This descriptive cross sectional study was conducted to assess patient's satisfaction by evaluating the waiting time experienced by 27 (54%) inpatients and 23 (46%) outpatients who sought treatment at a private hospital in Selangor from 15th of May 2006 until 3rd of]une 2006. Majority of the patients (78%) were in the range between Z 1 - 40 years old and well»educated. Almost half (48%) were in the human resources employment category, 20% were in administration and marketing and 10% were professionals. Majority of them earned from RM1000-1999 (34%) and RMZ000-3999 (32%). Almost all of them (96%) agreed that the medical care that they had been receiving in the hospital was just about perfect. 98% agreed that the doctors treated them in a very friendly and courteous manner and 96% rated the care given by nurses as g0od/ excellent. 88% to 92% said that their communication with the doctors, nurses and other staff were good/ excellent. 80% waited less than 15 minutes at the registration counter, 52% waited less than 15 minutes to see the doctor and 44% waited less than 15 minutes at other places such as pharmacy and x-ray. Overall, 94% rated the level of services in the hospital as good/ excellent, Almost all (90%) would like to recommend the hospital to their friends and relatives. Our study demonstrated that the majority of the patients were satisfied with the doctors, nurses and environment of the private hospital. The average waiting time of patient before being attended to by a doctor was less than 30 minutes.
Study site: Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
A cross»sectional study using self administered questionnaires on sociodemographic and service factors influencing locum practice was undertaken among all Government medical officers in Negeri Sembilan and Malacca for 8 months from 2 7 April 1999 to 9. l January ZOOO. Universally chosen samples were made of 335 Government medical officers from both the 'Public Health Division' and ”Hospital Division' and from 154 who responded, only 147 samples were chosen and analysed in the study. Results revealed that locum were still being practised by 51 .9% of male Government medical officers, 41 .0% of Government medical ofhcers aged less than 30 years, 43.4% of Government medical officers who had served less than 5 years and 55.6% of Government medical officers who had earned nett income less than RM 1 000. Meanwhile, 80.9% of Government medical officers who had earned gross income more than RM 5 OOO did not practice locum during the study. Logistic Regression analysis then revealed that locum practice among Government medical ofhcers can positively be influenced by gender (male) , Malay ethnic, service duration of less than 5 years, practice in the 'Public Health Divisionl and nett income of less than RM 1 OOO (p
MeSH terms: Cross-Sectional Studies; Government; Income; Male; Public Health; Surveys and Questionnaires; Logistic Models; Norepinephrine Plasma Membrane Transport Proteins
The objective of this pilot cross-sectional study was to assess effcacy of training dental officers (DO) and nurses (DN) in the Index of Orthodontic Treatment Need (IOTN). A conventional training method of lectures, manual; and md5,0n* exettise was used for bath Lest groups. 30 study models in all grades in the Aesthetic component (AC) and dental health component (DHC) were graded by 27 subjects (13 DO, 14 DN) after training. Results were cnrrlparedfor agreement with an exper; group, Kappa statistic: was used to assess strength in agreement in correct grouping of AC and DHC in the Categorie; gf treatment need, Wilcoxon Rank sum test was used to compare mean kappa and % 0 correct res ames in the test. Spearman rank correlation was used to test association of 11g experience with mean kappa values. There was ‘m0demte’ agreement in correct groupingfor ojjqcers in AC (K=O.5l) and DHC (K`=O.4l); Cmd 'fair’ j‘0'f TluTS€S in AC (K=O.40) and DHC (K:O,34). There was no significant difference between groups. Subjects were better at identifying cases with definite need than little/ borderline need for treatment. There was more inaccurate grading in DHC Gmde+qualifier for both groups (p
MeSH terms: Baths; Cross-Sectional Studies; Esthetics; Malocclusion; Oral Health; Statistics, Nonparametric; Index of Orthodontic Treatment Need
The high morbidity and mortality caused by smoking is a major public health problem today. Smoking prevention has been acknowledged and identified as a long-term measure to overcome this problem. This is a longitudinal knowledge; attitude and practice (KAP) study among form five students over l year. The response rate at follow‘up was 251/337 (74.5 %). The smoking prevalence changed after 1 year (from 29.7% to 26. 7%) after one year. The male to female smoking rates were 52.1% to 3.1% respectively. Students who smoke were found to have a positive attitude as well as poor knowledge of the risks of smoking. The initiation risk factors identified were being male and having a friend who smokes Positive peer influence also contributed to smoking cessation after a period of one year. Holistic measures that stress on micro macro and approaches such as health education programe to enhance knowledge of smoking hazards and community participation ( cooperation of school, family and community member) should be fomtulated in order to reduce initiation of smoking among the adolescents. Quit smoking programmes must also be readily available.
