Browse publications by year: 2002

  1. Kananatu K
    Asia Pac J Public Health, 2002;14(1):23-8.
    PMID: 12597514
    This paper presents an overview of the Malaysian healthcare system and its method of financing. The development of the healthcare delivery system in Malaysia is commendable. However, the strength and weaknesses of the public healthcare system and the financing problems encountered are also discussed. Cost of healthcare and funding of both the public and private sectors were also revealed. One must optimise the advantages of operating a health financing scheme which is affordable and controllable which contribute towards cost-containment and quality assurance. Thus, there is a need for the establishment of a National Healthcare Financing, a mechanism to sustain the healthcare delivery network and operate it as a viable option. A model of the National Health Financing Scheme (NHFS) was proposed.
    MeSH terms: Delivery of Health Care/economics*; Delivery of Health Care/organization & administration; Delivery of Health Care/standards; Health Expenditures/trends; Financing, Government*; Humans; Malaysia; National Health Programs/economics*; Public Health Administration; Quality Assurance, Health Care; Social Change; Health Care Costs/trends; Models, Organizational; Private Sector; Health Care Reform/economics*
  2. Yusof K, Neoh KH, bin Hashim MA, Ibrahim I
    Asia Pac J Public Health, 2002;14(1):29-34.
    PMID: 12597515
    The equitable access to quality healthcare by Malaysians has consistently been the primary objective of the Ministry of Health (MOH). The epidemiological transition to chronic illnesses, advances in medical technology, escalating healthcare costs and rising patient expectations has necessitated the strategic use of information systems in healthcare delivery. Malaysia has broken new ground by implementing a nationwide network to address inadequate access to healthcare, as well as to lower costs and achieve better health outcomes. Teleconsultation refers to the electronic transmission of medical information and services from one site to another using telecommunication technologies. This technology transforms the healthcare system by rapidly matching patient needs with the appropriate level of care however geographically remote they may be. Our findings suggest that even in these early stages of implementation, teleconsultation has led to cost savings, a more efficient allocation of resources, enhanced diagnostic options and better health outcomes.
    MeSH terms: Delivery of Health Care/organization & administration*; Diffusion of Innovation; Health Services Accessibility; Humans; Malaysia; Public Health Administration; Quality Assurance, Health Care; Social Change; Telemedicine/organization & administration*; Efficiency, Organizational; Health Care Reform*; Remote Consultation*; Health Transition
  3. Zaini A, Nayan NF
    Asia Pac J Public Health, 2002;14(1):44-6.
    PMID: 12597518 DOI: 10.1177/101053950201400110
    WHO's Declaration of the "Health for All" (HFA) goal was pronounced in 1978 in Alma Ata, and it was planned that HFA would be achieved through primary health care programmes and approaches by 2000. However, it is now 2002 and despite the technological advancements in medicine, science, and ICT, Health for All is far from reality. Instead, more and more conflicts are emerging with lethal consequences, such as, bioterrorism, biological agent abuse, global-terrorism, and environmental destruction is occurring at a greater scale that we have witnessed before. We may have the latest technology and knowledge today, but ironically, we are using them to inflict more suffering and pain in the world. In the Asia-Pacific, the past 30 years has seen dramatic advancement and lifestyle changes. We are now paying a high price for such progress in terms of risk factors to the health of the population, such as, ageing diseases, obesity, smoking, diabetes, hypertension, and related conditions. The social, political, economic and environmental factors appeared to have deterred and negated WHO's HFA goal to attain basic human rights and health care for all. The HFA will not be achieved in the future if we do not learn from history and start taking measures now.
    MeSH terms: Asia, Southeastern/epidemiology; Health Status; Humans; Life Style; Malaysia/epidemiology; Organizational Innovation; Organizational Objectives; Pacific Islands/epidemiology; Primary Health Care; Social Change*; World Health Organization; Health Care Reform*; Healthy People Programs*
  4. Lee L, Patrick W, Asia-Pacific Academic Consortium for Public Health
    Asia Pac J Public Health, 2002;14(1):47-8.
