MyMedR

Fulltext Peritoneal trophoblastic implant

Rachagan SP, Kutty K, Govindan KS

Med J Malaysia, 1997 Sep;52(3):293-4.

A case of persistent trophoblastic tissue on the pelvic peritoneum is presented. While most cases are secondary to conservative surgery for tubal ectopic pregnancy, primary implantation can also occur as highlighted by this case. A brief pathophysiology of the condition is presented. The importance of monitoring the serum for beta subunit human chorionic gonadotrophin (HCG) is emphasised.

Matched MeSH terms: Chorionic Gonadotropin, beta Subunit, Human/blood

Fulltext Epidural blood patch for post dural puncture headache

Vijayan R, Chan L

Med J Malaysia, 1995 Jun;50(2):196-7.

PMID: 7565198

Matched MeSH terms: Blood Patch, Epidural*

A comparative study on the biological properties of venoms from juvenile and adult common tiger snake (Notechis scutatus) venoms

Tan NH, Ponnudurai G, Mirtschin PJ

Comp. Biochem. Physiol., B, 1993 Nov;106(3):651-4.

PMID: 8281760

1. The biological properties of venoms from juvenile and adult common tiger snakes (Notechis scutatus) were compared. 2. The lethality, procoagulant activity and enzymatic activities of the juvenile venom were not substantially different from those of the adult venom. 3. Electrophoretic studies, however, indicated some minor differences in the protein composition of the juvenile and adult venoms.

Matched MeSH terms: Blood Coagulation Factors/analysis*

Simple liquid chromatographic method for the determination of cefotaxime in human and rat plasma

Ling SS, Yuen KH, Barker SA

J Chromatogr B Analyt Technol Biomed Life Sci, 2003 Jan 05;783(1):297-301.

PMID: 12450550

A high-performance liquid chromatographic method with ultraviolet (UV) detection was developed for measuring cefotaxime in rat and human plasma. The method used direct injection of the plasma supernatant after deproteinization with 70% perchloric acid. Degradation of cefotaxime in acidic medium was retarded by adding phosphate buffer before centrifuging the sample. The mobile phase was 0.05 M aqueous ammonium acetate-acetonitrile-tetrahydrofuran (87:11:2, v/v) adjusted to pH 5.5. Analysis was run at a flow-rate of 1.0 ml/min, and a detection wavelength of 254 nm was used. The method has a quantification limit of 0.20 microgram/ml. The within- and between-day coefficients of variation and accuracy values were less than 8% and +/-3%, respectively, while the recovery values were greater than 87% over the concentration range tested (0.20-50 microgram/ml). The speed, sensitivity, specificity and reproducibility of this method make it particularly suitable for the routine determination of cefotaxime in human plasma. Moreover, only a relatively small sample plasma volume (100 microliter) is required, allowing this method to be applied to samples taken from neonates.

Matched MeSH terms: Cefotaxime/blood*

Simple high-performance liquid chromatographic method for the determination of ranitidine in human plasma

Wong CF, Peh KK, Yuen KH

J Chromatogr B Biomed Sci Appl, 1998 Oct 23;718(1):205-10.

PMID: 9832378

A simple high-performance liquid chromatographic method was developed for the determination of ranitidine in human plasma. Prior to analysis, ranitidine and the internal standard (metoprolol) were extracted from alkalinized plasma samples using dichloromethane. The mobile phase was 0.05 M potassium dihydrogenphosphate-acetonitrile (88:12, v/v) adjusted to pH 6.5. Analysis was run at a flow-rate of 1.3 ml/min and at a detection wavelength of 229 nm. The method is sensitive with a detection limit of 1 ng/ml at a signal-to-noise ratio of 3:1, while the quantification limit was set at 15 ng/ml. The calibration curve was linear over a concentration range of 15-2000 ng/ml. Mean recovery value of the extraction procedure was about 90%, while the within-day and between-day coefficients of variation and percent error values of the assay method were all less than 15%.

