Browse publications by year: 2020

Fulltext Epidemiology and determinants of serologically diagnosed HIV-1 and HIV-1&2 in tertiary hospitals of Eastern Peninsular Malaysia

Siti Aishah Muhadi, Habsah Hasan, Nurahan Maning, Nik Rosmawati Nik Husain, Fatimah Haslina Abdullah

Malaysian Journal of Medicine and Health Sciences, 2020;16(201):9-15.
MyJurnal

Introduction: HIV is the leading cause of mortality and morbidity worldwide. There are two types of HIV, HIV-1, and HIV-2, which are geographically different in epidemiology and determinants. Objective: To determine the epidemiology and determinants of HIV-1 and HIV-1&2 in the three tertiary hospitals of Eastern Peninsular Malaysia. Method: A cross-sectional study of confirmed serologically HIV-1 and HIV-1&2 from January 2016 until December 2018. SPSS analysed all collected data, descriptive statistics for sociodemographic data and Pearson chi-square for the association between type of HIV with HCV, HBV, syphilis, and tuberculosis. In identifying the risk factor associated with HIV-1&2, several variables were tested by the Multiple Logistic Regression Model. A P-value of
Fulltext Knowledge and attitude towards vaccine preventable diseases and vaccination among prospective Malaysian Hajj Pilgrims in Klang Valley, Malaysia

Zhi Han Tan, Fatin Nor Aisyah Mohammed Zamli, Lukman Hariz Mohd Izal, Narcisse Joseph, Nurul Azmawati Mohamed, Syafinaz Amin Nordin

Malaysian Journal of Medicine and Health Sciences, 2020;16(201):2-8.
MyJurnal

Introduction: Hajj is a unique religious mass gathering among Muslims hosted by Kingdom of Saudi Arabia (KSA) annually. It is a fifth pillar that is compulsory to be carried among muslim. Infections due to Neisseria meningitidis, Streptococcus Pneumoniae and Influenza virus are very high among Hajj pilgrims in KSA. Study shows knowledge and attitude towards vaccine preventable disease and vaccination which is very important for the prevention of these infectious diseases. This study aims to determine knowledge and attitude among the prospective Malaysian hajj pilgrims on vaccine preventable disease and vaccination. Method: A cross sectional study was conducted among prospective hajj pilgrims in June 2019. Self-administered questionnaires were given to the respondents through simple random sampling. The socio-demographic characteristics were described using descriptive analysis. Chi-square test was used to analyse the association between the socio-demographic and Malaysian hajj pilgrims’ knowledge and attitude towards the vaccine preventable diseases and vaccination. Results: A total of 135 respondents were recruited in the study. There were statistically significant associations between the knowledge and the highest education level (p=0.01), and also between the knowledge and the occupation (p=0.02) on vaccine preventable disease and vaccination. Conclusion: There is a lack of knowledge among the Malaysian hajj pilgrims about these vaccine preventable diseases and vaccination, especially those who have lower education level and also unemployed. Tabung Haji are highly advised to focus on these group and prepare a special course that focused on these vaccine preventable diseases so that Malaysian Hajj pilgrims will be protected.
Outer hair cell functioning in infants with iron deficiency anemia

Sundagumaran H, Seethapathy J

Int J Pediatr Otorhinolaryngol, 2020 Nov;138:110393.
PMID: 33152983 DOI: 10.1016/j.ijporl.2020.110393

BACKGROUND: Distortion product otoacoustic emissions (DPOAE) in infants with Iron Deficiency Anemia (IDA) helps in understanding the cochlear status especially the functioning of outer hair cells.
OBJECTIVES: To analyze the presence of DPOAE across frequencies and DP amplitude in infants with and without IDA.
METHOD: DPOAE were recorded on 40 infants with IDA and 40 infants without IDA in the age range of 6-24 months. Cubic DPOAEs (2f1-f2) were measured at six f2 frequencies (1500 Hz, 2000 Hz, 3000 Hz, 4500 Hz, 6000 Hz & 8000 Hz) with primary tone stimulus of intensity L1 equal to 65 dBSPL and L2 equal to 55 dBSPL. Immittance audiometry was performed using 226 Hz probe tone prior to DPOAE recording to ascertain normal middle ear functioning.
RESULTS: DPOAEs were present in all infants with and without IDA across frequencies tested. DP amplitude across the frequencies did not show any statistically significant difference (p

