Displaying publications 1 - 20 of 48 in total

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  1. Spatial and temporal variation of vegetation cover in the main mining area of Qibaoshan Town, China: Potential impacts from mining damage, solid waste discharge and land reclamation
    Yu H, Zahidi I
    Sci Total Environ, 2023 Feb 10;859(Pt 2):160392.
    PMID: 36423851 DOI: 10.1016/j.scitotenv.2022.160392
    The increasing frequency of mining activities in the world has led to many environmental pollution problems, such as mine wastewater discharge, mine solid waste dumps, and mine dust dispersion. These problems have negative implications for the environment and the public health of people living nearby the mining areas. Despite this, there are few methods to determine the state of mine pollution on a regional scale. Therefore, we applied remote sensing technologies to assess the mine pollution situation, especially the mine solid waste pollution, of a mining area, taking Qibaoshan Town, Liuyang City, Hunan Province, China, as an example. In our research, we have calculated the vegetation cover change of the Qibaoshan Town over the years (2000-2020), charted the vegetation coverage grade maps, and analysed the tendency of vegetation cover changes, to infer the mine pollution situation, the progress of pollution treatment and the efforts made by the local government and the mines on mine pollution disposal and the land reclamation. Additionally, mining damage can bring about geological hazards such as surface subsidence leading to vegetation destruction, while mining solid waste pollution and discharge can occupy a large amount of land and thus lead to vegetation reduction. As a result, this method of calculating FVC changes in a mining area is particularly suitable for assessing the extent of mining damage, the status of solid waste pollution and discharge, and the progress of land reclamation. In the abstract, we claim that this short communication article serves as a guide to start a conversation, and encourages experts and scholars to engage in this area of research.
  2. Environmental hazards posed by mine dust, and monitoring method of mine dust pollution using remote sensing technologies: An overview
    Yu H, Zahidi I
    Sci Total Environ, 2023 Mar 15;864:161135.
    PMID: 36566867 DOI: 10.1016/j.scitotenv.2022.161135
    The over-exploitation of mineral resources has led to increasingly serious dust pollution in mines, resulting in a series of negative impacts on the environment, mine workers (occupational health) and nearby residents (public health). For the environment, mine dust pollution is considered a major threat on surface vegetation, landscapes, weather conditions and air quality, leading to serious environmental damage such as vegetation reduction and air pollution; for occupational health, mine dust from the mining process is also regarded as a major threat to mine workers' health, leading to occupational diseases such as pneumoconiosis and silicosis; for public health, the pollutants contained in mine dust may pollute surrounding rivers, farmlands and crops, which poses a serious risk to the domestic water and food security of nearby residents who are also susceptible to respiratory diseases from exposure to mine dust. Therefore, the second section of this paper combines literature research, statistical studies, and meta analysis to introduce the public mainly to the severity of mine dust pollution and its hazards to the environment, mine workers (occupational health), and residents (public health), as well as to present an outlook on the management of mine dust pollution. At the same time, in order to propose a method for monitoring mine dust pollution on a regional scale, based on the Dense Dark Vegetation (DDV) algorithm, the third section of this paper analysed the aerosol optical depth (AOD) change in Dexing City of China using the data of 2010, 2014, 2018 and 2021 from the NASA MCD19A2 Dataset to explore the mine dust pollution situation and the progress of pollution treatment in Dexing City from 2010 to 2021. As a discussion article, this paper aims to review the environmental and health risks caused by mine dust pollution, to remind the public to take mine dust pollution seriously, and to propose the use of remote sensing technologies to monitor mine dust pollution, providing suggestions for local governments as well as mines on mine dust monitoring measures.
  3. Fulltext Online Binge-Watching Among Chinese College Students: Implications for Loneliness, Anxiety, and Depression
    Yu H, Alizadeh F
    Psychol Res Behav Manag, 2024;17:295-303.
    PMID: 38292254 DOI: 10.2147/PRBM.S447311
    PURPOSE: This study aimed to investigate binge-watching behavior and addiction among a sample of 446 Chinese college students and assess its consequences for mental health, with a particular focus on feelings of loneliness, anxiety, and depression.

    PARTICIPANTS AND METHODS: We conducted an online survey to gather data, examining participants' binge-watching habits and preferred platforms. We also utilized regression analysis to assess the impact of binge-watching addiction on mental health, exploring the associations between binge-watching addiction and feelings of loneliness, anxiety, and depression.

