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  1. Shanmuga Sundara Raj S, Fun HK, Lu ZL, Xiao W, Gong XY, Gen CM
    Acta Crystallogr C, 2000 Aug;56 (Pt 8):1015-6.
    PMID: 10944310
    The whole molecule of the title compound, C(19)H(14)N(4)O(2), is essentially planar, with a highly conjugated pi system. In the crystal, the molecules are packed as chains along the [011] direction connected by O-H.N intermolecular hydrogen bonds.
  2. Shanmuga Sundara Raj S, Fun HK, Lu ZL, Xiao W, Gong XY, Gen CM
    Acta Crystallogr C, 2000 Aug;56 (Pt 8):1013-4.
    PMID: 10944309
    The crystal structure of the title compound, C(15)H(14)N(2)O(2). H(2)O, is in the keto tautomeric form and the configuration at the azomethine C=N double bond is E. The molecule is non-planar, with a dihedral angle of 27.3 (1) degrees between the aromatic rings. The crystal structure is stabilized by extensive hydrogen bonding involving the water molecule and hydrazone moiety.
  3. Bai X, Xiao W, Soh KG, Zhang Y
    Front Public Health, 2024;12:1415477.
    PMID: 38989125 DOI: 10.3389/fpubh.2024.1415477
    PURPOSE: Falls are the leading cause of accidental death among older persons, with postmenopausal women facing a greater hazard of falling due to osteoporosis. This study aimed to examine the effects of Taijiquan practice on balance control and functional fitness in at-risk females.

    METHODS: Chinese women who self-reported a tendency to fall and had a baseline one-leg stand test time (4.1 s in the Taijiquan group) below the national average for their age group (60-64 years: 10.9 s, 65-69 years: 9.9 s) were assigned to either a control group (n = 26, mean age = 63.9 years) or a Taijiquan group (n = 24, mean age = 63.9 years). The Taijiquan group participated in a 12-week supervised intervention, while the control group maintained their daily activities. The average duration of each exercise session was 52 min. Static balance and functional fitness were assessed at the beginning and end of the intervention.

    RESULTS: After 12 weeks, the Taijiquan group significantly outperformed the control group in terms of balance, flexibility, and muscular fitness (all p 

  4. Bai X, Xiao W, Soh KG, Agudamu, Zhang Y
    PLoS One, 2023;18(10):e0293483.
    PMID: 37883372 DOI: 10.1371/journal.pone.0293483
    Healthy aging is a global goal to enhance the quality of life for older persons. This study evaluated the benefits of 12-week concurrent brisk walking and Taijiquan. Healthy Chinese women aged 60 years and above were enrolled to the control (n = 26) and intervention (n = 25) groups. Participants in the intervention group engaged in three exercise sessions per week for 12 weeks, whereas control group engaged in free-living activities. Each exercise session consisted of 20-45 minutes of walking and 20-45 minutes of Yang style 24-form Taijiquan. 12-week exercise improved (p < 0.05) the sit and reach test (within-group mean difference: +5.6 cm; Hedges' g = 0.77), handgrip strength (mean difference: +3.1 kg; g = 0.89), arm curl (mean difference: +2.1 repetitions; g = 0.69), chair stand (mean difference: +2.6 repetitions; g = 0.63), and one-legged standing (mean difference: +2.2 seconds; g = 1.07). There was no improvement in the circulatory health, body composition, or life satisfaction. Therefore, this concurrent brisk walking and Taijiquan training, which targets major whole-body muscle groups, could improve aging-critical flexibility, muscular fitness, and balance in older women. The exercise meets the current WHO guideline, is safe to perform, and could be campaigned as a health promotion for older persons.
  5. Bai X, Soh KG, Omar Dev RD, Talib O, Xiao W, Cai H
    Front Public Health, 2021;9:829367.
    PMID: 35174137 DOI: 10.3389/fpubh.2021.829367
    BACKGROUND: Although the elderly frequently engages in brisk walking as a form of exercise, little has been reported in the literature about the effect of brisk walking on health-related physical fitness, balance, and overall life satisfaction.

    OBJECTIVES: The purpose of this systematic review is to determine the effect of brisk walking on the elderly's health-related physical fitness, balance, and life satisfaction.

    DESIGN: We conducted a comprehensive search from the PubMed, Web of Science, Scopus, and SPORTDiscus databases from January to September 2021. We selected studies through PICOS and conducted a systematic literature review according to the PRISMA guidelines.

