MyMedR

Abstracts of the 9th Liver Update, July 13-17, 2011, Petaling Jaya, Malasia

Med J Malaysia, 2011 Jul;66 Suppl A:1-63.

PMID: 22457903

Matched MeSH terms: Liver Diseases*

Proceedings of the 6th Liver Update, 21-24 July 2005

Med J Malaysia, 2005 Jul;60 Suppl B:1-186.

PMID: 16231444

Matched MeSH terms: Liver Diseases*

Hepatobiliary practical: how to get the best out of a liver biopsy

Looi LM

Med J Malaysia, 2005 Jul;60 Suppl B:144-5.

PMID: 16108199

The liver biopsy has a unique place in the investigation of liver disease because the concepts and classification of liver disease are rooted in morphology. Today, the use of the liver biopsy has extended beyond that of diagnosis, to the assessment of disease progression, response to therapy and transplant rejection. To get the best out of the liver biopsy, it is necessary to appreciate the usefulness and limitations of the biopsy specimen. Aspects to consider include: (1) minimizing sampling errors, and appreciating that the changes in the biopsy may not be representative of the primary pathology, (2) good laboratory quality practices to avoid processing artifacts, which may render a biopsy undiagnosable, (3) the appropriate use of special stains and other laboratory techniques, (4) adoption of a systematic and algorithmic approach in the microscopic examination of the biopsy, and (5) good clinicopathological correlation.

Matched MeSH terms: Liver Diseases/pathology*

Editorial: Assessing advanced fibrosis in metabolic-associated steatotic liver disease-the MAFLD fibrosis score. Authors' reply

Cheung JTK, Chan WK, Zheng MH, Wong VW

Aliment Pharmacol Ther, 2023 Dec;58(11-12):1236-1237.

PMID: 37986596 DOI: 10.1111/apt.17774

Matched MeSH terms: Liver Diseases*

Focal nodular hyperplasia of the liver

Chong KC

Med J Malaysia, 1974 Jun;28(4):296-9.

PMID: 4278779

Matched MeSH terms: Liver Diseases/diagnosis; Liver Diseases/pathology*

GUT 2004. Abstracts of the annual meeting of the Malaysian Society of Gastroenterology and Hepatology. 24-27 June 2004

Med J Malaysia, 2004 Jun;59 Suppl C:1-107.

PMID: 15641189

Matched MeSH terms: Liver Diseases*

Liver transplantation--patient selection and timing

McCormick A, Sultan J

Med J Malaysia, 2005 Jul;60 Suppl B:83-7.

PMID: 16108182

Liver transplantation has been successfully used in the treatment of a large number of liver diseases. The largest patient group comprises patients with end stage decompensated liver disease. Decompensation is defined as the presence of cirrhosis and one or more of the following: jaundice, ascites, hepatic encephalopathy, hepatorenal syndrome or bleeding oesophageal varices. In general patients in this category should be considered for liver transplantation, if available. Guidelines for liver transplant assessment have been published by both the British Society of Gastroenterology and the American Association for the Study of Liver Disease. These guidelines provide a good basis for patient selection. As new information becomes available the indications for individual diseases may change somewhat. One of the most important changes in recent years was the introduction of the MELD/PELD scoring system. This is the model for end stage liver disease which provides a reasonably robust estimate of prognosis for individual patients. Prior to this patient waiting time on the transplant list was one of the principal determinants of priority for liver allocation. The MELD scoring system has been widely adopted with the aim of allocating the available livers to patients in the greatest clinical need.

Matched MeSH terms: Liver Diseases/classification; Liver Diseases/surgery*

Capillaria hepatica infection of wild rodents in Peninsular Malaysia

Liat LB, Fong YL, Krishnasamy M

Southeast Asian J. Trop. Med. Public Health, 1977 Sep;8(3):354-8.

PMID: 607425

Capillaria hepatica infection in wild rodents collected from the States of Kelantan, Selangor and Johore in Peninsular Malaysia since 1973 is reported. A total of 1,258 rodents consisting of 20 species of house, field and forest rats, and 7 species of squirrels were examined for the parasite and 17 species consisting of 111 murids and 1 flying squirrel were found infected. The house rat, Rattus norvegicus had the highest prevalence rate, followed by 3 species of field rats, R. tiomanicus, R. argentiventer and Bandicota indica. The prevalence of infection was low among forest rats with the exception of Lenothrix canus. Only 1 flying squirrel, Hylopetes spadiceus was found with the parasite. The prevalence of infection in relation to the host behaviour and habitats was discussed. C. hepatica appears to be widespread throughout Malaysia with a wide range of hosts among rodent species. Some new host records are presented herein.

