Browse publications by year: 2020

  1. A. N. Azahari, N. D.M Yusob, H.A. Saidun, N.K.Y Ali, R. Abdullah, R. Hashim, et al.
    MyJurnal
    Introduction: Various phantom with varied materials has been proposed to replace the human body. Besides, there is always a demand to use the local material as a phantom material, which is readily available and inexpensive. Wood is usually preferred because it is multifunction, environmentally friendly, low in toxic, inexpensive, as well as easy to use and prepare. Previous studies have found that Rhizophora spp. is a suitable natural source material and has been suggested due to its comparable dosimetric properties to commercial phantom. Methods: In this study, fabricated Rhizophora spp. particleboards phantom was opted as a solid-equivalent phantom medium at low energy photon beams using Gafchromic film x-ray quality assurance 2 (XRQA2). Additionally, the characteristics of XRQA2 film in the diagnostic energy range were generated. Results: Interestingly, the density of the fabricated Rhizophora spp particleboards was observed to have the same density with the water equivalent material (ρ= 1.00 g.cm-3) and has shown to have loosened agreement with PDD of water phantom at approximately 25% of the dose error. Also, further analysis using XRQA 2 film showed that energy was independent at different ranges. Conclusion: The analysis of fabricated Rhizophora spp particleboards undertaken here has extended our knowledge of the possibility of man- ufacturing cost-effective water equivalent phantom by using binder-less particleboard from Rhizophora spp. There- fore, a definite need for smaller interspacing particles should be considered to elevate the potential of Rhizophora spp particle boards as water equivalent materials.
    MeSH terms: Cost-Benefit Analysis; Humans; Radiometry; Water; Wood; X-Ray Film; X-Rays; Human Body; Phantoms, Imaging; Rhizophoraceae
  2. Mohamed Abdelrasoul, Jahangir Bin Kamaldin, Jer Ping Ooi, Ahmed Abd El-Fattah, Gihan Kotry, Omneya Ramadan, et al.
    MyJurnal
    Introduction: Melatonin (MEL) loaded alginate-chitosan/beta-tricalcium phosphate (Alg-CH/β-TCP) composite hy- drogel has been formulated as a scaffold for bone regeneration. MEL in the scaffold was anticipated to accelerate bone regeneration. The objective of this study is to observe signs of systemic toxicity and physical changes on surface defected bone for bone regenerative performance of the composite. Methods: The proximal-medial metaphyseal cortex of the left tibia of New Zealand white rabbit was the surgical site of the defect. A total of nine rabbits were randomly allocated to three groups; Group I; implanted with MEL loaded Alg-CH/β-TCP, Group II; Alg-CH/β-TCP and Group III defects were sham control. The rabbits were daily observed to determine systemic toxicity effects by composites. The physical changes to implanted site were observed using digital x-ray radiography and computerized tomography at weeks 0, 2, 4, 6 and 8 of post-implantation. Results: There were no clinical signs of systemic toxicity for all groups of rabbits. Digital radiography did not show adverse effects to the bone. Computerized tomography showed reduction in the area size and depth volume of the implantation site, but accelerated regeneration within the 8 weeks was not significantly different (P
    MeSH terms: Alginates; Animals; Bone and Bones; Bone Regeneration; Calcium Phosphates; Melatonin; Rabbits; Radiographic Image Enhancement; Radiography; Tibia; Tomography; X-Rays; Chitosan
  3. Khadijah Abdul Hamid, Sazilah Ahmad Sarji, Mohammad Nazri Md Shah, Ibrahim Lutfi Shuaib
    MyJurnal
    Introduction: The purpose of this study was to determine the usefulness of SPECT-CT in differentiating metastatic and degenerative disease of the spine. Methods: Twenty-eight patients aged 50 years and above diagnosed with various cancers were referred for whole body (WB) planar bone scintigraphy. Those with a maximum three foci of tracer up- take in the spine were selected for the study. SPECT-CT of these areas of uptake was performed and the lesions were classified as degenerative, indeterminate or metastasis. A repeat study (WB planar bone scintigraphy and SPECT-CT) was performed between 3 to 12 months later. These areas of uptake were reassessed and compared with the first WB planar bone scintigraphy and SPECT-CT. The second SPECT-CT was used as the standard for the diagnosis. Results: Thirty-seven lesions in 28 patients were assessed. The sensitivity of the first WB planar bone scintigraphy, second WB planar bone scintigraphy and first SPECT-CT is 75%, 62.5% and 75% respectively. The specificity of the first WB planar bone scintigraphy, second WB planar bone scintigraphy and first SPECT-CT is 86%, 93%, 90% respectively. There was 2.7% of ‘indeterminate lesion’ in the first WB planar bone scintigraphy, 5.4% in the second WB planar bone scintigraphy, and 5.4% in the first SPECT-CT. The indeterminate lesions were resolved in the second SPECT-CT. Conclusion: SPECT- CT is useful in differentiating degenerative disease from metastatic lesions in the spine.
