Different disease risk for diabetic nephropathy (DN) may be partly due to the diverse genetic susceptibility of the disease. This systematic review aimed to identify the genetic variants with a substantial effect on DN and to evaluate the genetic models used in the reviewed studies. We searched the ScienceDirect and PubMed databases for all eligible studies comparing genetic variants in patients with and without DN from 2005-2016. We included a total of 14 studies and identified 13 genes with 17 related variants. The OR was from 2.9 to 9.95. The genes were involved in the pathogenesis of DN via the hemodynamic (ACE, AGT, AGTR1), metabolic (ACACB, MTHFR, PPARGC1A) and inflammatory (TNF-, TGFβ1, eNOS, CCR5, HSP70-1, MPO, OPN gene promoter) pathways. The results of these studies were presented according to pre-specified genetic models: basic, additive, dominant and recessive. No genetic model selection was biologically justified. We identified 17 genetic variants that were significantly associated with DN and were determined using different genetic models. To reduce error, further replication with the best genetic model should be carried out to determine the role of these variants in DN.
Introduction Sleep has played a very important role in maintaining our health with good
living quality therefore the aim of this study is to determine the pattern of
sleep duration, especially short sleep and its associated factors among
workers in a tertiary institution.
Methods A cross-sectional study was conducted from January until May 2012 among
128 randomly selected Universiti Kebangsaan Malaysia Medical Centre
(UKMMC) staffs. Data was collected using a guided standardized data sheet
which consist of three sections; (1):sociodemographic &socioeconomic, (2):
lifestyle and, (3): anthropometric measurement and sleep diary. Data entry
and analysis were done using Statistical Package for Social Sciences (SPSS)
version 20.0.
Results Majority of the staffs had normal sleep duration (67.2%) followed by short
sleep duration (26.6%) and long sleep duration (6.3%). Simple logistic
regression analysis indicated that late night snacking was significantly related
to short sleep (cOR=3.47, 95% CI: 1.12, 12.23, p=0.048).
Conclusions Adequate sleep is important to maintain one’s health. Steps can be taken to
limit late night snacking in order to improve the sleep pattern in this study
population.
ABSTRACTS FOR THE 1ST INTERNATIONAL BORNEO HEALTHCARE AND PUBLIC HEALTH CONFERENCE AND 4TH BORNEO TROPICAL MEDICINE AND INFECTIOUS DISEASE CONGRESS
New Frontiers in Health: Expecting the Unexpected
Held at the Faculty of Medicine and Health Sciences,
Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia On 3rd-5th September 2019
Introduction: Obesity is a global epidemic with major healthcare implications and costs. The availability of Smart-phone app as a new technological innovation developed is increasing rapidly. This new technological innovation can have a huge potential for interventions to help weight loss and combat obesity. To perform a systematic review and meta-analysis of studies to compare the effectiveness of Smartphone apps compared with other methods to promote weight loss and obesity. Methods: We conducted a systematic review and meta-analysis of relevant studies identified by a search of independently screened studies for inclusion criteria and extracted data. We included arti-cles that assessed any (Smartphone/Mobile phone app intervention with anthropometric measurement like weight/BMI, waist circumference), adult or children population then exclude articles in which the primary outcome is not weight/BMI/Waist circumference, non-original articles (Reviews, Editorials, Non-research letters), case reports or case series, non RCT study design, participant with co-morbidities or condition like pregnancy and Intervention using SMS or any text messaging. Results: We included 7 articles in this systematic review and meta-analysis. This me-ta-analysis shows that smartphone app interventions compared with conventional or other interventions is non-sig-nificant decreases in body weight, with the pooled estimates of the net change in body weight being -1.62 kg (95% CI –3.61 to 0.36; I2 = 93%). Pooled results indicated a non-significant net difference in BMI between smart phone app and control intervention groups (WMD 0.26 kg/m2, 95% CI -0.83 to 1.34; I2 = 68%). For waist circumference, there is non-significant net difference in BMI between smart phone app and control intervention groups (WMD -5.2 cm 95% CI --0.15 to 4.60; I2 = 93%). Conclusion: Smartphone apps intervention alone is not producing substantial evidence of weight loss despite there might be effective for certain groups. However, there are still explorable pros-pect on the use of smartphone app in combination of other approach to assist and promote weight loss as the use of smartphone are proven to influence health related behavioural modification.