    PMID: 12597519
    MeSH terms: Awards and Prizes*; Faculty, Medical; Humans; Leadership*; Malaysia; Public Health*; History, 20th Century; History, 21st Century
  5. Siow KK, Ong ST, Lian CB, Ngeow WC
    J Oral Sci, 2002 Dec;44(3-4):165-71.
    PMID: 12613507
    Thirty-one patients treated at the Faculty of Dentistry, University of Malaya, were assessed for their satisfaction following orthognathic surgery. The female to male ratio was 22:9 with an age range of 17 to 36. Almost all patients (97%) listed appearance as one of their rationales for surgery. More males (78%) than females (59%) wanted functional improvement, while more females (91%) than males (33%) hoped for improvement in self-confidence. All patients reported esthetic improvement while 68% each reported improvement in mastication and self-confidence. Slightly more than half (52%) chose esthetic improvement as the single most important factor resulting in satisfaction. Almost ninety percent of male patients claimed satisfaction with functional improvement, while 68% of those who found satisfaction in improved self-confidence were females. Eighty-seven percent rated their post-surgical changes as being well accepted by their family. The impact of these findings on the success of the surgery and the need to reinforce verbal communication with printed pamphlets are emphasized.
    MeSH terms: Adolescent; Adult; Attitude to Health; Cleft Lip/surgery*; Cleft Palate/surgery*; Esthetics, Dental; Female; Humans; Hypesthesia/etiology; Malaysia; Male; Malocclusion/surgery*; Malocclusion, Angle Class II/surgery; Malocclusion, Angle Class III/surgery; Mastication/physiology; Maxilla/abnormalities; Maxilla/surgery; Motivation; Patient Education as Topic; Postoperative Complications; Prognathism/surgery; Self Concept; Sex Factors; Statistics as Topic; Treatment Outcome; Patient Satisfaction*
  6. Malik AS, Malik RH
    Med Teach, 2002 Nov;24(6):616-21.
    PMID: 12623455
    The curriculum of the Faculty of Medicine and Health Sciences (FMHS) is designed particularly to cater for the health needs of the State of Sarawak, Malaysia. The framework of the curriculum is built on four strands: biological knowledge, clinical skills, behavioural and population aspects. The training is community based and a graduate of FMHS is expected to possess the ability to deal with many ethnic groups with different cultures and beliefs; expertise in tropical infectious diseases; skills to deal with emergencies such as snakebite and near drowning; qualities of an administrator, problem-solver and community leader; and proficiency in information and communication technology. The content of the curriculum strives for commitment to lifelong learning and professional values. The FMHS has adopted a 'mixed economy' of education strategies and a 'mixed menu approach' to test a wide range of curriculum outcomes. The FMHS fosters intellectual and academic pursuits, encourages friendliness and a sense of social responsibility and businesslike efficiency.
    MeSH terms: Curriculum*; Education, Medical, Undergraduate/organization & administration*; Humans; Malaysia; Problem Solving; Professional Competence; Schools, Medical/organization & administration*; Social Responsibility; Cultural Diversity; Needs Assessment
  7. Chang MS
    Ann Trop Med Parasitol, 2002 Dec;96 Suppl 2:S71-6.
    PMID: 12625920
    An estimated 13 million people in the Oriental Region have brugian filariasis. The filarial parasites that cause this disease exist in periodic and sub-periodic forms and are transmitted by four genera of mosquito: Anopheles, Mansonia and, less frequently, Coquillettidia and Ochlerotatus. In most endemic countries, control of the disease has been entirely based on chemotherapy, although house-spraying and use of insecticide-treated bednets can be quite effective against the vectors of nocturnally periodic Brugia malayi and B. timori. The vector-control methods that may be applied against the Mansonia mosquitoes that transmit the parasites causing sub-periodic brugian filariasis are reviewed here. Most of the conventional methods for controlling the immature, aquatic stages of mosquitoes have proved unsatisfactory against Mansonia. The reason is that, unlike the those of other genera, the larvae and pupae of Mansonia spp. are relatively immobile and obtain air not at the water surface but from the underwater roots, stems and leaves of floating plants to which the larvae and pupae attach. Removal of host plants can be very effective in reducing Mansonia productivity, whereas large-scale use of herbicides is restricted by the potential adverse effects on the ecosystem. Environmental management in water-development projects remains the best option.
