Browse publications by year: 2001

  1. Tee ES
    Biomed Environ Sci, 2001 Jun;14(1-2):87-91.
    PMID: 11594485
    A workshop on National Plans of Action for Nutrition: Constraints, Key Elements for Success, and Future Plans was convened and organized by the WHO Regional Office for the Western Pacific in collaboration with the Institute for Medical Research Malaysia and co-sponsored with FAO and UNICEF from 25-29 October 1999. It was attended by representatives of 25 countries in the region and resource persons, representatives from WHO and other international agencies. The objectives of the workshop were to review the progress of countries in developing, implementing and monitoring national plans of action for nutrition (NPANs) in the Western Pacific Region and to identify constraints and key elements of success in these efforts. Most of the countries have NPANs, either approved and implemented or awaiting official endorsement. The Plan formulation is usually multisectotal, involving several government ministries, non-governmental organizations, and international agencies. Often official adoption or endorsement of the Plan comes from the head of state and cabinet or the minister of health, one to six years from the start of its formulation. The NPAN has stimulated support for the development and implementation of nutrition projects and activities, with comparatively greater involvement of and more support from government ministries, UN agencies and non-governmental agencies compared to local communities, bilateral and private sectors and research and academic institutions. Monitoring and evaluation are important components of NPANs. They are, however, not given high priority and often not built into the plan. The role of an intersectoral coordinating body is considered crucial to a country's nutrition program. Most countries have an intersectoral structure or coordinating body to ensure the proper implementation, monitoring and evaluation of their NPANs. The workshop identified the constraints and key elements of success in each of the four stages of the NPAN process: development, operationalization, implementation, and monitoring and evaluation. Constraints to the NPAN process relate to the political and socioeconomic environment, resource scarcity, control and management processes, and factors related to sustainability. The group's review of NPAN identified successful NPANs as those based on recent, adequate and good quality information on the nutritional situation of the country, and on the selection of strategies, priorities and interventions that are relevant to the country and backed up by adequate resources. Continued high level political commitment, a multisectoral approach, and adequate participation of local communities are other key elements for success. The participants agreed on future actions and support needed from various sources for the further development, implementation, monitoring and evaluation of their NPANs. The recommendations for future actions were categorized into actions pertaining to countries with working NPAN, actions for countries without working NPAN and actions relevant to all countries. There was also a set of suggested actions at the regional level, such as holding of regular regional NPAN evaluation meetings, inclusion of NPAN on the agenda of regional fora by the regional organizations, and strengthening of regional nutrition networks.
    MeSH terms: Humans; International Cooperation*; Policy Making; Public Health*; World Health Organization*; Nutrition Policy*; Guideline Adherence
  2. Boey CC, Goh KL
    J Psychosom Res, 2001 Oct;51(4):559-62.
    PMID: 11595243
    This study aimed to look at the link between childhood recurrent abdominal pain (RAP) and the presence of recent life-events in an urban community in Malaysia. School children aged from 9 to 15 years in the city of Petaling Jaya were randomly selected to fill in a questionnaire and to be interviewed. The prevalence of RAP among 1488 school children studied was 9.6% (95% confidence interval (CI), 8.18-11.25). Higher prevalences of RAP were found in children who had experienced the following life-events in the previous year: loss of a family member through death (P
    MeSH terms: Adolescent; Child; Female; Humans; Life Change Events*; Malaysia; Male; Recurrence; Risk Factors; Somatoform Disorders/psychology*; Urban Population*; Abdominal Pain/psychology*
  3. Jusoh WJ, Heaney JG, Goldsmith RE
    Psychol Rep, 2001 Jun;88(3 Pt 2):1142-4.
    PMID: 11597068
    Consumers' self-assessments of materialism and status consumption may be influenced by external economic conditions. In this study, 239 Malaysian students were asked to describe their levels of materialism using Richins and Dawson's 1992 Materialism scale and status consumption using Eastman, Goldsmith, and Flynn's 1999 Status Consumption Scale. Half the students were told to respond assuming that they were in an expanding economy, and half as if the economy was in a recession. Comparison of the groups' mean scores showed no statistically significant differences.
