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Fulltext Toxicovigilance--the need for concern

Chandrasekharan N

Med J Malaysia, 1989 Dec;44(4):273-4.
PMID: 2520034
Matched MeSH terms: Poisoning/prevention & control*
Silent killer-the dangers of carbon monoxide poisoning during international travel

Long IJ, Flaherty GT

J Travel Med, 2017 05 01;24(3).
PMID: 28355614 DOI: 10.1093/jtm/tax002
Matched MeSH terms: Carbon Monoxide Poisoning/prevention & control*
Accidental poisoning: selected aspects of its epidemiology and prevention

Arokiasamy JT

Med J Malaysia, 1994 Jun;49(2):109-12.
PMID: 8090087

http://www.e-mjm.org/1994/v49n2/Accidental_Poisoning.pdf

Matched MeSH terms: Poisoning/prevention & control
Lead levels in new enamel household paints from Asia, Africa and South America

Clark CS, Rampal KG, Thuppil V, Roda SM, Succop P, Menrath W, et al.

Environ Res, 2009 Oct;109(7):930-6.
PMID: 19656507 DOI: 10.1016/j.envres.2009.07.002

In 2006 a report on the analysis for lead in 80 new residential paints from four countries in Asia revealed high levels in three of the countries (China, India and Malaysia) and low levels in a fourth country (Singapore) where a lead in paint regulation was enforced. The authors warned of the possible export of lead-painted consumer products to the United States and other countries and the dangers the lead paint represented to children in the countries where it was available for purchase. The need for a worldwide ban on the use of lead in paints was emphasized to prevent an increase in exposure and disease from this very preventable environmental source. Since the earlier paper almost 300 additional new paint samples have been collected from the four initial countries plus 8 additional countries, three from Asia, three from Africa and two from South America. During the intervening time period two million toys and other items imported into the United States were recalled because the lead content exceeded the United States standard. High lead paints were detected in all 12 countries. The average lead concentration by country ranged from 6988 (Singapore) to 31,960ppm (Ecuador). One multinational company sold high lead paint in one country through January 2007 but sold low lead paint later in 2007 indicating that a major change to cease adding lead to their paints had occurred. However, the finding that almost one-third of the samples would meet the new United States standard for new paint of 90ppm, suggests that the technology is already available in at least 11 of the 12 countries to produce low lead enamel paints for domestic use. The need remains urgent to establish effective worldwide controls to prevent the needless poisoning of millions of children from this preventable exposure.

Matched MeSH terms: Lead Poisoning/prevention & control
Fulltext Lead poisoning in childhood

Nasir HM, Kassim MS, Malinee T, Khairul AM, Low BH

Med J Malaysia, 1993 Sep;48(3):361-3.
PMID: 8183154

We report here a case of lead poisoning in a 20 month old girl who presented with acute encephalopathy and status epilepticus. The major clues leading to the diagnosis were the occupational family history and dense lead lines on X-ray of the long bones. She showed evidence of neurological dysfunction in the initial phase, but she improved steadily, regaining her motor power partially and her vision, although some cognitive and language deficits were already evident. She will need long-term neurological assessment and evaluation to ascertain the extent of permanent brain damage.

Matched MeSH terms: Lead Poisoning/prevention & control
Optimization of process conditions for removal of cadmium using bioactive constituents of Moringa oleifera seeds

Jamal P, Muyibi SA, Syarif WM

Med J Malaysia, 2008 Jul;63 Suppl A:105-6.
PMID: 19025007

Pollutants, especially heavy metals like cadmium, Chromium, lead and mercury, play a significant role in causing various water-borne diseases to humans. This study evaluates the sorption properties of bioactive constituents of Moringa oleifera seeds for decontamination of cadmium at laboratory scale. The performance of the bioactive constituent extracted by salt extraction method was enhanced by process optimization with various concentration of bioactive dosages, agitation speed, contact time, pH and heavy metal concentrations. Statistical optimization was carried out for evaluating the polynomial regression model through effect of linear, quadratic and interaction of the factors. The maximum removal of cadmium was 72% by using 0.2 g/l of bioactive dosage.