    RESULTS: Our findings revealed that the Chinese college students in our study typically defined binge-watching sessions as lasting approximately 7.22 hours, with an average of 10.83 episodes. Regarding the self-assessment of binge-watching, the average duration of participants was 5.76 hours, and the average number of episodes was 7.42. Tencent Video, iQIYI, and Bilibili emerged as the dominant platforms for binge-watching among the respondents. Regression analysis demonstrated a significant link between binge-watching addiction and mental health, with positive associations observed between binge-watching addiction and increased feelings of loneliness, anxiety, and depression.

    CONCLUSION: The results of this study reinforce previous findings regarding the detrimental effects of excessive media consumption on mental well-being. Moreover, they provide valuable insights into the global prevalence of binge-watching and its impact on the psychological health of young adults in the digital age, emphasizing the need for proactive measures to address this issue.

  4. Fulltext Ameliorative Effects of Television Watching Behavior and Motivation on the Fear of COVID-19 in Older Chinese Adults During the Pandemic
    Yu H, Alizadeh F
    Psychol Res Behav Manag, 2024;17:2631-2640.
    PMID: 39006888 DOI: 10.2147/PRBM.S462085
    PURPOSE: The aim of this study was to investigate the television (TV) consumption patterns (viewing behavior and motivation) of older adults in Wuhan, China, during the COVID-19 pandemic and its impact on older adults' mental health, particularly in relation to COVID-19-induced fear.

    PARTICIPANTS AND METHODS: A questionnaire survey was conducted with 405 older adults in Wuhan, China. The data were analyzed using a structural equation model to understand the relationship between TV viewing behavior, motivation, and fear related to COVID-19.

    RESULTS: The findings indicate that the motivation to watch TV has a positive influence on viewing behavior among older adults during the pandemic. However, this motivation negatively impacts their COVID-19-related fear. Furthermore, a negative correlation was observed between viewing behavior and fear. The primary motivations for TV viewing among older adults during the pandemic were identified as social interaction and emotion management, followed by information seeking and value expression.

    CONCLUSION: The findings suggest that TV viewing plays a significant role in the mental well-being of older adults during the COVID-19 pandemic. By addressing the motivations of social interaction, emotion management, information seeking, and value expression, public health organizations and TV stations can contribute to the mental health of this vulnerable population.

  5. Spatiotemporal variation of vegetation cover in mining areas of Dexing City, China
    Yu H, Zahidi I, Liang D
    Environ Res, 2023 May 15;225:115634.
    PMID: 36889570 DOI: 10.1016/j.envres.2023.115634
    Dexing City is an important mining city in China, abounding in copper ore, lead ore, zinc ore, and other metal resources, and there are two large open-pit mines in its territory, Dexing Copper Mine and Yinshan Mine. The two open-pit mines have been expanding their mining production scale since 2005, with frequent mining activities; and the expansion of the pits and the discharge of solid waste will undoubtedly increase the land use and cause the destruction of vegetation. Therefore, we plan to visualize the change in vegetation cover in Dexing City from 2005 to 2020 and the expansion of the two open-pit mines by calculating changes of the Fractional Vegetation Cover (FVC) in the mining area using remote sensing technology. In this study, we calculated the FVC of Dexing City in 2005, 2010, 2015 and 2020 using data from NASA Landsat Database via ENVI image analysis software, plotted the FVC reclassified maps via ArcGIS, and conducted field investigations in the mining areas of Dexing City. In this way, we can visualize the spatial and temporal changes of vegetation cover in Dexing City from 2005 to 2020, and appreciate the situation of mining expansion and its solid waste discharge in Dexing City. The results of this study showed that the vegetation cover of Dexing City remained stable from 2005 to 2020, as the expansion of mining scale and mine pits was accompanied by active environmental management and land reclamation, setting a positive example for other mining cities.
  6. Mine land reclamation, mine land reuse, and vegetation cover change: An intriguing case study in Dartford, the United Kingdom
    Yu H, Zahidi I, Liang D
    Environ Res, 2023 May 15;225:115613.
