Displaying publications 1 - 20 of 202 in total

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  1. Bardhan PN
    Malayan Medical Journal, 1937;12:114-5.
    Matched MeSH terms: Influenza, Human
  2. Lancet, 1895;146:542-543.
    DOI: 10.1016/S0140-6736(01)13533-6
    Matched MeSH terms: Influenza, Human
  3. Arumugam H, Wong KH, Low ZY, Lal S, Choo WS
    J Appl Microbiol, 2025 Mar 03;136(3).
    PMID: 40058769 DOI: 10.1093/jambio/lxaf056
    The influenza virus, especially influenza A (IAV), has remained a constant global health threat due to its high morbidity rate and ability to undergo antigenic shifts and drifts, causing pandemics and epidemics. Due to the rapid evolution of IAV, novel therapeutics are urgently required to combat these viruses effectively, as they develop resistance against current therapeutics. Natural products have been the subject of debate for alternative IAV therapy, where the abundance of bioactive compounds offers numerous potentials for novel anti-IAV drug discovery. Therefore, this review discusses the antiviral effects of natural plant extracts against IAV. Examples are Silybum marianum, Scutellaria baicalensis, Angelica dahurica, Peganum harmala, Sambucus nigra, Echinacea purpurea, Panax ginseng, and Camellia sinensis. Most studies found that Si. marianum inhibits viral ribonucleic acid (RNA) synthesis. In contrast, Sc. baicalensis, A. dahurica, Sa. nigra, C. sinensis, and E. purpurea were effective in preventing the entry or binding of IAV into host cells. On the other hand, Sc. baicalensis and Pa. ginseng exert their anti-IAV effect via immunomodulation. Peganum harmala, on the contrary, exhibits a direct virucidal effect against IAV. These studies have shown promising results from using natural products against IAV, which may aid in formulating combinatorial compounds as anti-IAV therapy.
    Matched MeSH terms: Influenza, Human/drug therapy
  4. Prameela KK
    Med J Malaysia, 2011 Jun;66(2):166-9; quiz 170.
    PMID: 22106709
    Essential nutritive and immunological ingredients abundantly present in breastmilk make it the choice infant nutrition. The uniqueness of mother's milk, in contrast to most therapeutics and immunizations, lies in its potential to adapt itself to the requirements of the infant so that timely immune defenses are tapped from its constituents by immune regulation, modulation and immune acceleration to stimulate novel substances; these render it pertinent as defense when faced with challenging organisms. While it is appreciated that immunity can be transferred from mother to infant through breastmilk following maternal influenza vaccination, the immense benefits conferred by breastfeeding per se during influenza pandemics may not be fully valued. This is substantiated by debates and ambiguities for continued breastfeeding in the face of maternal influenza infections. This article emphasises the utmost importance of breastfeeding in viral pandemics in the light of the changing immunological strategies used by viruses at different times and the urgent need for such opportune defenses. The prolific interaction of its constituents is frequently understated as enormous advantages to the suckling infant.
    Matched MeSH terms: Influenza, Human/immunology; Influenza, Human/epidemiology; Influenza, Human/prevention & control*
  5. Thian BYZ, Fatimah MNN, Wong CL, Ong HK, Mariatulqabtiah AR, Ho KL, et al.
    Dev Comp Immunol, 2025 Jan;162:105275.
    PMID: 39341478 DOI: 10.1016/j.dci.2024.105275
    Avian influenza A viruses (IAVs) pose a persistent threat to poultry industry worldwide, despite the presence of vaccines. Additionally, reverse-zoonosis transmission potentially introduces human-originated IAVs into poultry and complicates the efforts to control the spread of influenza. Current avian influenza vaccines are primarily based upon the rapidly mutating hemagglutinin (HA) and neuraminidase (NA) glycoproteins, which limit their efficacy against diverse strains of IAVs. Hence, the highly conserved ectodomains of matrix 2 protein (M2e) of IAVs are widely studied as alternatives to the HA and NA. However, the differences in the M2e amino acid sequences between avian and human IAVs generate antibodies that do not cross-react reciprocally with IAVs from other origins. To broaden and enhance the immunogenicity of M2e, we fused two copies each of the M2e derived from avian and human IAVs at the C-terminal end of the Macrobrachium rosenbergii nodavirus (MrNV) capsid protein (NvC). Transmission electron microscopic and dynamic light scattering analyses revealed that the chimeric protein self-assembled into virus-like particles (VLPs). Immunization of chickens with the chimeric VLPs demonstrated a robust induction of broadly reactive immune responses against both the M2e of avian and human IAVs. Additionally, the chimeric VLPs elicited the production of cytotoxic T lymphocytes (CTL), macrophages, as well as a well-balanced Th1 and Th2 population, indicating their potential in activating cell-mediated immune responses in chickens. Furthermore, the chimeric VLPs triggered the production of both Th1- and Th2-cytokines, attesting their potential in mounting a robust and balanced immune response in avian species. This study demonstrated the potential of these chimeric VLPs in stimulating and broadening cross-reactive immune responses in chickens against both avian and human IAVs.
    Matched MeSH terms: Influenza, Human/immunology; Influenza, Human/prevention & control; Influenza, Human/virology
  6. Wiwanitkit V
    Med J Malaysia, 2011 Mar;66(1):75.
    PMID: 23765153
    Matched MeSH terms: Influenza, Human*
  7. Samsudin EZ, Yasin SM, Ruslan NH, Abdullah NN, Noor AFA, Hair AFA
    BMC Infect Dis, 2024 Jan 16;24(1):93.
    PMID: 38229063 DOI: 10.1186/s12879-024-08993-y
    BACKGROUND: Recent pandemics have had far-reaching effects on the world's largest economies and amplified the need to estimate the full extent and range of socioeconomic impacts of infectious diseases outbreaks on multi-sectoral industries. This systematic review aims to evaluate the socioeconomic impacts of airborne and droplet-borne infectious diseases outbreaks on industries.