Matched MeSH terms: Cadmium Poisoning/prevention & control*
Real-time determination of kinetics of adsorption of lead(II) onto palm shell-based activated carbon using ion selective electrode

Aroua MK, Leong SP, Teo LY, Yin CY, Daud WM

Bioresour Technol, 2008 Sep;99(13):5786-92.
PMID: 18023577

In this study, the kinetics of adsorption of Pb(II) from aqueous solution onto palm shell-based activated carbon (PSAC) were investigated by employing ion selective electrode (ISE) for real-time Pb(II) and pH monitoring. Usage of ISE was very appropriate for real-time adsorption kinetics data collection as it facilitated recording of adsorption data at very specific and short time intervals as well as provided consistent kinetics data. Parameters studied were initial Pb(II) concentration and agitation speed. It was found that increases in initial Pb(II) concentration and agitation speed resulted in higher initial rate of adsorption. Pseudo first-order, pseudo second-order, Elovich, intraparticle diffusion and liquid film diffusion models were used to fit the adsorption kinetics data. It was suggested that chemisorption was the rate-controlling step for adsorption of Pb(II) onto PSAC since the adsorption kinetics data fitted both the pseudo second-order and Elovich models well.

Matched MeSH terms: Lead Poisoning/prevention & control
The lead content of currently available new residential paint in several Asian countries

Clark CS, Rampal KG, Thuppil V, Chen CK, Clark R, Roda S

Environ Res, 2006 Sep;102(1):9-12.
PMID: 16782088

Worldwide prohibitions on lead gasoline additives were a major international public health accomplishment, the results of which are still being documented in parts of the world. Although the need to remove lead from paints has been recognized for over a century, evidence reported in this article indicates that lead-based paints for household use, some containing more than 10% lead, are readily available for purchase in some of the largest countries in the world. Sixty-six percent of new paint samples from China, India, and Malaysia were found to contain 5000 ppm (0.5%) or more of lead, the US definition of lead-based paint in existing housing, and 78% contained 600 ppm (0.06%) or more, the limit for new paints. In contrast, the comparable levels in a nearby developed country, Singapore, were 0% and 9%. In examining lead levels in paints of the same brands purchased in different countries, it was found that some brands had lead-based paints in one of the countries and paints meeting US limits in another; another had lead-free paint available in all countries where samples were obtained. Lead-based paints have already poisoned millions of children and likely will cause similar damage in the future as paint use increases as countries in Asia and elsewhere continue their rapid development. The ready availability of lead-based paints documented in this article provides stark evidence of the urgent need for efforts to accomplish an effective worldwide ban on the use of lead in paint.

Matched MeSH terms: Lead Poisoning/prevention & control*
Effect of griseofulvin on the toxicity of signal grass (Brachiaria decumbens) in sheep

Haisah AH, Elsheikh HA, Khairi HM, Salam Abdullah A, Rajion MA

Vet Hum Toxicol, 2003 Mar;45(2):68-71.
PMID: 12678289

The effect of griseofulvin treatment on signal grass (Brachlaria decumbens) toxicity was studied in 27 male Wiltshire Indigenous Malaysian crossbred sheep. Grazing on signal grass generally decreased the activity of the drug metabolizing enzymes in livers and kidneys. Griseofulvin oral administration of 5 mg/kg body weight for 5 consecutive days every other week for 10 w increased the hepatic concentration of cytochrome P-450 and the activity of phase II drug metabolizing enzymes (UDP-glucuronyltransferase and glutathione-S-transferase) while it decreased the hepatic and increased the renal activity of phase I enzymes aminopyrine-N-demethylase and aniline-4-hydroxylase. Griseofulvin did not protect sheep against B decumbens toxicity as 5/7 animals treated with griseofulvin and grazed on B decumbens showed signs of the plant toxicity.