    PMID: 36870554 DOI: 10.1016/j.envres.2023.115613
    Dartford, a town in England, heavily relied on industrial production, particularly mining, which caused significant environmental pollution and geological damage. However, in recent years, several companies have collaborated under the guidance of the local authorities to reclaim the abandoned mine land in Dartford and develop it into homes, known as the Ebbsfleet Garden City project. This project is highly innovative as it not only focuses on environmental management but also provides potential economic benefits, employment opportunities, builds a sustainable and interconnected community, fosters urban development and brings people closer together. This paper presents a fascinating case that employs satellite imagery, statistical data, and Fractional Vegetation Cover (FVC) calculations to analyse the re-vegetation progress of Dartford and the development of the Ebbsfleet Garden City project. The findings indicate that Dartford has successfully reclaimed and re-vegetated the mine land, maintaining a high vegetation cover level while the Ebbsfleet Garden City project has advanced. This suggests that Dartford is committed to environmental management and sustainable development while pursuing construction projects.
  7. Fulltext Reclaiming abandoned mine tailings ponds for agricultural use: Opportunities and challenges
    Yu H, Zahidi I, Fai CM
    Environ Res, 2023 Sep 01;232:116336.
    PMID: 37321336 DOI: 10.1016/j.envres.2023.116336
    Tailings ponds, large man-made structures conceived during the mining process for waste storage, often become deserted post-mining, leaving behind a stark, contaminated landscape. This paper posits that these forsaken tailings ponds can be rejuvenated into fertile agricultural land through adept reclamation efforts. Serving as a discussion paper, it engages in a stimulating exploration of the environmental and health risks linked to tailings ponds. It sheds light on the potential and impediments in the transformation of these ponds into agricultural land. The discussion concludes that despite the substantial hurdles in repurposing tailings ponds for agriculture, there are encouraging prospects with the application of multifaceted efforts.
  8. Fulltext Vegetation as an ecological indicator in assessing environmental restoration in mining areas
    Yu H, Zahidi I, Chow MF
    iScience, 2023 Sep 15;26(9):107667.
    PMID: 37680487 DOI: 10.1016/j.isci.2023.107667
    As global demand for natural resources escalates, the environmental impact stemming from resource extraction has risen to the forefront of contemporary discussions. This paper probed the potential of using vegetation cover as an ecological barometer to gauge the level of environmental damage and restoration in mining areas: a decline in vegetation cover may signify detrimental impacts from intense mining activities, while an increase may indicate effective local environmental stewardship. Therefore, this paper undertook an assessment and discussion of mining damage and environmental management at China's Ta'ershan Mining Area since 2007, calculating and visualizing FVC (Fractional Vegetation Cover) of the Ta'ershan Mining Area to track changes in vegetation cover between 2007 and 2021. Changes in vegetation cover in the Ta'ershan Mining Area could act as a reflection of both mining-induced damage and subsequent successful environmental management by local authorities, providing a practical way to evaluate ecological effects in resource development.
  9. Modified prairie dog optimization algorithm for global optimization and constrained engineering problems
    Yu H, Wang Y, Jia H, Abualigah L
    Math Biosci Eng, 2023 Oct 13;20(11):19086-19132.
    PMID: 38052592 DOI: 10.3934/mbe.2023844
    The prairie dog optimization (PDO) algorithm is a metaheuristic optimization algorithm that simulates the daily behavior of prairie dogs. The prairie dog groups have a unique mode of information exchange. They divide into several small groups to search for food based on special signals and build caves around the food sources. When encountering natural enemies, they emit different sound signals to remind their companions of the dangers. According to this unique information exchange mode, we propose a randomized audio signal factor to simulate the specific sounds of prairie dogs when encountering different foods or natural enemies. This strategy restores the prairie dog habitat and improves the algorithm's merit-seeking ability. In the initial stage of the algorithm, chaotic tent mapping is also added to initialize the population of prairie dogs and increase population diversity, even use lens opposition-based learning strategy to enhance the algorithm's global exploration ability. To verify the optimization performance of the modified prairie dog optimization algorithm, we applied it to 23 benchmark test functions, IEEE CEC2014 test functions, and six engineering design problems for testing. The experimental results illustrated that the modified prairie dog optimization algorithm has good optimization performance.
  10. Phylogeny and evolution of the Drosophila nasuta subgroup based on mitochondrial ND4 and ND4L gene sequences
    Yu H, Wang W, Fang S, Zhang YP, Lin FJ, Geng ZC
    Mol Phylogenet Evol, 1999 Dec;13(3):556-65.