Introduction A study was conducted to determine the level of mothers' perception on children with cleft deformity and its associated factors
Methods This was a cross sectional study involving 110 mothers with children attending the Plastic And Reconstructive Surgery Clinic. Data was gathered from a face to face interview based on a questionnaire that assesses the level of perception and its associated factors. The level of perception was evaluated from a scoring method and divided into four domains namely psychosocial, care management, treatment and education.
Results The level of perception was high in all four domains ranged from 62% for treatment and 80% for education. Factors that were significantly associated with the level of perception were ethnicity, religion, type of cleft deformity and level of information.
Conclusions Information regarding cleft deformity must be tailored toward mothers’ personal characteristics and type of cleft deformity to improve mothers' perception on this problem.
Study site: Plastic And Reconstructive Surgery Clinic, Hospital Kuala Lumpur, Malaysia
Introduction Tuberculosis (TB) is a major global health challenge especially in low- and middle-income countries reflects improper, delayed or missed diagnosis. Contact screening should be utilized both as an efficient and effective targeted approach to intensify TB case finding.
Methods Through a comprehensive systematic literature review of online database, this paper aims at providing an insight into the current practice of TB contact screening and to provide evidence based practice for formulation of appropriate policies in low- and middle-income countries. There are 24 articles included in this review from studies published from 2005 to 2014.
Results Findings in literature varies substantially. Generally, contact screening is better intensified with clear operational guidelines, adequate training, include close contact outside household as appropriate and follow up at least for 1 year. Prioritizing high risk close contacts is helpful in resource limited setting. Tuberculin skin test is still of value as screening tool and intensified case finding must be accompanied with effective management protocol. Prophylaxis treatment is recommended especially for children especially less than 5 years old, unvaccinated, malnourished, living with person having HIV and close contact with MDR-TB.
Conclusions Policy recommendations in improving TB management must incorporate complementary strategies to enhance case finding, effective management protocol for follow up or prophylaxis treatment, training for public health capacity and concerted dedication from various stakeholders
Introduction Pneumococcal disease causes considerable morbidity and mortality,
including among adults. Adult pneumococcal vaccines help to prevent these
burdens, yet, they are underutilized. Our objective is to systematically collect
and summarize the available evidence on the potential factors that lead to
pneumococcal vaccination acceptance among of adult community.
Methods A systematic literature search was conducted involving studies published
from January 1999 to December 2015. The studies were identified by
searching electronic resources (PubMed/MEDLINE and Pro Quest database)
and manual searches of references. The keywords “vaccine/ immunization”,
“uptake/ coverage”, “determinant/ factor”, and “Streptococcus pneumoniae/
pneumococcus/ pneumococcal” were used. Final studies result and data were
reviewed by two independent authors. Disagreement was resolved through
discussion and consensus.
Results A total of 171 studies were identified, only 17 studies were included in final
discussion with 10 domains identified in the paper. 7 studies (41%) had
reported that the provider domain, patients’ perception and
socio-demographic factor have had the most effect on the pneumococcal
vaccination acceptance rate. In addition, only 18% (3) of reviewed papers had
highlighted that socio-economic was a factor influenced the pneumococcal
vaccination acceptance while 24% (4 studies) were attributed to the comorbid
domains.
Conclusions Healthcare provider and patients’ perception about pneumococcal vaccination
for adult population are significant domains which influence the acceptance
towards vaccination. Strong recommendations from healthcare provider for
pneumococcal vaccination would be an important step to increase vaccination
acceptance among the population.
Introduction The Acquired Immuno Deficiency Syndrome (AIDS) is caused by Human Immunodeficiency Virus (HIV) infection and a disease with high morbidity and mortality.Young mothers are sub-populations that are at high risk for HIV through sexual activity. In addition, information on the level of knowledge, attitude and practice among young mothers in Malaysia regarding HIV/AIDS prevention is still limited.Therefore, the objective of this study is to examine the level of knowledge, attitudes and practices towards the prevention of HIV/AIDS among young mothers and the factors that influence them.
Methods A cross-sectional study was conducted at a tertiary hospital in a city center among 147 young mothers aged 18-30 years old at the Post Natal and Obstetrics and Gynecology Ward (O & G). Data collection was conducted in April-November 2014 and the respondents' selection was based on simple random sampling. A questionnaire containing validated instruments was used in this study. Approval for conducting research has been obtained from the UKM Research Ethics Committee before the data collection procedure is implemented.
Results Majority of the young mothers have good knowledge (78.8%) and practice (71.2%) towards HIV/AIDS prevention. While more than half of them (56.7%) have positive attitude towards the prevention of HIV/AIDS. Living in the urban area and being married are significantly associated with having good knowledge and positive attitude towards HIV/AIDS prevention. While, mothers who are 5 years older compared to the younger ones and being married are significantly associated with having good practice towards HIV/AIDS prevention.