    RESULTS: Thirteen studies met all criteria; 11 were classed as low risk of bias, while two were classified as high risk of bias. Generally, brisk walking has been shown to improve cardiorespiratory fitness, muscular strength, and body composition. Limited evidence was presented on flexibility, muscular endurance and development and life satisfaction, and there was conflicting evidence on balance. Moreover, evidence of restriction proves that high-intensity (80-85%) brisk walking is more effective than moderate-intensity (60-75%) brisk walking on the aerobic capacity of the elderly. Furthermore, there was less research conducted on males.

    CONCLUSION: Brisk walking has been shown to improve cardiorespiratory fitness, muscular strength, and body composition. Other outcomes (balance, flexibility, muscular endurance, and life satisfaction) and the impact of the intensity of brisk walking on the elderly should be confirmed. Therefore, there remains insufficient research on brisk walking, while single brisk walking cannot meet requirements of elderly in terms of their health-related physical fitness, balance, and life satisfaction. Future research should aim to examine the effectiveness of combining several types of exercises to promote general health in the elderly, as the World Health Organization recommends. Unintelligible FITT (frequency, intensity, time, type) principles of brisk walking training should be trenched for the results of scientific and effective physical exercise.

  6. Deng N, Soh KG, Abdullah B, Huang D, Xiao W, Liu H
    PLoS One, 2023;18(7):e0288340.
    PMID: 37459333 DOI: 10.1371/journal.pone.0288340
    BACKGROUND: The literature has proven that plyometric training (PT) improves various physical performance outcomes in sports. Even though PT is one of the most often employed strength training methods, a thorough analysis of PT and how it affects technical skill performance in sports needs to be improved.

    METHODS: This study aimed to compile and synthesize the existing studies on the effects of PT on healthy athletes' technical skill performance. A comprehensive search of SCOPUS, PubMed, Web of Science Core Collection, and SPORTDiscus databases was performed on 3rd May 2023. PICOS was employed to establish the inclusion criteria: 1) healthy athletes; 2) a PT program; 3) compared a plyometric intervention to an active control group; 4) tested at least one measure of athletes' technical skill performance; and 5) randomized control designs. The methodological quality of each individual study was evaluated using the PEDro scale. The random-effects model was used to compute the meta-analyses. Subgroup analyses were performed (participant age, gender, PT length, session duration, frequency, and number of sessions). Certainty or confidence in the body of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

    RESULTS: Thirty-two moderate-high-quality studies involving 1078 athletes aged 10-40 years met the inclusion criteria. The PT intervention lasted for 4 to 16 weeks, with one to three exercise sessions per week. Small-to-moderate effect sizes were found for performance of throwing velocity (i.e., handball, baseball, water polo) (ES = 0.78; p < 0.001), kicking velocity and distance (i.e., soccer) (ES = 0.37-0.44; all p < 0.005), and speed dribbling (i.e., handball, basketball, soccer) (ES = 0.85; p = 0.014), while no significant effects on stride rate (i.e., running) were noted (ES = 0.32; p = 0.137). Sub-analyses of moderator factors included 16 data sets. Only training length significantly modulated PT effects on throwing velocity (> 7 weeks, ES = 1.05; ≤ 7 weeks, ES = 0.29; p = 0.011). The level of certainty of the evidence for the meta-analyzed outcomes ranged from low to moderate.

    CONCLUSION: Our findings have shown that PT can be effective in enhancing technical skills measures in youth and adult athletes. Sub-group analyses suggest that PT longer (> 7 weeks) lengths appear to be more effective for improving throwing velocity. However, to fully determine the effectiveness of PT in improving sport-specific technical skill outcomes and ultimately enhancing competition performance, further high-quality research covering a wider range of sports is required.

  7. Zhang J, Xiao W, Soh KG, Yao G, Anuar MABM, Bai X, et al.
    BMC Public Health, 2024 Apr 02;24(1):949.
    PMID: 38566018 DOI: 10.1186/s12889-024-18243-0
    BACKGROUND: Evidence indicates that the Sport Education Model (SEM) has demonstrated effectiveness in enhancing students' athletic capabilities and fostering their enthusiasm for sports. Nevertheless, there remains a dearth of comprehensive reviews examining the impact of the SEM on students' attitudes toward physical education learning.

    PURPOSE: The purpose of this review is to elucidate the influence of the SEM on students' attitudes toward physical education learning.