    MeSH terms: Aged; Humans; Middle Aged; Neoplasms; Radionuclide Imaging; Reference Standards; Spine; Tomography, X-Ray Computed; Whole Body Imaging; Single Photon Emission Computed Tomography Computed Tomography
  4. Syazana Jumaan, Jahangir Kamaldin, Rosliza Jajuli, Izfa Riza Hazmi
    MyJurnal
    Introduction: The study is introducing a laboratory technique to sustain the longevity of Heterotrigona itama sting- less bees collected from the farm in order to facilitate future health research on Kelulut honey. Methods: The worker bees were held in laboratory at 26 ± 2 oC, 57 ± 8 % relative humidity (RH) and 12:12 hours (light:dark period) in a cup covered with meshed cloth and installed with an inverted-wick system consists of a drinking straw with the bottom end loosely plugged with cotton wool. The artificial diet was pipetted into the straw to wet the cotton wool. The bees were divided into five diet groups, namely a) unfed - control, b) distilled water, c) purified tap water, d) non-carbonated isotonic drink or e) 5% honey solution. Feeding activity and survival of worker bees were observed daily. Results: The worker bees are seen to frequent and lick the cotton wool wetted with artificial diets. Comparison between the artificial diets, Kaplan-Meier statistical analysis showed that the 5% honey solution and non-carbonated isotonic drink have significantly (P < 0.05) extended the longevity of the worker bees with 50% survival probability at least 8 days. When the similar holding and feeding technique used for the bees from commercial farms, the 50% survival probability was extended to 14 days. Conclusion: The inverted-wick system with the use of 5% honey solu- tion or isotonic drink as the artificial diet is capable to hold the H. itama worker bees at least for a week with survival above 50% for laboratory experiments.

    MeSH terms: Animals; Bees; Bites and Stings; Diet; Honey; Humidity; Laboratories; Longevity; Probability; Water; Nutrition Therapy; Farms
  5. Salbiah Isa, Rohayu Hami, Hanita Hashim, Mohd Nizam S., Harani MS., Sairi S., et al.
    MyJurnal
    Introduction: Laboratory turnaround time (LTAT) is considered a reliable indicator of the quality and efficiency of a laboratory’s service. LTAT achievement, particularly of urgent tests, remains unsatisfactory and challenging in many clinical laboratories especially in tertiary health care centres with high workload and restricted resources. The unresolved issue of unsatisfactory urgent renal profile (RP) LTAT below the standard performance goal prompted our interest to improve laboratory’s handling of urgent test request. We thus implemented the Lean principle in the management of urgent test requests using urgent RP as the test model. Methods: The implementation of laboratory Lean involved 4 steps process; (1) Development of burning platform for change (2) Identification of waste (3) Plan- ning and implementation of control measures (4) Measuring, monitoring, and sustaining the improvement. Urgent RP LTAT and the percentage of the request met the time requirement determined based on the data extracted from laboratory information system (LIS) before and after the implementation of Lean was compared to assess the effec- tiveness. Results: Urgent RP LTAT after the implementation of Lean was reduced i.e 35 min (before) vs 31 min (after), with the percentage of LTAT met the time requirement was significantly increased above the set target i.e 82.8% (before) to 93.5% (after) with P-value = 0.001. Conclusion: Implementation of innovation using Lean management has significantly improved urgent RP LTAT achievement, thus optimised urgent test management in our Chemical Pathology laboratory. Lean is a strongly recommended strategy to improve urgent test LTAT especially in laboratories with restricted resources.
