Displaying publications 1 - 20 of 473 in total

  1. Fadilah SAW, Raymond AA, Najihah I, Cheong SK
    Med. J. Malaysia, 2002 Jun;57(2):211-4.
    PMID: 24326654
    Patients (particularly elderly) undergoing evaluation for peripheral neuropathy of unknown cause should be screened for the presence of a monoclonal protein (M protein). The association of a neuropathy and a paraproteinaemia such as Waldenstrom's Macroglobulinaemia (WM) is not uncommon with the former antedating the haematologic symptoms by several years. Response to treatment has varied from good to very poor. We describe a case of WM presenting as a subacute demyelinating peripheral neuropathy. There was prompt resolution of the neuropathy with intravenous immunoglobulin therapy. Subsequent treatment with cyclophosphamide and plasmapheresis resulted in complete clinical remission with no further neurological relapses.
    Matched MeSH terms: Neoplasm Recurrence, Local*
  2. Chai CK, Tang IP, Tan TY
    Med. J. Malaysia, 2013 Jun;68(3):269-70.
    PMID: 23749022 MyJurnal
    Primary lacrimal sac lymphoma is rare. The common clinical features are epiphora and medial canthal swelling which mimic nasolacrimal duct obstruction. Histological examination is therefore important to avoid delay in diagnosis and treatment. We report a case of primary lacrimal sac lymphoma in a 72-year-old female who developed a metachronous tumour at the hard palate one year after excision of the lacrimal sac tumour.
    Matched MeSH terms: Neoplasm Recurrence, Local*
  3. Idayu MY, Irfan M, Othman NH
    Med. J. Malaysia, 2012 Jun;67(3):329-30.
    PMID: 23082428 MyJurnal
    Oral leiomyomas are rare benign tumour of smooth muscle. The first case of oral leiomyoma was reported by Blanc in 1884 and since then more cases has been published following advancement in immunohistochemical study. This tumour has an excellent prognosis and recurrences are extremely rare. We report a case of a recurrent glossal leiomyoma in a patient with HIV infection and the lesion recurred one year after the first excision.
    Matched MeSH terms: Neoplasm Recurrence, Local/pathology; Neoplasm Recurrence, Local/surgery*
  4. Kulenthran A, Sivanesaratnam V
    Int J Gynaecol Obstet, 1988 Oct;27(2):289-91.
    PMID: 2903099
    Three sisters who developed recurrent uterine myomata from a very young age are presented. Despite repeated attempts at myomectomy, all three cases had hysterectomies ultimately. Complications encountered during surgery were severe hemorrhage, inadvertent injury to bladder and bowel in two patients and a rare complication of colonic-uteric-cutaneous fistula occurring post-operatively in one patient. Histology of the final hysterectomy specimens in two cases showed low grade leiomyosarcoma and cellular myoma, respectively.
    Matched MeSH terms: Neoplasm Recurrence, Local/genetics*
  5. Kanneppady, Sham Kishor, Sakri, Santosh B., Chatra, Laxmikanth, Prashanth, Shenoy K.
    Malaysian Dental Journal, 2010;31(2):79-83.
    Adenoid cystic carcinoma (ACC) is a rare malignant tumor that arises within secretary glands, most commonly the major and minor salivary glands. It has a tendency for a prolonged clinical course, perineural invasion, with local recurrences and distant metastases. The three recognized histopathologic pattern of ACC are cribriform, tubular, and solid with the cribriform being most common. Standard treatment for salivary gland ACC is surgery and postoperative radiotherapy. We report a case of ACC of palate in a 30-year-old female and review the literature.
    Matched MeSH terms: Neoplasm Recurrence, Local; Recurrence
  6. Tuck, Sang Hoe, Kok, Wai Chum