    PMID: 10620413
    The sequences of the mitochondrial ND4 gene (1339 bp) and the ND4L gene (290 bp) were determined for all the 14 extant taxa of the Drosophila nasuta subgroup. The average A + T content of ND4 genes is 76.5% and that of ND4L genes is 83.5%. A total of 114 variable sites were scored. The ND4 gene sequence divergence ranged from 0 to 5.4% within the subgroup. The substitution rate of the ND4 gene is about 1.25% per million years. The base substitution of the genes is strongly transition biased. Neighbor-joining and parsimony were used to construct a phylogeny based on the resultant sequence data set. According to these trees, five distinct mtDNA clades can be identified. D. niveifrons represents the most diverged lineage. D. sulfurigaster bilimbata and D. kepulauana form two independent lineages. The other two clades are the kohkoa complex and the albomicans complex. The kohkoa complex consists of D. sulfurigaster sulfurigaster, D. pulaua, D. kohkoa, and Taxon-F. The albomicans complex can be divided into two groups: D. nasuta, D. sulfurigaster neonasuta, D. sulfurigaster albostrigata, and D. albomicans from Chiangmai form one group; and D. pallidifrons, Taxon-I, Taxon-J, and D. albomicans from China form the other group. High genetic differentiation was found among D. albomicans populations. Based on our phylogenetic results, we hypothesize that D. niveifrons diverged first from the D. nasuta subgroup in Papua New Guinea about 3.5 Mya. The ancestral population spread to the north and when it reached Borneo, it diversified sequentially into the kohkoa complex, D. s. bilimbata, and D. kepulauana. About 1 Mya, another radiation occurred when the ancestral populations reached the Indo-China Peninsula, forming the albomicans complex. Discrepancy between morphological groupings and phylogenetic results suggests that the male morphological traits may not be orthologous.
  11. Fulltext Crosstalk Between circRNA and Tumor Microenvironment of Hepatocellular Carcinoma: Mechanism, Function and Applications
    Xie C, Hao X, Yuan H, Wang C, Sharif R, Yu H
    Onco Targets Ther, 2024;17:7-26.
    PMID: 38283733 DOI: 10.2147/OTT.S437536
    Hepatocellular carcinoma (HCC) is one of the most common aggressive tumors in the world. Despite the availability of various treatments, its prognosis remains poor due to the lack of specific diagnostic indicators and the high heterogeneity of HCC cases. CircRNAs are noncoding RNAs with stable and highly specific expression. Extensive research evidence suggests that circRNAs mediate the pathogenesis and progression of HCC through acting as miRNA sponges, protein modulators, and translation templates. Tumor microenvironment (TME) has become a hotspot of immune-related research in recent years due to its effects on metabolism, secretion and immunity of HCC. Accordingly, understanding the role played by circRNAs in TME is important for the study of HCC. This review will discuss the crosstalk between circRNAs and TME in HCC. In addition, we will discuss the current deficiencies and controversies in research on circRNAs and predict future research directions.
  12. Fulltext Sungai Lembing's green tourism: Pioneering the future of resource-based urban renewal
    Yu H, Gunaratna G, Zahidi I, Fai CM
    Innovation (Camb), 2024 Mar 04;5(2):100578.
    PMID: 38445020 DOI: 10.1016/j.xinn.2024.100578
  13. From waste to wealth: The "Blue Circle" vision for a sustainable ocean future
    Yu H, Zahidi I, Fai CM, Liang D, Madsen DØ
    Sci Bull (Beijing), 2024 Apr 30;69(8):993-996.
    PMID: 38433031 DOI: 10.1016/j.scib.2024.02.024
  14. Fulltext Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice
    Bao R, Liu M, Wang D, Wen S, Yu H, Zhong Y, et al.
    Front Pharmacol, 2019;10:1464.