    MeSH terms: Animals; Brugia*; Diethylcarbamazine/therapeutic use; Disease Vectors*; Elephantiasis, Filarial/prevention & control*; Elephantiasis, Filarial/transmission; Environment; Filaricides/therapeutic use; Humans; Insecticides/pharmacology; Larva; Mosquito Control/methods*; Culicidae/parasitology*; Pupa; Brugia malayi
  8. Chuang LM, Tsai ST, Huang BY, Tai TY, Diabcare-Asia 1998 Study Group
    Diabet Med, 2002 Dec;19(12):978-85.
    PMID: 12647837 DOI: 10.1046/j.1464-5491.2002.00833.x
    AIMS: To establish the status of diabetes control in Asia, the Diabcare-Asia 198 study collected data from 230 diabetes centres in Bangladesh, People's Republic of China, India, Indonesia, Malaysia, Philippines, Singapore, South Korea, Sri Lanka, Taiwan, Thailand and Vietnam from March to December 1998.

    METHODS: Data were obtained either by patient interview during the enrolment visit or by reviewing medical records for the most recent laboratory assessment and clinical examinations. Blood samples were also collected during patients'. visits for central assessments of HbA1c (normal range 4.7-6.4%).

    RESULTS: The mean of centrally measured HbA1c was 8.6 +/- 2.0% for 18 211 patients (82% of the analysis population). Of the patients with central HbA1c measurements, the majority (55%) had values exceeding 8%, indicative of poor glycaemic control. The prevalence of retinopathy, microalbuminuria and neuropathy was also higher in the group of patients with higher HbA1c. Based on the findings from central HbA1c measurements and reported local HbA1c assessments, it also appears that more patients with poor glycaemic control did not have access to glycated haemoglobin measurements. Mean HbA1c of thediabetic populations in Bangladesh, Indonesia, Korea, Malaysia and Taiwan were significantly lower (all P = 0.0001, except P = 0.0007 for Malaysia), while that of China, India, Philippines and Vietnam was significantly higher (all P = 0.0001) than the grand mean.

    CONCLUSIONS: In our study population of the Asian diabetes patients treated at diabetes centres, more than half were not well controlled. The prevalence of diabetic microvascular complications was higher in the group of patients with higher HbA1c. Further therapeutic actions to improve glycaemic control are required to prevent chronic diabetic complications.
    MeSH terms: Adolescent; Adult; Aged; Aged, 80 and over; Asia/epidemiology; Blood Glucose/metabolism*; Child; Child, Preschool; Cross-Sectional Studies; Diabetes Mellitus/blood; Diabetes Mellitus/epidemiology; Diabetes Mellitus/prevention & control*; Female; Hemoglobin A, Glycosylated/analogs & derivatives*; Hemoglobin A, Glycosylated/analysis; Humans; Hyperglycemia/blood; Male; Middle Aged; Residence Characteristics
  9. Ng KP, Soo-Hoo TS, Na SL, Ang LS
    Mycopathologia, 2002;155(4):203-6.
    PMID: 12650596
    A total of 576 dermatophytes were isolated from patients with a variety of skin infections from January 1993 to May 2000. Ten species of dermatophytes were identified: Epidermophyton floccosum (0.7%), Microsporum audouinii (1.1%), M. canis (3.1%), M. gypseum (0.3%), Trichophyton concentricum (3.5%), T. equinum (0.2%), T. mentagrophytes (36.1%), T. rubrum (53.8%), T. verrucosum (0.2) and T. violaceum (1.0%). The body sites most frequently affected by dermatophytes were the buttocks, nails and trunk. Anthropophilic dermatophytes made up 60.1% of the isolates; the most common species was T. rubrum, T. mentagrophytes and M. canis were the two main zoophilic dermatophytes. T. mentagrophytes was isolated from all body sites except the scalp. M. canis was found to be associated with domestic dogs and was not isolated from ethnic Malays. The only geophilic dermatophyte was M. gypseum, an uncommon dermatophyte associated with tinea pedis.