This study examines the level of quality initiatives commitment among public hospital managers and its determinants in view of limited study :0 date and a decline in self-initiated quality initiatives activities in Sarawak, Malaysia. This is a cross-sectional study with universal sampling method conducted in all the Z1 public iwspimls in Sarawak. The study population were the senior, middle and lower level managers. The research wal was self-administered structured questionnaire. A total of 382 managers responded, corresponding ta a response irate of 8 7. 2%. As a complement, four focus group discussions were conducted, consisting 31 participants. It was found that the level of quality initiatives commitment 0f managers was generally high (mecm= 4.23, SD=O.45). The regression analysis indicated that empowerment, communication and procedural justice (promotion) accounted for 38.9%, 346% and 1.2% respectively of the variation in commitment level. Dissatisfaction with resources, top management commitment and peer influence are among others being identified by participants of focus groups as important determinants of quality initiatives commitment. It is strongly recommended that there should be greater empowerment of hospital managers, more structured and effective communication, greater transparency in procedure for promotion and commitment of resources to quality efforts.
MeSH terms: Peer Influence; Cross-Sectional Studies; Glycosides; Hospitals, Public; Malaysia; Phenylpropionates; Surveys and Questionnaires; Regression Analysis; Social Justice; Trisaccharides; Focus Groups
Recent years have witnessed unprecedented changes in the design and demands of work, and the emergence of job stress as a major concern. The aim of the study was to determine the psychosocial problems in relation to nature of work among female nurses at Hospital Selayang. The study was a cross-sectional study and the study population comprised of female nurses who are currently working at Hospital Selayang. A total of 393 study subjects were randomly selected and each respondent has been given a set of complete validated self-administrated Copenhagen Psychosocial Questionnaire. The result showed that the prevalence of having psychosocial problems was 24.9%. It is show that married nurses with more than three children has 3.54 (95%CI: 1.81-6.94) higher risks to have the problems compared to those with 3 or less children. Shiftwork nurses have 1.74 (95%CI: 1.01-2.99) more risk to have psychosocial problems compared to those who are not doing shiftwork. From the crude odds ratio, nurses who have served the service for more than seven years, there was 1.53 times more risk (95%CI: 0.89-2.63) to have psychosocial problems compared to those who only have service of seven years or less. From multivariate analysis, the risk of having psychosocial problems among nurses who are doing shiftwork found to be two times greater than those who are not doing shiftwork (OR=2.15; 95%CI: 1.12- 4.11) . Psychosocial problems in relation to nature of work among nurses at Hospital Selayang are higher among nurses who are doing shdtwork. The hospital management needs to overcome the problems and organizing the mental health programs among workers.
A cross»sectional study was conducted to determine the knowledge on family planning among Malay women who delivered at Hospital Universiti Sains Malaysia (H USM), Kelantan and their husbands. Three hundred and fifty five women were selected by systematic random sampling. An interview-guided questionnaire that included infomation on socio-demographic, obstetric and knowledge on family planning was conducted to the women and self-administered questionnaire was given to their husbands. There were 15 questions on knowledge which were validated prior to the study. More than half of the women (53.5%) and the husbands (57.7%) had poor knowledge score (less than 75%) on family planning. A majority (86.8%) of the women and 87.9% of the husbands knew the optimal age of a woman to be pregnant, but very few (3.4%) of the women and Ss 1% of the husbands could answer correctly all the questions on the effects of poor spacing. The level of knowledge on family planning among Malay women who delivered at H USM and their husbands were poor. Therefore, new and improved health education materiab and programmes are needed, to target both the women and their husbands.