    PMID: 31920654 DOI: 10.3389/fphar.2019.01464
    Background:Eurycoma longifolia is a tropical medicinal plant belonging to Simaroubaceae distributed in South East Asia. The stems are traditionally used for the treatment of sexual insufficiency, fever, hypertension, and malaria. Furthermore, it has antidiabetic and anticancer activities. Recently, it has been reported to reduce uric acid, but the mechanism is unclear. Hypothesis/Purpose: The aim of this study is to explore the effect and mechanism of E. longifolia stem 70% ethanol extract (EL) and its active compounds on uric acid excretion. Study Design and Methods: Potassium oxonate (PO) induced hyperuricemia rats model and adenine-PO induced hyperuricemia mice model were used to evaluate the effects of EL. Ultraperformance liquid chromatography was used to determine the levels of plasma or serum uric acid and creatinine. Hematoxylin-eosin staining was applied to observe kidney pathological changes, and western blot was applied to detect protein expression levels of uric acid transporters. Effects of constituents on urate uptake were tested in hURAT1-expressing HEK293T cells. Results: EL significantly reduced serum and plasma uric acid levels at dosages of 100, 200, and 400 mg/kg in hyperuricemia rats and mice, increased the clearance rate of uric acid and creatinine, and improved the renal pathological injury. The protein expression levels of urate reabsorption transporter 1 (URAT1) and glucose transporter 9 were down-regulated, while sodium-dependent phosphate transporter 1 and ATP-binding cassette transporter G2 were up-regulated in the kidney after EL treatment. The quassinoids isolated from EL showed inhibitory effects on urate uptake in hURAT1-expressing HEK293T cells, and the effect of eurycomanol was further confirmed in vivo. Conclusion: Our findings revealed that EL significantly reduced blood uric acid levels, prevented pathological changes of kidney in PO induced hyperuricemia animal model, and improved renal urate transports. We partly clarified the mechanism was related to suppressing effect of URAT1 by quassinoid in EL. This study is the first to demonstrate that EL plays a role in hyperuricemia by promoting renal uric acid excretion.
  15. Influence of substrate on ultrafast water transport property of multilayer graphene coatings
    Kueh TC, Yu H, Soh AK, Wu HA, Hung YM
    Nanotechnology, 2020 Sep 11;31(37):375704.
    PMID: 32480382 DOI: 10.1088/1361-6528/ab9864
    The ultrafast water transport in graphene nanoplatelets (GNPs) coating is attributed to the low friction passages formed by pristine graphene and the hydrophilic functional groups which provide a strong interaction force to the water molecules. Here, we examine the influence of the supporting substrate on the ultrafast water transport property of multilayer graphene coatings experimentally and by computational modelling. Thermally cured GNPs manifesting ultrafast water permeation are coated on different substrate materials, namely aluminium, copper, iron and glass. The physical and chemical structures of the GNPs coatings which are affected by the substrate materials are characterized using various spectroscopy techniques. Experimentally, the water permeation and absorption tests evidence the significant influence of the substrate on the rapid water permeation property of GNPs-coating. The water transport rates of the GNPs coatings correspond to the wettability and the free surface energy of their substrates where the most hydrophilic substrate induces the highest water transport rate. In addition, we conduct molecular dynamics (MD) simulations to investigate the transport rate of water molecules through multilayer GNPs adjacent to different substrate materials. The MD simulations results agree well with the experimental results inferring the strong influence of the substrate materials on the fast water transport of GNPs. Therefore, selection of substrate has to be taken into consideration when the GNPs-coating is placed into applications.
  16. Research on the descaling characteristics of a new electrochemical water treatment device
    Wei Y, Wang D, Li G, Yu H, Dong X, Jiang H
    Water Sci Technol, 2023 Nov;88(10):2566-2580.
    PMID: 38017678 DOI: 10.2166/wst.2023.365
    In recent years, chemical water treatment equipment has gained significant attention due to its environmental-friendly features, multifunctionality, and broad applicability. Recognizing the limitations of existing chemical treatment equipment, such as challenges in scale removal and the high water content in scale deposits, we propose a novel drum design for both anode and cathode, enabling simultaneous scale suction and dehydration. We constructed a small experimental platform to validate the equipment's performance based on our model. Notably, under the optimal operating parameters, the hardness removal rate for circulating water falls within the range of 19.6-24.46%. Moreover, the scale accumulation rate per unit area and unit time reaches 13.7 g h-1 m-2. Additionally, the energy consumption per unit weight of the scale remains impressively low at 0.16 kWh g-1. Furthermore, the chemical oxygen demand (COD) concentration decreased from an initial 106.0 mg L-1 to a mere 18.8 mg L-1, resulting in a remarkable total removal rate of 82.26%. In conclusion, our innovative electrochemical water treatment equipment demonstrates exceptional performance in scale removal, organic matter degradation, and water resource conservation, offering valuable insights for future research and development in chemical treatment equipment and electrochemical theory.
  17. Fulltext TRANSPARENT TESTA GLABRA1 Regulates the Accumulation of Seed Storage Reserves in Arabidopsis
    Chen M, Zhang B, Li C, Kulaveerasingam H, Chew FT, Yu H
    Plant Physiol, 2015 Sep;169(1):391-402.
