Browse publications by year: 2005

  1. Agusa T, Kunito T, Yasunaga G, Iwata H, Subramanian A, Ismail A, et al.
    Mar Pollut Bull, 2005;51(8-12):896-911.
    PMID: 16023148
    Concentrations of trace elements (V, Cr, Mn, Co, Cu, Zn, Ga, Se, Rb, Sr, Mo, Ag, Cd, Sn, Sb, Cs, Ba, Hg, Tl, Pb and Bi) were determined in muscle and liver of 12 species of marine fish collected from coastal areas in Malaysia. Levels of V, Cr, Mn, Co, Cu, Zn, Ga, Sr, Mo, Ag, Cd, Sn, Ba and Pb in liver were higher than those in muscle, whereas Rb and Cs concentrations showed the opposite trend. Positive correlations between concentrations in liver and muscle were observed for all the trace elements except Cu and Sn. Copper, Zn, Se, Ag, Cd, Cs and Hg concentrations in bigeye scads from the east coast of the Peninsular Malaysia were higher than those from the west, whereas V showed the opposite trend. The high concentration of V in the west coast might indicate oil contamination in the Strait of Malacca. To evaluate the health risk to Malaysian population through consumption of fish, intake rates of trace elements were estimated on the basis of the concentrations of trace elements in muscle of fish and daily fish consumption. Some specimens of the marine fish had Hg levels higher than the guideline value by US Environmental Protection Agency (EPA), indicating that consumption of these fish at the present rate may be hazardous to Malaysian people. To our knowledge, this is the first study on multielemental accumulation in marine fish from the Malaysian coast.
    MeSH terms: Analysis of Variance; Animals; Environmental Monitoring/statistics & numerical data*; Fishes/metabolism*; Liver/chemistry; Malaysia; Species Specificity; Mass Spectrometry; Water Pollutants, Chemical/analysis*; Muscle, Skeletal/chemistry; Risk Assessment; Metals, Heavy/analysis*
  2. Abdullah JM, Kumaraswamy N, Awang N, Ghazali MM, Abdullah MR
    Asian J Surg, 2005 Jul;28(3):163-7.
    PMID: 16024307
    To use data from a prospective, longitudinal study to determine whether psychomotor functions improve spontaneously during the first year following paediatric traumatic brain injury without modern rehabilitation facilities in a rural area of Malaysia.
    MeSH terms: Age Factors; Analysis of Variance; Brain Injuries/complications; Brain Injuries/diagnosis*; Brain Injuries/rehabilitation*; Child; Cognition Disorders/diagnosis*; Cognition Disorders/etiology; Cognition Disorders/epidemiology*; Developing Countries; Female; Follow-Up Studies; Humans; Longitudinal Studies; Malaysia/epidemiology; Male; Neuropsychological Tests; Probability; Prospective Studies; Severity of Illness Index; Socioeconomic Factors; Time Factors; Glasgow Coma Scale; Injury Severity Score; Incidence; Multivariate Analysis; Treatment Outcome; Risk Assessment
  3. Alias A, Krishnapillai R, Teng HW, Abd Latif AZ, Adnan JS
    Asian J Surg, 2005 Jul;28(3):168-70.
    PMID: 16024308
    OBJECTIVE: Head injury caused by fan blades is rare among children. We analysed 14 cases of such injury and discuss the causes, type of injury and preventive measures.

    METHODS: A retrospective analysis of 14 cases of children who were admitted to the Pediatric Neurosurgical Unit of Hospital Kuala Lumpur after sustaining head injuries caused by fan blades between January 2000 and December 2002 was performed.

    RESULTS: The causes of fan-blade head injury included jumping on the upper bunk of a bunk-bed, climbing on a ladder, climbing up onto a table, and being lifted by an adult. Thirteen patients were injured by ceiling fans and one by falling onto an uncovered table fan. School-aged boys were the predominant victims. Mean patient age was 7.9 years (range, 1.0-12.2 years). There was a twin peak incidence of when the accidents occurred: just before lunch in the afternoon and bedtime at night. The types of injury were scalp lacerations, compound depressed fractures and multiple intracranial haemorrhages. Two patients had the complication of wound infection, and one of these patients developed cerebral spinal fluid leak. One patient died from severe head injuries.