    METHODS: A structured, systematic review was performed according to the PRISMA guidelines. Databases of PubMed, Scopus, Web of Science, IDEAS/REPEC, OSHLINE, HSELINE, and NIOSHTIC-2 were reviewed. Study quality appraisal was performed using the Table of Evidence Levels from Cincinnati Children's Hospital Medical Center, Joanna Briggs Institute tools, Mixed Methods Appraisal Tool, and Center of Evidence Based Management case study critical appraisal checklist. Quantitative analysis was not attempted due to the heterogeneity of included studies. A qualitative synthesis of primary studies examining socioeconomic impact of airborne and droplet-borne infectious diseases outbreaks in any industry was performed and a framework based on empirical findings was conceptualized.

    RESULTS: A total of 55 studies conducted from 1984 to 2021 were included, reporting on 46,813,038 participants working in multiple industries across the globe. The quality of articles were good. On the whole, direct socioeconomic impacts of Coronavirus Disease 2019, influenza, influenza A (H1N1), Severe Acute Respiratory Syndrome, tuberculosis and norovirus outbreaks include increased morbidity, mortality, and health costs. This had then led to indirect impacts including social impacts such as employment crises and reduced workforce size as well as economic impacts such as demand shock, supply chain disruptions, increased supply and production cost, service and business disruptions, and financial and Gross Domestic Product loss, attributable to productivity losses from illnesses as well as national policy responses to contain the diseases.

    CONCLUSIONS: Evidence suggests that airborne and droplet-borne infectious diseases have inflicted severe socioeconomic costs on regional and global industries. Further research is needed to better understand their long-term socioeconomic impacts to support improved industry preparedness and response capacity for outbreaks. Public and private stakeholders at local, national, and international levels must join forces to ensure informed systems and sector-specific cost-sharing strategies for optimal global health and economic security.

    Matched MeSH terms: Influenza, Human/economics
  8. Wang CC, Chen PY, Wang JD, Liu FC, Huang FL, Lee CY
    Pediatr Neonatol, 2009 Apr;50(2):54-8.
    PMID: 19453079 DOI: 10.1016/S1875-9572(09)60033-4
    An epidemic of influenza B/Malaysia/2506/2004 was reported in Taiwan during the 2006-2007 flu season. We investigated the flu vaccination history and clinical and Laboratory characteristics of children with influenza B infection.
    Matched MeSH terms: Influenza, Human/complications; Influenza, Human/virology
  9. Samad AH, Usul MH, Zakaria D, Ismail R, Tasset-Tisseau A, Baron-Papillon F, et al.
    J Occup Health, 2006 Jan;48(1):1-10.
    PMID: 16484757
    This study was designed to evaluate the health and economic benefits of a workplace vaccination programme against influenza funded by the employer. Employees of a Malaysian petrochemical plant volunteered to take part in this prospective, non-randomised, non-placebo-controlled study. Demographic and health information, including influenza-like symptoms, sick leave and post-vaccination adverse events were collected via questionnaires. Cost-benefit analyses were performed from the employer's perspective.