MeSH terms: Cross-Sectional Studies; Demography; Family Planning Services; Female; Health Education; Humans; Malaysia; Pregnancy; Surveys and Questionnaires; Sex Education; Spouses
Employee satnfaction surveys can provide the information needed to improved levek of productivity, job and loyalty. Management can identify the factors of job issues and provide solutions to improve the working environment. A cross sectional descriptive study on employee satisfaction among a health care district office’s staff was conducted in Perak in March - April 2006. A total of 19 staff were randomly picked and interviewed in the data collection process. Almost all understand the objectives of the administration unit (94%) and were satisfied with the management leadership’s style (78%- l 00%) . Majority agreed that their relationship with immediate superior and within the group was harmonious and professional (89%) and they preferred an open problem solving method in handling conflict (72 %). The most common type of incentive rewarded by the administration to express gratitude to their staff was certificate (56%); bonus and medal (33%); and informal gesture (28%). Majority (83%) were also satisfied by the method used to disseminate the information in their units. Majority agreed that the working environment in the administration unit were conducive (72%), their ideas were equally considered during decision making sessions (89%) and training opportunities were similarly given to them by the management (72%). This study revealed that employee satisfaction was determined by several factors such as management leadership's style, opportunity to contribute skills and idea; reward and incentive; and conducive king environment.
MeSH terms: Cross-Sectional Studies; Decision Making; Gestures; Humans; Leadership; Malaysia; Motivation; Personal Satisfaction; Problem Solving; Surveys and Questionnaires; Reward; Workplace
We report a case of clear cell sugar tumour of the lung (CCTL) occurring in a 26-year-old lady. The patient was asymptomatic and the lesion was picked up in the course of a pre-employment medical examination. A well-defined 5 cm nodule in the right lower lobe was detected on routine chest X-Ray. Microscopical examination of the coin lesion showed clear cells containing abundant diastase-sensitive intracytoplasmic glycogen, as demonstrated with periodic acid-Schiff stains. Tumour immunoreactivity for HMB-45 and non-reactivity for cytokeratin support the histological diagnosis. To our knowledge, this is the first reported case of CCTL in Malaysia.
Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired haemopoietic stem cell disorder
arising from somatic mutation of the X-linked PIG-A gene which leads to deficiency of the
glycosylphosphatidylinositol (GP1) membrane anchor proteins such as CD 59 (MIRL: membrane
inhibitor of reactive lysis) and CD 55 (DAF: decay accelerating factor). Allogeneic peripheral
blood stem cell transplant (PBSCT) is a curative mode of treatment in symptomatic PNH patients.
Assessment of donor chimerism for PBSCT can be performed by various methods including short
tandem repeat loci (STR) and variable number of tandem repeats (VNTR). Flow cytometry, which
is much cheaper and faster, also can be used to assess engraftment in patients with PNH. Engrafted
patients will show the presence of CD 55 and CD 59 on their red cells and white cells. We describe
here the usefulness of flow cytometry in the assessment of donor chimerism following allogeneic
PBSCT, in a case of PNH.