Matched MeSH terms: Ranitidine/blood*

Blood pressure profile in continuous ambulatory peritoneal dialysis patients

Cader RA, Gafor HA, Mohd R, Ibrahim S, Wan Haslina WH, Bain A, et al.

EXCLI J, 2012;11:116-24.

PMID: 27366136

Cardiovascular mortality is the leading cause of death in end stage renal disease. Despite being on continuous ambulatory peritoneal dialysis (CAPD), blood pressure (BP) remains poorly controlled. A higher pulse pressure and non dipping are associated with increased cardiovascular mortality. We studied BP control and the prevalence of non dipping in CAPD patients.

Matched MeSH terms: Blood Pressure; Blood Pressure Determination

Long term visit-to-visit variability of systolic blood pressure and cardiovascular disease events in a primary care setting: a 10-year retrospective cohort study [Abstract OS 04-05]

Ching SM, Chia YC, Lim HM

J Hypertens, 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e56.

PMID: 27753921

Conference abstract:
OBJECTIVE: This study aims to determine the relationship of long term visit to visit variability (VVV) of SBP and cardiovascular disease (CVD) in a primary care setting.
DESIGN AND METHOD: This is a retrospective study of a cohort of 1416 patients over a period of 10 years (1998-2007). Demographic data, three monthly clinic BP readings and CVD events were captured from patient records. We derived the mean BP and VVV of SBPs for each subject and divided them into three groups defined as non hypertension, developed hypertension along the 10-year follow-up and persistent hypertension. We examined differences in cardiovascular events across these groups.
RESULTS: Mean age of the participants at baseline was 56.5 ± 10.1 years, 34.6% were males. Table 1 describes mean SBP, BPV and CVD events of the study population.Those with both low mean SBP and low BPV have the lowest CVD events, conversely those with both high mean SBP and high BPV have highest CVD events. In those patients with the same mean SBP, whether high or low, those with higher BPV have more events than those with lower BPV. However patients with low mean SBP but high BPV have more CVD events compared with those patients with high mean SBP but low BPV (p = 0.04) suggesting BPV is more important than mean SBP in causing CVD events.We used ROC of VVV SBP to identify the cut off point of 12.9 mmHg as the indicator for increase in CVD events.
CONCLUSIONS: In our study, we found that patients with hypertension have higher BPV than normotensive subjects. Furthermore those with higher BPV also had more CVD events. As such, we should prioritize lowering not only mean systolic BP but lowering BPV as well. Long term VVV SBP should be another target in the management of patients with hypertension.

Matched MeSH terms: Blood Pressure*

Fulltext The effect of Ramadan fasting on fasting serum glucose in healthy adults

Larijani B, Zahedi F, Sanjari M, Amini MR, Jalili RB, Adibi H, et al.

Med J Malaysia, 2003 Dec;58(5):678-80.

PMID: 15190653

The effect of Ramadan fasting on fasting serum glucose (FPG) is still a matter of controversy. One hundred and fifteen healthy volunteers fasted for > or = 25 days during Ramadan. Blood samples were taken 1 week before Ramadan and on the 14th and 28th day of Ramadan. Serum glucose was determined by the glucose oxidase method. FPG decreased from 88.4 + 9.0 mg/dl to 62.9 +/- 7.7 mg/dl (p < 0.001). Men and women both experienced a significant drop in FPG. Calorie intake decreased in all groups (p < 0.001) and was positively correlated with decreasing FPG. FPG decreases with Ramadan fasting and has no serious adverse effect on fasting adults.

Matched MeSH terms: Blood Glucose/analysis*

Fulltext Pancreatitis in primary hyperparathyroidism

Abdullah M

Med J Malaysia, 2003 Oct;58(4):600-3.