MeSH terms: Acoustic Stimulation; Audiometry; Child, Preschool; Cochlea; Humans; Infant; Otoacoustic Emissions, Spontaneous; Hair Cells, Auditory, Outer*
Fulltext Performance of HEC-HMS and ArcSWAT models for assessing climate change impacts on streamflow at Bernam River Basin in Malaysia

Habibu Ismail, Md Rowshon Kamal, Lai Sai Hin, Ahmad Fikri Abdullah

Pertanika Journal of Science & Technology, 2020;28(3):1027-1048.
MyJurnal

Hydrological models are reliable tools that have been extensively used for hydrological studies. However, the complexity of some of these models has been a major setback, which affects their performance. This study compared Hydrologic Engineering Corps Hydrologic Modeling System (HEC-HMS) with most widely applied Soil Water Assessment Tool (ArcSWAT) model and used to assess impacts of climate change on streamflow at Bernam Basin, Malaysia for 2010-2039, 2040-2069 and 2070-2099 to the baseline period (1976- 2005) using an ensemble of ten GCMs under three RCP scenarios (RCPs 4.5, 6.0 and 8.5). The models performed satisfactorily. However, HEC-HMS performed better compared to ArcSWAT with 0.74, 0.71, 4.21 and 0.37; and 0.71, 0.69, 5.32 and 0.31 for R2 , NSE, PBIAS and RSR, respectively, during the calibration and validation periods. Future periods suggest a decreasing pattern in streamflow, with a higher percentage (−5.94%) expected for the RCP 8.5 scenario in the late century (2080s) during dry season period. In the wet season, streamflow decreases in all future periods except for RCP4.5 where it is expected to increase (0.36%). Therefore, the Basin may likely experience tremendous pressure in the late century due to low streamflow, particularly in dry season months.
Fulltext Modified imperialistic competitive algorithm in hopfield neural network for boolean three satisfiability logic mining

Nur Ezlin Zamri, Alyaa Alway, Mohd. Asyraf Mansor, Mohd Shareduwan Mohd Kasihmuddin, Saratha Sathasivam

Pertanika Journal of Science & Technology, 2020;28(3):983-1008.
MyJurnal

Artificial neural networks (ANNs) are actively utilized by researchers due to their extensive capability during the training process of the networks. The intricate training stages of many ANNs provide a powerful mechanism in solving various optimization or classification tasks. The integration of an ANN with a robust training algorithm is the supreme model to outperform the existing framework. Therefore, this work presented the inclusion of three satisfiability Boolean logic in the Hopfield neural network (HNN) with a sturdy evolutionary algorithm inspired by the Imperialist Competitive Algorithm (ICA). In general, ICA stands out from other metaheuristics as it is inspired by the policy of extending the power and rule of a government/country beyond its own borders. Existing models that incorporate standalone HNN are projected as non-versatile frameworks as it fundamentally employs random search in its training stage. The main purpose of this work was to conduct a comprehensive comparison of the proposed model by using two real data sets with an elementary HNN with exhaustive search (ES) versus a HNN with a standard evolutionary algorithm, namely- the genetic algorithm (GA). The performance evaluation of the proposed model was analyzed by computing plausible errors, such as root mean square error (RMSE), mean absolute error (MAE), global minima ratio (Rm), computational time (CT) and accuracy (Q). The computational simulations were carried out by operating the different numbers of neurons in order to validate the efficiency of the proposed model in the training stage. Based on the simulations,
the proposed model was found to execute the best performance in terms of attaining small
errors and efficient computational time compared to other existing models.
Fulltext Palm oil trend analysis via logic mining with discrete hopfield neural network

Alyaa Alway, Nur Ezlin Zamri, Mohd Shareduwan Mohd Kasihmuddin, Saratha Sathasivam, Mohd. Asyraf Mansor

Pertanika Journal of Science & Technology, 2020;28(3):967-981.
MyJurnal

Analyzing commodity prices contributes greatly to traders, economists and analysts in
ascertaining the most feasible investment strategies. Limited knowledge about the price
trend of the commodities indeed will affect the economy because commodities like palm
oil and gold contribute a huge source of income to Malaysia. Therefore, it is important to
know the optimal price trend of the commodities before making any investments. Hence,
this paper presents a logic mining technique to study the price trend of palm oil with other
commodities. This technique employs 2-Satisfiability based Reverse Analysis Method
(2-SATRA) consolidated with 2-Satisfiability logic in Discrete Hopfield Neural Network
(DHNN2-SAT). All attributes in the data set are represented as a neuron in DHNN which
will be programmed based on a 2-SAT logical rule. By utilizing 2-SATRA in DHNN2-SAT,
the induced logic is generated from the commodity price data set that explains the trend
of commodities price. Following that, the performance evaluation metric; error analysis
and accuracy will be calculated based on the induced logic. In this case, the experimental
result has shown that the best-induced logic identifies which trend will lead to an increase
in the palm oil price with the highest accuracy rate.
Fulltext Extra derivative implicit block methods for integrating general second order initial value problems