Matched MeSH terms: Liver Diseases/etiology; Liver Diseases/veterinary*

Fulltext A fatal case of chikungunya virus infection with liver involvement

Chua HH, Abdul Rashid K, Law WC, Hamizah A, Chem YK, Khairul AH, et al.

Med J Malaysia, 2010 Mar;65(1):83-4.

PMID: 21265260 MyJurnal

Recovery from chikungunya is previously considered universal and mortality due to the virus is rare and unusual. Findings from recent chikungunya outbreaks occurred in Reunion Island and India have since challenged the conventional view on the benign nature of the illness. Malaysia has experienced at least of 4 outbreaks of chikungunya since 1998. In the present on-going large outbreak due to chikungunya virus of Central/East African genotype, a previous healthy sixty six years gentleman without co-morbidity was noted to have severe systemic infection by the virus and involvement of his liver. He subsequently passed away due to cardiovascular collapse after 5 days of illness.

Matched MeSH terms: Liver Diseases/etiology*

EUS and hepatobiliary disease

Ponnudurai R

Med J Malaysia, 2005 Jul;60 Suppl B:81-2.

PMID: 16108181

Matched MeSH terms: Liver Diseases/ultrasonography*

Fulltext Ultrasound diagnosis of liver and biliary tract lesions

Md Alif AK

Med J Malaysia, 1981 Jun;36(2):100-3.

PMID: 7343816

Over a two year period, 323 livers were examined using ultrasound. Majority of these cases were icteric and ultrasound could distinguish obstructive from non-obstructive jaundice. Primary and secondary liver tumours were also detected. Liver abscesses, and radiolucent gallstones were picked up by ultrasound, the areas under study being scanned using standard methods as outlined by various ultrasonographists.

Matched MeSH terms: Liver Diseases/diagnosis*

Radioisotope colour scanning of the liver in the diagnosis of liver disease

Dharmalingam SK, Mahadev V

Med J Malaya, 1970 Dec;25(2):83-90.

PMID: 4251140

Matched MeSH terms: Liver Diseases/diagnosis*

Fulltext An international multidisciplinary consensus statement on MAFLD and the risk of CVD

Zhou XD, Targher G, Byrne CD, Somers V, Kim SU, Chahal CAA, et al.

Hepatol Int, 2023 Aug;17(4):773-791.

PMID: 37204656 DOI: 10.1007/s12072-023-10543-8

BACKGROUND: Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25-30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined with obesity, type 2 diabetes mellitus and atherogenic dyslipidemia, which are established cardiovascular risk factors. Unlike CVD, which has received attention in the literature on fatty liver disease, the CVD risk associated with MAFLD is often underestimated, especially among Cardiologists.

METHODS AND RESULTS: A multidisciplinary panel of fifty-two international experts comprising Hepatologists, Endocrinologists, Diabetologists, Cardiologists and Family Physicians from six continents (Asia, Europe, North America, South America, Africa and Oceania) participated in a formal Delphi survey and developed consensus statements on the association between MAFLD and the risk of CVD. Statements were developed on different aspects of CVD risk, ranging from epidemiology to mechanisms, screening, and management.

CONCULSIONS: The expert panel identified important clinical associations between MAFLD and the risk of CVD that could serve to increase awareness of the adverse metabolic and cardiovascular outcomes of MAFLD. Finally, the expert panel also suggests potential areas for future research.

Matched MeSH terms: Liver Diseases*; Non-alcoholic Fatty Liver Disease*

Mitochondrial hepatopathies: advances in genetics and pathogenesis

Lee WS, Sokol RJ

Hepatology, 2007 Jun;45(6):1555-65.