    MeSH terms: Dermatomycoses/microbiology*; Dermatomycoses/epidemiology; Arthrodermataceae/classification; Arthrodermataceae/isolation & purification*; Humans; Malaysia/epidemiology; Prevalence
  10. Jaarin K, Gapor MT, Nafeeza MI, Fauzee AM
    Int J Exp Pathol, 2002 Dec;83(6):295-302.
    PMID: 12657138 DOI: 10.1046/j.1365-2613.2002.00242.x
    This study examined the effects of vitamin E on the prevention of aspirin-induced gastric lesions. The study was divided into two phases. Phase 1 determined the effects of various doses of palm vitamin E on the factors affecting mucosal integrity. Thirty-two male rats of the Sprague-Dawley strain (200-250 g) were randomly divided into four groups. Group I was fed a normal diet (control), Groups II, III and IV were fed a diet supplemented with palm vitamin E in a dose of 60 mg/kg food, 100 mg/kg food and 150 mg/kg food, respectively. The rats were killed after 4 weeks of feeding for the determination of gastric malondialdehyde (MDA), acid and mucus content. There was a significant decrease in gastric MDA and gastric acid in all the palm vitamin E supplemented groups compared to control. However, these doses of palm vitamin E had no significant effect on gastric mucus. The phase 2 study determined the effect of multiple doses of palm vitamin E and tocopherol on the prevention of aspirin-induced gastric lesions. Fifty rats of the same weight and strain were randomized into seven groups. Group I was fed a normal diet; groups II to IV were fed with a palm vitamin E enriched diet in doses of 60 mg, 100 mg and 150 mg/kg food, respectively; groups V to VII were fed with a tocopherol-enriched diet in doses of 20 mg, 30 mg and 50 mg/kg food, respectively. After 4 weeks of feeding with the respective diets the rats were challenged with a single intra-gastric dose of 400 mg/kg body weight aspirin suspended in propylene glycol. The rats were killed 6 h post-aspirin exposure for the determination of gastric lesion index and gastric parameters as mentioned in the phase I study. The gastric lesions index was significantly lower in all the vitamin E groups compared to control. The lowest ulcer index was observed in the groups that received 100 mg of palm vitamin E and 30 mg tocopherol in the diet. However, there was no significant difference in ulcer indices between palm vitamin E and tocopherol-treated groups. The lower ulcer index was only accompanied by lower gastric MDA content. We conclude that both palm vitamin E in doses of 60 mg, 100 mg and 150 mg/kg food as well as tocopherol in doses of 20 mg, 30 mg and 50 mg/kg food are equally effective in preventing aspirin-induced gastric lesions. The most probable mechanism is through their ability in limiting the lipid peroxidation that is involved in aspirin-induced gastric lesions.
    MeSH terms: Animals; Anti-Inflammatory Agents, Non-Steroidal/adverse effects*; Aspirin/adverse effects*; Dose-Response Relationship, Drug; Gastric Mucosa/pathology; Gastric Mucosa/chemistry; Male; Malondialdehyde/analysis; Phytotherapy/methods*; Plant Oils*; Random Allocation; Stomach Ulcer/chemically induced; Stomach Ulcer/pathology; Stomach Ulcer/prevention & control*; Time Factors; Vitamin E/therapeutic use*; Wound Healing; Rats, Sprague-Dawley; Tocopherols/therapeutic use; Rats
  11. Thong KL, Hoe CH, Koh YT, Yasin RM
    J Health Popul Nutr, 2002 Dec;20(4):356-8.
    PMID: 12659418
    MeSH terms: Drug Resistance, Microbial*; Dysentery, Bacillary/microbiology; Dysentery, Bacillary/epidemiology*; Humans; Malaysia/epidemiology; Microbial Sensitivity Tests; Shigella/drug effects; Shigella/isolation & purification*; Prevalence; Drug Resistance, Multiple*
  12. Ang HH, Lee KL
    J Basic Clin Physiol Pharmacol, 2002;13(3):249-54.