    MeSH terms: Adult; Female; Humans; Malaysia; Male; Self-Assessment*; Social Class
  4. Shamsuddin K, Mahdy ZA, Siti Rafiaah I, Jamil MA, Rahimah MD
    Int J Gynaecol Obstet, 2001 Oct;75(1):27-32.
    PMID: 11597616 DOI: 10.1016/s0020-7292(01)00468-4
    OBJECTIVES: To assess the prevalence and association of frequently used screening risk factors for gestational diabetes mellitus (GDM) and to compare the validity and cost of universal screening with risk factor screening.

    METHOD: A cross-sectional survey of 768 pregnant women at > or = 24 weeks' gestation who were attending the antenatal clinic at the Hospital Universiti Kebangsaan Malaysia (HUKM) was made. Risk factors were determined using a questionnaire. An abnormal oral glucose tolerance test was defined as a 2-h post-prandial blood sugar level of > or = 7.8 mmol/l.

    RESULTS: A total of 191 pregnant mothers (24.9%) had GDM. The most commonly identified screening factors were positive family history of diabetes mellitus (31.4%), history of spontaneous abortion (17.8%), vaginal discharge and pruritus vulvae in current pregnancy (16.0%), and maternal age greater than 35 years (14.7%). Five hundred and thirteen mothers (66.8%) had at least one risk factor. All screening risk factors, except past history of diabetes mellitus in previous pregnancy and maternal age, were not significantly associated with abnormal glucose tolerance (GT). Risk factor screening gave a sensitivity of 72.2% and a specificity of 35.0%. Universal screening would cost RM 12.06 while traditional risk factor screening would cost RM 11.15 per identified case and will have missed 53 of the 191 cases.

    CONCLUSIONS: Risk factor screening scored poorly in predicting GDM. Cost analysis of universal compared with traditional risk factor screening showed a negligible difference. Thus universal screening appears to be the most reliable method of diagnosing GDM.
    MeSH terms: Adult; Blood Glucose/analysis; Cost-Benefit Analysis/economics; Cross-Sectional Studies; Female; Glucose Tolerance Test/economics; Humans; Mass Screening/economics*; Maternal Age; Parity; Pregnancy; Pregnancy Outcome; Surveys and Questionnaires; Risk Factors; Sensitivity and Specificity; Reproducibility of Results; Diabetes, Gestational/diagnosis*; Diabetes, Gestational/economics; Diabetes, Gestational/etiology*
  5. Chua BH, McMinn PC, Lam SK, Chua KB
    J Gen Virol, 2001 Nov;82(Pt 11):2629-39.
    PMID: 11602774
    The complete nucleotide sequences are reported of two strains of echovirus 7, the prototype Wallace strain (Eo7-Wallace) and a recent Malaysian strain isolated from the cerebrospinal fluid of a child with fatal encephalomyelitis (Eo7-UMMC strain). The molecular findings corroborate the serological placement of the UMMC strain as echovirus 7. Both Eo7-Wallace and Eo7-UMMC belong to the species human enterovirus B and are most closely related to echovirus 11. Eo7-UMMC has undergone significant genetic drift from the prototype strain in the 47 years that separate the isolation of the two viruses. Phylogenetic analysis revealed that Eo7-UMMC did not arise from recombination with another enterovirus serotype. The molecular basis for the severely neurovirulent phenotype of Eo7-UMMC remains unknown. However, it is shown that mutations in the nucleotide sequence of the 5' untranslated region (UTR) of Eo7-UMMC result in changes to the putative structure of the 5' UTR. It is possible that these changes contribute to the neurovirulence of Eo7-UMMC.