Matched MeSH terms: Poisoning/prevention & control*
Lead in blood and hair of shipyard workers, Sabah, Malaysia

Mokhtar MB, Awaluddin AB, Yusof AB, Bakar BB

Bull Environ Contam Toxicol, 2002 Jul;69(1):8-14.
PMID: 12053250
Matched MeSH terms: Lead Poisoning/prevention & control
Fulltext Circumstances surrounding accidental poisoning in children

Azizi BH, Zulkifli HI, Kassim MS

Med J Malaysia, 1994 Jun;49(2):132-7.
PMID: 8090091

Circumstances surrounding accidental ingestion of poisons were investigated in families of 70 hospitalised children. Indian children were more likely to be hospitalised for poisoning. Poor safety measures directly contributed to poisoning incidents. Poisons had not been stored safely and only in 12.9 per cent of families were the poisons allegedly kept in cupboards. Kerosene had been ingested from soft drink containers in 70 per cent of instances. Medications had been taken mainly from plastic envelopes (57.9%) or bottles (31.6%). Safety practices in the homes of cases and 140 controls were compared. As a whole parents of victims had poor safety practices when compared with parents of controls. Poisoning incidents were discovered by mothers in 75.0 per cent of the cases. Vomiting was induced by parents in 32.3 per cent of cases involving medications and non-volatile items, and in 41.6 per cent of kerosene ingestions. Before hospitalisation 59.4 per cent were brought to general practitioners and 22.7 per cent to government clinics. Mothers were the main attendants when children were brought for medical care. This study highlights the need for measures to prevent childhood poisoning and reduce its morbidity. Household products and medications should be made safer to children through improved packaging, prescribing instructions and education. Safety and first aid education may be directed towards parents, particularly mothers, through the media and health facilities.

Matched MeSH terms: Poisoning/prevention & control
Fulltext Water Spinach, Ipomoea aquatic (Convolvulaceae), Ameliorates Lead Toxicity by Inhibiting Oxidative Stress and Apoptosis

Dewanjee S, Dua TK, Khanra R, Das S, Barma S, Joardar S, et al.

PLoS One, 2015;10(10):e0139831.
PMID: 26473485 DOI: 10.1371/journal.pone.0139831

BACKGROUND: Ipomoea aquatica (Convolvulaceae), an aquatic edible plant, is traditionally used against heavy metal toxicity in India. The current study intended to explore the protective role of edible (aqueous) extract of I. aquatica (AEIA) against experimentally induced Pb-intoxication.
METHODS: The cytoprotective role of AEIA was measured on mouse hepatocytes by cell viability assay followed by Hoechst staining and flow cytometric assay. The effect on ROS production, lipid peroxidation, protein carbonylation, intracellular redox status were measured after incubating the hepatocytes with Pb-acetate (6.8 μM) along with AEIA (400 μg/ml). The effects on the expressions of apoptotic signal proteins were estimated by western blotting. The protective role of AEIA was measured by in vivo assay in mice. Haematological, serum biochemical, tissue redox status, Pb bioaccumulation and histological parameters were evaluated to estimate the protective role of AEIA (100 mg/kg) against Pb-acetate (5 mg/kg) intoxication.
RESULTS: Pb-acetate treated hepatocytes showed a gradual reduction of cell viability dose-dependently with an IC50 value of 6.8 μM. Pb-acetate treated hepatocytes exhibited significantly enhanced levels (p < 0.01) of ROS production, lipid peroxidation, protein carbonylation with concomitant depletion (p < 0.01) of antioxidant enzymes and GSH. However, AEIA treatment could significantly restore the aforementioned parameters in murine hepatocytes near to normalcy. Besides, AEIA significantly reversed (p < 0.05-0.01) the alterations of transcription levels of apoptotic proteins viz. Bcl 2, Bad, Cyt C, Apaf-1, cleaved caspases [caspase 3, caspase 8 and caspase 9], Fas and Bid. In in vivo bioassay, Pb-acetate treatment caused significantly high intracellular Pb burden and oxidative pressure in the kidney, liver, heart, brain and testes in mice. In addition, the haematological and serum biochemical factors were changed significantly in Pb-acetate-treated animals. AEIA treatment restored significantly the evaluated-parameters to the near-normal position.
CONCLUSION: The extract may offer the protective effect via counteracting with Pb mediated oxidative stress and/or promoting the elimination of Pb by chelating. The presence of substantial quantities of flavonoids, phenolics and saponins would be responsible for the overall protective effect.