    PMID: 26152712 DOI: 10.1104/pp.15.00943
    Seed storage reserves mainly consist of starch, triacylglycerols, and storage proteins. They not only provide energy for seed germination and seedling establishment, but also supply essential dietary nutrients for human beings and animals. So far, the regulatory networks that govern the accumulation of seed storage reserves in plants are still largely unknown. Here, we show that TRANSPARENT TESTA GLABRA1 (TTG1), which encodes a WD40 repeat transcription factor involved in many aspects of plant development, plays an important role in mediating the accumulation of seed storage reserves in Arabidopsis (Arabidopsis thaliana). The dry weight of ttg1-1 embryos significantly increases compared with that of wild-type embryos, which is accompanied by an increase in the contents of starch, total protein, and fatty acids in ttg1-1 seeds. FUSCA3 (FUS3), a master regulator of seed maturation, binds directly to the TTG1 genomic region and suppresses TTG1 expression in developing seeds. TTG1 negatively regulates the accumulation of seed storage proteins partially through transcriptional repression of 2S3, a gene encoding a 2S albumin precursor. TTG1 also indirectly suppresses the expression of genes involved in either seed development or synthesis/modification of fatty acids in developing seeds. In addition, we demonstrate that the maternal allele of the TTG1 gene suppresses the accumulation of storage proteins and fatty acids in seeds. Our results suggest that TTG1 is a direct target of FUS3 in the framework of the regulatory hierarchy controlling seed filling and regulates the accumulation of seed storage proteins and fatty acids during the seed maturation process.
  18. Fulltext Effects and improvement mechanisms of ultrasonic pretreatment on the quality of fermented skim milk
    Yu H, Cheng X, Li H, Du Q, Zeng X, Wu Z, et al.
    Ultrason Sonochem, 2024 Jun 15;108:106958.
    PMID: 38889569 DOI: 10.1016/j.ultsonch.2024.106958
    Fermented skim milk is an ideal food for consumers such as diabetic and obese patients, but its low-fat content affects its texture and viscosity. In this study, we developed an effective pretreatment method for fermented skim milk using low-frequency ultrasound (US), and investigated the molecular mechanism of the corresponding quality improvement. The skim milk samples were treated by optimal ultrasonication conditions (336 W power for 7 min at 3 °C), which improved the viscosity, water-holding capacity, sensory attributes, texture, and microstructure of fermented skim milk (P 
  19. Acidified sucralfate encapsulated chitosan derivative nanoparticles as oral vaccine adjuvant delivery enhancing mucosal and systemic immunity
    Zhao Z, Qiao S, Jin Z, Li H, Yu H, Zhang C, et al.
    Int J Biol Macromol, 2024 Sep 07;279(Pt 3):135424.
    PMID: 39245128 DOI: 10.1016/j.ijbiomac.2024.135424
    Oral vaccines are generally perceived to be safe, easy to administer, and have the potential to induce both systemic and mucosal immune responses. However, given the challenges posed by the harsh gastrointestinal environment and mucus barriers, the development of oral vaccines necessitates the employment of a safe and efficient delivery system. In recent years, nanoparticle-based delivery has proven to be an ideal delivery vector for the manufacture of oral vaccines. Hence, considering the above, the sucralfate acidified (SA) encapsulated N-2-Hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC)/N,O-carboxymethyl chitosan (CMCS) nanoparticles (SA@N-2-HACC/CMCS NPs) were prepared, and the BSA was used as a model antigen to investigate the immune responses. The SA@N-2-HACC/CMCS NPs had a particle size of 227 ± 7.0 nm and a zeta potential of 8.43 ± 2.62 mV. The NPs displayed slow and sustained release and high stability in simulated gastric juice and intestinal fluid. RAW 264.7 macrophage-like cell line demonstrated enhanced uptake of the SA@N-2-HACC/CMCS/BSA Nps. The vaccine via oral administration markedly enhanced the residence time of BSA in the intestine for more than 12 h and elicited the production of IgG and sIgA. The SA@N-2-HACC/CMCS NPs developed here for oral administration is an excellent technique for delivering antigens and provides a path of mucosal vaccine research.
  20. Fulltext Plastic pollution: What have we done? What more can we do?
    Yu H, Deng Z, Zahidi I, Fai CM, Liang D, Madsen DØ
    Ecotoxicol Environ Saf, 2024 Nov 01;286:117164.
    PMID: 39396399 DOI: 10.1016/j.ecoenv.2024.117164
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