    PMID: 12670032 DOI: 10.1515/jbcpp.2002.13.3.249
    The effect of increasing doses of various fractions of Eurycoma longifolia Jack extracts on libido was examined in middle-aged male rats. The results showed that a high dose (800 mg/kg) of all E. longifolia Jack extracts significantly increased mount frequency (MF) (P < 0.05) over that of untreated controls, but had no effect on the frequency of intromission or ejaculation. Methanol, chloroform, water, and butanol fractions exhibited MF of 2.5 +/- 0.1, 2.6 +/- 0.3, 2.5 +/- 0.1 and 2.6 +/- 0.2, respectively, in adult, middle-aged male rats, and retired breeders versus 2.3 +/- 0.1 in untreated controls. This translated to a minor increase in MF of 8.7%, 13.0%, 8.7%, and 13.0% for these fractions, respectively, during the 20-minute observation period. The results of this study show that E. longifolia Jack extracts can increase libido in middle-aged male rats.
    MeSH terms: Animals; Dose-Response Relationship, Drug; Ejaculation/drug effects; Libido/drug effects*; Male; Plant Extracts/pharmacology; Solvents; Stimulation, Chemical; Rats, Sprague-Dawley; Plant Roots/chemistry; Eurycoma/chemistry*; Rats
  13. Ang HH, Lee KL
    Fundam Clin Pharmacol, 2002 Dec;16(6):479-83.
    PMID: 12685506 DOI: 10.1046/j.1472-8206.2002.00106.x
    The effects of various fractions of Eurycoma longifolia Jack were studied on the orientation activities of the inbred, adult middle-aged Sprague-Dawley rats, 9 months old and retired breeders towards the receptive females (anogenital sniffing, licking, mounting), the environment (climbing, raring, exploration), themselves (nongenital grooming, genital grooming) and mobility (restricted, unrestricted) after treating these subjects twice daily for 10 days. Results showed that subjects treated with 800 mg/kg of E. longifolia Jack increased orientation activities towards the receptive females (anogenital sniffing, licking and mounting), increased genital grooming towards themselves and restricted movements to a particular area of the cage but decreased interest in the external environment (climbing, raring, exploration) as compared with the controls during the investigation period. In conclusion, this study gives further evidences that different fractions of E. longifolia Jack modified the orientation activities of the middle-aged male rats.
    MeSH terms: Animals; Aphrodisiacs/pharmacology; Dose-Response Relationship, Drug; Female; Male; Plant Extracts/pharmacology; Sexual Behavior, Animal/drug effects*; Rats, Sprague-Dawley; Plant Roots/chemistry; Eurycoma*; Rats
  14. Biswal BM, Sain AH, Othman NH, Baba A
    Trop Gastroenterol, 2002 Jul-Sep;23(3):134-7.
    PMID: 12693156
    Colorectal cancer is one of the most common malignancies in the West, but in Asia the incidence is low. However in Malaysia, colorectal cancer is increasing with a reported figure of 15% of all cancer cases. Adjuvant chemo and radiotherapy are now more frequently used in such patients. The present retrospective analysis was performed to document the effect of such therapy among patients with colorectal cancer in Malaysia.
    MeSH terms: Adult; Aged; Antimetabolites, Antineoplastic/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Female; Fluorouracil/administration & dosage; Humans; Malaysia/epidemiology; Male; Middle Aged; Radiotherapy Dosage; Retrospective Studies; Colorectal Neoplasms/drug therapy*; Colorectal Neoplasms/epidemiology; Colorectal Neoplasms/radiotherapy*; Incidence; Chi-Square Distribution; Survival Analysis; Treatment Outcome; Chemotherapy, Adjuvant; Radiotherapy, Adjuvant
  15. Rahman WA, Adanan CR, Abu Hassan A
    PMID: 12693589
    Using the cow-baited trap (CBT) method, 1,845 Anopheles mosquitos, comprising 14 species, were caught in malaria-endemic area of Hulu Perak district, Peninsular Malaysia. The two dominant species were An. barbirostris (18.59%) and An. aconitus (18.86%). Anopheles maculatus, the main malaria vector, constituted 9.11% of the total number of mosquitos sampled. Three hundred and seventy-seven Anopheles larvae, comprising 8 species, were sampled using the North Carolina Biological Station dipper. Anopheles barbirostris larvae amounted to 64.69% of the total number of larvae; An. aconitus accounted for 10.65% of larvae. Seven habitats were identified as breeding places of Anopheles. Most species were found to breed in paddies, fishponds, and rivers. Other less popular habitats were temporary pools, mountain streams, and spring wells.