PMID: 15190638

The cause and effect relationship between acute pancreatitis and primary hyperparathyroidism (pHPT) still evokes controversy. Our paper reviews the debate in the medical literature. In this controversy we add a case of a 49-year old non-alcoholic man presenting with recurrent attacks of acute pancreatitis. His raised serum calcium was realized rather late. Eventually, high intact parathyroid hormone levels led to open neck exploration and finding of a solitary parathyroid adenoma. Post-surgery, serum calcium returned to normal and abdominal symptoms disappeared. The case report and the accompanying literature review support our belief, that acute pancreatitis is one of the symptoms of pHPT often caused by a parathyroid adenoma and curable by its excision.

Matched MeSH terms: Calcium/blood

Can fluoride-oxalate and sodium citrate stabilise homocysteine levels after blood collection?

Lopez JB, Peng CL

Clin Chem Lab Med, 2003 Oct;41(10):1369-72.

PMID: 14580168

The concentration of homocysteine (Hcy) rises rapidly after the collection of blood. This feature requires blood to be collected into the anticoagulants EDTA or heparin and the plasma to then be immediately separated; alternatively, the blood may be kept on ice and centrifuged within 1 hour. The use of chemical preservatives has been proposed as a means of stabilising Hcy levels in whole blood after collection. The objective of this study was to determine whether the commonly available fluoride-oxalate (Fl-Ox) and sodium citrate (Na-Cit) containers could stabilise Hcy levels in blood. Our results showed that when blood was collected into potassium EDTA (K-EDTA) tubes, Hcy levels rose from initial levels, on standing at room temperature (approximately 25 degrees C), by an average of 21% after 3 hours and 32% after 5 hours. The initial Hcy levels of blood collected into Fl-Ox and Na-Cit containers, however, were lower, at averages of 89% and 91%, respectively, compared to that of the same samples when collected into K-EDTA tubes. Hcy in these samples subsequently rose on standing, and after 5 hours was, on the average, 10 and 13% higher, respectively, compared with the initial levels in K-EDTA tubes. We conclude that Fl-Ox and Na-Cit do not stabilise Hcy in blood after collection and should not be used as preservatives.

Matched MeSH terms: Homocysteine/blood*

The amount and types of fatty acids acutely affect insulin, glycemic and gastrointestinal peptide responses but not satiety in metabolic syndrome subjects

Chang CY, Kanthimathi MS, Tan AT, Nesaretnam K, Teng KT

Eur J Nutr, 2018 Feb;57(1):179-190.

PMID: 27632019 DOI: 10.1007/s00394-016-1307-9

PURPOSE: Limited clinical evidence is available on the effects of amount and types of dietary fats on postprandial insulinemic and gastrointestinal peptide responses in metabolic syndrome subjects. We hypothesized that meals enriched with designated: (1) amount of fats (50 vs 20 g), (2) fats with differing fatty acid composition (saturated, SFA; monounsaturated, MUFA or n-6 polyunsaturated fatty acids, PUFA) would affect insulinemic and gastrointestinal peptide releases in metabolic syndrome subjects.

METHODS: Using a randomized, crossover and double-blinded design, 15 men and 15 women with metabolic syndrome consumed high-fat meals enriched with SFA, MUFA or n-6 PUFA, or a low-fat/high-sucrose (SUCR) meal. C-peptide, insulin, glucose, gastrointestinal peptides and satiety were measured up to 6 h.

RESULTS: As expected, SUCR meal induced higher C-peptide (45 %), insulin (45 %) and glucose (49 %) responses compared with high-fat meals regardless of types of fatty acids (P < 0.001). Interestingly, incremental area under the curve (AUC0-120min) for glucagon-like peptide-1 was higher after SUCR meal compared with MUFA (27 %) and n-6 PUFA meals (23 %) (P = 0.01). AUC0-120min for glucose-dependent insulinotropic polypeptide was higher after SFA meal compared with MUFA (23 %) and n-6 PUFA meals (20 %) (P = 0.004). Significant meal x time interaction (P = 0.007) was observed for ghrelin, but not cholecystokinin and satiety.