    METHODS: Employing the preferred reporting items of the Systematic Review and Meta-analysis (PRISMA) statement guidelines, a systematic search of PubMed, SCOPUS, EBSCOhost (SPORTDiscus and CINAHL Plus), and Web of Science databases was conducted in mid-January 2023. A set of keywords associated with the SEM, attitudes toward physical education learning, and students were employed to identify relevant studies. Out of 477 studies, only 13 articles fulfilled all the eligibility criteria and were consequently incorporated into this systematic review. The validated checklist of Downs and Black (1998) was employed for the assessment, and the included studies achieved quality scores ranging from 11 to 13. The ROBINS-I tool was utilized to evaluate the risk of bias in the literature, whereby only one paper exhibited a moderate risk of bias, while the remainder were deemed to have a high risk.

    RESULTS: The findings unveiled significant disparities in cognitive aspects (n = 8) and affective components (n = 12) between the SEM intervention and the Traditional Teaching (TT) comparison. Existing evidence suggests that the majority of scholars concur that the SEM yields significantly superior effects in terms of students' affective and cognitive aspects compared to the TT.

    CONCLUSIONS: Nonetheless, several issues persist, including a lack of data regarding junior high school students and gender differences, insufficient frequency of weekly interventions, inadequate control of inter-group atmosphere disparities resulting from the same teaching setting, lack of reasonable testing, model fidelity check and consideration for regulating variables, of course, learning content, and unsuitable tools for measuring learning attitudes. In contrast, the SEM proves more effective than the TT in enhancing students' attitudes toward physical learning.

    SYSTEMATIC REVIEW REGISTRATION: ( https://inplasy.com/ ) (INPLASY2022100040).

  8. Deng N, Soh KG, Abdullah B, Huang D, Sun H, Xiao W
    Front Physiol, 2023;14:1234114.
    PMID: 37664429 DOI: 10.3389/fphys.2023.1234114
    Background: Tennis is among the world's most popular and well-studied sports. Physical training has commonly been used as an intervention among athletes. However, a comprehensive review of the literature on the effects of physical training programs on female tennis players' performance is lacking. Therefore, this systematic review and meta-analysis aimed to determine the effects of physical training on performance outcomes in female tennis players. Methods: A comprehensive search was conducted on Web of Science, PubMed, SPORTDicus, Scopus, and CNKI from inception until July 2023 to select relevant articles from the accessible literature. Only controlled trials were included if they examined the effects of physical training on at least one measure of tennis-specific performance in female tennis players. The Cochrane RoB tool was employed to assess the risk of bias. The CERT scale was used to examine the quality of program information. The GRADE approach was adopted to evaluate the overall quality of the evidence. The Comprehensive Meta-Analysis software was used for the meta-analysis. Results: Nine studies were selected for the systematic review and seven for the meta-analysis, totaling 222 individuals. The study's exercise programs lasted 6-36 weeks, with training sessions ranging from 30 to 80 min, conducted one to five times per week. Muscle power (ES = 0.72; p = 0.003), muscle strength (ES = 0.65; p = 0.002), agility (ES = 0.69; p = 0.002), serve velocity (ES = 0.72; p = 0.013), and serve accuracy (ES = 1.14; p = 0.002) demonstrated significant improvement following physical training, while no notable changes in linear sprint speed (ES = 0.63; p = 0.07) were detected. Conclusion: Although research on physical training in sports is diversified, studies on training interventions among female tennis players are scarce. This review found that existing training programs yield some favorable outcomes for female tennis players. However, further research with high methodological quality is warranted on the tailoring of specific training programs for female tennis players. There should be more consistent measuring and reporting of data to facilitate meaningful data pooling for future meta-analyses.
  9. Zhang J, Geok Soh K, Bai X, Mohd Anuar MA, Xiao W
    PLoS One, 2024;19(12):e0311957.
    PMID: 39630649 DOI: 10.1371/journal.pone.0311957
    BACKGROUND: There is a notable gap in systematic reviews concerning hybrid pedagogical models (PMs) integrated with the Sport Education Model (SEM) and their impact on students' outcomes.

    PURPOSE: Which hybrid PMs incorporating SEM are currently the mainstream choices in research, and what are the main factors supporting their integration? How does SEM function as a foundational model in these hybrid teaching approaches? What learning outcomes are optimized through the hybrid models that combine SEM with other PMs?

    METHODS: A systematic search was conducted in major databases in December 2023 following PRISMA guidelines. Out of the identified 1342 studies, 30 met the eligibility criteria, all of which were deemed to be of high quality.