    MeSH terms: Amino Acid Sequence; Base Sequence; Cerebrospinal Fluid/virology; Child, Preschool; Enterovirus Infections/virology*; Gene Frequency*; Humans; Male; Molecular Sequence Data; Nucleic Acid Conformation; Phylogeny; Genome, Viral*; Sequence Analysis, DNA; Encephalitis, Viral/virology*; Enterovirus B, Human/classification; Enterovirus B, Human/genetics*; Enterovirus B, Human/chemistry
  6. Manickam S, Abidi SS
    Stud Health Technol Inform, 2001;84(Pt 1):643-7.
    PMID: 11604816
    Development and usage of Case Based Reasoning (CBR) driven medical diagnostic system requires a large volume of clinical cases that depict the problem-solving methodology of medical experts. Successful usage of CBR based systems in healthcare is constrained by the need for a continuous supply of current and correct clinical cases (in an electronic medium) from medical experts. To address this constraint we present a strategy to pro-actively transform generic Electronic Patient Records (EPR) to Operable CBR-oriented Cases (OCC) that are compliant to specialised CBR-based medical systems. EPR-OCC transformation methodology is based on XML parse-trees, Unified Medical Language Source (UMLS) meta-thesauri and medical knowledge ontologies. The featured work involves the implementation of a Java-based computer system for the automatic transformation of XML-based EPR-originating from heterogeneous EPR repositories accessible over the Internet/WWW-to specialised OCC that can then be seamlessly incorporated within Intelligent CBR-based Medical Diagnostic Systems.
    MeSH terms: Diagnosis, Computer-Assisted*; Humans; Programming Languages; Medical Records Systems, Computerized/organization & administration*; Unified Medical Language System; Internet
  7. Abidi SS, Han CY, Abidi SR
    Stud Health Technol Inform, 2001;84(Pt 2):1425-9.
    PMID: 11604961
    We present an Internet-based Personalised Healthcare Information (PHI) dissemination system. Information personalisation is guided by the individual's current health profile as recorded in his/her EMR. A PHI package is composed by intelligently selecting and synthesizing various topic-specific documents, each corresponding to some health parameter noted in the EMR. To ensure medical consistency, constraint satisfaction techniques are employed during the information selection phase. The resultant PHI package--covering both long-term and immediate health-maintenance requirements--can be pro-actively pushed to the individual via email, thereby ensuring the timely availability of situation-specific health maintenance information. The featured work is in line with the Malaysian Multimedia Super Corridor Telemedicine initiative and can serve as a test-bed to evaluate the effectiveness of PHI, system design and operational considerations for larger-scale deployment.
    MeSH terms: Health Status; Humans; Patient Education as Topic/methods*; Medical Records Systems, Computerized; Patient Satisfaction; Telemedicine; Internet*
  8. Zamri-Saad M, Mera HR
    PMID: 11666033
    An experiment was designed to study the in vivo effect of Pasteurella haemolytica A2 infection on the phagocytosis activity of caprine broncho-alveolar macrophages and the extent of pneumonic lesions. Twelve healthy local Kacang goats, about 7 months of age, were divided into two groups of six. Goats in group 1 were inoculated intratracheally with 4 ml inoculum containing 2.8 x 10(9) colony-forming units (CFU)/ml of Staphylococcus aureus. Goats in group 2 were inoculated intratracheally with 4 ml of inoculum containing 9.5 x 10(8) CFU/ml of Pasteurella haemolytica A2 isolated earlier from pneumonic lungs of goat. At intervals of 3 and 7 days post-challenge five goats from each group were killed and the lungs were washed with sterile phosphate-buffered saline. Smears were prepared from the lung washing fluid and the number of macrophages with phagocytic activity was determined. At day 3 post-infection, goats of both groups showed a similar pattern of pneumonic lesion. The lung washing fluid of goats in group 2 was found to contain numerous neutrophils and macrophages. Goats in group 2 showed significantly (P < 0.05) higher extent of lung lesions than group 1. Similarly, the average extent of lung lesions was significantly (P < 0.05) more severe in group 2 at day 7 post-infection. The lung washing fluid contained mostly macrophages. The phagocytic activity following S. aureus infection was more efficient and significantly (P < 0.01) higher compared with infection by P. haemolytica A2. There were weak correlations between the extent of pneumonic lesion and the phagocytic activity. Thus, goats with poor phagocytic activity were likely to develop more extensive lung lesions.
