MyMedR

Walker JHC

Malayan Medical Journal, 1926;1:13-4.

Matched MeSH terms: Skin Neoplasms

Fulltext Calcifying Epithelial Odontogenic Tumour - Case Report And Review Of The Literature

Khoo, Suan Phaik, Jalil, N., Yaacob, H.B.

Ann Dent, 1997;4(1):-.

MyJurnal

The calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic neoplasm which was first described by Pindborg in 1955. It accounts for less than 1% of all odontogenic lesions. A case of CEOT which presented together with cardiac abnomlalities is presented here and the literature of CEOT is reviewed.

Matched MeSH terms: Skin Neoplasms

Incarcerated strangulated anal fibroepithelial polyp: a rare case of anorectal emergency

Nor AM, Mohamad AM, Elagili F, Hamdan A

ANZ J Surg, 2021 12;91(12):2855-2856.

PMID: 34913562 DOI: 10.1111/ans.17303

Matched MeSH terms: Skin Neoplasms*

Fulltext A rare synchronous presentation of primary malignant melanoma in cervix and vagina

Pai UKN, Pillai S, Arunkumar NR

J Cancer Res Ther, 2023 Oct 01;19(7):2108-2110.

PMID: 38376333 DOI: 10.4103/jcrt.jcrt_1309_21

Malignant melanoma, primarily a cutaneous malignancy, can also involve mucosal surfaces and constitutes 2% to 7% of all gynecological malignancies. Primary melanoma of the uterine cervix is an uncommon tumor and has poor prognosis. In the female genital tract, the synchronous occurrence of primary malignant melanoma in the cervix and vagina is rare. We report a case of a 48-year-old female patient who presented with a blackish vaginal mass and associated growth in the cervix. Biopsy from the vaginal mass was reported as malignant melanoma. Following this, she underwent radical surgery and adjuvant radiotherapy. After 12 months, the patient is doing well.

Matched MeSH terms: Skin Neoplasms*

Congenital papulonodular eruption: presenting sign of congenital leukaemia cutis

Nanda A, El-Kamel MF, Al-Oneizi EM, Al-Ajmi M, Al-Enezi EM, Madda JP

Clin Exp Dermatol, 2012 Jul;37(5):509-11.

PMID: 22712859 DOI: 10.1111/j.1365-2230.2011.04270.x

Congenital leukaemia (CL) is a rare malignancy that accounts for < 1% of cases of childhood leukaemias. Leukaemia cutis (LC) refers to cutaneous infiltration with leukaemic cells, and is seen in 30-50% of CL cases. It may precede, follow or occur simultaneously with leukaemia. If left untreated, the prognosis is usually poor, but early diagnosis and treatment may result in a favourable prognosis. We report a case of congenital leukaemia cutis with a progressive, violaceous papulonodular eruption (a 'blueberry muffin' rash), which had been noted at birth, as a presenting sign of acute myeloid leukaemia (AML), which on investigation was classified as AML, FAB M2 type with a t(8; 21)(p11;q22) chromosomal defect. The patient had a favourable response to AML chemotherapy.

Matched MeSH terms: Skin Neoplasms/congenital*; Skin Neoplasms/pathology

Fulltext Cyclin D1 expression in acral melanoma: a case control study in Sarawak

Ibrahim ZA, Narihan MZ, Ojep DN, Soosay AE, Pan KL

Malays J Pathol, 2012 Dec;34(2):89-95.

PMID: 23424770 MyJurnal

Acral melanoma has been reported to have distinctive clinical presentation and ethnic distribution compared to other histological types of malignant melanoma. Acral melanoma also exhibits distinctive focused gene amplifications, including cyclin D1 overexpression. We reviewed archived histological material of malignant melanoma in the Sarawak General Hospital from year 2004 to 2010. 43 tumours, comprising 28 acral melanoma and 15 non-acral melanoma, had sufficient material to be included in the study. The majority (36%) of acral melanoma tumours occurred in the heel. The tumours were analyzed for cyclin D1 expression by immunohistochemistry. 68% of acral melanoma were cyclin D1 positive compared to a positivity of 33% in non-acral tumours. This difference was statistically significant (p < 0.05). This finding may improve the histological diagnosis of acral melanoma and detection of positive resection margins.

