Displaying publications 1 - 20 of 222 in total

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  1. Stanton AT, Fletcher W
    Matched MeSH terms: Melioidosis
  2. Khaira BS, Young WB, De HPV
    Br Med J, 1959;1:949-952.
    Matched MeSH terms: Melioidosis
  3. Tian Seng N
    Med J Malaysia, 1979 Mar;33(3):269-71.
    PMID: 522734
    Matched MeSH terms: Melioidosis*
  4. Sam IC, Puthucheary SD
    J Infect, 2007 May;54(5):519-20.
    PMID: 16965821
    Matched MeSH terms: Melioidosis/diagnosis; Melioidosis/epidemiology*
  5. Ang YM
    Med J Malaysia, 2005 Mar;60(1):99-102.
    PMID: 16250291 MyJurnal
    Meliodosis is an infectious disease encountered mainly in tropics. It is not an uncommon problem in Malaysia especially in areas with agricultural activities. Although it can occur in all age groups, there have been few reported cases in children. Men are more commonly affected than women due to outdoor activities. Neonatal cases have been reported in Hawaii and Thailand. These infants presented with neonatal sepsis or meningitis. The mode of transmission to these infants has not been elucidated. This is the report of such a case first reported in Hospital Tengku Ampun Afzan, Kuantan.
    Matched MeSH terms: Melioidosis/diagnosis*; Melioidosis/therapy*
  6. Saroja S
    Aust. Vet. J., 1979 Sep;55(9):439-40.
    PMID: 543838
    This paper records 2 fatal cases of melioidosis in wallabies from Australia maintained in the Botanical Gardens, Penang, for about 3 months. The nature of lesions described is different from that described by various workers.
    Matched MeSH terms: Melioidosis/microbiology; Melioidosis/pathology; Melioidosis/veterinary*
  7. Lancet, 1933;222:369-70.
    DOI: 10.1016/S0140-6736(00)44480-6
    Matched MeSH terms: Melioidosis
  8. Gilmour CCB
    Matched MeSH terms: Melioidosis
  9. Hong KW, Tee KK, Yin WF, Roberts RJ, Chan KG
    Microbiol Resour Announc, 2019 Oct 24;8(43).
    PMID: 31649075 DOI: 10.1128/MRA.00898-19
    Burkholderia pseudomallei is the etiological agent of melioidosis, which has been studied by transcriptome and secretome analyses. However, little is known about the methylome of this pathogen. Here, we present the complete genome and methylome of melioidosis-causing B. pseudomallei strain 982.
    Matched MeSH terms: Melioidosis
  10. Jayaram M
    Med J Malaysia, 2005 Dec;60(5):531-4.
    PMID: 16515101
    Matched MeSH terms: Melioidosis/epidemiology*
  11. Halder D, Abdullah WA, Johari MR, Choo KE
    Singapore Med J, 1993 Feb;34(1):85-6.
    PMID: 8266140
    We report a neonate with melioidosis. The presentation, progress and treatment are described, followed by a discussion on melioidosis.
    Matched MeSH terms: Melioidosis*
  12. Smith KV, Grimmond T, Monk I
    Med J Aust, 1975 Sep 20;2(12):479-80.
    PMID: 1196186
    This report is of a man who suffered from chronic melioidosis contracted in Malaysia. In the course of the disease he had a lobe of a lung resected, developed empyema and, while this was still draining, developed infection in an ankle. Both the empyema thoracis and the ankle infection were due to Pseudomonas pseudomallel. He now appears to be cured, probably by massive doses of tetracycline.
    Matched MeSH terms: Melioidosis*
  13. Zueter A, Yean CY, Abumarzouq M, Rahman ZA, Deris ZZ, Harun A
    BMC Infect Dis, 2016;16:333.
    PMID: 27423906 DOI: 10.1186/s12879-016-1583-2
    Over the last two decades, many epidemiological studies were performed to describe risks and clinical presentations of melioidosis in endemic countries.

    Study site: Hospital Universiti Sains Malaysia (HUSM)
    Matched MeSH terms: Melioidosis
  14. Lancet, 1944;243:542-3.
    DOI: 10.1016/S0140-6736(00)77058-9
    Matched MeSH terms: Melioidosis
  15. Stanton AT, Fletcher W
    Matched MeSH terms: Melioidosis
  16. Choi JY, Hii KC, Bailey ES, Chuang JY, Tang WY, Yuen Wong EK, et al.
    Am J Trop Med Hyg, 2020 02;102(2):388-391.
    PMID: 31769397 DOI: 10.4269/ajtmh.19-0625
    Burkholderia pseudomallei infections are prevalent in Southeast Asia and northern Australia and often misdiagnosed. Diagnostics are often neither sensitive nor rapid, contributing up to 50% mortality rate. In this 2018 pilot study, we enrolled 100 patients aged 6 months-79 years from Kapit Hospital in Sarawak, Malaysia, with symptoms of B. pseudomallei infection. We used three different methods for the detection of B. pseudomallei: a real-time polymerase chain reaction (PCR) assay, a rapid lateral flow immunoassay, and the standard-of-care bacterial culture-the gold standard. Among the 100 participants, 24 (24%) were positive for B. pseudomallei by one or more of the detection methods. Comparing the two individual diagnostic methods against the gold standard-bacterial culture-of any positive test, there was low sensitivity for each test (25-44%) but high specificity (93-98%). It seems clear that more sensitive diagnostics or a sensitive screening diagnostic followed by specific confirmatory diagnostic is needed for this disease.
    Matched MeSH terms: Melioidosis/diagnosis*; Melioidosis/microbiology*; Melioidosis/epidemiology
  17. Raja NS, Ahmed MZ, Singh NN
    J Postgrad Med, 2005 Apr-Jun;51(2):140-5.
    PMID: 16006713
    Infectious diseases account for a third of all the deaths in the developing world. Achievements in understanding the basic microbiology, pathogenesis, host defenses and expanded epidemiology of infectious diseases have resulted in better management and reduced mortality. However, an emerging infectious disease, melioidosis, is becoming endemic in the tropical regions of the world and is spreading to non-endemic areas. This article highlights the current understanding of melioidosis including advances in diagnosis, treatment and prevention. Better understanding of melioidosis is essential, as it is life-threatening and if untreated, patients can succumb to it. Our sources include a literature review, information from international consensus meetings on melioidosis and ongoing discussions within the medical and scientific community.
    Matched MeSH terms: Melioidosis/diagnosis; Melioidosis/epidemiology*; Melioidosis/therapy*; Melioidosis/transmission
  18. Kingsley PV, Leader M, Nagodawithana NS, Tipre M, Sathiakumar N
    PLoS Negl Trop Dis, 2016 12;10(12):e0005182.
    PMID: 28005910 DOI: 10.1371/journal.pntd.0005182
    BACKGROUND: Melioidosis is a tropical infectious disease associated with significant mortality due to early onset of sepsis.