    MeSH terms: Administration, Intranasal; Animals; Bronchi/immunology*; Bronchi/microbiology; Bronchoalveolar Lavage Fluid/cytology; Goats; Phagocytosis; Pasteurellosis, Pneumonic/immunology*; Pasteurellosis, Pneumonic/pathology; Staphylococcus aureus/immunology; Goat Diseases/immunology*; Goat Diseases/pathology; Macrophages, Alveolar/immunology*; Macrophages, Alveolar/microbiology; Mannheimia haemolytica/immunology*
  9. Ahmad NL, Norsidah AM
    Anaesth Intensive Care, 2001 Oct;29(5):510-4.
    PMID: 11669433
    In this prospective, randomized controlled trial, changes in endotracheal tube cuff pressure were studied in 60 patients undergoing elective surgery under general anaesthesia with nitrous oxide and oxygen. The cuffs were inflated with either air or distilled water. The mean pressure in the air-filled cuffs increased steadily throughout the procedure, reaching 47.5 +/- 7.3 cmH2O at one hour compared with 31.6 +/- 2.4 cmH2O mean pressure in the water-filled cuffs. The pressure and the rate of rise in cuff pressure were significantly lower (P<0.05) in the water-filled cuffs throughout the hour of study. When an endotracheal tube cuff is distended with water, the rise in cuff pressure during nitrous oxide anaesthesia is lower than that of an air-filled cuff.
    MeSH terms: Adolescent; Adult; Aged; Air; Anesthesia, Inhalation*; Female; Humans; Male; Middle Aged; Nitrous Oxide*; Pressure; Prospective Studies; Water*; Anesthetics, Inhalation*
  10. Deurenberg-Yap M, Chew SK, Lin VF, Tan BY, van Staveren WA, Deurenberg P
    Int. J. Obes. Relat. Metab. Disord., 2001 Oct;25(10):1554-62.
    PMID: 11673781 DOI: 10.1038/sj.ijo.0801739
    OBJECTIVE: To investigate the effect of body mass index (BMI) and body fat distribution as measured by waist-to-hip ratio (WHR) on the cardiovascular risk factor profile of the three major ethnic groups in Singapore (Chinese, Malay and Indian people) and to determine if WHO recommended cut-off values for BMI and WHR are appropriate for the different sub-populations in Singapore.
    DESIGN: Cross-sectional population study.
    SUBJECTS: A total of 4723 adult subjects (64% Chinese individuals, 21% Malay individuals and 15% Indian individuals) were selected through a multi-staged sampling technique to take part in the National Health Survey in 1998.
    MEASUREMENTS: Data on socio-economic status (education level, occupation, housing type) and lifestyle habits (smoking and physical activity), body weight, body height, waist and hip circumferences and blood pressure measured using standardised protocols. Fasting venous blood samples were obtained for determination of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), triglycerides (TG). Venous blood samples were taken for 2 h oral glucose tolerance test (2 h glu).
    RESULTS: Absolute and relative risks for at least one cardiovascular risk factor (elevated TC, elevated TC/HDL ratio, elevated TG, hypertension and diabetes mellitus) were determined for various categories of BMI and WHR. At low categories of BMI (BMI between 22 and 24 kg/m(2)) and WHR (WHR between 0.80 and 0.85 for women, and between 0.90 and 0.95 for men), the absolute risks are high, ranging from 41 to 81%. At these same categories the relative risks are significantly higher compared to the reference category, ranging from odds ratio of 1.97 to 4.38. These categories of BMI and WHR are all below the cut-off values of BMI and WHR recommended by WHO.