Matched MeSH terms: Skin Neoplasms/metabolism; Skin Neoplasms/pathology*

Fulltext Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management

Leung AKC, Lam JM, Leong KF

Curr Pediatr Rev, 2019;15(1):42-46.

PMID: 30465511 DOI: 10.2174/1573396315666181120163952

BACKGROUND: The diagnosis of solitary cutaneous mastocytoma is mainly clinical, based on lesion morphology, the presence of a positive Darier sign, and the absence of systemic involvement. Knowledge of this condition is important so that an accurate diagnosis can be made.

OBJECTIVE: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and management of a solitary cutaneous mastocytoma.

METHODS: A PubMed search was completed in Clinical Queries using the key term "solitary cutaneous mastocytoma". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. Only papers published in English language were included. The information retrieved from the above search was used in the compilation of the present article.

RESULTS: Typically, a solitary cutaneous mastocytoma presents as an indurated, erythematous, yellow- brown or reddish-brown macule, papule, plaque or nodule, usually measuring up to 5 cm in diameter. The lesion often has a peau d'orange appearance and a leathery or rubbery consistency. A solitary cutaneous mastocytoma may urticate spontaneously or when stroked or rubbed (Darier sign). Organomegaly and lymphadenopathy are characteristically absent. The majority of patients with skin lesions that erupt within the first two years of life have spontaneous resolution of the lesions before puberty. Treatment is mainly symptomatic. Reassurance and avoidance of triggering factors suffice in most cases.

CONCLUSION: The diagnosis is mainly clinical, based on the morphology of the lesion, the presence of a positive Darier sign, and the absence of systemic involvement. A skin biopsy is usually not necessary unless the diagnosis is in doubt.

Matched MeSH terms: Skin Neoplasms/diagnosis*; Skin Neoplasms/therapy

Fulltext Pilomatrixoma (calcifying epithelioma) in Sarawak

Kothare SN

Singapore Med J, 1981 Apr;22(2):96-8.

PMID: 7268457

This is a report of 9 cases of Pilomatrixoma (Calcifying Epithelioma) recorded in 188 benign tumours of the skin and adnexa in Sarawak during 1976 and 1977, with an incidence of 4.7 per cent. Out of the seven Chinese patients four were females. One more female was a Kayan and the race of another female patient was not recorded. Except one, all were below the age of 20 years; the youngest being only 6 months old. In one lesion ossification was also detected.

Matched MeSH terms: Skin Neoplasms/epidemiology*; Skin Neoplasms/pathology

Fulltext Images in clinical medicine. Nevus comedonicus

Bhullar A, Shamsudin N

N Engl J Med, 2015 Jun 25;372(26):2541.

PMID: 26107054 DOI: 10.1056/NEJMicm1406555

Matched MeSH terms: Skin Neoplasms/pathology*

Syringocystadenoma papelliferum

Dutt AK

Med J Malaya, 1969 Jun;23(4):296-7.

PMID: 4310351

Matched MeSH terms: Skin Neoplasms*

A SWEAT GLAND TUMOUR OF THE MIXED-SALIVARY TYPE OF THE RIGHT MIDDLE TOE

KHOO TK, TZE KB

Med J Malaysia, 1964 Dec;19:128-33.

PMID: 14279235

Matched MeSH terms: Skin Neoplasms*

Management of a cutaneous squamous cell carcinoma in an American flamingo (Phoenicopterus ruber)

Abu J, Wünschmann A, Redig PT, Feeney D

J. Avian Med. Surg., 2009 Mar;23(1):44-8.

PMID: 19530406

A 32-year-old female American flamingo (Phoenicopterus ruber) was presented with a squamous cell carcinoma of the middle digit of the right foot. No clinical, hematologic, or radiologic evidence of metastasis was present. Salvage amputation of the digit resulted in complete cure, whereas previous electrosurgery and radiation therapy were unsuccessful. Three years later, another squamous cell carcinoma was diagnosed in the middle digit of the left foot. The digit was also amputated. Seven months after the second amputation, the bird did not have any recurrence or signs of metastasis.