Mohammed Yousif Turki, Fudziah Ismail, Norazak Senu

Pertanika Journal of Science & Technology, 2020;28(3):951-966.
MyJurnal

This paper focuses on the construction of two-point and three-point implicit block
methods for solving general second order Initial Value Problems. The proposed methods
are formulated using Hermite Interpolating Polynomial. The block methods approximate
the numerical solutions at more than one point at a time directly without reducing the
equation into the first order system of ordinary differential equations. In the derivation of
the method, the higher derivative of the problem is incorporated into the formula to enhance
the efficiency of the proposed methods. The order and zero- stability of the methods are
also presented. Numerical result
Fulltext Construction of 3D-terrain model from contour lines using parameterized B-Spline ruled surface

Muhammad Ammad, Ahmad Ramli

Pertanika Journal of Science & Technology, 2020;28(3):937-950.
MyJurnal

In this paper work, three-dimensional terrain models were reconstructed from twodimensional contour lines. Firstly, spatial curves were generated from contour lines using
parameterized cubic B-spline curve interpolation. Then surfaces were constructed by using
B-spline ruled surface. In the reconstruction process, some issues such as keyholes and
branching may arise. Therefore, we propose a method that handles the branching object to
construct a bilinear patch by following the proposed data point’s extraction algorithm. We
also solved keyholes issues by retaining the same knot vector condition on B-spline ruled
surface. Results are also demonstrated for models with branching and without branching.
Fulltext Work Engagement and Work-related Musculoskeletal Disorders Among Nurses

Nur Azma Amin, RM Noah, Oxley JA, Quek KF, Rusli BN

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):128-134.
MyJurnal

Introduction: Work-related musculoskeletal disorders (WRMSDs) is an alarming occupational health concern
worldwide. Nurses are among the professional at high risk of WRMSDs. Objective: This study explores
the prevalence WRMSDs and the association with work engagement among nurses. Methods: This
cross-sectional study used self-administered survey was disseminated to female nurses working at the
hospitals in the Klang Valley, Malaysia. The Standardized Nordic Musculoskeletal Questionnaire (N-SNMQ)
was used to determine the annual prevalence of WRMSDs. Level of work engagement was assessed
using Utrecht Work Engagement (M-UWES). Multivariate logistic regression was performed to assess
the association between WRMSDs and work engagement. Results: This study received high response
rate (83.3%) with annual prevalence of 73.1%. Most common WRMSDs was reported in neck (48.9%)
followed by feet (47.2%) while least was documented in arms and elbows (6.6%). After covariates
adjustment (age, years of employment), the adjusted logistic regression analyses highly engaged nurses
(AOR:0.71-0.74, 95%CI 0.56 – 0.95) were found to be unlikely sustained of WRMSDs. Conclusion: The
findings of this study addressed high prevalence of WRMSDs among nurses. High work engagement
could facilitate to reduce risk of WRMSDs, hence offer preventive strategies, making a substantial impact
on reducing WRMSDs.
Fulltext Knowledge, attitude and practice on food waste management among food vendors in Universiti Putra Malaysia, Serdang, Selangor

MN Naim, Haliza Abdul Rahman

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):118-127.
MyJurnal

Introduction: Malaysian produced about 38,000 tons of waste per day in 2017, and 15,000 tons of it was food waste. Objective: To determine the knowledge, attitude, and practice of food waste management among food vendors in Universiti Putra Malaysia (UPM), Serdang. Methods: Universal sampling has been conducted to the respondents who are all food vendors under UPM Holdings provision. In this study, a modified questionnaire has distributed online to 37 food vendors. Fisher’s Exact test was applied to determine the association among variables. Results: All respondents in UPM had a moderate level of knowledge, attitude, and practice on food waste management. The results highlighted that attendance in food waste management training has a significant association with food waste management (p
Fulltext Fatigue among traffic police officers in metropolitan city: exploring factors of noise exposure and work stressors