The molecular basis of variable phenotypes in β-thalassaemia patients patients with identical genotypes has enotypes has been associated with co-inheritance of α-thalassaemia and persistence of HbF production in adult life. The Xmn I restriction site at -158 position of the G γ-gene is associated with increased expression of the G γ-globin gene and higher production of HbF. This stud his study aims to determine the fre aims to determine the frequency of the different genotypes of the Gγ Xmn I polymorphism in β-thalassaemia patients in the ethnic groups in Malaysia. Molecular characterisation and frequency of the Gγ Xmn I polymorphism were studied in fifty-eight Chinese and forty-nine β-thalassaemia Malay patients by Xmn I digestion after DNA amplification of a 650 bp sequence. The in-house developed technique did not require further purification or concentration of amplified DNA before restriction enzyme digestion. The cheaper Seakem ® LE agarose was used instead of Nusieve agarose and distinct well separated bands were observed. Genotyping showed that the most frequent genotype observed in the Malaysian Chinese was homozygosity for the absence of the Xmn I site (-/-) (89.7%). In the Malays, heterozygosity of the Xmn I site (+/-) was most common (63.3%). Homozygosity for the Xmn I site (+/+) was absent in the Chinese, but was confirmed in 8.2% of the Malays. The ratio of the (+) allele (presence of the Xmn I site) to the (–) allele (absence of the Xmn I site)) was higher in the Malays (0.66) compared to the Chinese (0.05). The (+/-) and (+/+) genotypes are more commonly observed in the Malays than the Chinese in Malaysia.
Pseudomonas sp. strain SS22 telah dipencilkan daripada kolam oksidasi kilang minyak kelapa sawit di Malaysia. Dalam kajian ini, keupayaaan bakteria ini mentransformasikan asid oleik kepada produk baru telah dikaji. Produk biotransformasi dianalisis dengan kromatografi lapisan nipis (KLN), kromatografi gas (KG), spektroskopi inframerah gandingan fourier (SIGF) dan kromatografi gas-spektrometri jisim (KG-s.1). Analisis KLN menunjukkan bahawa hanya satu produk baru terbentuk selepas 7 hari eraman pada suhu 37°C, goncangan pada 150 ppm. Semakin lama eraman menyebabkan pengurangan titik produk pada 14 harL Analisis KG menunjukkan bahawa 5 puncak produk baru pada masa penahanan 13.1(*A), 15.0 (*C), 15.3 (*D), 16.8 (*E) dan 18.4 (*F) minit telah terbentuk selepas 7 hari eraman. Spektrum inframerah (Im) bagi produk yang terbentuk daripada asid oleik selepas 7 hari, menunjukkan kewujudan regangan OH/NH pada 3417 cm-'. Serapan pada 2673 cm-', kemungkinan regangan CH bersama-sama dengan kumpulan karbonil. Serapan pada 1712 cm-' adalah konstan dengan regangan c=o daripada keton atau asid karboksilik. Regangan CH pada 2932, 2854, 1462 dan 1379 cm-1 merupakan kumpulan alkil, menandakan produk hidrokarbon juga wujud dalam produk campuran. Kehadiran CH/C-C pada serapan 969 dan 725 cm-', menandakan kewujudan alkena trans (C=C). Analisis KG-SJ mengesahkan bahawa produk tersebut merupakan campuran asid 9(E)- heksadekenoik, asid kaprilik, asid miristik dan hidrokarbon. Walaupun produk yang terbentuk bercampur, asid 9(E)-heksadekenoik boleh digunakan sebagai komponen membran lipidnya. Penghasilan produk tersebut boleh dipertingkatkan dengan mengoptimumkan keadaan pertumbuhan.
Tujuan kajian ini adalah untuk mengenal pasti perkaitan antara tahap kemurungan, kesihatan mental, kesan sokongan sosial dan kesejahteraan psikologi di kalangan mangsa rogol dengan aspek demografik. Subjek kajian seramai 30 wanita telah dipilih dari Pusat Perlindungan dan Pemulihan Wanita, di Batu Caves, Selangor. Kaedah ujian yang digunakan terdiri daripada Beck Depression Inventory, General Health Questionnaire-28, Provision Social Relation dan soalan demografik. Soalan diedarkan di kalangan mangsa diikuti dengan penerangan ringkas ke atas kaedah ujian. Analisis data menunjukkan terdapat perbezaan yang signifikan di antara faktor umur dan kesejahteraan psikologi mangsa (p = 0.004). Selain itu, kemurungan didapati mempengaruhi secara signifikan ke atas kesihatan mental (R' = 0.60, [F (1, 27) = 40.312, p < 0.0011). Kajian inijuga mendapati hubungan yang positif antara kesihatan mental dan kemurungan (r = 0.77). Ini bermaksud semakin tinggi kemurungan yang dialami mangsa, semakin tinggi kesan ke atas kesihatan mentalnya.