Matched MeSH terms: Skin Neoplasms/pathology; Skin Neoplasms/surgery; Skin Neoplasms/veterinary*

p16 gene expression in basal cell carcinoma

Eshkoor SA, Ismail P, Rahman SA, Oshkour SA

Arch Med Res, 2008 Oct;39(7):668-73.

PMID: 18760195 DOI: 10.1016/j.arcmed.2008.06.003

Basal cell carcinoma (BCC) develops predominantly in sun-exposed skin in fair-skinned individuals prone to sunburn. BCC typically occurs in adults. High exposure to ultraviolet (UV) radiation increases rate of developing BCC, a slowly growing tumor that occurs in hair-growing squamous epithelium and rarely metastasizes. In genetic studies, BCC patients have cell-cycle abnormalities of different parts of the signaling pathway. Retinoblastoma regulatory pathway is important in cell cycle arrest. In this pathway, p16INK4a, an inhibitor of Rb pathway, binds to CDK4 and CDK6 competitively with cyclin D1 to prevent phosphorylation of tumor suppressor pRB gene. Alteration of this pathway contributes to development of human cancers and also is effective in skin cancers. In this study, we analyzed mRNA expression using in situ RT-PCR and the role of immunohistochemical expression of p16INK4a in BCC.

Matched MeSH terms: Skin Neoplasms/genetics*; Skin Neoplasms/metabolism; Skin Neoplasms/pathology

Fulltext Syringocystadenoma papilliferum arising in a naevus sebaceous

Faheem NAA, Kwan Z, Yong ASW, Ch'ng CC, Tan KK, Naicker M, et al.

Malays J Pathol, 2019 Apr;41(1):47-49.

PMID: 31025637

Naevus sebaceus is a cutaneous hamartoma with the potential of developing into benign or malignant neoplasms. Syringocystadenoma papilliferum (SCAP) have been reported to originate from naevus sebaceus. SCAP is a rare, benign adnexal skin tumour of apocrine or eccrine type of differentiation which typically presents as a nodule or a plaque on the scalp or face. We report a case of syringocystadenoma papilliferum arising in an undiagnosed pre-existing naevus sebaceus in a 56-year-old female.

Matched MeSH terms: Skin Neoplasms

Merkel cell carcinoma: Preparing to go the distance

Arumugam M, Jamil A, Amiseno RA, Rosli N, Abdul Shukor N

Malays J Pathol, 2020 Aug;42(2):277-281.

PMID: 32860382

INTRODUCTION: Merkel cell carcinoma (MCC) is a rare and aggressive malignancy of the skin, with poor clinical outcomes. Typical conditions include a rapidly growing, solitary dome-shaped, violaceous nodule. Several root causes have been identified - sun exposure, age, lighter skin, immunocompromised state, and polyomavirus infection. Wide local excision is the best treatment. The tumour is radiotherapy-responsive. However, the success rate of the treatment with chemotherapy is rather limited. Immunotherapy has shown promising results. Early detection is important to prevent morbidity and mortality.

CASE REPORT: In this literature work, we reported on a particular case of MCC, as exhibited by an 84-year-old Chinese woman, and discussed the clinical features and management of MCC.

DISCUSSION: We highlighted that MCC cases have a link to the polyomavirus 5. Patients who were identified with the Polyomavirus 5, and underwent immunotherapy, were seen to depict much better prognosis.

Matched MeSH terms: Skin Neoplasms/etiology; Skin Neoplasms/pathology; Skin Neoplasms/surgery

Fulltext Malignant melanoma of parotid gland in a child-our unique experience

Apparau D, Apparau H, Mohamad I, Bhavaraju VMK

AME Case Rep, 2018;2:4.

