Browse publications by year: 2011

  1. Viprakasit V, Ibrahim H, Ha SY, Ho PJ, Li CK, Chan LL, et al.
    Int. J. Hematol., 2011 Mar;93(3):319-328.
    PMID: 21374076 DOI: 10.1007/s12185-011-0789-8
    Although thalassaemia is highly prevalent in the Asia-Pacific region, clinical data on efficacy and safety profiles of deferasirox in patients from this region are rather limited. Recently, data from the multicentre Evaluation of Patients' Iron Chelation with Exjade (EPIC) study in 1744 patients with different anaemias has provided an opportunity to analyse 1115 thalassaemia patients, of whom 444 patients were from five countries in the Asia-Pacific region (AP) for whom thalassaemia management and choice of iron chelators were similar. Compared to the rest of the world (ROW), baseline clinical data showed that the AP group appeared to be more loaded with iron (3745.0 vs. 2822.0 ng/ml) and had a higher proportion on deferoxamine monotherapy prior to the study (82.9 vs. 58.9%). Using a starting deferasirox dose based on transfusional iron intake and tailoring it to individual patient response, clinical efficacy based on serum ferritin reduction in AP and ROW thalassaemia patients was similar. Interestingly, the AP group developed a higher incidence of drug-related skin rash compared to ROW (18.0 vs. 7.2%), which may indicate different pharmacogenetic backgrounds in the two populations. Our analysis confirms that, with appropriate adjustment of dose, deferasirox can be clinically effective across different regions, with manageable side effects.
    MeSH terms: Adolescent; Adult; Asia, Southeastern; Benzoates/administration & dosage*; Child; Child, Preschool; Female; Ferritins/blood; Humans; Iron Chelating Agents/administration & dosage*; Male; Thalassemia/blood; Thalassemia/drug therapy*; Triazoles/administration & dosage*
  2. Heng LL, Caguioa P, Chin NS, Chiou TJ, Lee JW, Miyakawa Y, et al.
    Int. J. Hematol., 2011 Aug;94(2):142-149.
    PMID: 21766185 DOI: 10.1007/s12185-011-0894-8
    Patients with primary immune thrombocytopenia (ITP) from the Asia-Pacific region often exhibit characteristics distinct from those of patients from the West. Moreover, as the region itself is heterogeneous, the ITP landscape among individual Asia-Pacific countries can be diverse. The recently released international consensus report on ITP places new emphasis on ITP, but does not address the unique ITP landscape in the Asia-Pacific region, which is home to 60% of the world's population. In an attempt to characterize how the ITP landscape differs between the West and the Asia-Pacific region, an expert panel with representatives from Northeast Asia, Southeast Asia, and Australia was convened. Important differences were identified between the guidance provided in the international consensus report and experience in the Asia-Pacific region, namely diagnostic practices, incidence and approach to ITP secondary to H. pylori infection, systemic lupus erythematosus-related ITP, the use of bone marrow examination, initial treatment strategies, and the role of splenectomy, rituximab, and thrombopoietin receptor agonists.
    MeSH terms: Adult; Asia/ethnology; Asia/epidemiology; Ethnic Groups; Far East/ethnology; Far East/epidemiology; Humans; Practice Guidelines as Topic
  3. Farzaneh F, Esmaeilnia H, Barouti E, Salehpour S, Khodakarami N, Alizadeh K, et al.
    Med. J. Malaysia, 2011 Dec;66(5):468-73.
    PMID: 22390103
    This study aimed to determine knowledge and attitude of women to HPV and its association with cervical cancer and prevention methods. In a cross-sectional study, 500 women, aged between 20 and 50 presenting to local health centers in Tehran, were asked about demographic factors and questioned about cervical cancer, HPV, and prevention methods. Responses were tabulated and summarized. Although knowledge of HPV, its relation to cervical cancer and prevention methods among Iranian women is not enough, their attitude towards education in this regards is extremely high. The results reflect the need of advertising and educational programs for public about HPV prevention methods, to reduce the prevalence of this infection and its severe consequences.
    MeSH terms: Adult; Uterine Cervical Neoplasms; Cross-Sectional Studies; Female; Humans; Iran/epidemiology; Health Knowledge, Attitudes, Practice*; Middle Aged; Surveys and Questionnaires; Prevalence; Focus Groups; Papillomavirus Infections*; Papillomavirus Vaccines*
  4. Sulaiman W, Husin NM, Baba MS
    Oman Med J, 2011 Nov;26(6):e026.