    CONCLUSION: Safety awareness among parents and caretakers are important as fan-blade head injury among children is preventable.

    MeSH terms: Accidents, Home/statistics & numerical data*; Child; Child, Preschool; Female; Follow-Up Studies; Craniocerebral Trauma/etiology*; Craniocerebral Trauma/epidemiology*; Craniocerebral Trauma/therapy; Humans; Malaysia/epidemiology; Male; Retrospective Studies; Risk Factors; Skull Fractures/etiology; Skull Fractures/epidemiology; Skull Fractures/therapy; Cohort Studies; Injury Severity Score; Incidence; Survival Rate; Age Distribution; Sex Distribution; Intracranial Hemorrhage, Traumatic/etiology; Intracranial Hemorrhage, Traumatic/epidemiology; Intracranial Hemorrhage, Traumatic/therapy
  4. Singh M, Sharma A, Duthie G, Balasingh D, Kandasamy P
    Asian J Surg, 2005 Jul;28(3):189-91.
    PMID: 16024313
    Treatment of anal fissures has changed dramatically in the past decade. This is primarily due to a better understanding of its pathophysiology and the implications of the various available options. Only a few anal fissures fail to respond to medical therapy. Sphincterotomy and anal dilatation have fallen out of favour due to the risk of incontinence. Island flaps have been proposed to address this, but 60-70% of the flap donor sites break down with complications. We propose using a rotation flap to overcome this problem.
    MeSH terms: Adult; Aged; Chronic Disease; Fecal Incontinence/prevention & control; Female; Fissure in Ano/diagnosis*; Fissure in Ano/surgery*; Follow-Up Studies; Humans; Malaysia; Male; Middle Aged; Postoperative Complications; Prospective Studies; Severity of Illness Index; Surgical Flaps*; Wound Healing/physiology; Treatment Outcome; Risk Assessment
  5. Lukman MR, Jasmi AY, Sarinah B, Nurismah MI, Aishah MA
    Asian J Surg, 2005 Jul;28(3):227-9.
    PMID: 16024322
    Extragonadal teratomas and germ cell tumours are uncommon. Most teratomas of the head and neck present in the paediatric age group. Occurrence of such tumours in an adult is extremely rare and, to date, less than 40 cases have been reported in the literature. We report a case of a young man presenting with impending airway obstruction secondary to a malignant teratoma of the neck.
    MeSH terms: Adult; Airway Obstruction/diagnosis*; Airway Obstruction/etiology; Biopsy, Needle; Combined Modality Therapy; Follow-Up Studies; Head and Neck Neoplasms/pathology*; Head and Neck Neoplasms/therapy; Humans; Immunohistochemistry; Malaysia; Male; Teratoma/pathology*; Teratoma/therapy; Tomography, X-Ray Computed; Treatment Outcome; Chemotherapy, Adjuvant; Risk Assessment
  6. Goh BS, Gendeh BS, Rose IM, Pit S, Samad SA
    Otolaryngol Head Neck Surg, 2005 Jul;133(1):27-31.
    PMID: 16025048
    To determine the prevalence of allergic fungal sinusitis (AFS) in refractory chronic rhinosinusitis (CRS) in adult Malaysians.
    MeSH terms: Adult; Chronic Disease; Cross-Sectional Studies; Humans; Therapeutic Irrigation; Malaysia/epidemiology; Mycoses/complications*; Nasal Cavity; Respiratory Hypersensitivity/microbiology*; Respiratory Hypersensitivity/epidemiology*; Respiratory Hypersensitivity/pathology; Rhinitis/microbiology*; Rhinitis/epidemiology; Rhinitis/pathology; Sinusitis/microbiology*; Sinusitis/epidemiology; Sinusitis/pathology; Prevalence
  7. Choo YM, Ng MH, Ma AN, Chuah CH, Hashim MA
    Lipids, 2005 Apr;40(4):429-32.
    PMID: 16028723
    The application of supercritical fluid chromatography (SFC) coupled with a UV variable-wavelength detector to isolate the minor components (carotenes, vitamin E, sterols, and squalene) in crude palm oil (CPO) and the residual oil from palm-pressed fiber is reported. SFC is a good technique for the isolation and analysis of these compounds from the sources mentioned. The carotenes, vitamin E, sterols, and squalene were isolated in less than 20 min. The individual vitamin E isomers present in palm oil were also isolated into their respective components, alpha-tocopherol, alpha-tocotrienol, gamma-tocopherol, gamma-tocotrienol, and delta-tocotrienol. Calibration of all the minor components of palm as well as the individual components of palm vitamin E was carried out and was found to be comparable to those analyzed by other established analytical methods.
    MeSH terms: Carotenoids/analysis*; Carotenoids/chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Phytosterols/analysis*; Phytosterols/chemistry; Plant Oils/chemistry*; Squalene/analysis*; Squalene/chemistry; Time Factors; Vitamin E/analysis*; Vitamin E/chemistry; Chromatography, Supercritical Fluid*
  8. Kabeir BM, Abd-Aziz S, Muhammad K, Shuhaimi M, Yazid AM
    Lett Appl Microbiol, 2005;41(2):125-31.
    PMID: 16033508
    To develop medida, a Sudanese fermented thin porridge as a probiotic dietary adjunct with high total solids.
    MeSH terms: Bifidobacterium/growth & development*; Culture Media/metabolism*; Culture Media/chemistry; Fermentation; Refrigeration*; Oryza/chemistry*; Acetic Acid/analysis; Lactic Acid/analysis
  9. Cyranoski D
    Nature, 2005 Jul 21;436(7049):313.
    PMID: 16034382
    MeSH terms: Animals; Classification; Conservation of Natural Resources/trends*; Malaysia; Plant Oils/economics; Trees/physiology; Biodiversity*
  10. Subramaniam P, Henderson-Smart DJ, Davis PG
    PMID: 16034858
    BACKGROUND: Cohort studies (Avery 1987; Jonsson 1997) have suggested that early post-natal nasal continuous positive airways pressure (CPAP) may be beneficial in reducing the need for intubation and intermittent positive pressure ventilation, and in preventing chronic lung disease in preterm or low birth weight infants.