    A five-week-old infant presented with infantile acute lymphoblastic leukaemia. He devel-oped an early CNS and bone marrow relapse despite intensive treatment. This paper discusses infantile leukaemia and its treatment.
    Matched MeSH terms: Neoplasm Recurrence, Local; Recurrence
  7. Chiou CF, Wang BC, Caldwell R, Furnback W, Lee JS, Kothandaraman N, et al.
    Neuropsychiatr Dis Treat, 2015;11:1989-94.
    PMID: 26346330 DOI: 10.2147/NDT.S86722
    Schizophrenia results in substantial health care utilization costs. Much of these costs can be attributed to health care use resulting from nonadherence to treatment, relapse, and hospitalization.
    Matched MeSH terms: Recurrence
  8. Khoo SP, High AS, Awang MN
    Singapore Dent J, 1995 Jul;20(1):21-3.
    PMID: 9582685
    A case of unicystic ameloblastoma which recurred after 15 years showing unusual histological features is reported. The prominent pseudo-glandular features present are described. This case highlights the importance of extensive histological examination for more characteristic features of ameloblastoma to reach a correct diagnosis.
    Matched MeSH terms: Neoplasm Recurrence, Local/pathology*; Neoplasm Recurrence, Local/radiography; Neoplasm Recurrence, Local/surgery
  9. Khadijah, H.A.A., Seed, H.F., Lee, V.Y., Wan Salwina, W.I.
    Although comorbidity of obsessive compulsive disorder (OCD) with schizophrenia is well-established, the occurrence of psychotic symptoms especially hallucinations with OCD still requires further studies. We report a case of a child with OCD who experienced auditory hallucination with the recurrence of his OCD symptoms and the management involved. We discussed the possible differentials when auditory hallucinations occur in the context of OCD.
    Matched MeSH terms: Recurrence
  10. Chen Y, Ahmad M
    Future Oncol, 2018 Jun;14(15):1487-1496.
    PMID: 29767550 DOI: 10.2217/fon-2017-0671
    Psychotherapies were offered to alleviate psychological and physical symptoms; however, most psychological interventions were only delivered after cancer treatment. Newly diagnosed cancer patients experienced psychological distress while waiting for treatments. This review paper focused on randomized control trial studies, aimed to investigate the effectiveness of psychological intervention among newly diagnosed cancer patients. Eight randomized control trial papers were found in recent 10 year period through electronic database. A moderate to large effect size was detected on the outcomes, ranging from 0.43 to 0.89. This indicated that psychological-based prehabilitation with standard care yielded better outcomes than standard care alone. Psychological-based prehabilitation provides evidence in its effectiveness to reduce psychological distress, functional impairment, recurrence of cancer, numbers of immune reactivity and sleeping quality; however, inconsistent with longer survival result among cancer patients. In conclusion, psychological-based prehabilitation before cancer treatment is necessary for better treatment outcome, and future research is needed to investigate more directly the outcome.
    Matched MeSH terms: Recurrence
  11. Thong HK, Athar PPSH, Mustaffa WMW
    Open Access Maced J Med Sci, 2019 Jul 15;7(13):2142-2145.
    PMID: 31456841 DOI: 10.3889/oamjms.2019.577
    BACKGROUND: Lymphoepithelial cysts, which are benign and slow-growing tumours, usually involve the head and neck regions. Benign lymphoepithelial cysts (BLECs) are the most common cause of parotid swelling in human immunodeficiency virus (HIV)-positive patients and are less common in immunocompetent patients.