CONCLUSIONS: The amount of fat regardless of the types of fatty acids affects insulin and glycemic responses. Both the amount and types of fatty acids acutely affect the gastrointestinal peptide release in metabolic syndrome subjects, but not satiety.

Matched MeSH terms: Blood Glucose/analysis*; C-Peptide/blood; Gastric Inhibitory Polypeptide/blood*; Insulin/blood*; Metabolic Syndrome X/blood*; Ghrelin/blood

Fulltext Intervention for Diabetes with Education, Advancement and Support (IDEAS) study: protocol for a cluster randomised controlled trial

Lee JY, Chan CK, Chua SS, Ng CJ, Paraidathathu T, Lee KK, et al.

BMC Health Serv Res, 2016 Sep 29;16(1):524.

PMID: 27683021 DOI: 10.1186/s12913-016-1782-y

BACKGROUND: The high market penetration of mobile phones has triggered an opportunity to combine mobile technology with health care to overcome challenges in today's health care setting. Although Malaysia has a high Internet and mobile penetration rate, evaluations of the efficacy of incorporating this technology in diabetes care is not common. We report the development of a telemonitoring coaching system, using the United Kingdom (UK) Medical Research Council (MRC) framework, for patients with type 2 diabetes mellitus.

METHODS: The Intervention for Diabetes with Education, Technological Advancement and Support (IDEAS) study is a telemonitoring programme based on an empowerment philosophy to enable participants to be responsible for their own health decision and behaviour. An iterative cycle of development, piloting, and collating qualitative and quantitative data will be used to inform and refine the intervention. To increase compliance, the intervention will be designed to encourage self-management using simple, non-technical knowledge. The primary outcomes will be HbA1c, blood pressure, total cholesterol, and quality of life and diabetes self-efficacy. In addition, an economic analysis on health service utilisation will be collected.

DISCUSSION: The mixed-method approach in this study will allow for a holistic overview of using telemonitoring in diabetes care. This design enables researchers to understand the effectiveness of telemonitoring as well as provide insights towards the receptiveness of incorporating information technology amongst type 2 diabetes patients in a community setting.

TRIAL REGISTRATION: ClinicalTrials.gov NCT02466880 Registered 2 June 2015.

Matched MeSH terms: Blood Pressure; Blood Pressure Determination

Fulltext Immune response in acute Toxoplasma infection of Balb/C, ICR and CBA/J mice

Suresh K, Mak JW, Yong HS

Southeast Asian J Trop Med Public Health, 1991 Sep;22(3):452-4.

PMID: 1818401

Matched MeSH terms: Antibodies, Protozoan/blood*; Immunoglobulin G/blood; Immunoglobulin M/blood; Mice, Inbred BALB C/blood; Mice, Inbred CBA/blood; Mice, Inbred ICR/blood; Toxoplasmosis, Animal/blood

Comparative analyses of IgA1 binding lectins from seeds of six distinct clones of Artocarpus integer

Hashim OH, Gendeh GS, Jaafar MI

Biochem. Mol. Biol. Int., 1993 Jan;29(1):69-76.

PMID: 8490570

Purified lectins from seeds of six distinct clones of Artocarpus integer (lectin C) were shown to be structurally and functionally similar. All lectins comprised of two types of non-covalently-linked subunits with apparent M(r) of 13,300 and 16,000. The lectins appeared to interact with several human serum proteins, with the predominance of the IgA1 and C1 inhibitor molecules. Interaction was not detected with IgA2, IgD, IgG and IgM. The lectin Cs were also shown to precipitate monkey, sheep, rabbit, cat, hamster, rat and guinea-pig serum. Due to their uniform properties, lectin C may provide better alternative to the Artocarpus heterophyllus lectin, jacalin, for use in future investigations.