    OBJECTIVES: To determine if prophylactic nasal CPAP commenced soon after birth regardless of respiratory status in the very preterm or very low birth weight infant reduces the use of IPPV and the incidence of chronic lung disease (CLD) without adverse effects.

    SEARCH STRATEGY: The search was updated in April 2005. The standard search strategy of the Neonatal Review Group was used. This included searches of the Oxford Database of Perinatal Trials, Cochrane Library Issue 1 2005, MEDLINE 1966-April 2005, previous reviews including cross references, abstracts, conferences, symposia, proceedings, expert informants, journal hand searching mainly in the English language.

    SELECTION CRITERIA: All trials using random or quasi-random patient allocation of very preterm infants < 32 weeks gestation and / or < 1500 gms at birth were eligible. Comparison had to be between prophylactic nasal CPAP commencing soon after birth regardless of the respiratory status of the infant compared with "standard" methods of treatment where CPAP or IPPV is used for a defined respiratory condition.

    DATA COLLECTION AND ANALYSIS: Standard methods of the Cochrane Collaboration and its Neonatal Review Group, including independent assessment of trial quality and extraction of data by each author, were used. Data were analysed using relative risk (RR). Meta-analysis was performed using a fixed effects model.

    MAIN RESULTS: There are no statistically significant differences in any of the outcomes studied in either of the eligible trials (Han 1987; Sandri 2004) reporting on 82 and 230 infants respectively. In Han 1987 there are trends towards increases in the incidence of BPD at 28 days [RR 2.27 (0.77, 6.65)], death [RR 3.63 (0.42, 31.08)] and any IVH [RR 2.18 (0.84, 5.62)] in the CPAP group. In Sandri 2004 there is a trend towards an increase in IVH grade 3 or 4 [RR 3.0 (0.96, 28.42)] in the CPAP group. No outcome was significantly different in any of the meta-analyses.