    CASE PRESENTATION: Here, we present two cases of immunocompetent patients with long-standing, progressively enlarging parotid swelling. Postoperative histopathological examination of these patients revealed features of BLEC.

    CONCLUSION: Wide surgical excision is the gold standard for treatment and recurrences is rare. These cases are of particular interest because of the rarity of BLEC in HIV-negative patients and highlight an important differential diagnosis of parotid swelling.

    Matched MeSH terms: Neoplasm Recurrence, Local
  12. Smadel JE, Bailey CA, Diercks FH
    Am J Hyg, 1950;51:229-41.
    DOI: 10.1093/oxfordjournals.aje.a119387
    Two field trials were conducted in Malaya in which 75 volunteers were exposed in hyperendemic areas of scrub typhus. Thirty-four of these individuals received chloromycetin prophylactically for a total period of 3 weeks during and following exposure. They did not show clinical evidence of scrub typhus throughout the period of prophylaxis or the ensuing 5 days. However, scrub typhus developed in 15 volunteers in the prophylactic groups of the two trials 5 to 14 days after drug was discontinued. Although the attack rate among the volunteers in the two field trials varied markedly, there was no essential difference in the ultimate infection rates among the controls and those given prophylaxis in each test. Scrub typhus when it developed among volunteers in the prophylactic group was not significantly different from the disease in the controls except for the absence of eschar formation. Relapses were prominent features of the disease in the volunteers of both prophylactic and control groups. These had not been observed previously in untreated cases of scrub typhus or in naturally occurring cases which were treated with chloromycetin. Fifty-four per cent of the 37 persons in the two trials who contracted scrub typhus suffered one or more relapses. Various factors probably contributed to this phenomenon but the opinion is that the short course of chloromycetin therapy given very early in the illness probably was an important factor. Ten volunteers had received experimental scrub typhus vaccine during earlier investigations because of possible exposure to infection. The vaccination did not influence the incidence of infection or the course of the disease in those persons developing scrub typhus. Prolonged administration of chloromycetin as a prophylactic measure and its use in the treatment of the initial attacks of scrub typhus, as well as the relapses, indicated that the drug is of low toxicity for man, and that drug fast strains of Rickettsia tsutsugamushi are not readily produced.
    Matched MeSH terms: Recurrence
  13. Sia KJ, Kong CK, Tan TY, Tang IP
    Med. J. Malaysia, 2014 Dec;69(6):281-3.
    PMID: 25934961
    CASE REPORT: Five cases of Kimura's disease had been treated in our centre from year 2003 to 2010. All cases were presented with head and neck mass with cervical lymphadenopathy. Surgical excision was performed for all cases. Definite diagnosis was made by histopathological examination of the resected specimens. One out of five cases developed tumour recurrence four years after resection.