PMID: 17538929

Hepatic involvement is a common feature in childhood mitochondrial hepatopathies, particularly in the neonatal period. Respiratory chain disorders may present as neonatal acute liver failure, hepatic steatohepatitis, cholestasis, or cirrhosis with chronic liver failure of insidious onset. In recent years, specific molecular defects (mutations in nuclear genes such as SCO1, BCS1L, POLG, DGUOK, and MPV17 and the deletion or rearrangement of mitochondrial DNA) have been identified, with the promise of genetic and prenatal diagnosis. The current treatment of mitochondrial hepatopathies is largely ineffective, and the prognosis is generally poor. The role of liver transplantation in patients with liver failure remains poorly defined because of the systemic nature of the disease, which does not respond to transplantation. Prospective, longitudinal, multicentered studies will be needed to address the gaps in our knowledge in these rare liver diseases.

Matched MeSH terms: Liver Diseases/etiology; Liver Diseases/genetics*; Liver Diseases/pathology*

Fulltext Maternal deaths due to liver disease in Malaysia

Ravindran J, Jayadev R, Lachmanan SR, Merican I

Med J Malaysia, 2000 Jun;55(2):209-19.

PMID: 19839149

Liver disease is an important and serious condition in pregnancy. The Confidential Enquiries Into Maternal Deaths in Malaysia showed that there were 23 maternal deaths attributed to liver disease between 1991-1994. Over the same period, there were 1066 reported maternal deaths with 929 of them being due to direct and indirect causes. Thus 2.15% of such deaths were due to liver disease in Malaysia. The three main causes of maternal deaths due to liver disease in pregnancy were hepatitis (6 cases), acute fatty liver in pregnancy (6 cases) and septicaemia (4 cases). Liver disease is common at a mean of thirty weeks of gestation with a preponderance to women of low parity. Only two patients in this series had no antenatal care. The majority of cases (45.8%) presented between 28-37 weeks of gestation. All cases delivered by spontaneous vaginal delivery. Remediable factors that were identified included failure to appreciate the severity of disease. Case summaries of all the cases of maternal deaths due to liver disease are discussed and a guideline to management of liver disease in pregnancy presented.

Matched MeSH terms: Liver Diseases/ethnology; Liver Diseases/mortality*; Liver Diseases/physiopathology

Liver disease in mitochondrial disorders

Lee WS, Sokol RJ

Semin Liver Dis, 2007 Aug;27(3):259-73.

PMID: 17682973

Liver involvement, a common feature in childhood mitochondrial hepatopathies, particularly in the neonatal period, may manifest as neonatal acute liver failure, hepatic steatohepatitis, cholestasis, or cirrhosis with chronic liver failure of insidious onset. There are usually significant neuromuscular symptoms, multisystem involvement, and lactic acidemia. The liver disease is usually progressive and eventually fatal. Current medical therapy of mitochondrial hepatopathies is largely ineffective, and the prognosis is usually poor. The role of liver transplantation in patients with liver failure remains poorly defined because of the systemic nature of the disease that does not respond to transplantation. Several specific molecular defects (mutations in nuclear genes such as SCO1, BCS1L, POLG, DGUOK, and MPV17 and deletion or rearrangement of mitochondrial DNA) have been identified in recent years. Prospective, longitudinal multicenter studies will be needed to address the gaps in our knowledge in these rare liver diseases.

Matched MeSH terms: Liver Diseases/diagnosis; Liver Diseases/etiology*; Liver Diseases/therapy*

Fulltext Hepatic calculi

Balasegaram M

Ann Surg, 1972 Feb;175(2):149-54..

PMID: 5059599

Matched MeSH terms: Liver Diseases/complications*; Liver Diseases/etiology*; Liver Diseases/surgery*

Fulltext Effects of Curcuma xanthorrhiza Extracts and Their Constituents on Phase II Drug-metabolizing Enzymes Activity

Salleh NA, Ismail S, Ab Halim MR

Pharmacognosy Res, 2016 Oct-Dec;8(4):309-315.