    MeSH terms: Animals; Anopheles/parasitology*; Anopheles/physiology*; Environment; Humans; Insect Vectors/parasitology*; Insect Vectors/physiology*; Larva/physiology; Malaria/prevention & control*; Malaysia; Population Density; Reproduction
  16. Tay ST, Rohani MY, Ho TM, Devi S
    PMID: 12693591
    The seroprevalence of various Orientia tsutsugamushi (OT) strains among Malaysian patients with suspected scrub typhus infections was determined using an indirect immunoperoxidase (IIP) assay. IgG against a single OT strain were detected in six sera (3 Karp, 1 Gilliam and 2 TC586), whereas IgM antibodies against a single OT strain (Gilliam) were noted in 3 sera (Gilliam). IgG reactive to all OT strains were present in 33 (47.1%) of the 70 sera and IgM reactive to all OT strains were present in 22 (78.6%) of the 28 sera. The fact that most sera were reactive to multiple OT strains suggests that group-specific antigens are involved in scrub typhus infections, whereas very few were due to strain-specific epitopes present on these strains. Peak IgG and IgM titers were noted more frequently against Gilliam, Karp, and TA763 strains: this suggests that these strains may be the commonest infecting strains among Malaysian patients. Two predominant OT polypeptides consistently reacted with patients' sera were the 70 kDa and 56 kDa proteins.
    MeSH terms: Antigens, Bacterial/analysis*; Humans; Immunoglobulin G/blood; Immunoglobulin M/blood; Immunoenzyme Techniques/methods; Malaysia/epidemiology; Orientia tsutsugamushi/classification*; Orientia tsutsugamushi/immunology*; Scrub Typhus/microbiology*; Scrub Typhus/epidemiology*; Immunoblotting; Seroepidemiologic Studies
  17. Tay ST, Rohani MY, Ho TM, Devi S
    PMID: 12693592
    The pathogenicity of Malaysian isolates of Orientia tsutsugamushi was investigated by a mouse virulence assay. The isolates could be differentiated as low (4 isolates), moderately (3 isolates) and highly virulent (2 isolates) based on the different responses in infected mice. No direct correlation between severity of human scrub typhus infections and virulence of the O. tsutsugamushi in mice was observed. Mice infected with virulent strains of O. tsutsugamushi showed splenomegaly, ascitis accumulation and enlargement of kidneys and livers whereas avirulent O. tsutsugamushi strains were asymptomatic and exhibited ruffled fur for a short period after infection. There was low antibody response in mice infected with isolates of low pathogenicity as compared with those of highly virulent isolates. Upon dissection of the infected mice, enlargement of mouse organs such as spleen, kidney and liver was noted. Presence of rickettsemia in mice was confirmed by the growth of O. tsutsugamushi in the L929 cells when inoculated with blood from infected mice. O. tsutsugamushi was also cultured from the peritoneal exudates of the infected mice. However, DNA of O. tsutsugamushi was only detected in the peritoneal exudates (by PCR) and blood (by cell culture) and not from other tissue samples.