    PMID: 28861180 DOI: 10.5001/omj.2011.119
    A 33-year old Malay woman with undiagnosed systemic lupus erythematosus (SLE) and other comorbids presented with acute glomerularnephritis, hypertensive emergency and later acute confusional state. Cranial MRI revealed features consistent with posterior reversible encephalopathy syndrome (PRES).
  5. Rao M, Ashwini LS, Somayaji SN, Mishra S, Guru A, Rao A
    Oman Med J, 2011 Nov;26(6):e027.
    PMID: 28861181 DOI: 10.5001/omj.2011.120
    Variation in the origin of long flexor tendons in the anterior compartment of forearm is common. During routine cadaveric dissection at Melaka Manipal Medical College (Manipal Campus), we observed a separate muscle belly and tendon of flexor digitorum superficialis (FDS) to the fifth digit in the right upper limb of a 60 year-old male cadaver. The anomalous muscle belly originated from the common flexor tendon from the medial epicondyle of the humerus and continued as a thin tendon at the middle of the forearm to get inserted into the middle phalanx of the fifth digit. This can be considered as a case of split flexor digitorum superficialis. Such muscle variations and knowledge of their frequency, appearance, and location can be helpful for surgeons.
  6. Campos-Arceiz A, Steele MA, Carlo TA, Xiong W
    Integr Zool, 2011 Jun;6(2):71-73.
    PMID: 21645272 DOI: 10.1111/j.1749-4877.2011.00241.x
    MeSH terms: Animals; Diet*; Feeding Behavior; Fruit*; Seed Dispersal*
  7. Seung OP, Sulaiman W
    Oman Med J, 2011 Sep;26(5):e022.
    PMID: 28845225 DOI: 10.5001/omj.2011.96
    Adult-onset Still's disease (AOSD) is a rare clinical entity with unknown etiology, characterized by arthritis, fever, evanescent rash and other systemic presentations. This report described a 45-year-old male who presented with sore throat, fever, arthritis, evanescent rash, raised liver enzymes and hyperferritinemia. He was diagnosed to have AOSD based on Yamuguchi criteria after the exclusion of other potential diagnoses. The patient partially responded to combined celecoxib and prednisolone. He was also prescribed methotrexate and his symptoms improved.
  8. Manns M, Zeuzem S, Sood A, Lurie Y, Cornberg M, Klinker H, et al.
    J. Hepatol., 2011 Sep;55(3):554-563.
    PMID: 21237227 DOI: 10.1016/j.jhep.2010.12.024
    BACKGROUND & AIMS: There is increasing interest in identifying patients with chronic hepatitis C genotype 2 or 3 infection in whom it is possible to lower the burden of therapy while retaining high levels of efficacy.

    METHODS: Treatment-naive patients with chronic hepatitis C genotype 2/3 infection were randomized to receive peginterferon alfa-2b (1.5μg/kg/wk) for 24weeks (group A); peginterferon alfa-2b (1.0μg/kg/wk) for 24weeks (group B); or peginterferon alfa-2b (1.5μg/kg/wk) for 16weeks (group C), each in combination with weight-based ribavirin (800-1200mg/d). The study population comprised two cohorts: the Hep-Net cohort enrolled in Germany and an International cohort enrolled at study sites throughout Europe and Asia. The primary end point was sustained virological response (SVR).

    RESULTS: The study included 682 patients; 80.2% had genotype 3 infection. In the intent-to-treat population, SVR rates were 66.5%, 64.3%, and 56.6% in groups A, B, and C, and were similar in Asian and white patients. Treatment differences (A vs. B and A vs. C) failed to reach the predefined margin for noninferiority of -10%; and thus groups B and C failed to show noninferiority relative to group A. Among patients with undetectable HCV RNA at week 4, SVR rates were 75.3%, 75.9%, and 72.4%, respectively. Relapse rates were 17.8%, 16.3%, and 29.3%, respectively. Treatment-emergent serious adverse events were highest in group A and lowest in group C, and adverse events leading to discontinuation were similar across treatment arms.