    MeSH terms: Clinical Laboratory Information Systems; Efficiency; Goals; Health Resources; Laboratories; Reference Standards; Workload; Efficiency, Organizational; Laboratory Chemicals
  6. Tan Pei Pei, Hafizuddin Mohamed Fauzi, Ernest Mangantig, Rosnah Bahar, Nur Arzuar Abdul Rahim
    MyJurnal
    Introduction: Unsafe blood products cause transfusion-transmissible infections. A good knowledge and perception about blood safety issues is crucial to ensure safe blood supply. The objective is to develop and validate a question- naire about the knowledge and perception among blood donors on blood safety issues. Method: A cross-sectional study was conducted among 130 blood donors who attended the National Blood Centre, Kuala Lumpur in April and May 2018. The questionnaire was developed in the Malay language after extensive literature search. The self-admin- istrated questionnaire consisted 39 items which required around 20 minutes to complete. The validation involved content validity, construct validity using exploratory factor analysis and reliability using test-retest analysis in IBM SPSS statistics. The same group of respondents was retested after two weeks using the same questionnaire. Results: Content validity was established through multidisciplinary expert meeting and two content reviewers. The factors loadings of all questionnaires were more than 0.40. Knowledge questions were divided into three domains; percep- tion questions were divided into four domains. The intraclass correlation (ICC) values of the test-retest were more than 0.80 for the three knowledge domains and more than 0.60 for the four perception domains. The third domain of the perception section which consisted two questions had the lowest ICC value of 0.686 (95% CI 0.583-0.767). One of the questions was restructured to improve clarity. Conclusions: The questionnaire on knowledge and perception on blood safety issues has good validity and reliability, with appropriate items which warranted its utilization among blood donors.
    MeSH terms: Blood Donors; Cardiovascular System; Cross-Sectional Studies; Factor Analysis, Statistical; Humans; Language; Malaysia; Perception; Surveys and Questionnaires; Reproducibility of Results; Blood Safety
  7. Hassanin Abdulkhabeer Ali Alyassiri, Anis Farhan Kamaruddin, Khoirulzariah Ismail, Noor Ayuni Ahmad Shafiai, Norma Ab Rahman, Wan Muhamad Amir W Ahmad
    MyJurnal
    Introduction: Coated archwires improve aesthetics during orthodontic treatment. However, little is known regarding
    their clinical benefit. This randomised controlled trial (RCT) compared the tooth alignment (TA), coating loss (CL),
    colour change (∆E*), and patient perception of coated archwires with their controls. Details of ∆E* and perception were reported in the second part of the articles. Methods: This RCT was done at three centres. Participants
    were randomised to receive one of four treatment interventions using 0.014” superelastic coated nickel-titanium
    archwires from Orthocare, RMO, G&H, and conventional uncoated 3M Unitek® archwires. These archwires were
    ligated during bonding and collected after eighth week and questionnaires were distributed to participants in the
    experimental groups only. After removal, TA and CL were measured using Little’s Irregularity Index and Autodesk®
    AutoCAD® software, respectively. At the time of this preliminary reporting, 84 participants had completed the trial. Two archwires fractured and were excluded. Therefore, 166 archwires (n = 166) were analysed. Results: Only
    non-extraction cases showed statistically significant differences in TA change between all groups (p = 0.005) and
    RMO showed significantly lowest mean of TA (1.5 mm). RMO and Orthocare showed significant TA change in the
    upper and lower arches (p = 0.037, 0.048). CL was found to be insignificant for both extraction and non-extraction
    cases (p >0.05). Comparison between upper and lower arches revealed no significant difference in TA and CL in all
    groups (p >0.05). Conclusion: From this preliminary analysis, Orthocare provides better TA in non-extraction cases
    despite highest percentage of coating loss.