MeSH terms: Ataxia Telangiectasia; Depression; Personality Inventory; Fenofibrate; Psychiatric Status Rating Scales; Surveys and Questionnaires; Caves
The purpose of this study was to identify the most common forms of age-related cataracts and to estimate possible risk factors for age-related cataracts in a sample of cataract patients at the National University of Malaysia Hospital. Thirty five patients (17 males and 18 female) with cataracts were recruited from the ophthalmology ward and clinic at the hospital. The age range of the patients was between 39 to 93 years (mean 64.9 11.5 years). The Lens Opacities Classification System (Locs) III was used to grade nuclear, cortical and posterior subcapsular lens opacities. Grading of the cataract was carried out and the following information was collected: initial visual acuity and best-corrected visual acuity, demographic details, health history, dietary intake of antioxidants and lifetime ocular ultraviolet B exposure. Analyses were conducted using a standard case-control design. T-tests were used to assess the significance of continuous variables and chi-squared tests were used for categorical variables. The overall prevalence of cortical cataract was 34.4% (12 patients), nuclear cataract was 60.0% (21 patients), and posterior subcapsular cataract was 57.1% (20 patients). No significant potential risk factor was found for nuclear cataracts. In the case of posterior subcapsular cataract, hypertension was the only potential significant risk factor (x2 = 4.38, p = 0.036), and in the case of cortical cataract, cigarette smoking was the only significant risk factor. Although lifetime effective ocular UV-B exposure was found to be not a significant potential risk factor, but it was seen that for cortical cataracts, the mean difference of lifetime effective ocular UV-B exposure between those with cortical and those without cortical cataracts was larger compared to others with nuclear and posterior subcapsular cataracts. Hypertension was found to be a potential significant risk factor for posterior subcapsular cataract whereas cigarette smoking was a potentially significant risk factor for cortical cataract. Although not statistically significant, lifetime effective ocular UV-B exposure maybe a potential risk factor for cortical cataract.
Obesity prevalence and body image consciousness are on the rise, and women often try to lose weight using a variety of methods. This paper reports the knowledge on body weight management amongst working women aged 30 – 45 years in Kuala Lumpur. Respondents comprised 131 school teachers and 122 civil servants. Anthropometric measurements included body weight and height; while knowledge on weight management was assessed using a questionnaire. The respondents were Malay (64%), Chinese (26%) and Indian women (10%) with mean age of 38.3 ± 4.6 years old. The respondents were grouped into two weight categories based on body mass index (BMI): normal weight (BMI 18.5 to 24.9 kg/m2) and overweight (BMI ≥ 25.0 kg/m2). Mean body weight and BMI were significantly different (p < 0.001) between the two weight categories. Overweight and normal weight groups had mean body weight of 69.0 ± 9.5 kg and 53.5 ± 5.3 kg; while mean BMI were 29.2 ± 3.6 kg/ m2 dan 21.9 ± 1.7 kg/m2; respectively. Mean scores for knowledge on weight management were similar for both weight categories, 62.4 ± 13.7 and 61.8 ± 13.4 for overweight and normal weight, respectively. A majority of overweight (71%) and normal weight (73%) women had moderate level (scores 50–74%) of weight management knowledge. However, it was interesting to note that there were more overweight women (20%) who had high knowledge level (scores ≥ 75%) as compared to normal weight women (15%). Only 9% of overweight and 12% of normal weight women demonstrated low knowledge level (scores <50%). School teachers were significantly (p < 0.001) more knowledgeable than civil servants in weight management matters with mean knowledge scores of 65.5 ± 12.3 and 58.4 ± 13.9, respectively. On the whole, the results indicated that women were fairly knowledgeable in healthy body weight management. Knowledge on body weight management is essential for preventing comorbidity risks related to overweight problem. The study also revealed that there was a need for nutrition education related to body image and effective weight management. Key words: Body weight management, working women, overweight, obesity
The water decoction of Labisia pumila var. alata is used traditionally in childbirth, as well as for the treatment of flatulence, dysentery, dysmenorrhoea and join pains. This study was carried out to determine the best method and optimum parameters of aqueous axtraction of the leaves and roots of this species. The laboratory methos esed were maceration, ddecoction, reflux and Saxhlet, whereas the parameters studied were temperature, duration and pH of axtraction. The yields and thin layer chromatographic profiles of the freeze-dried extracts were analysed. The study showed that in general the percentage yields of the water soluble extracts were higher for the roots than the leaves, as well as the extracts obtained from heating than those obtained at room temperature. The most effective extraction parameters for L. pumila var. alata were as follows:maceration (25 C, at least 6 hr), decoction (60 C, not exceeding 10 min) and reflux (100 C, not exceeding 4 hr). Saxhlet method was found to be the least effective. The pH analysis had shown the possibility of degradation of some of the phytochemicals at extreme pH values of 1,2 and 14.
