MyMedR

Editorial: finding the ideal prokinetic for gastroparesis-we are not there yet

Mahadeva S

Aliment Pharmacol Ther, 2021 07;54(2):210-211.

PMID: 34170545 DOI: 10.1111/apt.16470

Matched MeSH terms: Humans

Basaloid Nasopharyngeal Carcinoma: An Entity That Remains Oblivious

Ganeson SK, Saniasiaya J, Mohamad I, Abdul Gani N

Gulf J Oncolog, 2020 Sep;1(34):83-86.

PMID: 33431368

INTRODUCTION: Basaloid squamous cell carcinoma of the nasopharynx is a rare entity with only scarce cases reported in the English Literature. It is a histological variant of squamous cell carcinoma with aggressive nature and comprises of both basal cell carcinoma and squamous cell carcinoma.

CASE PRESENTATION: Herein, we report on a middleaged male who presented with left-sided spontaneous epistaxis and aural fullness with no neck node which turned out to be basaloid cell carcinoma of nasopharynx.

DISCUSSION AND CONCLUSION: We highlight high clinical suspicion of rare variant of nasopharyngeal carcinoma although no palpable node was evident upon presentation.

Matched MeSH terms: Humans

Will flight shaming influence the future of air travel?

Flaherty GT, Holmes A

J Travel Med, 2020 03 13;27(2).

PMID: 31776567 DOI: 10.1093/jtm/taz088

Matched MeSH terms: Humans

An update on male infertility: Factors, mechanisms, and interventions

Ko E, Ramasamy R, Durairajanayagam D, Baskaran S, Agarwal A

Andrologia, 2021 02;53(1):e13741.

PMID: 33135797 DOI: 10.1111/and.13741

Matched MeSH terms: Humans

Current tools for the diagnosis and detection of spotted fever group Rickettsia

Husin NA, AbuBakar S, Khoo JJ

Acta Trop, 2021 Jun;218:105887.

PMID: 33713627 DOI: 10.1016/j.actatropica.2021.105887

Spotted fever group (SFG) rickettsiae causes a number of diseases in humans worldwide, which can range from mild to highly lethal. Since the clinical presentations of rickettsioses caused by SFG rickettsiae are variable and may be similar to the diseases caused by other rickettsiae, such as Orientia tsutsugamushi (agent for scrub typhus), Coxiella burnetii (agent for Q fever) and the typhus group rickettsiae (agents for epidemic and murine typhus), the accurate diagnosis of infections caused by SFG Rickettsia remains challenging especially in resource-poor settings in developing countries. This review summarizes the various diagnostic and detection tools that are currently available for the confirmation of infections by SFG rickettsiae. The advantages and challenges pertaining to the different serological and molecular detections methods, as well as new assays in development, are discussed. The utility of the detection tools contributing to the surveillance of SFG rickettsiae in arthropods and animals are reviewed.

Matched MeSH terms: Humans

Hepatitis C virus (HCV) diagnosis via microfluidics

Narayanamurthy V, Jeroish ZE, Bhuvaneshwari KS, Samsuri F

Anal Methods, 2021 02 14;13(6):740-763.

PMID: 33511975 DOI: 10.1039/d0ay02045a

Humans are subjected to various diseases; hence, proper diagnosis helps avoid further disease consequences. One such severe issue that could cause significant damage to the human liver is the hepatitis C virus (HCV). Several techniques are available to detect HCV under various categories, such as detection through antibodies, antigens, and RNA. Although immunoassays play a significant role in discovering hepatitis viruses, there is a need for point-of-care tests (POCT). Some developing strategies are required to ensure the appropriate selection of POCT for HCV detection, initiate appropriate antiviral therapy, and define associated risks, which will be critical in achieving optimal outcomes. Though molecular assays are precise, reproducible, sensitive, and specific, alternative strategies are required to enhance HCV diagnosis among the infected population. Herein, we described and assessed the potential of various microfluidic detection techniques and confirmatory approaches used in present communities. In addition, current key market players in HCV chip-based diagnosis and the future perspectives on the basis of which the diagnosis can be made easier are presented in the present review.