    MeSH terms: Alloys; Color; Esthetics; Humans; Nickel; Orthodontic Wires; Perception; Surveys and Questionnaires; Software; Titanium
  8. Tan Jih Huei, Henry Tan Chor Lip, Chan Chee Kong, Ariz Chong B. Abdullah@Chong Chee Yong, Noor Azman Bin A. Rahman
    MyJurnal
    The incidence of neurenteric cyst (NC) is rare amongst spine tumors. It is most often asymptomatic but may present
    with sensory and motor symptoms. When associated with thoracic vertebra fusion it is not reported before, this complicates the placement of pedicle screw during posterior instrumentation. Herein, we report a case of thoracic spinal
    neurenteric cyst in a 40-year-old man that presents with chronic back pain, left lower limb weakness and numbness.
    Elective excision of NC over T6-T7 with laminectomy and multilevel posterior instrumentation was successfully
    performed with significant improvement of the symptoms. Neurenteric cyst is a rare spinal cord lesion which may
    cause permanent neurological sequalae. Complete surgical excision with spine fixation in this case provides good
    long-term outcome.
    MeSH terms: Adult; Back Pain; Humans; Hypesthesia; Laminectomy; Male; Neural Tube Defects; Spinal Cord; Spinal Neoplasms; Spine; Incidence; Lower Extremity; Pedicle Screws
  9. Wan Suriana Wan Ab Rahman, Zefarina Zulkafli, Mohd Nazri Hassan, Wan Zaidah Abdullah, Azlan Husin, Anani Aila Mat Zain
    MyJurnal
    Haemophilia A is an inherited bleeding disorder, commonly involve soft tissues and joints. Gastrointestinal tract
    bleeding, are not uncommon but seldom highlighted. A 23-year-old male with underlying severe haemophilia A was
    presented with a generalised abdominal pain for 2 days, abdominal distension, diarrhoea and vomiting. He did not
    have any trauma to the abdomen. Abdominal examination revealed generalized tenderness with sign of guarding
    on palpation. Laboratory investigations revealed isolated, prolonged activated partial thromboplastin time (APTT)
    with normal total white blood cell count and haemoglobin level. In view of acute abdomen, which was not resolved
    by conservative treatment, an emergency laparotomy was done with FVIII concentrate and recombinant factor VII
    (rFVII) coverage. Intraoperative findings noted patchy gangrenous spots of about 30 cm in length in the small bowel.
    Histopathology examination revealed an evidence of haemorrhage within the submucosal and intramuscularis layer
    from the resected specimen. This case highlighted the possibility of gastrointestinal bleeding without prior trauma,
    which can be presented as acute abdomen in severe haemophilia patient.
