Displaying all 12 publications

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  1. Ramesh M, Narasimhan M, Krishnan R, Aruna RM, Kuruvilla S
    J Oral Maxillofac Pathol, 2017 Sep-Dec;21(3):345-350.
    PMID: 29391706 DOI: 10.4103/jomfp.JOMFP_247_16
    Background: Fluoride is needed for the normal development of bone and teeth; in high levels, it affects developing teeth and bone. Dental fluorosis (DF) is caused by ingestion of excess fluoride mainly through drinking water.

    Aim: The present study aims to observe and understand the histological changes of fluorosed teeth under light microscope (LM).

    Materials and Methods: Teeth which were indicated for extractions for orthodontic or periodontal problems were selected. Thirty extracted teeth were selected with varying degrees of DF based on modified Dean's fluorosis index. Ground sections of these teeth were prepared and the sections were studied under binocular LM. Photomicrographs were taken under high power objective using 15 megapixels Nikon camera.

    Results and Conclusion: Qualitative histologic changes in different grades of fluorosed teeth were evaluated in enamel, dentin, cementum and between their junctions. Fluoride interacts with enamel in both mineral phases and organic macromolecules by strong ionic and hydrogen bonds resulting in incomplete crystal growth at prism peripheries. This presents as hypomineralization of enamel and dentin, increased interglobular dentin, increased secondary curvatures and changes in cementum such as diffuse cementodentinal junction and increased thickness of Tomes' granular layer. Changes in the structure of the teeth with Dean's index below 2 and teeth with Dean's index of 2 and above were compared using Chi-square test. P value was found to be highly significant being 0.00047. Many of the features of dental fluorosis seen in the present study under light microscope are comparable to those results studied under specialized microscopes.
  2. Ramesh M, Malathi N, Ramesh K, Aruna RM, Kuruvilla S
    J Pharm Bioallied Sci, 2017 Nov;9(Suppl 1):S88-S91.
    PMID: 29284943 DOI: 10.4103/jpbs.JPBS_77_17
    Background: High levels of fluoride in the drinking water, especially ground water, results in skeletal fluorosis which involves the bone and major joints. This study was conducted to assess the prevalence of skeletal fluorosis to compare with dental fluorosis in an endemically fluorosed population in the District of Salem, Tamil Nadu.

    Materials and Methods: Institutional ethical clearance was obtained. A total of 206 patients who reported to the Department of Hematology for blood investigations were the participants in this study. Age, sex, place, weight, height, dental fluorosis, and skeletal complaints were noted down. Body mass index was calculated, and statistical analysis was performed.

    Results: Dental fluorosis was present in 63.1% and absent in 36.9% of the samples reported. Skeletal fluorosis was present in 24.8% and was absent in 75.2%. A large number of the patients had knee pain and difficulty in bending. Chi-square test was used for statistical analysis. Skeletal fluorosis and age were compared and P value was 0.00 and was significant. Dental fluorosis and skeletal fluorosis were compared and P value was found to be 0.000 and significant.

    Discussion and Conclusion: There is a need to take measures to prevent dental and skeletal fluorosis among the residents of Salem district. Calcium balance should be maintained, and fluoride intake should be minimized to reduce the symptoms. The government should provide water with low fluoride level for drinking and cooking. Once the symptoms develop, treatment largely remains symptomatic, using analgesics and physiotherapy.