    RESULTS: Seven hybrid types were identified, primarily composed of two PMs, among which the blend of SEM and Teaching Games for Understanding (TGfU) emerges as the mainstream in current research. SEM, serving as the foundational structure, provides a stable framework for the hybrid, termed the "SEM + 1 model," yielding positive effects on enhancing students' learning outcomes.

    CONCLUSIONS: Pedagogical models align with PMs' motivational aspects, thus enhancing learning outcomes. However, evidence for partial hybrids is lacking. Future research should explore diverse interventions, addressing coherence and teacher competence, while maintaining fidelity.

  10. Zhang D, Soh KG, Chan YM, Feng X, Bashir M, Xiao W
    Heliyon, 2024 Dec 15;10(23):e39531.
    PMID: 39687180 DOI: 10.1016/j.heliyon.2024.e39531
    OBJECTIVES: Fundamental motor skills (FMS) are the foundation of children's movement, requiring tailored training and guidance for development. As an emerging training method, functional training is optimistic in promoting the development of children's fundamental motor skills. However, current studies have not assessed the effect of functional training on fundamental motor skills. This review aims to address this gap by evaluating the effects of functional training on fundamental motor skills.

    DESIGN: A search was conducted in five databases: PubMed, Scopus, ProQuest, Web of Science, and SPORT Discus, from January 2000 to June 2023.

    METHOD: This search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

    RESULTS: The results of the search identified a total of twenty-six articles. Improvements were primarily demonstrated in the three main areas of fundamental motor skills: locomotor skills (n = 17), balance skills (n = 10), and object control skills (n = 2).

    CONCLUSIONS: The results suggest that functional training programs can improve children's fundamental motor skills. Existing evidence also concludes that functional training significantly impacts locomotor and balance skills, whereas further research is required to confirm its positive effects on object control skills.

  11. Xiao W, Bu T, Zhang J, Cai H, Zhu W, Bai X, et al.
    BMC Sports Sci Med Rehabil, 2025 Jan 03;17(1):2.
    PMID: 39754208 DOI: 10.1186/s13102-024-01040-y
    BACKGROUND: The evidence indicates that functional training is beneficial for athletes' physical and technical performance. However, a systematic review of the effects of functional training on athletes' physical and technical performance is lacking. Therefore, this study uses a literature synthesis approach to evaluate the impact of functional training on the physical and technical performance of the athletic population and to extend and deepen the existing body of knowledge.

    METHODS: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and the researchers performed a systematic search of five international electronic databases using the predefined terms "functional training" and "athletes" on 15th November 2023: Web of Science, CINAHL PLUS, PubMed, Scopus, and SPORTDiscus. A PICOS approach was used to identify the following inclusion criteria: (1) athletes, (2) a functional training program, (3) an active control group, (4) a measure of physical and/or technical performance, and (5) randomized controlled studies. A methodological quality assessment of the original research was conducted using the Physiotherapy Evidence Database (Pedro) scale. The review was performed using the PRIMSA guidelines and registered in PROSPERO (ID: CRD42022347943).

    RESULTS: Of the 1059 potentially eligible studies identified, 28 studies met the inclusion criteria. The studies included were conducted on 819 athletes from 12 different countries and were published between 2011 and 2023. The assessment was performed on the Pedro scale, and the mean Pedro score for the included studies was 5.57 (moderate quality, ranging from 4 to 10). The eligibility study reported on 14 different types of sports, with 22 studies focusing on physical performance and 11 studies focusing on technical performance. These studies have shown that functional training can significantly improve the physical and technical performance of athlete populations, but in some studies, no significant difference in the data was observed between groups.

    CONCLUSION: Functional training is an effective training method for enhancing the physical and technical performance of athlete populations. However, no significant difference in the data was observed between the functional training groups and the regular training group, which may be due to the duration of the training program, the different training experiences of the athletes, and the different focuses of the training regimens. Therefore, future studies should focus on the physical and technical performance of different sports groups with different types and durations of functional training programs to expand the current evidence base.

  12. Xiao W, Bu T, Zhao F, Zhang J, Bai X, Geok SK
    BMC Sports Sci Med Rehabil, 2025 Mar 08;17(1):43.
    PMID: 40057803 DOI: 10.1186/s13102-025-01085-7
    PURPOSE: Functional training to improve athletes' technical performance and movement quality is becoming increasingly popular, but few studies have focused on young tennis players. The aims of this study were to compare the effects of 12 weeks of functional training on skilled youth male tennis players' skill performance and movement quality.