PMID: 27695274 DOI: 10.4103/0974-8490.188873

BACKGROUND: Curcuma xanthorrhiza is a native Indonesian plant and traditionally utilized for a range of illness including liver damage, hypertension, diabetes, and cancer.
OBJECTIVE: The study determined the effects of C. xanthorrhiza extracts (ethanol and aqueous) and their constituents (curcumene and xanthorrhizol) on UDP-glucuronosyltransferase (UGT) and glutathione transferase (GST) activities.
MATERIALS AND METHODS: The inhibition studies were evaluated both in rat liver microsomes and in human recombinant UGT1A1 and UGT2B7 enzymes. p-nitrophenol and beetle luciferin were used as the probe substrates for UGT assay while 1-chloro-2,4-dinitrobenzene as the probe for GST assay. The concentrations of extracts studied ranged from 0.1 to 1000 μg/mL while for constituents ranged from 0.01 to 500 μM.
RESULTS: In rat liver microsomes, UGT activity was inhibited by the ethanol extract (IC50 =279.74 ± 16.33 μg/mL). Both UGT1A1 and UGT2B7 were inhibited by the ethanol and aqueous extracts with IC50 values ranging between 9.59-22.76 μg/mL and 110.71-526.65 μg/Ml, respectively. Rat liver GST and human GST Pi-1 were inhibited by ethanol and aqueous extracts, respectively (IC50 =255.00 ± 13.06 μg/mL and 580.80 ± 18.56 μg/mL). Xanthorrhizol was the better inhibitor of UGT1A1 (IC50 11.30 ± 0.27 μM) as compared to UGT2B7 while curcumene did not show any inhibition. For GST, both constituents did not show any inhibition.
CONCLUSION: These findings suggest that C. xanthorrhiza have the potential to cause herb-drug interaction with drugs that are primarily metabolized by UGT and GST enzymes.
SUMMARY: Findings from this study would suggest which of Curcuma xanthorrhiza extracts and constituents that would have potential interactions with drugs which are highly metabolized by UGT and GST enzymes. Further clinical studies can then be designed if needed to evaluate the in vivo pharmacokinetic relevance of these interactions Abbreviations Used: BSA: Bovine serum albumin, CAM: Complementary and alternative medicine, cDNA: Complementary deoxyribonucleic acid, CDNB: 1-Chloro-2,4-dinitrobenzene, CuSO4.5H2O: Copper(II) sulfate pentahydrate, CXEE: Curcuma xanthorrhiza ethanol extract, CXAE: Curcuma xanthorrhiza aqueous extract, GC-MS: Gas chromatography-mass spectroscopy, GSH: Glutathione, GST: Glutathione S-transferase, KCl: Potassium chloride, min: Minutes, MgCl2: Magnesium chloride, mg/mL: Concentration (weight of test substance in milligrams per volume of test concentration), mM: Milimolar, Na2CO3: Sodium carbonate, NaOH: Sodium hydroxide, nmol: nanomol, NSAIDs: Non-steroidal antiinflammatory drug, p-NP: para-nitrophenol, RLU: Relative light unit, SEM: Standard error of mean, UDPGA: UDP-glucuronic acid, UGT: UDP-glucuronosyltransferase.
KEYWORDS: Curcuma xanthorrhiza; UDP-glucuronosyltransferase; glutathione transferase; xanthorrhizol

Matched MeSH terms: Liver Diseases

Experimental Brachiaria decumbens toxicity in cattle

Noordin MM, Salam Abdullah A, Rajion MA

Vet Res Commun, 1989;13(6):491-4.

PMID: 2631385

Although Brachiaria decumbens was not toxic when fed to cattle, the infusion of rumen liquor from B. decumbens intoxicated sheep into the rumen of cattle produced evidence suggesting hepatic and renal dysfunction. Several biochemical changes were observed including increases in serum aspartate amino transferase, serum creatinine and blood urea nitrogen and a marked reduction in the plasma bromosulphthalein clearance.

Matched MeSH terms: Liver Diseases/blood; Liver Diseases/etiology; Liver Diseases/veterinary

Fulltext Hepatic mesenchymal hamartoma: a case report and radiological findings

Lai FM, Jayakumar CR, Saw L, Kumar G

Singapore Med J, 1996 Apr;37(2):226-8.

PMID: 8942272

Primary tumours of the liver are uncommon in childhood. Of these, more than two-thirds are malignant. As such, benign hepatic tumours are often not considered in the differential diagnosis of a hepatic mass in childhood. We report a case of hepatic mesenchymal hamartoma, a rare benign tumour, in a 10-month-old infant. This tumour is characterised by an admixture of ductal structures within a copious loose connective tissue stroma. Only approximately 160 cases had been reported in the literature. Awareness of the ultrasound (U/S) and computed tomography (CT) features, although not diagnostic, is helpful in distinguishing it from the more common malignant tumours. A correct preoperative diagnosis is important as surgical excision is often curative.

Matched MeSH terms: Liver Diseases/diagnosis*; Liver Diseases/radiography; Liver Diseases/ultrasonography

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