    CONCLUSION: Surgical excision is our choice of treatment because the outcome is immediate and definite tissue diagnosis is feasible after resection. Oral corticosteroid could be considered as an option in advanced disease. However, tumour recurrence is common after cessation of steroid therapy.
    Matched MeSH terms: Recurrence
  14. Loh KY, Sivalingam N
    Med. J. Malaysia, 2003 Dec;58(5):788-92.
    PMID: 15190674
    Recurrent vaginal candidiasis is one of the most common reasons for patients visiting their primary care doctors. Majority of the cases are caused by Candida albicans. Controlling of risk factors such as diabetes mellitus, used of broad spectrum antibiotics, contraceptive pills and steroid therapy helps in managing recurrent vaginal candidiasis. Initial 14-day course of oral azoles and followed by 6 months maintenance are effective in treating majority of the cases. Failure to treat recurrent vaginal candidiasis can lead to various bio-psycho-social complications.
    Matched MeSH terms: Recurrence
  15. Lee YK
    Med. J. Malaysia, 1975 Mar;30(3):231-3.
    PMID: 1160685
    Matched MeSH terms: Neoplasm Recurrence, Local
  16. Rozita, A.M., Marniza, S., Mastura, M.Y., Wan Zamaniah, W.I., Yip, C.H., Taib, N.A.
    JUMMEC, 2010;13(1):24-32.
    Despite being the major cause of cancer-related death in Malaysian women,local data on patterns of breast cancer relapse and their long term outcomes are still scarce. We conducted a retrospective study on all patients treated for non-metastatic invasive breast cancer in 1999-2000 at the University of Malaya Medical Centre (UMMC), who subsequently developed relapse. We sought to analyse the patterns of relapse, their associated clinicopathological features and the overall survival ratefollowing the relapses. Univariate and multivariate analyses were used to analyse demographics and clinicopathological factors. Survival was analysed using the Kaplan and Meier method and compared by the log rank test. A total of 268 patients with a mean age of 50, were identified for the study. At a median follow-up of 50 months, 73 patients (27.2%) had relapsed. Local, regional and distant relapse rates were 5.5%, 1.9% and 19.8% respectively, whereas, the 5-year survival rates were 61%, 40% and 21% respectively (p < 0.01). Most relapses occurred within the first five years of diagnosis. Patients with long disease-free interval had better survival. The most common distant relapse site was the lungs while bone was the distant relapse site with the best prognosis. Disease stage, nodal status and oestrogen receptor status were found to have correlation with the risk of relapse. We concluded that the survival of patients with relapsed breast cancer was associated with the site(s) of first relapse and the disease free interval and clinicopathological factors can be used to predict the risk of relapse.
    Matched MeSH terms: Neoplasm Recurrence, Local; Recurrence
  17. Rohaizam J, Subramaniam SK, Vikneswaran T, Tan VE, Tan TY
    Med. J. Malaysia, 2009 Sep;64(3):213-5.
    PMID: 20527270 MyJurnal
    Shifting the paradigm of treatment of a locally recurrent nasopharyngeal carcinoma (NPC) from the non-surgical management to a surgical modality has always been a challenge. However, many studies on endoscopic nasopharyngectomy have proven it to be a reliable form of treatment with an excellent outcome. Since 2007, in Sarawak General Hospital, six cases of endoscopic nasopharyngectomy for locally recurrent NPC have been performed with encouraging results.
    Matched MeSH terms: Neoplasm Recurrence, Local/surgery
  18. Fauzi MA, Fadilah SA, Bahariah K
    Med. J. Malaysia, 2007 Mar;62(1):66-7.
    PMID: 17682575 MyJurnal
    Multiple lung cavitations and endobronchial nodules are rare presentations of newly diagnosed and recurrent Hodgkin's disease. The clinical and radiological features can be confused with pulmonary tuberculosis, which can be difficult to exclude in endemic areas. However, the presence of endobronchial nodules point, towards Hodgkin's disease. Differential diagnosis is aided by the fact that these lesions usually respond promptly to specific therapy. We present a case of an adolescent male who had constitutional and pulmonary symptoms associated with pulmonary cavities and endobronchial nodules subsequently confirmed to be Hodgkin's disease.
    Matched MeSH terms: Neoplasm Recurrence, Local*
  19. Zain R, Ling KC
    Med. J. Malaysia, 1985 Mar;40(1):49-51.
    PMID: 3831736
    This is a case report of a recurrent lesion diagnosed histologically as a unicystic ameloblastoma. The concomitant presence of a traumatic neuroma was observed within the wall of the recurrent lesion. The mode of development of the traumatic neuroma, and the reason for the recurrence were presented.
    Matched MeSH terms: Neoplasm Recurrence, Local/pathology*
  20. Cheah SK, Lau FN, Yusof MM, Phua VC
    Asian Pac. J. Cancer Prev., 2014 Jan;14(11):6513-8.
    PMID: 24377559
    BACKGROUND: To evaluate the treatment outcome and major late complications of all patients with recurrent nasopharyngeal carcinoma (NPC) treated with intracavitary brachytherapy (ICBT) in Hospital Kuala Lumpur.

    MATERIALS AND METHODS: This retrospective study was conducted at the Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Malaysia. All patients with histologically confirmed recurrent NPC in the absence of distant metastasis treated in the period 1997-2010 were included in this study. These patients were treated with ICBT alone or in combination with external beam radiotherapy (EBRT). Treatment outcomes measured were local recurrence free survival (LRFS), disease free survival (DFS) and overall survival (OS).

    RESULTS: Thirty three patients were eligible for this study. The median age at recurrence was 56 years with a median time to initial local recurrence of 27 months. Majority of patients were staged as rT1-2 (94%) or rN0 (82%). The proportion of patients categorised as stage III-IV at first local recurrence was only 9%. Twenty one patients received a combination of ICBT and external beam radiotherapy while 12 patients were treated with ICBT alone. Median interval of recurrence post re-irradiation was 32 months (range: 4-110 months). The median LRFS, DFS and OS were 30 months, 29 months and 36 months respectively. The 5 year LRFS, DFS and OS were 44.7%, 38.8% and 28.1% respectively. The N stage at recurrence was found to be a significant prognostic factor for LRFS and DFS after multivariate analysis. Major late complications occurred in 34.9% of our patients.

    CONCLUSIONS: Our study shows ICBT was associated with a reasonable long term outcome in salvaging recurrent NPC although major complications remained a significant problem. The N stage at recurrence was a significant prognostic factor for both LRFS and DFS.

    Matched MeSH terms: Neoplasm Recurrence, Local/mortality; Neoplasm Recurrence, Local/pathology; Neoplasm Recurrence, Local/radiotherapy*
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