 post-insertion, showed no significant changes in erythrogram and leukogram parameters. Local response, evaluated through vulvar inspection and vaginal cytology on days 0, 1, 3, and 7, revealed no neutrophil infiltration in 4 out of 5 cats, indicating compatibility with vaginal tissue. Furthermore, epithelial cell profile changes were observed, showing an increase in superficial cells, which is typical during the estrus phase.
CONCLUSION: These findings suggest that the IVD is biocompatible and suitable for use as a contraceptive and identity device in cats. However, further long-term studies are necessary to evaluate the device's prolonged efficacy and potential for contraception failure prevention by mating trials.
OBJECTIVE: The aim of this study is to develop, validate, and field-evaluate SmartGlove BISINDO, an AI-assisted wearable sign language-to-speech system that embeds large language model (LLM)-powered NLG into a BISINDO translation pipeline for the first time.
METHODS: This study followed the design science research (DSR) framework, covering phases 1 through 5 (problem identification, solution objectives, prototype design and development, demonstration, and evaluation). Data were collected from 12 purposively selected informants (6 domain experts and 6 deaf education companions/teachers) across 3 Indonesian cities (Malang, Surabaya, and Makassar), using a needs-analysis questionnaire and an expert validation sheet, and analyzed through statistical triangulation of agreement percentage, content validity ratio (CVR), and Aiken V. The validated prototype was field-tested in Makassar and Malang with 15 participants with communication disorders and 4 observers or companions; it was evaluated by a disability expert in Surabaya.
RESULTS: The needs analysis yielded a grand mean of 4.77 (SD 0.51) across 4 clusters, with 89% mean agreement, indicating very high priority for all identified needs. The prototype's 5-layer architecture integrates wearable sensors, on-device gesture classification, and LLM-based NLG. Expert validation showed an overall Aiken V of 0.94, with all 14 items exceeding the 0.75 validity cutoff and with 11/14 items (79%) rated highly valid (V>0.90). The grand mean CVR was 0.76 (SD 0.16), exceeding the Lawshe minimum threshold of 0.56 (P
METHODS: A retrospective cohort study was conducted using clinical records of 230 living kidney donors who underwent nephrectomy at University Malaya Medical Centre between 2003 and 2021. Donor sociodemographic characteristics, comorbidities, and estimated glomerular filtration rate (eGFR) were assessed pre-donation and at 1 year post-donation. Impaired kidney function was defined as eGFR