Conclusions The level of knowledge, attitudes and practices as well as the associated factors could be the baseline to formulate health intervention to prevent HIV/AIDS among this vulnerable group.
Stage of cervical cancer may adversely affect the quality of life (QOL) among patients. The objective of this study was to predict the QOL among cervical cancer patients by the stage of their cancer. A cross-sectional study from September 2012 until January 2013 was conducted among cervical cancer patients who completed treatment. All patients completed a interviewer-guided questionnaire comprising four sections: (A) socio- demographic data, (B) medical history, (C) QOL measured by general health status questionnaire (QLQ-30) and (D) cervical cancer specific module CX-24 (EORTC) was used to measured patient's functional, symptom scale and their global health status. Results showed that global health status, emotional functioning and pain score were higher in stage III cervical cancer patients while role functioning was higher in stage I cervical cancer patients. Patients with stage IV cancer have a lower mean score in global health status (adjusted b-22.0, 95 CI% -35.6, -8.49) and emotional functioning (adjusted b -22.5, 95 CI% -38.1, -6.69) while stage III had lower mean score in role functioning (adjusted b -14.3, 95 CI% -25.4, -3.21) but higher mean score in pain (adjusted b 22.1, 95 CI% 8.56, 35.7). In conclusion, stage III and IV cervical cancers mainly affect the QOL of cervical cancer patients. Focus should be given to these subgroups to help in improving the QOL.
Background: Impulse control behaviours are repetitive and excessive activities that may be sub-syndromal and not fulfil the criteria for impulse control disorder. These activities have potential to negatively impact on the daily lives of sufferers. We conducted a study to investigate the prevalence of impulse control behaviours and its associated features in Parkinson’s disease in our population. Methods: We conducted a prospective cross-sectional study on consecutive patients attending neurology clinic. Inclusion criteria include idiopathic Parkinson’s disease patients with Hoehn & Yahr stage I-IV. Eighty patients were enrolled and screened for impulse control behaviours using the Questionnaire for Impulsive-Compulsive Disorder for Parkinson’s disease (QUIP). Results: Prevalence of impulse control behaviours among our cohort was 11.3%; the features significantly associated with it were higher level of education (p=0.02), advanced stage of disease (p=0.03) and higher levodopa dosage (p= 0.01). The commonest impulse control behaviour in our cohort was compulsive medication use (7.5%), followed by hobbyism (6.3%), hypersexuality (5%), compulsive buying (3.75%), punding (2.5%), walkabout (2.5%), compulsive eating (1.25%) and pathological gambling (1.3%).
Conclusions: There is an association between impulse control behaviour and higher levodopa dosage in a study on patients with Parkinson’s disease in Malaysia. We also found a low prevalence of pathological gambling as compared to studies performed in the West.
Study site: Neurology clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
Background & Objectives: The burden of stroke is increasing, in part due to increasing prevalence of diabetes mellitus. Given the high prevalence of diabetes in the Malaysian population (22.6%), we aimed to determine the prevalence of diabetes in our stroke population. We also aimed to study the stroke subtype associated with diabetes. We hypothesized that lacunar infarction would be more prevalent in diabetics. Methods: We retrospectively reviewed data of consecutive patients with acute ischaemic stroke admitted from October 2004 to December 2010 from our stroke registry. Demographic data, risk factors profile and stroke subtypes were reviewed and analyzed. Results: Eight hundred and fifty eight patients were identified from the registry. As high as 59.3% (n=509) of our patients were diabetics, of which 49.2% (n=422) had pre-existing diabetes and 10.1% (n=87) were newly diagnosed. Lacunar infarction was the commonest stroke subtype, comprising 60.6% (n=519) of all strokes. Diabetes was significantly associated with lacunar infarction (OR 1.5, CI 95% 1.16-2.01, p=0.003), particularly in those aged ≤ 55 years (OR 2.29, 95% CI 1.12-4.67) and HbA1C ≥ 6.5% (χ2=8.77, p=0.003). Conclusions: The prevalence of diabetes in our stroke patients is amongst the highest reported. Diabetes mellitus, particularly those with poor glycaemic control is strongly associated with lacunar infarction.
Hypertension is one of the chronic diseases with a rising trend globally, including Malaysia. Patients' own perception of their illness is a strong factor that determines their health-seeking behaviour. The objective of this study was to evaluate the illness perception of hypertensive patients and the associated factors.