    MeSH terms: Abdomen; Abdomen, Acute; Adult; Diarrhea; Factor VII; Hemoglobins; Hemophilia A; Gastrointestinal Hemorrhage; Humans; Laboratories; Laparotomy; Leukocyte Count; Male; Palpation; Partial Thromboplastin Time; Vomiting; Abdominal Pain; Young Adult; Conservative Treatment
  10. Raymond DK Yeak, Nasir M Nizlan
    MyJurnal
    A 29-year-old man, who was a medical intern presented with history of recurrent shoulder dislocation. Radiographs
    and computed tomography imaging revealed a bony bankart lesion with glenoid bone loss of 25% with moderate
    Hill- Sachs lesion. Latarjet surgery was performed. At post-operative 8 months, the patient experienced pain and
    clicking in the left shoulder while performing cardiopulmonary resuscitation. At post-operative 1 year, magnetic resonance arthrography showed a united coracoid graft and intact posterior labrum. Left shoulder diagnostic arthroscopy and removal of Latarjet screws through a limited anterior deltopectoral approach were performed. The symptoms
    pain, clicking and instability sense was caused by either the prominent distal screw or the remnant suture material
    from the anchor which resulted in impingement of the infraspinatus muscle. We recommend the use of image intensifier to check on the position and length of the screw at the end of the surgery to avoid this complication
    MeSH terms: Adult; Arthrography; Arthroscopy; Bone Screws; Humans; Male; Magnetic Resonance Spectroscopy; Pain; Radiographic Image Enhancement; Scapula; Shoulder; Shoulder Dislocation; Shoulder Joint; Sutures; Tomography; Cardiopulmonary Resuscitation; Rotator Cuff; Bankart Lesions
  11. Madhusudhan Krishnamoorthy, Zaleha Kamaludin, Hasnan Jaafar, Norhafiza Mat Lazim
    MyJurnal
    Nasopharyngeal carcinoma is a commonly encountered malignancy in endemic regions of the world namely South
    East Asia, China and Hong Kong. In Malaysia, the ethnic Chinese population is particularly at risk due to genetic
    susceptibilities and environmental exposure to carcinogenic agents. We herein report a case of nasopharyngeal carcinoma in a middle-aged man of Malay ethnicity who presented with nasal blockage and neck nodes. The biopsy of
    the nasopharyngeal mass came back as papillary variant of nasopharyngeal carcinoma. The commonly reported histopathological types are the keratinizing and non-keratinizing types, and rarely the basaloid type. In this case report,
    we aim to highlight one of the rare variants of the non-keratinizing nasopharyngeal carcinoma. When diagnosing the
    non-keratinizing type, appreciation of the different morphological variants is crucial not only to help aid in procuring
    an acurrate histopathologic diagnosis, but also to help in subsequent treatment plan.
    MeSH terms: Aged; Biopsy; Carcinogens; China; Environmental Exposure; Ethnic Groups; Far East; Hong Kong; Humans; Malaysia; Middle Aged; Nasopharyngeal Neoplasms; Nasal Obstruction; Cancer Vaccines; Asian Continental Ancestry Group
  12. Kwan Z, Baharum N, Yong SS, Mohd Affandi A, Johar A
    Psychol Health Med, 2020 Oct 12.
    PMID: 33044840 DOI: 10.1080/13548506.2020.1831557
    The impact of psoriasis on quality of life may have implications for the sexual function of patients. We aimed to determine the frequency of sexual difficulties and associated factors among adult patients with psoriasis. This cross-sectional study involved 13 673 patients notified to the Malaysian Psoriasis Registry. Sexual function was defined based on the Dermatology Life Quality Index (DLQI). Sexual difficulties were reported among 9.5% of subjects with significant predictors identified as younger age, male gender, married status, ethnicity, nail involvement, face and neck involvement and severity of disease. Smokers were more likely to report experiencing sexual difficulties. However, the presence of either ischemic heart disease, diabetes mellitus, hypertension or dyslipidemia was associated with lower odds of sexual issues due to psoriasis. Clinicians should be aware of factors associated with sexual health in psoriasis to implement targeted interventions. Further studies need to be conducted to delineate the different aspects of sexual function and the magnitude of the problem.
    MeSH terms: Adult; Cross-Sectional Studies; Dermatology; Diabetes Mellitus; Ethnic Groups; Humans; Hypertension; Male; Marriage; Psoriasis; Quality of Life; Registries; Severity of Illness Index; Sexual Behavior; Myocardial Ischemia; Dyslipidemias
  13. Harman G, Khadka R, Doni F, Uphoff N
    Front Plant Sci, 2020;11:610065.