    CONCLUSIONS: The results show that, at relatively low BMI and WHR, Singaporean adults experience elevated levels of risks (absolute and relative) for cardiovascular risk factors. These findings, in addition to earlier reported high percentage body fat among Singaporeans at low levels of BMI, confirm the need to revise the WHO cut-off values for the various indices of obesity and fat distribution, viz BMI and WHR, in Singapore.
    MeSH terms: Adolescent; Adult; Aged; Body Constitution; Cardiovascular Diseases/ethnology; Cardiovascular Diseases/etiology*; Cardiovascular Diseases/epidemiology; China/ethnology; Cross-Sectional Studies; Female; Health Surveys; Humans; India/ethnology; Life Style; Malaysia/ethnology; Male; Middle Aged; Obesity/ethnology*; Obesity/epidemiology; Reference Values; Risk; Sex Characteristics; Singapore; Singapore/epidemiology; Social Class; Comorbidity; Body Mass Index; Odds Ratio
  11. Moissinac K, To BC, Gul YA, Liew NC
    Trop Doct, 2001 Oct;31(4):217.
    PMID: 11676058
    MeSH terms: Adult; Appendectomy; Appendicitis/pathology*; Appendicitis/surgery*; Diagnosis, Differential; Female; Humans; Male; Recurrence; Reoperation*
  12. Al-Haddawi MH, Jasni S, Israf DA, Zamri-Saad M, Mutalib AR, Sheikh-Omar AR
    Res Vet Sci, 2001 Jun;70(3):191-7.
    PMID: 11676614
    Sixteen 8- to 9-week-old Pasteurella multocida-free New Zealand White rabbits were divided into two equal groups. The first group was inoculated intranasally with P multocida serotype D:1 strain and the second group that was inoculated with phosphate-buffered saline (PBS) only was used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and from tracheal swabs of seven rabbits in this group. Four rabbits in group 1 died with clinical signs of septicaemia, two rabbits had mucopurulent nasal discharge and pneumonic lesions and the other two did not show any clinical signs or gross lesions. The ultrastructural changes detected were deciliation or clumping of cilia of ciliated epithelium, cellular swelling, vacuolation and sloughing. The subepithelial capillaries showed congestion, intravascular fibrin deposition, platelets aggregation and endothelial injury. Pasteurella multocida was observed attached to the injured endothelial cells. Heterophils, mast cells, vacuolated monocytes and macrophages infiltrated the lamina propria and between the degenerated epithelial cells.
    MeSH terms: Animals; Antibodies, Bacterial/blood; Bacterial Toxins/analysis; Bacterial Toxins/biosynthesis; Microscopy, Electron/veterinary; Nasal Cavity/microbiology; Nasal Cavity/pathology; Nasal Cavity/ultrastructure; Nasal Mucosa/microbiology; Nasal Mucosa/pathology*; Nasal Mucosa/ultrastructure; Nose Diseases/microbiology; Nose Diseases/pathology; Nose Diseases/veterinary*; Pasteurella Infections/microbiology; Pasteurella Infections/pathology; Pasteurella Infections/veterinary*; Rabbits/microbiology*; Trachea/microbiology; Trachea/pathology*; Trachea/ultrastructure; Tracheal Diseases/microbiology; Tracheal Diseases/pathology; Tracheal Diseases/veterinary*; Pasteurella multocida/growth & development*
  13. Fadilah SA, Cheong SK, Maimunah A, Toh ST, Shamin AS
    Postgrad Med J, 2001 Nov;77(913):733-4, 737-9.