This paper attempts to examine the real values of Malaysian herbal products in the aspects of quality, safety and efficacy as curing agents. In so doing it will also determine the driving force behind the intense public interest for herbal medicine as alternative or complementary to conventional medicine. Most herbal products in the Malaysian market are not sufficiently provided with information on their ingredients, indications, dosage, pharmacology, contraindications and possible side-effects. Most published information on the products on evidence of safety and efficacy is not supported with scientific evidence. The present practice of traditional medicine still depend heavily on information obtained through ethnopharmacological experiences. However, the herbal product market is experiencing a tremendous growth and there is an increased trend of incorporating herbal therapy into modern medical practice by many mainstream health professionals. Unfortunately, the popularity of herbal products is more associated with consumer attitudes and the ability of the herbalists to influence rather than their true quality as medicinal agents. Many people are exploited due to ignorance on the real value of herbals as therapeutic agents. It is especially disappointing when popular media, promotional literature and talk shows by individuals promoting quackery are given much publicity. Even worse, many individuals trained in the health sciences are promoting quackery. This has often left the consumers with the perception that the authority condones the improper use of herbal products. Thus, it is important for pharmacists and physicians to be trained in traditional herbal medicine so that they can educate the public on the benefits, quality, safety and proper use of herbal products.
The study examined the use of linguistic contextual cues among native, Malay-speaking normal hearing young adults. Ten undergraduate students of Universiti Kebangsaan Malaysia participated in the study. All subjects had normal hearing with the average hearing threshold levels for the overall left and the right ears of 7.8 dB (SD 4.1). The Malay Hearing in Noise Test (MyHINT) materials were employed and presented to the subjects at an approximately 65 dBA presentation level. Testing was conducted in a sound field in three different listening conditions: in quiet, in noise with +5 dB signal-to-noise ratio (SNR) and 0 dB SNR. In every test condition, three lists of MyHINT were administered to each subject. The magnitude of context effects was measured using the j factor, which was derived from measurements of recognition probabilities for whole sentences (13,) and the constituent words in the sentences (PP) in which j = log P./ log P P. Results showed that all subjects scored 100% identification of words in sentences and whole sentences in quiet listening condition, while subjects' performances in 0 dB SNR were significantly poorer than that in quiet and in +5 dB SNR (p < 0.001). The j-values were significantly correlated with the probability of recognizing words in the sentences (r = 0.515, p = 0.029) in which lower j values were associated with lower P ps. Subjects were not significantly different from each other in their use of contextual cues in adverse listening conditions [F(9, 7) = 1.34, p = 0.359]. Using the linear regression function for j on word recognition probabilities, the predicted P. were calculated. It was found that the predicted and measured probabilities of recognizing whole sentences were highly correlated: r = 0.973, p < 0.001. The results suggested that linguistic contextual information become increasingly important for recognition of sentences by normal hearing young adult listeners as SNR deteriorates.