Matched MeSH terms: Humans

Respect the Floor of the Mouth

Chong W, Hijazi M, Abdalrazig M, Patil N

J Emerg Med, 2020 Jul;59(1):e27-e29.

PMID: 32439254 DOI: 10.1016/j.jemermed.2020.04.015

Matched MeSH terms: Humans

Absence of the Musculocutaneous Nerve and Associated Compensation by the Median Nerve

Moore K, Prasad AM, Satheesha Nayak B

Kathmandu Univ Med J (KUMJ), 2021 6 24;18(71):313-315.

PMID: 34158443

The musculocutaneous and median nerves frequently show variations from their normal course. The purpose of this paper is to report a rare variation, in which the right musculocutaneous nerve was absent. Consequently, the median nerve supplied motor innervation to the flexor compartment of the arm and sensory innervation to the lateral aspect of the forearm. The primary targets of this paper are orthopedic surgeons, anesthesiologists and radiologists. In cases of injuries to the upper limb, knowledge of these variations can assist them in avoiding misdiagnoses.

Matched MeSH terms: Humans

Fulltext A case of surgical emphysema

Wilson F

Ind Med Gaz, 1927 Jun;62(6):355-356.

PMID: 29010578

Matched MeSH terms: Humans

Fulltext Notes on a case of cystic kidney

Viswalingam A

Ind Med Gaz, 1920 Jun;55(6):220.

PMID: 29008210

Matched MeSH terms: Humans

Dentistry and the Pandemic: A Year of Reckoning

Vijayan SP, Pandarathodiyil AK

J Contemp Dent Pract, 2021 Apr 01;22(4):325-326.

PMID: 34266997

In March 2020, the world that we know irrevocably changed forever. It feels like "Groundhog Day" all over again, and it seems that the nightmare is here to stay. It all began on the January 8, 2020, when China grimly announced that coronavirus disease-2019 (COVID-19) pandemic is caused by the "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2)1 but it was not until March 2020 that the situation swiftly careened out of control and is unequivocally posing the greatest challenge to humanity worldwide since the end of the Second World War. While the scientific community heroically galvanized itself and raced against time to provide viable solutions to this formidable foe in the form of vaccines, the worldwide dental fraternity has had to grapple with an extraordinary situation evolving in real-time and ensure that we responded robustly to this daunting health emergency that has spared no corner of our beloved planet. Initially, COVID-19 ensured cessation of all non-urgent dental care in most parts of the world but with increasingly significant inputs about the nature of the pathogen from the scientific community, the dental community has been able to cobble together a workable plan in reconfiguring and restructuring the dental practice in consonance with the situation at hand. It is fiendishly arduous to estimate the massive impact on the dental profession, but it is safe to assume it to be substantial.

Matched MeSH terms: Humans

Temporomandibular Joint Disorders: Is there a Need for Additional Subspeciality in Dentistry?

Arshad S, Awang RA, Malik S

J Coll Physicians Surg Pak, 2021 Aug;31(8):1004.

PMID: 34320727 DOI: 10.29271/jcpsp.2021.08.1004

Null.

Matched MeSH terms: Humans

Fulltext The remodelling index risk stratifies patients with hypertensive left ventricular hypertrophy

Le TT, Lim V, Ibrahim R, Teo MT, Bryant J, Ang B, et al.

Eur Heart J Cardiovasc Imaging, 2021 05 10;22(6):670-679.

PMID: 32255186 DOI: 10.1093/ehjci/jeaa040

AIMS: Hypertensive left ventricular hypertrophy (LVH) is associated with increased cardiovascular events. We previously developed the remodelling index (RI) that incorporated left ventricular (LV) volume and wall-thickness in a single measure of advanced hypertrophy in hypertensive patients. This study examined the prognostic potential of the RI in reference to contemporary LVH classifications.