    RESULTS: A total of 1,022 employees took part in the study, with 504 choosing to be vaccinated against influenza, and 518 remaining unvaccinated. The rate of influenza-like illness (ILI) was lower among vaccinated (8.13%) than non-vaccinated subjects (30.31%). Fever and respiratory symptoms were associated with all ILI cases. ILI-related sick leave was taken by 58.54% of vaccinated employees with ILI and 71.34% of non-vaccinated employees with ILI. Vaccination was financially beneficial, with the employer saving up to US dollar 53.00 per vaccinated employee when labour costs only were considered. Savings rose to up to US dollar 899.70 when the operating income of each employee was also considered. Workplace vaccination of healthy adults against influenza had a clear impact on ILI rates, absenteeism and reduced productivity in this Malaysian company. The health benefits translated into financial benefits for the employer, with cost savings significantly outweighting the costs of the vaccination programme.
    Matched MeSH terms: Influenza, Human/economics; Influenza, Human/immunology*
  10. Sam IC, Noraini W, Sandhu SS, Norizah I, Selvanesan S, Thayan R, et al.
    J Med Virol, 2019 03;91(3):498-502.
    PMID: 30199092 DOI: 10.1002/jmv.25313
    Influenza seasonality in equatorial countries is little understood. Seasonal and alert influenza thresholds were determined for Malaysia, using laboratory-based data obtained from the Malaysia Influenza Surveillance System and a major teaching hospital, from 2011 to 2016. Influenza was present year-round, with no clear annual seasons. Variable periods of higher transmission occurred inconsistently, in November to December, January to March, July to September, or a combination of these. These coincide with seasons in the nearby southeast Asian countries or winter seasons of the northern and southern hemispheres. Changes in the predominant circulating influenza type were only sometimes associated with increased transmission. The data can provide public health interventions such as vaccines.
    Matched MeSH terms: Influenza, Human/diagnosis*; Influenza, Human/epidemiology*
  11. Tan DS, Dhillon GS, Omar M, Eapen JS
    Med J Malaya, 1971 Jun;25(4):263-8.
    PMID: 4261297
    Matched MeSH terms: Influenza, Human/epidemiology*
  12. Tan DS, Omar M, Chew V
    Med J Malaysia, 1979 Jun;33(4):355-6.
    PMID: 522749
    Matched MeSH terms: Influenza, Human/immunology*
  13. VANREENEN RM, ELISBERG BL, WEBB PA, TRAUB RG, TRAUB R
    J R Army Med Corps, 1960 Jan;106:12-21.
    PMID: 13841274
    Matched MeSH terms: Influenza, Human/epidemiology*
  14. Chen C, Chong NS, Smith R
    Math Biosci, 2018 02;296:98-112.
    PMID: 29273381 DOI: 10.1016/j.mbs.2017.12.002
    Mass-media reports on an epidemic or pandemic have the potential to modify human behaviour and affect social attitudes. Here we construct a Filippov model to evaluate the effects of media coverage and quarantine on the transmission dynamics of influenza. We first choose a piecewise smooth incidence rate to represent media reports being triggered once the number of infected individuals exceeds a certain critical level [Formula: see text] . Further, if the number of infected cases increases and exceeds another larger threshold value [Formula: see text] ( [Formula: see text] ), we consider that the incidence rate tends to a saturation level due to the protection measures taken by individuals; meanwhile, we begin to quarantine susceptible individuals when the number of susceptible individuals is larger than a threshold value Sc. Then, for each susceptible threshold value Sc, the global properties of the Filippov model with regard to the existence and stability of all possible equilibria and sliding-mode dynamics are examined, as we vary the infected threshold values [Formula: see text] and [Formula: see text] . We show generically that the Filippov system stabilizes at either the endemic equilibrium of the subsystem or the pseudoequilibrium on the switching surface or the endemic equilibrium [Formula: see text] depending on the choice of the threshold values. The findings suggest that proper combinations of infected and susceptible threshold values can maintain the number of infected individuals either below a certain threshold level or at a previously given level.
    Matched MeSH terms: Influenza, Human/transmission*
  15. Loh LC, Hui DS, Beasley R
    Respirology, 2008 Mar;13 Suppl 1:S1.
    PMID: 18366520 DOI: 10.1111/j.1440-1843.2008.01245.x
    Matched MeSH terms: Influenza, Human/epidemiology*; Influenza, Human/prevention & control*; Influenza, Human/transmission
  16. de Jong JC, Rimmelzwaan GF, Donker GA, Meijer A, Fouchier RA, Osterhaus AD
    Ned Tijdschr Geneeskd, 2007 Sep 29;151(39):2158-65.
    PMID: 17957994
    The influenza epidemic of 2006/'07 began late in the season, like the two previous influenza epidemics. In week 8 a peak of modest height was reached. As usual, the causal strains were mainly A/H3N2 viruses and to a lesser extent A/H1N1 and B viruses. A new A/H1N1 virus variant has emerged, an event that on average takes place only every 10 years. However, almost all A/H1N1 virus isolates belonged to the old variant and were similar to the vaccine virus. The A/H3N2 virus isolates appeared to deviate from the vaccine strain, but after antigenic cartographic analysis and correction for low avidity they proved also closely related to the vaccine strain. The few type B virus isolates belonged to the B/Yamagata/16/88 lineage, whereas the used B vaccine virus had been chosen from the B/Victoria/2/87 lineage. The vaccine therefore will have provided almost optimal protection against the circulating influenza A/H1N1 and A/H3N2 viruses but not against the influenza B viruses. For the 2007/'08 influenza season the World Health Organization has recommended the following vaccine composition: A/Solomon Islands/3/06 (H1N1) (new), A/Wisconsin/67/05 (H3N2), and B/Malaysia/2506/04.
    Matched MeSH terms: Influenza, Human/epidemiology; Influenza, Human/prevention & control*; Influenza, Human/virology*
  17. Gupta V, Dawood FS, Muangchana C, Lan PT, Xeuatvongsa A, Sovann L, et al.
    PLoS One, 2012;7(12):e52842.
    PMID: 23285200 DOI: 10.1371/journal.pone.0052842
    Southeast Asia is a region with great potential for the emergence of a pandemic influenza virus. Global efforts to improve influenza surveillance in this region have documented the burden and seasonality of influenza viruses and have informed influenza prevention strategies, but little information exists about influenza vaccination guidelines and vaccine sales.
    Matched MeSH terms: Influenza, Human/history; Influenza, Human/epidemiology; Influenza, Human/prevention & control*
  18. Rahman MM, Wong KK, Alfizah H, Hussin S, Isahak I
    Pak J Med Sci, 2015 Jul-Aug;31(4):791-4.
    PMID: 26430404 DOI: 10.12669/pjms.314.7003
    To determine the efficacy of cell culture, immunoflourescence Assay (IFA) and real time polymerase chain reaction (rRT-PCR) in relation to diagnosis of influenza and Respiratory Syncytial Virus (RSV).
    Matched MeSH terms: Influenza, Human
  19. Hashim S, Ayub ZN, Mohamed Z, Hasan H, Harun A, Ismail N, et al.
    J Travel Med, 2016 Feb;23(2):tav019.
    PMID: 26858268 DOI: 10.1093/jtm/tav019
    BACKGROUND: Respiratory illness continues to exert a burden on hajj pilgrims in Makkah. The purpose of this study is to determine the prevalence of respiratory illness and its associated factors among Malaysian hajj pilgrims in 2013 and to describe its preventive measures.