PMID: 30264000 DOI: 10.21037/acr.2018.01.06

Malignant melanoma (MM) of parotid gland is a rare condition. This pathology is often a result of secondary metastasis from primary lesions in the head and neck skin. A MM arising de novo in parotid gland is very rare. This malignant tumour is more prevalent in adults rather than children and it tends to have several distinct features. Treatment options are limited especially for an advanced lesion. Despite best treatments this condition carries a poor prognosis. This case details our experience in treating a child with MM of parotid gland without other primary cutaneous lesions.

Matched MeSH terms: Skin Neoplasms

Confluent and reticulated papillomatosis: Case series of 3 patients from Kedah, Malaysia and literature review

Lee SW, Loo CH, Tan WC

Med J Malaysia, 2018 10;73(5):338-339.

PMID: 30350820 MyJurnal

Confluent and reticulated papillomatosis (CRP) was first described in 1927 by Gougerot and further characterised by Carteud.1 It is relatively rare, and the exact pathophysiology was not well known. Over the years, multiple treatment modalities were proposed. We report our experience with three cases of CRP which showed complete clearance with tetracycline group of antibiotics.

Matched MeSH terms: Skin Neoplasms

Fulltext Hidden Choroidal Melanoma Presented with Bullous Non-rhegmatogenous Retinal Detachment in a Myopic Asian Lady: A Rare Manifestation

Ibrahim N, Sakinah Z, Abdul Ghani Z, Ibrahim M

Cureus, 2019 Mar 27;11(3):e4335.

PMID: 31187000 DOI: 10.7759/cureus.4335

Choroidal melanoma is an uncommon malignant melanoma among non-Caucasians. We report here a case of a high myope patient who presented with symptoms of acute retinal detachment, which had been diagnosed as possible rhegmatogenous retinal detachment from the initial assessment. A detailed vitreoretinal evaluation revealed a glimpse of an obscured intraocular mass underneath the detached retina, which later proved to be a choroidal melanoma. This is an unexpected cause of retinal detachment in a myopic eye. Furthermore, the rare nature of choroidal melanoma in this particular region of the world makes this an ignored diagnosis at presentation.

Matched MeSH terms: Skin Neoplasms

Fulltext Nevus lipomatosus superficialis

Yap FB

Singapore Med J, 2009 May;50(5):e161-2.

PMID: 19495497

Nevus lipomatosus superficialis is a rare benign skin malformation characterised by ectopic adipocytes in the upper dermis. It is classified into two types: a classical Hoffman-Zurhelle type and the solitary type. A case of the classical type with multiple soft, non-tender, pedunculated, cerebriform, skin-coloured papules and nodules over the right lower back is presented in a 21-year-old Malay woman. She had a rare occurrence of ulceration and necrosis of the lesions.

Matched MeSH terms: Skin Neoplasms/diagnosis; Skin Neoplasms/pathology; Skin Neoplasms/surgery

Fulltext Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration

Shamsudin N, Chang CC

Singapore Med J, 2012 Sep;53(9):e198-200.

PMID: 23023915

We report a case of systemic diffuse large B-cell lymphoma presenting with extensive infiltration of the skin. A 56-year-old woman presented with a two-month history of pruritic erythematous plaques and nodules over the neck, trunk and upper limbs. She also had night sweats, weight loss, lethargy and reduced effort tolerance. Systemic examination revealed a pale, ill appearance with hepatosplenomegaly and lymphadenopathy. Blood investigations showed pancytopenia (haemoglobin 6.3 g/dL, total white cell count 3.0 × 10(9)/L, platelet count 138 × 10(9)/L) with a few suspicious mononuclear cells and a mildly elevated lactate dehydrogenase level (478 U/L). Skin biopsy demonstrated diffuse sheets and nodular infiltrates of CD20 and CD79a positive neoplastic cells in the dermis and subcutis. Computed tomography revealed multiple cervical, axillary, mediastinal, para-aortic and mesenteric lymph nodes. Bone marrow aspiration and trephine biopsy confirmed marrow involvement by non-Hodgkin's lymphoma. The patient was treated with chemotherapy, which resulted in resolution of the skin lesions.

Matched MeSH terms: Skin Neoplasms/complications; Skin Neoplasms/drug therapy; Skin Neoplasms/pathology; Skin Neoplasms/secondary*

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