    AUTHORS' CONCLUSIONS: There is currently insufficient information to evaluate the effectiveness of prophylactic nasal CPAP in very preterm infants. Neither of the included studies reviewed showed evidence of benefit in reducing the use of IPPV. The tendency for some adverse outcomes to be increased is of concern and further multicentre randomized controlled trials are needed to clarify this.

    MeSH terms: Chronic Disease; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases/mortality; Infant, Premature, Diseases/prevention & control*; Lung Diseases/prevention & control*; Positive-Pressure Respiration*
  11. Ziganshina LE, Vizel AA, Squire SB
    PMID: 16034951
    Fluoroquinolones are sometimes used to treat multiple-drug-resistant and drug-sensitive tuberculosis. The effects of fluoroquinolones in tuberculosis regimens need to be assessed.
    MeSH terms: Antitubercular Agents/therapeutic use*; Ciprofloxacin/therapeutic use; Humans; Tuberculosis, Pulmonary/drug therapy*; Ofloxacin/therapeutic use; Randomized Controlled Trials as Topic; Tuberculosis, Multidrug-Resistant/drug therapy*; Fluoroquinolones/therapeutic use*; Levofloxacin
  12. Solomon N
    Reprod Health Matters, 2005 May;13(25):174-81.
    PMID: 16035611
    MeSH terms: Humans; Human Rights*; Thailand
  13. Singh HJ, Abu Bakar A, Che Romli A, Nila A
    Hypertens Pregnancy, 2005;24(2):191-9.
    PMID: 16036403
    The aim of this study was to estimate the levels of leptin in the amnion, chorion laeve, and placenta and to examine for any differences in leptin levels in these tissues from preeclamptic and normotensive pregnant women.
    MeSH terms: Adult; Amniotic Fluid/chemistry*; Chorion/chemistry; Female; Humans; Placenta/chemistry*; Pre-Eclampsia/metabolism*; Pregnancy; Leptin/metabolism*
  14. Kuppusamy UR, Dharmani M, Kanthimathi MS, Indran M
    Biol Trace Elem Res, 2005 Jul;106(1):29-40.
    PMID: 16037608
    The trace elements copper, zinc, and selenium are important immune modulators and essential cofactors of the antioxidant enzymes. In the present study, the proliferative effect of human peripheral mononuclear cells (PBMCs) that have been exposed to copper, zinc, and selenium and the corresponding activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, were determined. Zinc and copper stimulated the PBMC proliferation in a dose-dependent manner within the dose range 25-200 micromol/L. SOD and GPx activities in PBMCs exposed to zinc were inhibited, whereas catalase activity was unaffected. All the three antioxidant enzymes in the cells exposed to copper were inhibited. Selenium exerted more potent inhibition of the cell proliferation while causing stimulation of the antioxidant enzymes at the lowest dose (25 micromol/L) than at the highest dose (200 micromol/L) tested. A significant negative correlation was observed between proliferation and antioxidant enzyme (SOD and GPx) activities in trace-element-exposed PBMC. The present findings substantiate the importance of trace elements as immune modulators and the involvement of enzymatic antioxidant system in the immune cell regulation.
    MeSH terms: Antioxidants/metabolism; Antioxidants/pharmacology*; Catalase/metabolism; Copper/metabolism; Glutathione Peroxidase/metabolism; Humans; Leukocytes, Mononuclear/cytology*; Leukocytes, Mononuclear/drug effects*; Selenium/pharmacology; Superoxide Dismutase/metabolism; Temperature; Trace Elements/metabolism*; Zinc/metabolism; Zinc Sulfate/pharmacology; Cell Proliferation
  15. Abas F, Lajis NH, Shaari K, Israf DA, Stanslas J, Yusuf UK, et al.
    J Nat Prod, 2005 Jul;68(7):1090-3.
    PMID: 16038556
    A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, HSQC, HMBC) NMR techniques. All diarylheptanoids and scopoletin showed significant antioxidant activity. Zerumin B, demethoxycurcumin, bisdemethoxycurcumin, and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.