METHODS AND RESULTS: Cardiovascular magnetic resonance was performed in 400 asymptomatic hypertensive patients. The newly derived RI (EDV3t, where EDV is LV end-diastolic volume and t is the maximal wall thickness across 16 myocardial segments) stratified hypertensive patients: no LVH, LVH with normal RI (LVHNormal-RI), and LVH with low RI (LVHLow-RI). The primary outcome was a composite of all-cause mortality, acute coronary syndromes, strokes, and decompensated heart failure. LVHLow-RI was associated with increased LV mass index, fibrosis burden, impaired myocardial function and elevated biochemical markers of myocardial injury (high-sensitive cardiac troponin I), and wall stress. Over 18.3 ± 7.0 months (601.3 patient-years), 14 adverse events occurred (2.2 events/100 patient-years). Patients with LVHLow-RI had more than a five-fold increase in adverse events compared to those with LVHNormal-RI (11.6 events/100 patient-years vs. 2.0 events/100 patient-years, respectively; log-rank P

Matched MeSH terms: Humans

Fulltext Navigating paradox in self-care

Christofield M, Moon P, Allotey P

BMJ Glob Health, 2021 06;6(6).

PMID: 34140304 DOI: 10.1136/bmjgh-2021-005994

Matched MeSH terms: Humans

QUIT!

Binns C, Low WY

Asia Pac J Public Health, 2021 07;33(5):477-478.

PMID: 34468241 DOI: 10.1177/10105395211034654

Matched MeSH terms: Humans

A family of three with haemoglobin Cheverly: low oxygen saturation in stable patients

Chow LC, Puah SH, Tiong XT, Aloysious NS, Leong TS, Chew LP

J R Coll Physicians Edinb, 2021 Sep;51(3):253-256.

PMID: 34528613 DOI: 10.4997/JRCPE.2021.309

Haemoglobin (Hb) Cheverly is a rare, low oxygen affinity haemoglobinopathy. It is a result of point mutation at the 45 codon of the beta globin genes that leads to substitution of phenylalanine by serine. It is characterised by spuriously low peripheral oxygen saturation with normal arterial oxygen saturation. We describe a family of three with Hb Cheverly in Sarawak General Hospital, Malaysia. It was discovered through incidental finding during hospital admission for unrelated complaints. Laboratory testing revealed abnormal haemoglobin detected at the C window of the high performance liquid chromatography. Subsequent DNA analysis detected replacement of thymidine by cytosine at the beta globin genes. Hb Cheverly may or may not have clinical significance as most of the patients live a normal life; however, it is crucial for us to make early diagnosis to prevent unnecessary extensive investigations for hypoxaemia detected via pulse oximetry, especially in the midst of COVID-19 pandemic.

Matched MeSH terms: Humans

Factors influencing COVID-19 vaccine hesitancy and acceptance among the Pakistani population

Chaudhary FA, Ahmad B, Khalid MD, Fazal A, Javaid MM, Butt DQ

Hum Vaccin Immunother, 2021 Oct 03;17(10):3365-3370.

PMID: 34236952 DOI: 10.1080/21645515.2021.1944743

This study examined the factors associated with acceptance of the COVID-19 vaccine compared to hesitance in the Pakistani population and specifically focusing on the perceived beliefs, knowledge, concerns, risk, and safety perception relating to the COVID-19 vaccine. A total of 423 subjects were recruited from the Pakistan Institute of Medical Sciences, Islamabad, Pakistan. A 27-item valid and reliable questionnaire was used to assess socio-demographic characteristics, acceptance, and hesitance toward COVID-19 vaccine, perceived beliefs, knowledge, perceived concerns, risk, and safety of COVID-19 vaccines and its source of information. Chi-square tests and logistic regression were used for analysis. About 53% of the participants were planning to get vaccinated and a significantly greater proportion of better educated, higher income, and healthier participants in the vaccine acceptance group (p

Matched MeSH terms: Humans

Managing Resistance to Change in Medical Education

Malik AS, Malik RH

J Coll Physicians Surg Pak, 2021 Oct;31(10):1141-1142.

PMID: 34601830 DOI: 10.29271/jcpsp.2021.10.1141

Null.

Matched MeSH terms: Humans

Fulltext Pneumomediastinum in a patient with severe Covid-19 pneumonia

Chang CY

Rev Soc Bras Med Trop, 2021;54:e03962021.

PMID: 34320135 DOI: 10.1590/0037-8682-0396-2021

Matched MeSH terms: Humans