    PMID: 33912198 DOI: 10.3389/fpls.2020.610065
    Plants exist in close association with uncountable numbers of microorganisms around, on, and within them. Some of these endophytically colonize plant roots. The colonization of roots by certain symbiotic strains of plant-associated bacteria and fungi results in these plants performing better than plants whose roots are colonized by only the wild populations of microbes. We consider here crop plants whose roots are inhabited by introduced organisms, referring to them as Enhanced Plant Holobionts (EPHs). EPHs frequently exhibit resistance to specific plant diseases and pests (biotic stresses); resistance to abiotic stresses such as drought, cold, salinity, and flooding; enhanced nutrient acquisition and nutrient use efficiency; increased photosynthetic capability; and enhanced ability to maintain efficient internal cellular functioning. The microbes described here generate effects in part through their production of Symbiont-Associated Molecular Patterns (SAMPs) that interact with receptors in plant cell membranes. Such interaction results in the transduction of systemic signals that cause plant-wide changes in the plants' gene expression and physiology. EPH effects arise not only from plant-microbe interactions, but also from microbe-microbe interactions like competition, mycoparasitism, and antibiotic production. When root and shoot growth are enhanced as a consequence of these root endophytes, this increases the yield from EPH plants. An additional benefit from growing larger root systems and having greater photosynthetic capability is greater sequestration of atmospheric CO2. This is transferred to roots where sequestered C, through exudation or root decomposition, becomes part of the total soil carbon, which reduces global warming potential in the atmosphere. Forming EPHs requires selection and introduction of appropriate strains of microorganisms, with EPH performance affected also by the delivery and management practices.
  14. Dhar BK, Ayittey FK, Sarkar SM
    Glob Chall, 2020 Sep 28.
    PMID: 33042575 DOI: 10.1002/gch2.202000038
    The purpose of the study is to find out the psychological impact of the COVID-19 pandemic on university students. The study focuses on the university students from different public and private universities of Bangladesh through a set of questionnaires according to the guideline of Generalized Anxiety Disorder Scale (GAD-7). The result among 15 543 respondents shows that 44.59% are suffering from severe anxiety, 48.41% moderate anxiety, and only 3.82% mild anxiety. The results highlight that all epidemic-related stressors are positively correlated with the level of anxiety. Among the epidemic-related stressors, worry about economic influences during and after COVID-19 (r = 0.342, p < 0.001) and worry about the influence of COVID-19 on daily life (r = 0.340, p < 0.001) have a highly positive impact on the level of anxiety. Following these stressors, worry about academic delays due to COVID-19 (r = 0.326, p < 0.001) and worry about the social support during COVID-19 (r = 0.321, p < 0.001) have moderately and positively correlated with the level of anxiety. The study suggests that proper government support, as well as social awareness, should be monitored during epidemics for decreasing anxiety and maintaining a good mental health of the university students.
    MeSH terms: Anxiety; Anxiety Disorders; Bangladesh; Government; Humans; Mental Health; Surveys and Questionnaires; Social Support; Stress, Psychological; Students; Universities; Pandemics
  15. Nurul Faaiqah Jainuddin, Azlindarita Aisyah Mohd Abdullah, Visvaraja Subrayan, Norlina Ramli, Nurliza Khaliddin
    MyJurnal
    Congenital cataract is a major cause of preventable blindness in children. It can be either hereditary or non-hereditary. In this case series, we present three cases of congenital cataract with a strong family history. The grandparents
    and parents of these patients had cataract diagnosed in late childhood whilst the patients in this case series were
    diagnosed with congenital cataract earlier. There was no history of consanguineous marriage in any of the families.
    These cases show that, in the presence of a strong family history, a child will present with congenital cataract earlier
    in their life. Hence, babies from such families should be screened at birth and at regular intervals within the first
    year of life to enable early diagnosis and subsequent surgical intervention to reduce the incidence and burden of
    amblyopia.