Irniza Rasdi, Nur Fatihah Din, Nurulizyati Roni, Ahmad Shahrul Nizam Isha@Isa

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):109-117.
MyJurnal

Introduction: Police work has been recognised worldwide as a very stressful job. Those especially in road traffic control department encounter an additional possible cause of fatigue which is noise exposure that rarely being explored. Methods: A cross-sectional study was conducted among traffic police officers in Kuala Lumpur to assess their level of fatigue and its risk factors including noise exposure, work stressors and individual factors. A total of 171 traffic police officers in Kuala Lumpur participated in this study. A set of questionnaires on socio-demographics, work characteristics, perception regarding noise pollution, PSQ and CIS were distributed to 200 traffic police officers in Kuala Lumpur. Five locations with heavy traffic volume in Kuala Lumpur were selected for ambient noise measure- ment, three times a day during peak hour by SLM. Results: The mean age, job tenure and BMI of respondents was 30.49±7.12yo, 4.73±4.62 years and 24.83 respectively. Most of them were Malay (81.9%), married (60.8%), and secondary school graduated (84.8%). The traffic noise exposure levels ranged between 69.50 dB(A) to 82.80 dB(A) (mean = 76.77±4.39 dB(A). Almost 20% of respondents reported to have fatigue level that puts them at risk for sub- sequent work disability. After considering several potential factors, lower educational levels (β=-3.67, p
Fulltext Distribution of musculoskeletal symptoms and ergonomic risk assessment among housekeepers at budget hotels in Sepang, Selangor

‘Aina Rusydina Ahmad Raji, Emilia Zainal Abidin

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):101-108.
MyJurnal

Introduction: : Hotel housekeepers are exposed to various ergonomic risks and there is a need to assess the physical risk factors for the work tasks performed. This study aims to determine the distribution of musculoskeletal symp- toms (MSS) and perform ergonomic risk assessment among hotel housekeepers working in budget hotels in District of Sepang, Selangor. Methods: A cross-sectional study was conducted among hotel housekeepers from 13 budget hotels around District of Sepang. Nordic questionnaire was used for the assessment of MSS. The overall risk level was determined by Workplace Ergonomic Risk Assessment (WERA) while Rapid Entire Body Assessment (REBA) was used to evaluate the whole body postural risks. Data obtained were entered into statistical program for further analysis according to objectives. Results: This study received 67.0% (n=40) response rate. In total, MSS was reported by 100% (n=40) of the participants in this study. Lower back is the most affected region (77.5%, n=31) and this was followed by heels (57.5, n=23) and shoulders (52.5%, n=21). WERA results showed that all housekeepers are found to be in medium action level of risk meanwhile REBA assessment reported scores that are categorised into medium, high and very high risk. This study suggests that there is the need for changes being implemented in daily work tasks performed. Conclusion: Hotel housekeepers were exposed to high body postural risk due to exposure to highly re- petitive movements and awkward posture while performing work tasks. Effective ergonomic intervention is needed for prevention of debilitating musculoskeletal disorders besides to increase work productivity.
Fulltext Thermal effect of spray drying process on the quality of ficus deltoidea extract

Nor Rashidah Ahmed, Harisun Yaakob, Ismail Ware, Husnul Hanani Soib, Fitrien Husin, Iylia Arina Md Zaki

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):95-100.
MyJurnal

Introduction: Spray dry is a single step of drying method to transform the fluid materials to dry particles. Common practice for producing the solid form is by using the freeze dry technique. However, the existing freeze dry process was associated with longer drying process, high maintenance and costly. Alternatively, researchers used spray drying during extraction process, yet, an elevated drying temperature applied may incur some effects on the quality and quantity of the extract. Therefore, the present study was aimed to investigate the thermal effect of spray drying process on the quality of spray dried Ficus deltoidea (F.deltoidea). Methods: The thermal effects of spray drying were identified at three different inlet air temperatures (160 oC, 191 oC and 220 oC) which are minimum, optimum and maximum of inlet air temperature, respectively. The Box-Behnken Design through response surface methodology was utilized to identify the optimum operating conditions at these temperatures. The quality of F. deltoidea in terms of yield, moisture content, marker compound (vitexin), total saponins, total protein and total polysaccharides were studied. Results: From the study, total saponins and polysaccharides exhibited better retentions during the spray drying process. Meanwhile, vitexin and total protein was found decreasing by 30% and 50% respectively, during the spray drying process. Conclusion: High operating of air inlet temperatures in spray drying process contribute to higher process yield, produce non-sticky particles with lower moisture contents compared to drying process at 160 oC.
Fulltext Pesticide exposure and neurobehavioral effects among mosquito control workers