    METHODS: A cross-sectional study was conducted in Makkah and Malaysia during the 2013 hajj season. A self-administered proforma on social demographics, previous experience of hajj or umrah, smoking habits, co-morbid illness and practices of preventive measures against respiratory illness were obtained.

    RESULTS: A total of 468 proforma were analysed. The prevalence of the respiratory illness was 93.4% with a subset of 78.2% fulfilled the criteria for influenza-like illness (ILI). Most of them (77.8%) had a respiratory illness of <2 weeks duration. Approximately 61.8% were administered antibiotics but only 2.1% of them had been hospitalized. Most of them acquired the infection after a brief stay at Arafat (81.2%). Vaccination coverages for influenza virus and pneumococcal disease were quite high, 65.2% and 59.4%, respectively. For other preventive measures practices, only 31.8% of them practiced good hand hygiene, ∼82.9% of pilgrims used surgical face masks, N95 face masks, dry towels, wet towels or veils as their face masks. Nearly one-half of the respondents (44.4%) took vitamins as their food supplement. Malaysian hajj pilgrims with previous experience of hajj (OR 0.24; 95% CI 0.10-0.56) or umrah (OR 0.19; 95% CI 0.07-0.52) and those who have practiced good hand hygiene (OR 0.35; 95% CI 0.16-0.79) were found to be significantly associated with lower risk of having respiratory illness. Otherwise, pilgrims who had contact with those with respiratory illness (OR 2.61; 95% CI 1.12-6.09) was associated with higher risk.

    CONCLUSIONS: The prevalence of respiratory illness remains high among Malaysian hajj pilgrims despite having some practices of preventive measures. All preventive measures which include hand hygiene, wearing face masks and influenza vaccination must be practiced together as bundle of care to reduce respiratory illness effectively.

    Matched MeSH terms: Influenza, Human/ethnology; Influenza, Human/epidemiology*; Influenza, Human/prevention & control
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