    CONCLUSIONS: For patients with chronic hepatitis C genotype 2/3 infection, 24weeks of peginterferon alfa-2b (1.5μg/kg/wk) plus weight-based ribavirin remains a standard-of-care therapy; however, treatment for 16weeks may be considered for patients with undetectable HCV RNA at week 4 of the treatment.

    MeSH terms: Adult; Body Weight; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; Polyethylene Glycols/administration & dosage*; Polyethylene Glycols/adverse effects; Polyethylene Glycols/therapeutic use; Recombinant Proteins/administration & dosage; Recombinant Proteins/adverse effects; Recombinant Proteins/therapeutic use; Recurrence; Ribavirin/administration & dosage*; Ribavirin/adverse effects; Ribavirin/therapeutic use; RNA, Viral/blood; Time Factors; Hepacivirus/genetics*; Interferon-alpha/administration & dosage*; Interferon-alpha/adverse effects; Interferon-alpha/therapeutic use; Hepatitis C, Chronic/drug therapy*; Hepatitis C, Chronic/ethnology; Hepatitis C, Chronic/virology*; Intention to Treat Analysis
  9. Thomas S, Beh L, Nordin RB
    J Public Health Africa, 2011 Sep 05;2(2):e23.
    PMID: 28299064 DOI: 10.4081/jphia.2011.e23
    Since 1957, there has been major reorganization of health care services in Malaysia. This article assesses the changes and challenges in health care delivery in Malaysia and how the management in health care processes has evolved over the years including equitable health care and health care financing. The health care service in Malaysia is changing towards wellness service as opposed to illness service. The Malaysian Ministry of Health (MOH), being the main provider of health services, may need to manage and mobilize better health care services by providing better health care financing mechanisms. It is recommended that partnership between public and private sectors with the extension of traditional medicine complementing western medicine in medical therapy continues in the delivery of health care.
  10. Jung JH, Arkoncel FR, Lee JW, Md Yusoff NA, Hong CH, Hong SJ, et al.
    J Robot Surg, 2011 Jun;5(2):149-51.
    PMID: 27637544 DOI: 10.1007/s11701-011-0250-2
    We report the technique and outcomes of immediate robot-assisted ureteral reimplantation due to unexpected ureteral injury during robot-assisted laparoscopic prostatectomy (RALP). A 61-year-old male was diagnosed with locally advanced prostate adenocarcinoma (T3bN0M0). Multiple positive margins at the bladder neck were noted on frozen section during RALP, and re-excision of the bladder neck was done. Unfortunately, the distal third of right ureter was transected. We immediately performed robot-assisted ureteroneocystostomy with double J stent insertion. No complications developed during the follow-up period.
  11. Tsapaki V, Faruque Ghulam M, Lim ST, Ngo Minh H, Nwe N, Sharma A, et al.
    Heart Asia, 2011;3(1):16-24.
    PMID: 27325974 DOI: 10.1136/ha.2009.001180
    Increasing use of interventional procedures in cardiology with unknown levels of radiation protection in many countries of Asia-Pacific region necessitates the need for status assessment. The study was part of an International Atomic Energy Agency (IAEA) project for achieving improved radiation protection in interventional cardiology (IC) in developing countries.
  12. Ab. Karim, M.S., Nasouddin, S.S., Othman, M., Mohd Adzahan, N., Hussin, S.R., Khozirah, S.
    Melicope ptelefolia (MP) is one of the alternative herbal resources which have a great potential to be marketed worldwide. Because of its exploratory nature, this study used qualitative research methodology, which is natural and highly interpretive in order to gain consumer insights. This preliminary qualitative study used an in-depth personal interview approach for data collection. Informants for this study were 30 regular consumers of MP, aged from 18 years old and above. From the findings, it is reported that MP had a slightly bitter taste, crunchy young leaves, pungent, and lemon-lime aroma. In terms of its physical characteristics, it is said that MP has trifoliate, green, thick, broad leaves and has small white and greenish flowers. Respondents have varying levels of awareness and knowledge regarding MP but most of them believed that medicinal products can be produced from this herb. Respondents also stressed the importance of scientific research to properly develop MP into medicinal products and turn it into alternative treatment that has commercial values in the market.