MeSH terms: Adult; Auditory Perception; Cues; Hearing Tests; Humans; Linguistics; Malaysia; Noise; Probability; Sound; Students; Linear Models; Young Adult; Signal-To-Noise Ratio
Polyvinyl chloride (PVC) and ammonio methacrylate copolymer (Eudragit RS 100) were used as models in binary mixture tablets of direct compression study. Eudragit RS 100 is a copolymer synthesized from acrylic and methacrylic acid esters with a low content of quaternary ammonium groups. Combination of PVC and Eudragit RS 100 of different polarities and knowing the surface free energy values allow the possibility of predicting the tensile strength of the tablets. Specimens of 500 mg in the form of thin plates (25 mm x 12.5 mm), were made by compressing each powder at 20 000 MP a compression pressure using a special punch and die set. A Howden Universal Testing Machine was used to compress the powder. Contact angle measurements of the samples were carried out using a Wilhelmy balance, ran by a Cahn Dynamic Contact Angle Machine while different test liquids media such as water, glycerol, formamide and PEG 200 were used in the study. The surface free energy values of the solid materials were calculated using Wu's equation. The results showed large differences between the advancing and receding contact angle values for both materials when tested with glycerol: PVC (0) and PVC (0,) were 93.2 and 65.24 while Eudragit RS 100 (0) and Eudragit RS 100 (0) were 94.56 and 68.18 respectively. The surface free energy values for PVC using PEG 200-glycerol liquid pair were Is: 38.01, ysci: 33.42, ysP: 4.59 and for Eudragit RS 100 using formamide-glycerol liquid pair were ys: 75.03, yd: 51.66, ysP : 23.37, respectively. The results showed harder solid material like Eudragit RS 100 had higher surface free energy compared to elastic material like PVC.
Kajian garis pangkal pengimejan resonans magnet kefungsian (fMRI) telah dijalankan ke atas 2 orang subjek lelaki sihat (kidal dan tidak kidal) masing-masing berumur 22 dan 25 tahun. Imbasan fMRI dijalankan menggunakan sistem pengimejan resonans magnet (MRI) 1.5 T di Jabatan Radiologi, Hospital Universiti Kebangsaan Malaysia. Kajian ini menggunakan gerakanjari tangan kanan dan kiri untuk merangsang aktiviti neuron di dalam korteks serebrum. Paradigma 5 kitar aktifIrehat digunakan dengan setiap kitar mengandungi satu blok aktif dan satu blok rehat yang masing-masing mengandungi 10 siri pengukuran. Imej fMRI dianalisis menggunakan pekej perisian MatLab dan pemetaan statistik berparameter 2 (sPM2). Proses pendaftaran jasad tegar menggunakan penjelmaan afin 6 parameter dilakukan ke atas kesemua imej kefungsian berwajaran T2*. Keputusan menunjukkan bahawa pergerakan subjek adalah minimum sama ada dalam arah translasi (< 1 mm) atau putaran (< 1 ). Kesemua imej dinormalkan melalui proses peledingan tak linear menggunakan penjelmaan afin 12 parameter dan didapati sepadan dengan pencontoh yang telahpun mematuhi ruang anatomi piawai. Walau bagaimanapun, bentuk, resolusi dan kontras imej kefungsian telah berubah sedikit berbanding dengan imej asal. Pelicinan imej menggunakan kernel Gaussian isotropik 6 mm menyebabkan data imej lebih bersifat parametrik dengan kehilangan yang ketara dalam resolusi dan kontras. Pengasingan struktur yang dilakukan ke atas imej berwajaran T1 mengklaskan tisu otak kepadajirim kelabu, jirim putih dan bendalir serebrospina. Pasca pemprosesan ruang bagi imej kefungsian dan struktur menjadikan data imej bersifat parametrik dengan taburan jenis Gaussian dan sedia untuk dianalisis menggunakan model linear am dan teori medan rawak Gaussian.
MeSH terms: Ataxia Telangiectasia; Magnetic Resonance Imaging; Malaysia; Neurons; Normal Distribution; Magnets