    OBJECTIVE: We sought to review case reports of melioidosis from Malaysia.

    METHODS: We conducted a computerized search of literature resources including PubMed, OVID, Scopus, MEDLINE and the COCHRANE database to identify published case reports from 1975 to 2015. We abstracted information on clinical characteristics, exposure history, comorbid conditions, management and outcome.

    RESULTS: Overall, 67 cases were reported with 29 (43%) deaths; the median age was 44 years, and a male preponderance (84%) was noted. Forty-one cases (61%) were bacteremic, and fatal septic shock occurred in 13 (19%) within 24-48 hours of admission; nine of the 13 cases were not specifically treated for melioidosis as confirmatory evidence was available only after death. Diabetes mellitus (n = 36, 54%) was the most common risk factor. Twenty-six cases (39%) had a history of exposure to contaminated soil/water or employment in high-risk occupations. Pneumonia (n = 24, 36%) was the most common primary clinical presentation followed by soft tissue abscess (n = 22, 33%). Other types of clinical presentations were less common-genitourinary (n = 5), neurological (n = 5), osteomyelitis/septic arthritis (n = 4) and skin (n = 2); five cases had no evidence of a focus of infection. With regard to internal foci of infection, abscesses of the subcutaneous tissue (n = 14, 21%) was the most common followed by liver (18%); abscesses of the spleen and lung were the third most common (12% each). Seven of 56 males were reported to have prostatic abscesses. Mycotic pseudoaneurysm occurred in five cases. Only one case of parotid abscess was reported in an adult. Of the 67 cases, 13 were children (≤ 18 years of age) with seven deaths; five of the 13 were neonates presenting primarily with bronchopneumonia, four of whom died. Older children had a similar presentation as adults; no case of parotid abscess was reported among children.

    CONCLUSIONS: The clinical patterns of cases reported from Malaysia are consistent for the most part from previous case reports from South and Southeast Asia with regard to common primary presentations of pneumonia and soft tissue abscesses, and diabetes as a major risk factor. Bacteremic melioidosis carried a poor prognosis and septic shock was strong predictor of mortality. Differences included the occurrence of: primary neurological infection was higher in Malaysia compared to reports outside Malaysia; internal foci of infection such as abscesses of the liver, spleen, prostate, and mycotic pseudoaneurysms were higher than previously reported in the region. No parotid abscess was reported among children. Early recognition of the disease is the cornerstone of management. In clinical situations of community-acquired sepsis and/or pneumonia, where laboratory bacteriological confirmation is not possible, empirical treatment with antimicrobials for B. pseudomallei is recommended.

    Matched MeSH terms: Melioidosis/complications; Melioidosis/microbiology*; Melioidosis/mortality; Melioidosis/epidemiology*
  19. Eu LC, Ong KC, Hiu J, Vadivelu J, Nathan S, Wong KT
    Mod. Pathol., 2014 May;27(5):657-64.
    PMID: 24186135 DOI: 10.1038/modpathol.2013.184
    Burkholderia pseudomallei causes a potentially fatal infection called melioidosis. We have developed a nonfluorescent, colorimetric in situ hybridization assay using a specific probe to target 16s rRNA of B. pseudomallei in formalin-fixed, paraffin-embedded infected tissues for diagnostic purposes and to study infectious disease pathology. A 63-base pair DNA probe was synthesized and labeled with digoxigenin by PCR. Probe specificity was confirmed by BLAST analysis and by testing on appropriate microbial controls. The in situ hybridization assay was specifically and consistently positive for B. pseudomallei, showing strongly and crisply stained, single bacillus and bacilli clusters in mainly inflamed tissues in seven human acute melioidosis cases and experimentally infected mouse tissues. Intravascular and extravascular bacilli were detected in both intracellular and extracellular locations in various human organs, including lung, spleen, kidney, liver, bone marrow, and aortic mycotic aneurysm, particularly in the inflamed areas. Intravascular, intracellular bacteria in melioidosis have not been previously reported. Although the identity of infected intravascular leukocytes has to be confirmed, extravascular, intracellular bacilli appear to be found mainly within macrophages and neutrophils. Rarely, large intravascular, extracellular bacillary clusters/emboli could be detected in both human and mouse tissues. B. cepacia and non-Burkholderia pathogens (16 microbial species) all tested negative. Nonpathogenic B. thailandensis showed some cross-hybridization but signals were less intense. This in situ hybridization assay could be usefully adapted for B. pseudomallei identification in other clinical specimens such as pus and sputum.
    Matched MeSH terms: Melioidosis/diagnosis*; Melioidosis/pathology
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