    MeSH terms: Animals; Ascitic Fluid/microbiology; Malaysia; Mice, Inbred ICR; Orientia tsutsugamushi/pathogenicity*; Scrub Typhus/microbiology*; Splenomegaly/microbiology; Splenomegaly/pathology; Mice
  18. Mohammad M, Mahdy ZA, Omar J, Maan N, Jamil MA
    PMID: 12693594
    A total of 1,661 pregnant women aged between 13 and 45 years were screened for bacteriuria by urine culture. Of the 1,661 culture results, 615 (37%) yielded no growth; 728 (43.8%) yielded no significant growth (presence of <10(5) organisms/ml urine of one or more types of bacteria); 286 (17.2%) yielded mixed growth (presence of >10(5) organisms/ml urine of more than one type of bacteria) and only 32 (1.9%) showed significant growth (presence of >10(5) organisms/ml urine of a single bacterium). Urine microscopy was also conducted. Two hundred and twenty-four (13.5%) specimens had >10 white blood cells/ml urine, of which 66 had >100 white blood cells; 13 were from the significant growth group. Three hundred and seventy-four (22.5%) specimens showed the presence of bacteria, 42 (2.5%) had red blood cells, 370 (22.3%) had epithelial cells, 58 (3.5%) had crystals, and 14 (0.8%) had yeasts. The most common bacterium isolated was Escherichia coli (12; 40%); the others included group B Streptococcus (5; 15%), Klebsiella spp (5; 15%), Diphtheroids (2), and Candida albicans (2). Fifty-two percent of tested strains were sensitive to ampicillin; 24 of 28 strains (85.7%) were sensitive to ciprofloxacin; all 7 strains tested were sensitive to nitrofurantoin and all 20 strains tested were sensitive to cotrimoxazole; 14/20 (70%) and 16/17 (94.1%) were sensitive to cephalexin and cefuroxime respectively. This study shows that asymptomatic bacteriuria does occur in pregnant women, albeit at a very low rate in an urban setting like Cheras. Urine microscopy is not specific and only serves as a guide to bacteriuria. The commonest causative organisms are those from the gastrointestinal tract and vagina. The antibiogram showed that cefuroxime and cephalexin are likely to be effective in treating bacteriuria: ampicillin must be reserved for Gram-negative organisms. For Gram-positive organisms, of which Group B Streptococcus is important, ampicillin is still effective in vitro. Nitrofurantion and cotrimoxazole have excellent activity in vitro and should be considered for therapy. 17.2% of the urine culture yielded mixed growth: likely to indicate that contamination of urine specimens still happens despite the strict instructions given to patients about the collection of a midstream urine specimen. Proper collection, appropriate transport, and the early processing of urine specimens remain essential.
    MeSH terms: Adolescent; Adult; Bacteriuria/diagnosis*; Bacteriuria/drug therapy; Bacteriuria/microbiology; Bacteriuria/epidemiology; Cross-Sectional Studies; Female; Hospitals, University; Humans; Malaysia; Malaysia/epidemiology; Microbial Sensitivity Tests; Middle Aged; Outpatient Clinics, Hospital; Pilot Projects; Pregnancy; Pregnancy Complications, Infectious/diagnosis*; Pregnancy Complications, Infectious/drug therapy; Pregnancy Complications, Infectious/microbiology; Pregnancy Complications, Infectious/epidemiology; Prenatal Diagnosis/methods*; Incidence; Urinalysis/methods; Drug Resistance, Bacterial
  19. Chan PW, Hussain S, Ghani NH, Debruyne JA, Liam CK
    PMID: 12693597
    A pilot study to evaluate the direct cost of treating 51 adults and 50 children with bronchial asthma was conducted. All aspects of the medical care provided over a 6-month period were considered. The mean treatment costs per month were US dollars 22.97 (adults) and US dollars 15.56 (children). The cost of maintenance therapy accounted for 55.5% and 73.4% of the total direct cost treatment for adults and children respectively. Only 27 (52.9%) adults and 17 (34.0%) children paid for their inhaled prophylactic drugs, amounting to 12.3% of the total maintenance therapy costs. Thirteen (25.4%) adults and 9 (18.0%) children were using alternative therapy at a monthly cost of US dollars 41.50 and US dollars 16.77 respectively. A substantial proportion of the direct cost of asthma treatment is heavily subsidized in Malaysia. Adequate attention to the allocation of the health budget, to ensure the optimal provision of health care, is warranted.
    MeSH terms: Adult; Asthma/economics*; Asthma/therapy; Child; Health Expenditures*; Hospitals, Teaching/economics*; Humans; Malaysia; Pilot Projects; Drug Costs; Hospital Costs*
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