    PMID: 11677287
    MeSH terms: Adult; Amphotericin B/therapeutic use; Antifungal Agents/therapeutic use; Aspergillosis/drug therapy; Aspergillosis/etiology*; Aspergillus fumigatus/isolation & purification*; Humans; Lung Diseases, Fungal/drug therapy; Lung Diseases, Fungal/etiology*; Male; Tomography, X-Ray Computed; Leukemia, Myeloid, Acute/complications*; Immunocompromised Host
  14. Jeyaratnam TS, Ahmad TS, Kassim NM
    Hand Surg, 2001 Jul;6(1):99-102.
    PMID: 11677671
    MeSH terms: Esthetics; Finger Injuries/diagnosis; Finger Injuries/surgery*; Hand Injuries/diagnosis; Hand Injuries/surgery; Humans; Male; Metacarpophalangeal Joint/injuries; Metacarpophalangeal Joint/surgery*; Middle Aged; Surgical Flaps*; Tendon Transfer/methods*; Tendons/surgery; Wound Healing; Treatment Outcome; Ulnar Artery/transplantation*; Reconstructive Surgical Procedures/methods; Recovery of Function
  15. Lui JL
    Dent Traumatol, 2001 Oct;17(5):227-30.
    PMID: 11678543
    The composite reinforcement technique has been used clinically to salvage damaged root-filled teeth compromised by caries, trauma, developmental abnormalities, internal resorption and iatrogenic causes. This clinical case report describes the use of the technique to reattach a fractured fragment in a compromised endodontically treated root besides reinforcing it for continued function in the mouth. Factors of clinical importance related to this additional application; including reattachment of tooth fragments, post crown retention, coronal microleakage and fracture resistance and strength, are also briefly discussed.
    MeSH terms: Acid Etching, Dental; Adult; Follow-Up Studies; Humans; Incisor/injuries*; Male; Root Canal Therapy*; Tooth Fractures/therapy*; Tooth Root/injuries*; Metal Ceramic Alloys/chemistry; Dental Prosthesis Design; Retreatment; Resin Cements/chemistry
  16. Karupaiah T, Swee CS, Abdullah R
    J Ren Nutr, 2001 Oct;11(4):220-7.
    PMID: 11680003
    To develop an education package with uniform nutrition messages appropriate for Malaysian patients undergoing hemodialysis.
    MeSH terms: Diet; Food Analysis; Food Habits; Health Education; Humans; Malaysia; Nutrition Disorders/etiology; Nutrition Disorders/prevention & control; Patient Education as Topic*; Teaching/methods*; Nutritional Sciences/education*
  17. Rehman A, Rahman AR, Rasool AH, Naing NN
    Int J Clin Pharmacol Ther, 2001 Oct;39(10):423-30.
    PMID: 11680667
    To examine the dose response relationship between Ang II and pulse wave velocity (an index of arterial stiffness) in healthy human volunteers.
    MeSH terms: Adult; Analysis of Variance; Angiotensin II/pharmacology*; Dose-Response Relationship, Drug; Double-Blind Method; Hemodynamics/drug effects*; Humans; Infusions, Intravenous; Male; Vasoconstrictor Agents/pharmacology*; Cross-Over Studies
  18. Fleischer RC, Perry EA, Muralidharan K, Stevens EE, Wemmer CM
    Evolution, 2001 Sep;55(9):1882-92.