    MeSH terms: Grandparents; Amblyopia; Blindness; Cataract; Child; Family; Humans; Infant; Infant, Newborn; Parents; Incidence; Early Diagnosis
  16. Abdul Aziz Mohamed Yusoff, Wan Salihah Wan Abdullah, Alarmelu Nithya Ramanathan, Jafri Malin Abdullah, Zamzuri Idris
    MyJurnal
    Although the precise etiology of Glioblastoma multiforme (GBM, WHO grade IV) remains unknown, its progression
    is believed to be driven by the accumulation of multiple genetic alterations. Here, we report a case of a patient who
    developed GBM, and associated with dual alterations, particularly 4977-bp deletion in mtDNA (mtDNA4977) and
    p.Arg132His (R132H) mutation in IDH1. A 35-year old Malaysian woman patient who primary diagnosed with astrocytoma WHO grade I and subsequently after four years developed a GBM, was detected with a mtDNA4977. This
    deletion appears to be a sporadic mutation. Additionally, analysis of patient’s tumor tissue also found to harbor a heterozygous IDH1 R132H mutation. This represents the first case report of coexisting mtDNA4977 together with IDH1
    R132H mutation in a Malaysian patient of GBM. The findings of dual alterations could be of therapeutic benefit if
    these alterations were justified to be contributing to GBM growth and aggressiveness.
    MeSH terms: Adult; Astrocytoma; DNA, Mitochondrial; Female; Glioblastoma; Heterozygote; Humans; Isocitrate Dehydrogenase; Mutation; World Health Organization
  17. Ahmedy F, Loo JL, Mazlan M
    Indian J Psychiatry, 2020 12 12;62(6):732-733.
    PMID: 33896983 DOI: 10.4103/psychiatry.IndianJPsychiatry_334_19
    A case of persistent aphagia in frontal lobe syndrome after traumatic brain injury (TBI) with successful use of olanzapine to improve the eating disorder is presented. A 20-year-old man suffered a severe TBI with right frontal intracerebral haemorrhage At four-month post-TBI, he had agitation, concurrent apathy with constant refusal for oral swallow despite gustatory sensory stimulation, hence the needs for nasogastric tube (NGT) feeding. He was diagnosed with frontal lobe syndrome and prescribed olanzapine 5mg daily that was optimised to 10mg due to worsened aggression. One month later, the aggression reduced with gradual improvement in oral intake. Percutaneous enterogastrostomy (PEG) tube insertion was cancelled and the NGT was sucessfully removed. Olanzapine prescription in this case improved aggression and aphagia simultaneously. Although olanzapine is proven beneficial and surgical intervention for long-term enteral feeding was avoided in this case, its usage requires judicious judgement.
    MeSH terms: Adult; Aggression; Feeding and Eating Disorders; Cerebral Hemorrhage; Deglutition Disorders; Enteral Nutrition; Frontal Lobe; Humans; Intubation, Gastrointestinal; Male; Prescriptions; Young Adult; Apathy; Chronic Traumatic Encephalopathy; Brain Injuries, Traumatic
  18. Roja VR, Narayanan P, Sekaran VC, Ajith Kumar MG
    Ghana Med J, 2020 Dec;54(4):238-244.
    PMID: 33883772 DOI: 10.4314/gmj.v54i4.6
    Objective: The primary objective of the study was to determine the association between the living environment and morbidity, nutritional status, immunization status, and personal hygiene of under-five children living in urban slums in southern India.

    Methods: This study included 224 mothers of under-five children living in urban slums of Udupi Taluk, Karnataka. A total of 17 urban slums were selected randomly using random cluster sampling.

    Results: Undernutrition was high among children of illiterate mothers (63.8%), and the children of working mothers were affected by more morbidity (96.6%) as compared with housewives. Morbidity was also found to be high among children belonging to families with low incomes (66.1%) and low socio-economic backgrounds (93.1%). Safe drinking water, water supply, sanitation, hygiene, age of the child, mother's and father's education, mother's occupation and age, number of children in the family, use of mosquito nets, type of household, and family income were significantly associated with child morbidity, nutritional status, immunization status, and personal hygiene of under-five children living in urban slums.