    MeSH terms: Humans; Oxides; Surveys and Questionnaires; Taste; Calcium Compounds; Rutaceae; Flowers; Qualitative Research
  13. MyJurnal
    The aim of this study was to examine vegetarian burger patties manufactured by two producers in Malaysia for the presence of Listeria monocytogenes. Brand A was produced by an established food manufacturer
    while Brand B was produced by a small-scaled food producer. A total of 108 samples of vegetarian burger
    patties produced by both manufacturers were sampled from retail market and were analyzed by combined
    MPN-PCR and MPN plating method. Of all the samples tested, ten (9.3%) were found to be contaminated with L. monocytogenes. The L. monocytogenes contamination level in vegetarian burger patties manufactured by producer A (20.9% of the samples were contaminated with 3-1100 MPN/g of L. monocytogenes) was significantly higher (P
    MeSH terms: Vegetarians; Listeriosis; Listeria monocytogenes; Malaysia; Meat Products; Polymerase Chain Reaction
  14. Redhwan AA, Low WY, Mustafa FM, Robert C, Ali A
    This study aimed to determine the perceptions and opinions of medical students about food allergy. Universal sampling was used to conduct focus group discussions. The majority of the participants 40 (67%) mentioned that the common symptoms of food allergy are: skin rashes, swollen lips, diarrhea, vomiting, bronchospasm, redness, itchiness, difficulty in breathing, stomach ache and fever. Majority of participants mentioned that seafood is the food that can cause most food allergies 52 (87%), followed by tree nuts 25 (42%), peanuts and dairy products 19 (32%). Regarding the most allergenic food named by the participants are seafood 23 (38%); followed by milk and dairy products 5 (8%) and nuts 5 (8%). The majority of participants mentioned that food allergy can be fatal 48 (80%), a child can catch food allergy 57 (95%), and 10 of 100 people would have food allergy 31 (52%). Half of the participants 30 (50%) mentioned that it is very hard to care for children with food allergy. The majority of participants mentioned that food allergies do run in families 50 (83%), avoiding allergenic food is the best preventive methods 36 (60%) and that food allergy can be treated and will go away and 32 (53%). This study showed that in spite of sufficient knowledge among medical students about food allergy, some misconceptions still exist such as the high prevalence of food allergy and that food allergy can be treated and will go away. Therefore, there is a need for improving the continuous medical education among medical students with regard to food allergy because they are our future physicians.
    MeSH terms: China/ethnology; Female; Food Hypersensitivity; Humans; India/ethnology; Malaysia; Malaysia/ethnology; Male; Milk; Nuts; Arachis; Students, Medical; Universities; Focus Groups; Seafood; Qualitative Research; Young Adult
  15. Wan Norhana, M. N., Masazurah A. R.
    Hepatitis A is a liver infection caused by the hepatitis A virus (HAV). Outbreaks of hepatitis A have been linked to the consumption of both raw and cooked shellfish. These outbreaks could induce a public confidence problem over shellfish safety and may result in important economic losses for the seafood industry. The work presented in this study investigated the presence of HAV in shellfish from Peninsular Malaysia. A total of 365 of cultured and wild shellfish from 36 sampling locations located throughout Peninsular Malaysia were examined using a commercial nucleic acid extraction and reverse transcription -polymerase chain reaction (RT-PCR) kit. HAV was not detected in almost all of the shellfish samples xamined. Only one cockle sample from Changkat, Seberang Perai was positive for HAV. The results suggest the absence of HAV or very low amount of HAV viral particles in most of the shellfish examined.