Matched MeSH terms: Blood Proteins/metabolism

An in-house assay for serum deoxythymidine kinase

Seah LH, Ton SH, Cheong SK, Hamidah NH

Malays J Pathol, 1991 Dec;13(2):109-13.

PMID: 1823092

An in-house method which utilizes 14C-thymidine as a substrate was used to assay deoxythymidine kinase in serum. The method is sensitive enough to detect normal levels of serum deoxythymidine kinase and the assay procedure also enables rapid handling of multiple samples. With a total reaction volume of 60 ul, the enzyme reaction was found to be linear with concentrations for up to 650 U/L of TK activity. On studying serum deoxythymidine kinase (s-TK) activity with incubation time, there was a proportional increase in activity with the length of incubation time. "Within-batch" precision showed a coefficient of variation (CV) of 4.7% for serum with extremely high s-TK levels and a CV of 8.8% for serum with normal s-TK levels. S-TK showed a CV of less than 16.0% in its activity when stored at -8 degrees C and at -20 degrees C. The normal reference range obtained for s-TK activity was 8.6 +/- 7.5 U/L.

Matched MeSH terms: Thymidine Kinase/blood*

Distribution of haptoglobins in different dialect groups of Chinese, Malays and Indians in Singapore

Saha N, Ong YW

Ann Acad Med Singap, 1984 Jul;13(3):498-501.

PMID: 6517517

A total of 870 subjects comprising 524 Chinese (from different dialect groups), 231 Malays and 115 Tamil Indians were investigated for the distribution of haptoglobin types and ABO blood groups. Haptoglobins were typed by PAG electrophoresis using discontinuous buffer system. The frequencies of Hp,1 Hp2 and Hp0 were found to be 0.330, 0.670 and 0.029 in Chinese; 0.298, 0.702 and 0.004 in Malays; and 0.167, 0.833 and 0.009 in Indians. The Hainanese had the highest frequency of Hp1 (0.375) followed by Cantonese (0.348), Teochew (0.333) and Hakkas (0.288). The distribution of all the phenotypes of haptoglobin was at equilibrium in all the population groups studied. No association of ABO blood groups was detected with the haptoglobin types. However, there was an excess of AB blood group in persons carrying Hp2 compared with those with Hp1.

Matched MeSH terms: ABO Blood-Group System/genetics

Fulltext Arteriovenous fistula of the superior thyroid artery: post thyroid operation

Abdul Ghani S, Hashim R

Med J Malaysia, 1984 Dec;39(4):314-6.

PMID: 6544941

A case of A. V. fistula of the superior thyroid vessels following thyroidectomy is reported. Though the standard treatment of such a fistula is ligation and excision, a more simple Iigation and division of the superior thyroid artery is adequate for reasons mention. The demonstration of the feeding vessel by angiogram has to be accurate.

Matched MeSH terms: Thyroid Gland/blood supply*

Fulltext Prenatal diagnosis of alpha thalassaemia major following cordocentesis--a case report

Raman S, Kuppuvelumani P, Menaka H

Med J Malaysia, 1991 Mar;46(1):110-3.

PMID: 1836033

The relevant investigations and management of a case of alpha-thalassaemia major suspected antenatally is discussed. The value of ultrasonically guided cordocentesis in the definite diagnosis of this condition is emphasised in the management of this pregnancy. We believe that this is the first time such a procedure has been done in this country.

Matched MeSH terms: Fetal Blood*

Fulltext Coronary artery disease in Malaysia: a perspective

Jeyamalar R

Med J Malaysia, 1991 Mar;46(1):1-6.

PMID: 1836032

Matched MeSH terms: Cholesterol/blood

Fulltext Weights and blood pressures of women who attend family planning clinics in Sarawak

Wadsworth GR

Med J Malaysia, 1981 Sep;36(3):148-50.

PMID: 7329371

Matched MeSH terms: Blood Pressure*

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