  3. Buse K, Tomson G, Kuruvilla S, Mahmood J, Alden A, van der Meulen M, et al.
    BMJ, 2022 Jan 26;376:e068124.
    PMID: 37462013 DOI: 10.1136/bmj-2021-068124
    Kent Buse and colleagues argue that unlocking the potential for intersectoral action on climate and health requires thinking politically about its facilitators and barriers
  4. Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.
    Natl Med J India, 2023;36(6):345-350.
    PMID: 38909307 DOI: 10.25259/NMJI_825_2023
  5. Fassil H, Borrazzo J, Greene R, Jacobs T, Norton M, Stanton ME, et al.
    Health Policy Plan, 2017 Sep 01;32(7):1072-1076.
    PMID: 28407108 DOI: 10.1093/heapol/czx018
    Reflecting on Storeng and Béhague ("Lives in the balance": the politics of integration in the Partnership for Maternal, Newborn and Child Health. Health Policy and Planning Storeng and Béhague (2016).) historical ethnography of the Partnership for Maternal, Newborn and Child Health (PMNCH), this commentary provides a more current account of PMNCH's trajectory since its inception in 2005. It highlights PMNCH's distinct characteristics and how it is positioned to play an instrumental role in the current global health landscape.
  6. Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.
    Indian J Med Res, 2023 Aug;158(2):101-105.
    PMID: 37675685 DOI: 10.4103/ijmr.ijmr_1574_23
  7. Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.
    Complement Ther Med, 2023 Oct;77:102970.
    PMID: 37591416 DOI: 10.1016/j.ctim.2023.102970
  8. Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.
    J Ayurveda Integr Med, 2023;14(4):100790.
    PMID: 37562183 DOI: 10.1016/j.jaim.2023.100790
  9. Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.
    J Integr Complement Med, 2023 Sep;29(9):527-530.
    PMID: 37713586 DOI: 10.1089/jicm.2023.29121.editorial
  10. Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.
    Ayu, 2022;43(3):71-74.
    PMID: 38075187 DOI: 10.4103/ayu.ayu_218_23
  11. Hinton R, Armstrong C, Asri E, Baesel K, Barnett S, Blauvelt C, et al.
    Global Health, 2021 02 01;17(1):18.
    PMID: 33522937 DOI: 10.1186/s12992-021-00664-w
    BACKGROUND: The success of the Sustainable Development Goals (SDGs) is predicated on multisectoral collaboration (MSC), and the COVID-19 pandemic makes it more urgent to learn how this can be done better. Complex challenges facing countries, such as COVID-19, cut across health, education, environment, financial and other sectors. Addressing these challenges requires the range of responsible sectors and intersecting services - across health, education, social and financial protection, economic development, law enforcement, among others - transform the way they work together towards shared goals. While the necessity of MSC is recognized, research is needed to understand how sectors collaborate, inform how to do so more efficiently, effectively and equitably, and ascertain similarities and differences across contexts. To answer these questions and inform practice, research to strengthen the evidence-base on MSC is critical.

    METHODS: This paper draws on a 12-country study series on MSC for health and sustainable development, in the context of the health and rights of women, children and adolescents. It is written by core members of the research coordination and country teams. Issues were analyzed during the study period through 'real-time' discussions and structured reporting, as well as through literature reviews and retrospective feedback and analysis at the end of the study.

    RESULTS: We identify four considerations that are unique to MSC research which will be of interest to other researchers, in the context of COVID-19 and beyond: 1) use theoretical frameworks to frame research questions as relevant to all sectors and to facilitate theoretical generalizability and evolution; 2) specifically incorporate sectoral analysis into MSC research methods; 3) develop a core set of research questions, using mixed methods and contextual adaptations as needed, with agreement on criteria for research rigor; and 4) identify shared indicators of success and failure across sectors to assess MSCs.

    CONCLUSION: In responding to COVID-19 it is evident that effective MSC is an urgent priority. It enables partners from diverse sectors to effectively convene to do more together than alone. Our findings have practical relevance for achieving this objective and contribute to the growing literature on partnerships and collaboration. We must seize the opportunity here to identify remaining knowledge gaps on how diverse sectors can work together efficiently and effectively in different settings to accelerate progress towards achieving shared goals.

  12. Kuruvilla S, Hinton R, Boerma T, Bunney R, Casamitjana N, Cortez R, et al.
    BMJ, 2018 Dec 07;363:k4771.
    PMID: 30530519 DOI: 10.1136/bmj.k4771
    Shyama Kuruvilla and colleagues present findings across 12 country case studies of multisectoral collaboration, showing how diverse sectors intentionally shape new ways of collaborating and learning, using “business not as usual” strategies to transform situations and achieve shared goals
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