    MeSH terms: Animals; Communicable Diseases; Disease Outbreaks; Hepatitis A; Malaysia; Nucleic Acids; Shellfish; Virion; Seafood; Reverse Transcriptase Polymerase Chain Reaction; Hepatitis A virus; Reverse Transcription; Cardiidae; Biological Processes
  16. MyJurnal
    To gain insight into the microbiological safety of food products routinely traded across international borders in Southeast Asian countries, beef imported from Malaysia to southern Thailand was examined for contamination with Escherichia coli O157 and its subsequent spread into the imported areas. We screened 31 samples exported from Malaysia and 36 domestic Thai samples. Isolation methods including an O157 antigen-targeted immunomagnetic separation technique, screening on CHROMagar O157 medium, and serotype confirmation of E. coli isolates by specific agglutination tests were employed. Fourteen strains of E. coli O157:H7 were isolated from eight Malaysian samples (25.8%) and six strains from four Thai samples (11.1%). These strains were of the stx1-stx2+eae+ genotype except one Malaysian strain which was of the stx1- stx2- eae+ genotype. All 19 O157:H7 strains possessing the stx2 gene produced little or no Stx2 (reversed passive latex agglutination titer ≤ 4). Of the 19 strains, five Malaysian (38.5%) and two Thai (33.3%) strains exhibited resistance to a set of antibiotics. Finally, the results of two DNA fingerprinting
    analyses (O157 IS-printing targeted to IS629 and pulsed-field gel electrophoresis, PFGE) of the O157:H7 strains possessing the stx2 gene, indicated that the Malaysian and Thai strains are closely related. Therefore, E. coli O157:H7 might be transferred from Malaysia to southern Thailand through beef trade.
    MeSH terms: Red Meat; Agglutination; Agglutination Tests; Animals; Animals, Domestic; Anti-Bacterial Agents; Cattle; Genotype; Latex; Latex Fixation Tests; Malaysia; Meat; Printing; Thailand; DNA Fingerprinting; Electrophoresis, Gel, Pulsed-Field; Immunomagnetic Separation; Escherichia coli O157; Serogroup
  17. Ghassem, M., Babji, A. S., Forsythe, S. J.
    Cronobacter sakazakii is an emerging food borne pathogen which has been associated with outbreaks of a rare form of infant meningitis. Although the origin of the microorganism has not been established, several
    infection cases have been associated with the consumption of contaminated powdered infant formula (PIF). In the present study, growth characteristics of three C. sakazakii strains isolated from PIF samples and C.
    muytjensii strain ATCC 51329, which was formerly the ATCC Preceptrol™ strain for the quality control of
    ‘Enterobacter sakazakii’ prior to the taxonomic revision, were investigated in Tryptone Soya broth (TSB) and
    reconstituted PIF at 4, 10, 25, 37, 45 and 50ºC. The viability of heat treated cells of Cronobacter strains was
    evaluated by plating on Violet Red Bile Glucose agar (VRBGA) and the Druggan-Forsythe-Iversen (DFI)
    chromogenic agar followed by incubation at 37ºC. These strains were also subjected to higher temperatures
    between 52 to 60ºC to measure their thermal tolerance. The mean generation time of all Cronobacter strains
    were slightly lower in PIF than in TSB. C. muytjensii ATCC 51329 showed lower generation time in all culture
    media and all temperatures compared to the Cronobacter food isolates, but the results were not significantly
    different (P>0.05). The results also indicated that combination of PIF: DFI culture media had higher recovery at
    all temperatures compared to other combinations. Survival study also indicated that C. muytjensii ATCC 51329
    had higher D-value compared to food isolates at all incubation temperatures.
    MeSH terms: Agar; Bile; Culture Media; Disease Outbreaks; Glucose; Hot Temperature; Humans; Infant; Meningitis; Quality Control; Temperature; Viola; Infant Formula; Cronobacter sakazakii; Biological Processes; Physiological Processes; Cronobacter
  18. Koh, S. P., Long, K., Yusoff, M. S. A., Arifin, N.
    The potential use of medium- and long-chain triacylglycerols (MLCT) oil blends in food applications such as frying oil and salad dressings were investigated. The frying strength of palm-based MLCT oil with different antioxidants under deep frying conditions was assessed. Palm-based MLCT oil showed better thermal-resistant oxidative strength than refined, bleached and deodorized (RBD) palm olein throughout the five consecutive days of frying. Sensory evaluation and rancidity assessment on fried chips showed no significant differences (P > 0.05) between chips fried in RBD palm olein and palm-based MLCT oil. MLCT-based salad dressings treated with different antioxidants showed similar rheological behaviors as compared to soybean based salad dressings. The overall quality of the physical appearance and organoleptic acceptability based on quantitative descriptive analysis showed no significant differences (P > 0.05) in all salad dressings. These findings indicated that MLCT-based oil blends can be used as healthy functional oil for daily consumption.
    MeSH terms: Body, Physical Appearance; Antioxidants; Bandages; Food; Oxidation-Reduction; Plant Oils; Sensation; Soybeans; Triglycerides
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