    Conclusion: Overall, in our study, family characteristics including parental education, occupation and income were significantly associated with outcomes among under-five children. The availability of safe drinking water and sanitation, and the use of mosquito nets to prevent vector-borne diseases are basic needs that need to be urgently met to improve child health.

    Funding: Self-funded.

    MeSH terms: Adult; Child; Child, Preschool; Cough/epidemiology; Cross-Sectional Studies; Diarrhea/epidemiology; Educational Status; Family Characteristics; Female; Fever/epidemiology; Humans; Hygiene*; India/epidemiology; Infant; Morbidity; Mothers*; Pneumonia/epidemiology; Poverty Areas*; Thinness; Malnutrition/epidemiology; Social Determinants of Health*
  19. Singh A, Priyambada P, Jabin G, Singh SK, Joshi BD, Venkatraman C, et al.
    Int J Legal Med, 2020 Sep;134(5):1613-1618.
    PMID: 32621146 DOI: 10.1007/s00414-020-02362-5
    Demand for pangolin scales in East Asia has increased dramatically in the past two decades, raising concern to the pangolin survival and bringing them to the brink of local extinction. Enumerating the number of individuals from the seized pangolin scales primarily goes undocumented, mostly due to the unavailability of the appropriate methods. In this study, we developed a Pangolin Indexing System, a multi-locus STR panel of eight dinucleotide microsatellites that showed promising results in individualization and assignment of scales into Chinese and Indian pangolins. The combined power of exclusion was 0.83 and 0.99 for Chinese and Indian pangolin. The select panel of eight polymorphic STRs exhibited the cumulative probability of identity 3.7 × 10-9 for Indian pangolin and 3.6 × 10-7 for Chinese pangolin and identified 51 unique genotypes from the 74 scales selected from the four pangolin seizures. The study demonstrated the first report of cross-species validation of STRs developed from Malayan pangolin to Indian pangolin and showed the potential application of Pangolin Indexing System in screening of large seizures through DNA profiling from the scales of Indian and Chinese pangolin.
    MeSH terms: Animals; China; Crime/prevention & control; Genetics, Population; Genotype; India; Malaysia; Species Specificity; DNA Fingerprinting/methods*; Dinucleotide Repeats*; Genetic Loci*; Endangered Species*
  20. Nurul Suhaili Kamarudin, Rosni Ibrahim, Nur Hanani Ahmad, Siti Norbaya Masri
    MyJurnal
    Rhinocerebral mucormycosis is a potentially fatal and progressive angioinvasive fungal infection. It is classically described in patients with uncontrolled diabetes mellitus and hematological malignancies. This report describes a case of progressive rhinocerebral mucormycosis in a patient with poorly controlled diabetes who was on prolonged prednisolone therapy for autoimmune kidney disease. The patient, who was a female, presented to hospital with headache, orbital pain and nasal bridge swelling. Black eschar on nasal mucosae was present on admission. Later, she was started on intravenous fluconazole for the diagnosis of fungal sinusitis. Subsequently, she developed intra- cerebral haemorrhage complicated with transtentorial herniation. Diagnosis of rhinocerebral mucormycosis was later observed by a laboratory finding and the treatment was changed to intravenous amphotericin B. However, the patient succumbed to her illness on the 6th day of hospitalisation. This report discusses the risk factors associated with rhinocerebral mucormycosis as well as the underlying pathogenesis. This report will also highlight the importance of early diagnosis and appropriate treatment for mucormycosis to improve prognosis in patients.
    MeSH terms: Amphotericin B; African Americans; Cerebral Hemorrhage; Diabetes Mellitus; Female; Headache; Hospitalization; Hospitals; Humans; Kidney Diseases; Laboratories; Mucormycosis; Pain; Prednisolone; Prognosis; Risk Factors; Sinusitis; Fluconazole; Hematologic Neoplasms; Early Diagnosis
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