Mohd Hashadi Ma Hussin, Nurul Izzah Abdul Samad, Siti Marwanis Anua, Mohd Firdaus Yhaya, Nurul Ainun Hamzah

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):83-94.
MyJurnal

Introduction: The use of pesticides in pest management has increased rapidly and occupational exposures had adversely affect human health. This study investigated the types of pesticides used and their neurobehavioral effects towards mosquito control workers. Methods: A cross-sectional study was conducted among 46 Kelantanese mosquito control workers in two vector control units by using purposive sampling. Risk assessment on pesticides was based on the Chemical Health Risk Assessment (CHRA). A questionnaire was used to assess neurobehavioral symptoms and neurobehavioral performance was conducted using the Neurobehavioral Core Test Battery (NCTB). The individuals’ cumulative pesticide exposure was calculated by average fogging session within a month (session/month) and multiplying with the average duration for each fogging session (hours/session). Results: The risk level was moderate for all pesticides, except for Actellic 50 EC. Neurobehavioral symptoms reported were fatigue after work (80.4%), drowsiness (39.1%), fatigue after wake-up early in the morning (32.6%), and dizziness (32.6%). None of the reported neurobehavioral symptoms was associated with cumulative pesticide exposure (p > 0.05). Cumulative pesticide exposure was associated with Digit Symbol (Adj OR = -0.19, 95% CI: -0.37,-0.01), Digit Span (Backward) (Adj OR = -0.28, 95% CI: -0.31,-0.05), Trail Making (A) (Adj OR = -0.32, 95% CI: -0.37,-0.01),
Minnesota Manual Dexterity (Dominant) (Adj OR = -0.20, 95% CI: -0.38,-0.03), and Minnesota Manual Dexterity
(Non-dominant) (Adj OR = -0.18, 95% CI: -0.36,-0.01). Conclusion: Cumulative pesticides exposures are associated with the perceptual-motor speed, short-term auditory memory, attention, and coordination. Effective risk communication is proposed as one strategy to reduce pesticide exposure in occupational setting.
Fulltext Quality of work life (QWL) and riding behaviour among civil servants in Klang Valley

Noor Hidayah Jaafa, Irniza Rasdi, Nur Jamima Mohamad, Azlan Darus

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):75-82.
MyJurnal

Introduction: The number of road accidents involving workers was on the rise, with more than 30,000 cases recorded and 76.9% involved motorcyclists and pillion riders. Despite of numerous studies have been conducted to explore the causes of this worrisome condition, little is known on the influence of working quality to riding behaviour. Methods: This cross-sectional study involved 187 riders (male: 66.3%; female: 33.7%) with average age was 33 years were randomly selected civil servants in Putrajaya, Kuala Lumpur, and Selangor. Self-administered questionnaire was used to collect information on socio-demographic and working background, riding experience, quality of working life (WRQoL) and riding behaviour (SMRBQ). Results: The most prevalent unsafe riding behaviour reported was tailgating the vehicles in front (88.2%) and speeding (70.6%). In multiple linear regressions, being male (β = 0.16, p = 0.03), type of motorcycle (β = 0.14, p = 0.04), and stress at work (β = 0.20, p < 0.01), predict erroneous riding. Whereas, lower educational level (β = 0.17, p = 0.02), stress at work (β = 0.19, p = 0.01), and lower job satisfaction (β = 0.15, p = 0.04) predict poorer helmet use behaviour. Also, male and younger riders reported to have higher level of time and money opportunistic riding behaviour. Conclusion: Findings of the study suggests that riding behaviour can be improved by increasing the quality of working life among workers such as work related stress, job satisfaction and also control at work. Thus, program planner should consider WRQoL in designing intervention related to road safety program.
Fulltext Association Between nitrate exposure in groundwater and its health risk among residents in Machang District, Kelantan

Nik Muhamad Azraie Nik Yahaya, Shaharuddin Mohd Sham, Zaenal Abidin, Mochammad Sholehhudin