    MeSH terms: Antineoplastic Agents, Phytogenic/isolation & purification*; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Agents, Phytogenic/chemistry; Antioxidants/isolation & purification*; Antioxidants/pharmacology; Antioxidants/chemistry; Diterpenes/isolation & purification*; Diterpenes/pharmacology; Diterpenes/chemistry; Drug Screening Assays, Antitumor; Glucosides/isolation & purification*; Glucosides/pharmacology; Glucosides/chemistry; Humans; Malaysia; Plants, Medicinal/chemistry*; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Inhibitory Concentration 50; Rhizome/chemistry; Curcuma/chemistry*
  16. Huger AM
    J Invertebr Pathol, 2005 May;89(1):78-84.
    PMID: 16039308
    In view of the increasing and devastating damage by rhinoceros beetle (Oryctes rhinoceros) to coconut palms in the middle of last century, many efforts were made to find an efficient natural control factor against this pest, which could not be controlled by pesticides. The basic procedures of these monitoring programmes are outlined together with the final detection of a virus disease in oil palm estates in Malaysia in 1963. In extensive laboratory studies, the virus was isolated and identified as the first non-occluded, rod-shaped insect virus, morphologically resembling the baculoviruses. Infection experiments clarified the pathology, histopathology, and virulence of the virus and demonstrated that the virus was extremely virulent to larvae after peroral application. These findings encouraged the first pilot release of virus in 1967 in coconut plantations of Western Samoa where breeding sites were contaminated with virus. Surprisingly, the virus became established in the Samoan rhinoceros beetle populations and spread autonomously throughout the Western Samoan islands. As a consequence, there was a drastic decline of the beetle populations followed by a conspicuous recovery of the badly damaged coconut stands. This unexpected phenomenon could only be explained after it was shown that the adult beetle itself is a very active virus vector and thus was responsible for the efficient autodissemination of the virus. The functioning of the beetle as a 'flying virus factory' is due to the unique cytopathic process developing in the midgut after peroral virus infection. Pathological details of this process are presented. Because of the long-term persistence of the virus in the populations, rhinoceros beetle control is maintained. Incorporation of virus into integrated control measures and successful virus releases in many other countries are recorded.
    MeSH terms: Animals; Asia, Southeastern; Beetles/virology*; Pacific Islands; Pest Control, Biological/history*; History, 20th Century
  17. Ramle M, Wahid MB, Norman K, Glare TR, Jackson TA
    J Invertebr Pathol, 2005 May;89(1):85-90.
    PMID: 16039309
    The rhinoceros beetle, Oryctes rhinoceros, has emerged as a serious pest of oil palm since the prohibition of burning as a method for maintaining estate hygiene in the 1990s. The abundance of beetles is surprising given that the Malay peninsula was the site of first discovery of the Oryctes virus, which has been used to effect good as a biological control agent in other regions. A survey of adult beetles was carried out throughout Malaysia using pheromone traps. Captured beetles were examined for presence of virus using both visual/microscopic examination and PCR detection methods. The survey indicated that Oryctes virus was common in Malaysia among the adult beetles. Viral DNA analysis was carried out after restriction with HindIII enzyme and indicated at least three distinct viral genotypes. Bioassays were used to compare the viral strains and demonstrate that one strain (type B) is the most virulent against both larvae and adults of the beetle. Virus type B has been cultured and released into healthy populations where another strain (type A) forms the natural background. Capture and examination of beetles from the release site and surrounding area has shown that the spread and persistence of the applied virus strain is accompanied by a reduction in palm frond damage.
    MeSH terms: Animals; Beetles/virology*; DNA, Viral; Malaysia; Pest Control, Biological*; Plant Oils*; Trees/parasitology*; Virus Diseases/epidemiology*; Incidence
  18. Ang HH, Lee KL, Kiyoshi M
    Int J Toxicol, 2005 May-Jun;24(3):165-71.