Matched MeSH terms: Lead Poisoning/prevention & control*
Enhancement of Hsp70 synthesis protects common carp, Cyprinus carpio L., against lethal ammonia toxicity

Sung YY, Roberts RJ, Bossier P

J Fish Dis, 2012 Aug;35(8):563-8.
PMID: 22724455 DOI: 10.1111/j.1365-2761.2012.01397.x

Exposure to TEX-OE®, a patented extract of the prickly pear cactus (Opuntia ficus indica) containing chaperone-stimulating factor, was shown to protect common carp, Cyprinus carpio L., fingerlings against acute ammonia stress. Survival was enhanced twofold from 50% to 95% after exposure to 5.92 mg L(-1) NH(3) , a level determined in the ammonia challenge bioassay as the 1-h LD50 concentration for this species. Survival of TEX-OE®-pre-exposed fish was enhanced by 20% over non-exposed controls during lethal ammonia challenge (14.21 mg L(-1) NH(3) ). Increase in the levels of gill and muscle Hsp70 was evident in TEX-OE®-pre-exposed fish but not in the unexposed controls, indicating that application of TEX-OE® accelerated carp endogenous Hsp70 synthesis during ammonia perturbation. Protection against ammonia was correlated with Hsp70 accretion.

Matched MeSH terms: Poisoning/prevention & control
Effect of phenobarbitone treatment against signal grass (Brachiaria decumbens) toxicity in sheep

Hasiah AH, Elsheikh HA, Abdullah AS, Khairi HM, Rajion MA

Vet J, 2000 Nov;160(3):267-72.
PMID: 11061964

The effect of phenobarbitone against signal grass (Brachiaria decumbens) toxicity was studied in 26 male crossbred sheep. Grazing on signal grass significantly decreased the concentration of cytochrome P-450 and the activity of drug metabolizing enzymes, viz. aminopyrine-N-demethylase, aniline-4-hydroxylase, UDP- glucuronyltransferase and glutathione-S-transferase in liver and kidneys of affected sheep.Oral administration of phenobarbitone (30 mg/kg body weight) for five consecutive days before grazing on B. decumbens pasture, and thereafter, for three consecutive days every two weeks, resulted in significant increases in hepatic and renal activities of drug-metabolizing enzymes. The induction of drug metabolizing activity in sheep grazing on signal grass group was found to be lower than in animals given phenobarbitone alone. Induction by phenobarbitone provided a degree of protection against the toxic effects of B. decumbens as indicated by the delay in the appearance of signs of toxicity. Furthermore, these were much milder compared to those in the sheep not treated with phenobarbitone. The present study suggests that phenobarbitone-type cytochrome P-450 isoenzyme-induction may increase resistance against signal grass (B. decumbens) toxicity in sheep.

Matched MeSH terms: Plant Poisoning/prevention & control
Djenkol bean poisoning (djenkolism): proposals for treatment and prevention

West CE, Perrin DD, Shaw DC, Heap GH, Soemanto

Southeast Asian J. Trop. Med. Public Health, 1973 Dec;4(4):564-70.
PMID: 4274568
Matched MeSH terms: Plant Poisoning/prevention & control
Protective effects of Etlingera elatior extract on lead acetate-induced changes in oxidative biomarkers in bone marrow of rats

Haleagrahara N, Jackie T, Chakravarthi S, Rao M, Pasupathi T

Food Chem Toxicol, 2010 Oct;48(10):2688-94.
PMID: 20600524 DOI: 10.1016/j.fct.2010.06.041

Several environmental toxins with toxic effects to the bone marrow have been identified. Pathology associated with lead intoxication is due to the cellular damage mediated by free radicals. In the current study, we examined the effect of Etlingera elatior extract on lead-induced changes in the oxidative biomarkers and histology of bone marrow of rats. Sprague-Dawley rats were exposed to 500 ppm lead acetate in their drinking water for 14 days. E. elatior extract was treated orally (100mg/kg body weight) in combination with, or after lead acetate treatment. The results showed that there was a significant increase in lipid hydroperoxide, protein carbonyl content and a significant decrease in total antioxidants, super oxide dismutase, glutathione peroxidase and glutathione--S-transferase in bone marrow after lead acetate exposure. Treatment with E. elatior decreased lipid hydroperoxides and protein carbonyl contents and significantly increased total antioxidants and antioxidant enzymes. Treatments with E. elatior extract also reduced, lead-induced histopathological damage in bone marrow. In conclusion, these data suggest that E. elatior has a powerful antioxidant effect, and it protects the lead acetate-induced bone marrow oxidative damage in rats.

Matched MeSH terms: Lead Poisoning/prevention & control*

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