    METHODS: Forty skilled youth male tennis players were assigned to the functional training group (n = 20) or the control training group (n = 20). The control group received a traditional resistance training program by their coach, whereas the functional training group was given Santana's Racket Sports Program. Each group received 60-minute training sessions three times per week for 12 weeks. At baseline (T0), after six weeks (T6), and after 12 weeks (T12), the participants' skill performance was measured according to the International Tennis Federation's protocol, and movement quality was measured according to the functional movement screening assessment recommended by Gray Cook. The data were analyzed via a generalized estimation equation model.

    RESULTS: The results revealed that there were no significant differences in skill performance or movement quality between the groups at baseline (p > 0.05), but there were significant differences in those variables between the groups after 6 weeks of the intervention and 12 weeks of the intervention (p 

  13. Xiao W, Soh KG, Wazir MRWN, Talib O, Bai X, Bu T, et al.
    Front Physiol, 2021;12:738878.
    PMID: 34552511 DOI: 10.3389/fphys.2021.738878
    There is evidence that functional training is beneficial for the overall physical fitness of athletes. However, there is a lack of a systematic review focused on the effects of functional training on athletes' physical fitness. Thus, the aimed of the present review is to clarify the effects of functional training on physical fitness among athletes. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) Statement guidelines, the systematic search of PubMed, SCOPUS, EBSCOhost (SPORTDiscus), and CINAHL Plus databases was undertaken on the 2nd November 2020 to identify the reported studies, using a combination of keywords related to functional training, physical fitness, and athletes. From the 145 studies, only nine articles met all eligibility criteria and were included in the systematic review. The assessment was performed on the Pedro scale, and the quality of the study included in the nine studies was fair (ranging from 3 to 4). The results showed that speed (n = 6) was the aspect of physical fitness studied in functional training interventions, followed by muscular strength (n = 5), power (n = 4), balance (n = 3), body composition (n = 3), agility (n = 3), flexibility (n = 1) and muscular endurance (n = 1). Existing evidence concludes that functional training significantly impacts speed, muscular strength, power, balance, and agility. Furthermore, there are still limit numbers of evidence showing effect of functional training on flexibility and muscular endurance. In contrast, no significant improvement was found in body composition where functional training was conducted. Systematic Review Registration:https://www.crd.york.ac.uk/prospero, identifier: CRD4202123092.
  14. Lin X, Hu W, Hii KS, Xiao W, Tan H, Ma L, et al.
    Mol Ecol, 2025 Apr;34(7):e17709.
    PMID: 40026276 DOI: 10.1111/mec.17709
    Climate change has significantly altered the spatiotemporal distribution and phenology of marine organisms, yet the long-term trends and mechanisms driving these changes remain insufficiently understood. In this study, we analysed historical Noctiluca scintillans bloom data from coastal China (1933, 1952, 1981-2023), sea surface temperature (SST) records from the past 40 years, and 509 field samples using Single Molecule Real-Time (SMRT) sequencing (2019-2024). Our results indicate that SST is the primary driver of N. scintillans blooms, exhibiting a nonlinear unimodal correlation. Long-term SST warming has caused a northward shift in bloom locations, aligning with the 21.9°C-22.7°C isotherms, as reflected by the increasing average latitudes of bloom occurrences. Over the past 4 decades, bloom frequency and duration have followed an overall increasing trend, displaying an approximate 10-year cyclical pattern. Ocean warming has also contributed to earlier bloom initiation, extended peak bloom periods and delayed bloom termination, shaping the long-term dynamics of N. scintillans blooms. SMRT sequencing confirmed that local N. scintillans populations persist year-round, serving as latent seed sources that can rapidly bloom when environmental conditions become favourable. These findings provide critical insights into the dynamics of harmful algal blooms in the context of climate change and lay a foundation for future ecological and environmental research.
  15. Zhong J, Jermusyk A, Wu L, Hoskins JW, Collins I, Mocci E, et al.
    J Natl Cancer Inst, 2020 Oct 01;112(10):1003-1012.
    PMID: 31917448 DOI: 10.1093/jnci/djz246
    BACKGROUND: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown.

    METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples).

    RESULTS: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEP1) and 11 at six known risk loci (5p15.33: TERT, CLPTM1L, ZDHHC11B; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTM1L, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction.

    CONCLUSIONS: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation.

  16. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al.
    Autophagy, 2016;12(1):1-222.
    PMID: 26799652 DOI: 10.1080/15548627.2015.1100356
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