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):70-74.
MyJurnal

Introduction: Nitrate (NO3-) in groundwater originates from natural sources or human-made activities, including agriculture and industries. Anthropological activities can contribute to a substantial increase and may lead to health problems, such as methemoglobinaemia. The purpose of this research was to identify the level of nitrate in ground- water in villages located near paddy fields and to ascertain health risk towards residents. Methods: This research was carried out in January 2020 involving three villages in Machang district in Kelantan state, located north-east of Peninsular Malaysia. A total of 74 respondents were recruited with an equal number of wells studied. Nitrate levels were identified using the Hanna Instrument multi-meter with the nitrate electrode attached. Age, depth of wells and distance from paddy fields were also recorded. Weight of respondents was measured to calculate the hazard quotient related to nitrate exposure. Results: Nitrate levels in groundwater did not exceed the maximum limit of 10 mg/L set by health authorities. It ranged from 0.56 to 6.58 mg/L with a mean ± SD of 2.25±1.26 mg/L. Most wells were more than 20 years old (83.78%) and more than 15m deep (44.59%). Distance from paddy fields ranged from 3 – 150 m with a mean ± SD of 73.78±38.82 m. Level of nitrate between sampling sites were not significantly different (p > 0.05). The same goes for other variables (p > 0.05). Conclusion: Hazard Quotient for all residents was less than 1 (HQ < 1), as they were exposed to low levels of nitrate.
Fulltext Urbanization and tuberculosis in Peninsular, Malaysia (2011-2015)

Kirandeep Kulwant Kaur, Salmiah Md Said, Poh Ying Lim, Sharifah Norkhadijah Syed Ismail

Malaysian Journal of Medicine and Health Sciences, 2020;16(111):63-69.
MyJurnal

Introduction: Tuberculosis (TB) is a major global concern as it continues to kill million people annually despite the availability of effective treatment. One of the social factors affecting the spread of tuberculosis is urbanization. Tuberculosis remains as the leading cause of death from communicable diseases in Malaysia for more than a decade. Geographic information system (GIS) has been used to understand the epidemiology of infectious diseases, to identify hot spots/ clusters of areas/ populations at high risk. The aim of this study was to determine the correlation between urbanization and TB in the Peninsular of Malaysia during 2011-2015 and develop TB incidence risk map using GIS. Methods: A cross-sectional study was conducted using TB cases data on tuberculosis incidence, tuberculosis deaths, urban population, population and population density from the Ministry of Health, Malaysia for the period 2011 to 2015. This data was analysed using SPSS version 23.0 and Arc GIS. Results: The number of TB cases and urbanization varied in the Peninsular. There was a statistically significant strong positive correlation between the number of TB cases and urban population (r=.884, p
Discovery of HLA-B*35:368, a novel HLA-B*35 variant, in a Singaporean Malay hematopoietic stem cell donor

Kaur A, Cho L, Cereb N, Lin PY, Yang KL

HLA, 2020 07;96(1):94-95.
PMID: 32166893 DOI: 10.1111/tan.13862

DNA substitutions from codons 69 to 71 of HLA-B*35:05:01:01 result in a novel allele, HLA-B*35:368.

MeSH terms: Alleles; Base Sequence; Exons/genetics; Hematopoietic Stem Cells; Histocompatibility Testing; Malaysia; Taiwan; Sequence Analysis, DNA; Hematopoietic Stem Cell Transplantation*
HLA-B*15:349:02, a novel variant of HLA-B*15, discovered in a Singaporean Malay bone marrow donor

Cho L, Kaur A, Cereb N, Lin PY, Yang KL

HLA, 2020 09;96(3):344-345.
PMID: 32212215 DOI: 10.1111/tan.13879

One nucleotide substitution in codon 112 of HLA-B*15:349:01 results in a novel allele, HLA-B*15:349:02.

MeSH terms: Alleles; Base Sequence; Bone Marrow*; Exons/genetics; Histocompatibility Testing; Humans; Malaysia; Tissue Donors; Sequence Analysis, DNA; Amino Acid Substitution
Identification of a novel HLA-A*01 variant, HLA-A*01:211, in a Singaporean Malay bone marrow donor

Kaur A, Cho L, Cereb N, Lin PY, Yang KL

HLA, 2020 09;96(3):329-330.
PMID: 32227684 DOI: 10.1111/tan.13884

One nucleotide substitution in codon 73 of HLA-A*01:01:01:01 results in a novel allele, HLA-A*01:211.

MeSH terms: Alleles; Base Sequence; Bone Marrow*; Exons/genetics; Histocompatibility Testing; Humans; Malaysia; Tissue Donors*; HLA-A Antigens/genetics; Sequence Analysis, DNA; Amino Acid Substitution

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