    PMID: 11681743
    Populations of the Asian elephant (Elephas maximus) have been reduced in size and become highly fragmented during the past 3,000 to 4,000 years. Historical records reveal elephant dispersal by humans via trade and war. How have these anthropogenic impacts affected genetic variation and structure of Asian elephant populations? We sequenced mitochondrial DNA (mtDNA) to assay genetic variation and phylogeography across much of the Asian elephant's range. Initially we compare cytochrome b sequences (cyt b) between nine Asian and five African elephants and use the fossil-based age of their separation (approximately 5 million years ago) to obtain a rate of about 0.013 (95% CI = 0.011-0.018) corrected sequence divergence per million years. We also assess variation in part of the mtDNA control region (CR) and adjacent tRNA genes in 57 Asian elephants from seven countries (Sri Lanka, India, Nepal, Myanmar, Thailand, Malaysia, and Indonesia). Asian elephants have typical levels of mtDNA variation, and coalescence analyses suggest their populations were growing in the late Pleistocene. Reconstructed phylogenies reveal two major clades (A and B) differing on average by HKY85/gamma-corrected distances of 0.020 for cyt b and 0.050 for the CR segment (corresponding to a coalescence time based on our cyt b rate of approximately 1.2 million years). Individuals of both major clades exist in all locations but Indonesia and Malaysia. Most elephants from Malaysia and all from Indonesia are in well-supported, basal clades within clade A. thus supporting their status as evolutionarily significant units (ESUs). The proportion of clade A individuals decreases to the north, which could result from retention and subsequent loss of ancient lineages in long-term stable populations or, perhaps more likely, via recent mixing of two expanding populations that were isolated in the mid-Pleistocene. The distribution of clade A individuals appears to have been impacted by human trade in elephants among Myanmar, Sri Lanka, and India, and the subspecies and ESU statuses of Sri Lankan elephants are not supported by molecular data.
    MeSH terms: Animals; Asia; Calibration; Cytochrome b Group/genetics; DNA, Mitochondrial/genetics*; Elephants/classification*; Elephants/genetics*; Geography; Phylogeny*; Reproducibility of Results; Evolution, Molecular
  19. Niti M, Ng TP
    Int J Epidemiol, 2001 Oct;30(5):966-73.
    PMID: 11689505
    BACKGROUND: Amenable mortality is used to assess the effects of health care services on gains in mortality outcomes. Possibly differing patterns of trends in amenable mortality may be expected in economically less developed countries, which have undergone rapid epidemiological transition and recent reforms in health care systems, but such studies are scarce. This study was set up to examine the trends in amenable mortality in Singapore from 1965 to 1994; to estimate the relative impact of medical care and primary preventive policy measures in terms of gains in mortality outcomes; to examine ethnic differences in amenable mortality among Chinese, Malays and Indians.

    METHODS: Age-standardized mortality rates were calculated for 16 amenable causes of death in Singapore for six 5-year periods (1965-1969,..., 1990-1994), and for each of the three main ethnic groups for three periods (1989-1991, 1992-1994, 1995- 1997). Amenable mortality rates were divided into those which can be reduced by timely therapeutic care for 'treatable' conditions (e.g. asthma and appendicitis), or by primary preventive measures for 'preventable' conditions (e.g. lung cancer and motor vehicle injury).

    RESULTS: Amenable mortality was higher in males (age-standardized rate 109.7 per 100 000 population) than in females (age-standardized rate 60.7 per 100 000 population). Amenable mortality declined by 1.77% a year in males and 1.72% a year in females. By comparison, the average yearly decline in non-amenable mortality was 0.91% in males and 1.17% in females. The decline in amenable mortality was largely due to 'treatable' causes rather than a decline in mortality due to 'preventable' causes of death. Amenable mortality was lowest for Chinese and highest for Malays. Over the recent 9-year period from 1989 to 1997, amenable mortality declined more in Chinese than in Malays and Indians. However, Indian females showed by far the sharpest decline, whereas Indian males, by contrast, showed an increase in amenable mortality, due to both treatable and preventable causes.

    CONCLUSIONS: In line with findings from European countries, amenable mortality in Singapore declined more than non-amenable mortality. There were more significant gains in mortality outcomes from medical care interventions than from primary preventive policy measures. Gender and ethnic differences in amenable mortality were also observed, highlighting issues of socioeconomic equities to be addressed in the financing and delivery of health care.

    MeSH terms: Adolescent; Adult; Aged; Cause of Death; Child; Child, Preschool; China/ethnology; Ethnic Groups/statistics & numerical data*; Female; Humans; India/ethnology; Malaysia/ethnology; Male; Middle Aged; Mortality/trends*; Quality of Health Care*; Singapore/epidemiology; Health Transition*
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