    PMID: 16040569 DOI: 10.1080/10915810590952942
    The DCA (Drug Control Authority) of Malaysia implemented the phase 3 registration of traditional medicines on 1 January 1992. As such, a total of 100 products in various pharmaceutical dosage forms of a herbal preparation containing Smilax luzonensis, either single or combined preparations, were analyzed for the presence of lead, using atomic absorption spectrophotometry. Results showed that 14% of the above products possessed 10.02 to 21.21 ppm of lead, and, therefore, they failed to comply with the quality requirement for traditional medicines in Malaysia ( <10 ppm). Although this study showed that 86% of the products complied with the quality requirement for traditional medicines in Malaysia pertaining to lead, they cannot be assumed safe from lead contamination because of batch-to-batch inconsistency.
    MeSH terms: Drug Contamination*; Lead/analysis*; Malaysia; Quality Control; Spectrophotometry, Atomic; Reproducibility of Results; Plant Preparations/standards; Plant Preparations/chemistry*; Smilax/chemistry*
  19. Sujak SL, Abdul-Kadir R, Omar R
    Asia Pac J Public Health, 2005;17(1):15-8.
    PMID: 16044826
    The objective of this study was to assess the perceptions of Malaysian HIV-positive subjects towards the attitude of dental personnel in providing oral care to them. The study design was cross-sectional with the sampling frame comprising of 27 Government Drug Rehabilitation Centres throughout Malaysia. A convenience sample was then taken from 20 centres with the highest enrolment of HIV-positive subjects. A self-administered questionnaire was used to elicit information on the perception of HIV-positive subjects towards the attitude of dental personnel in providing oral care to the patient with HIV-positive. The study sample consisted of 509 HIV-positive individuals with a mean age of 31.3+/-12.9 years old. Of these, only 15.1% attended a dental clinic after confirmation of HIV-positive status. The study demonstrated that 67.5% of the HIV-positive subjects disclosed their status voluntarily to the dentists and majority of the dentists (76.9%) did not show any negative reaction on knowing their HIV positive status. There was also no difference in the attitude of auxiliary staff toward the above disclosure. In conclusion, the study showed that oral health care personnel are more receptive to the HIV-positive subjects receiving dental care and treatment.
    MeSH terms: Adult; Attitude of Health Personnel; Cross-Sectional Studies; Dental Staff/psychology*; Dentists/psychology*; HIV Seropositivity/psychology*; Humans; Malaysia; Male; Disclosure*
  20. Ramanathan S, Karupiah S, Nair NK, Olliaro PL, Navaratnam V, Wernsdorfer WH, et al.
    PMID: 16046285
    A new approach using a simple solid-phase extraction technique has been developed for the determination of pyronaridine (PND), an antimalarial drug, in human plasma. After extraction with C18 solid-phase sorbent, PND was analyzed using a reverse phase chromatographic method with fluorescence detection (at lambda(ex)=267 nm and lambda(em)=443 nm). The mean extraction recovery for PND was 95.2%. The coefficient of variation for intra-assay precision, inter-assay precision and accuracy was less than 10%. The quantification limit with fluorescence detection was 0.010 microg/mL plasma. The method described herein has several advantages over other published methods since it is easy to perform and rapid. It also permits reducing both, solvent use and sample preparation time. The method has been used successfully to assay plasma samples from clinical pharmacokinetic studies.
    MeSH terms: Administration, Oral; Antimalarials/blood*; Antimalarials/isolation & purification; Antimalarials/pharmacokinetics; Calibration; Chromatography, Liquid/instrumentation; Chromatography, Liquid/methods*; Half-Life; Humans; Naphthyridines/blood*; Naphthyridines/isolation & purification; Naphthyridines/pharmacokinetics; Regression Analysis; Time Factors; Reproducibility of Results; Malaria, Falciparum/blood; Malaria, Falciparum/drug therapy; Area Under Curve
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