Browse publications by year: 2023

  1. Mafruchati M, Othman NH
    Heliyon, 2023 Dec;9(12):e22349.
    PMID: 38125449 DOI: 10.1016/j.heliyon.2023.e22349
    Fibroblast is one component of connective tissue cells in polygonal or stellate with cytoplasmic processes or projections. In vitro, tissue culture is an excellent medium used in biomedical research. The goal of this study was to analyze Toxicity and Malignancy in Embryo of Super Java Chicken as Potential Candidates of Strong Poultry in Indonesia. This study used Preparation of fibroblast primary cell culture of Java super chicken embryos, Pathogenicity test using fibroblast cells from Super Java chicken, Toxicity test using fibroblast cells from Super Java Chicken. Primary fibroblast cell culture of Java super chicken embryos was prepared from 10-day-old brood chicken eggs free of pathogens. Cells were prepared in 96-well microplates with minimal essential medium (MEM) containing 10 % fetal calf serum (FCS) 100 IU/ug penicillin/streptomycinVirus isolates were diluted in stages from 10-2 to 10-5 and inoculated into Java Super Chicken Fibroblast cell culture. The result showed that the negative control of the samples had a faster proliferative power than the fibroblast cell culture of Java super chicken, which was treated with concentrations of 10-2; 10-3; 10-4; 10-5. Moreover, before being inoculated with the virus, the confluent fibroblast cells of Java super chicken looked oval and regular. The day after infection, syncytia (large multinucleated cells) began to form on a small scale and became more pronounced on the second and third post-infection days. CPE was found in the 10-2,10-3 and 10-4 virus dilutions, and CPE was not found in the 10-5 dilution.
  2. Mustaffa SN, Md Yatim N, Abdul Rashid AR, Md Yatim N, Pithaih V, Sha'ari NS, et al.
    Heliyon, 2023 Dec;9(12):e22926.
    PMID: 38125452 DOI: 10.1016/j.heliyon.2023.e22926
    Uric acid is a waste product of the human body where high levels of it or hyperuricemia can lead to gout, kidney disease and other health issues. In this paper, Finite Difference Time Doman (FDTD) simulation method was used to develop a plasmonic optical sensor to detect uric acid with molarity ranging from 0 to 3.0 mM. A hybrid layer of gold-zinc oxide (Au-ZnO) was used in this Kretschmann-based Surface Plasmon Resonance (K-SPR) technique with angular interrogation at 670 nm and 785 nm visible optical wavelengths. The purpose of this study is to observe the ability of the hybrid material as a sensing performance enhancer for differentiating between healthy and unhealthy uric acid levels based on the refractive index values from previous study. Upon exposure to 670 nm wavelength, the average sensitivity of this sensor was found to be 0.028°/mM with a linearity of 98.67 % and Q-factor value of 0.0053 mM-1. While at 785 nm, the average sensitivity is equal to 0.0193°/mM with slightly lower linearity at 94.46 % and Q-factor value of 0.0076 mM-1. The results have proven the ability of hybrid material Au-ZnO as a sensing performance enhancer for detecting uric acid when compared with bare Au and can be further explored in experimental work.
  3. Khan S, Rukayadi Y, Jaafar AH, Ahmad NH
    Heliyon, 2023 Dec;9(12):e22771.
    PMID: 38125456 DOI: 10.1016/j.heliyon.2023.e22771
    Foodborne diseases continue to pose a significant global health concern, causing a considerable number of deaths worldwide. In response to concerns surrounding bacterial resistance and the limitations of traditional antibiotics, there is a growing interest in exploring natural antibacterial agents as potential alternatives for addressing foodborne pathogens. Nowadays efforts are being made on exploring the potential of natural antibacterial agents against foodborne pathogens. In this study, the antibacterial efficacy of silver nanoparticles synthesized using S. polyanthum leaves extract (SP-AgNPs) against selected Gram-negative and Gram-positive foodborne pathogens was investigated by using multiple assays, including the well diffusion assay (WDA), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-kill assay. The well diffusion assay demonstrated the inhibitory potential of SP-AgNPs against all tested foodborne pathogens, with inhibition zones ranging from 10.16 + 1.25 to 13.16 + 1.52 mm. Furthermore, the MIC values ranged from 0.008 to 0.125 mg/mL, indicating the potent antibacterial activity of SP-AgNPs across a broad spectrum of foodborne pathogens. The MBC values, ranging from 0.008 to 0.250 mg/mL, further confirming the bactericidal ability of SP-AgNPs against these pathogens. In the time-kill experiment, most foodborne pathogens were entirely killed after 4 h of incubation at 4 × MIC concentration. However, only E. coli, K. pneumoniae, and S. Typhimurium showed a reduction in population to 3 Log10 CFU/mL, indicating a strong bactericidal effect of SP-AgNPs on most tested pathogens. In conclusion, this study provides compelling evidence that SP-AgNPs exhibit potent antibacterial activity against selected foodborne pathogens. The findings suggest that SP-AgNPs synthesized using S. polyanthum leaves extract hold great promise as a novel antibacterial agent for effectively controlling foodborne pathogens. These findings contribute to continuing efforts in developing alternative strategies to prevent foodborne diseases and enhance food safety.
  4. He B, Ismail N, Leng KKK, Chen G
    Heliyon, 2023 Dec;9(12):e22828.
    PMID: 38125459 DOI: 10.1016/j.heliyon.2023.e22828
    This research demonstrates the application of novel optimization methods in the realm of renewable energy and contributes to the development of environmentally friendly electricity generation and consumption. In this study, an improved version of the Al-Biruni algorithm has been proposed for Hybrid Renewable Energy Systems (HRES) optimization, which includes fuel cells, photovoltaic cells, and windmills. The algorithm considers supply, demand, and energy storage constraints and seeks the best combination of energy sources to meet load demand while reducing total system cost. Inspired by ancient Iranian philosopher Abu Biruni, the proposed method includes modifications to explore solution space efficiently and improve answer value. The proposed HRES model is applied to a case study from Dunhuang City, China, and its findings are validated by comparing it with other optimization approaches. The Modified Al-Biruni Earth Radius (MBER) algorithm is found to be the most efficient and reliable system, costing 4.23 million units of currency. Compared to other optimization approaches, MBER exhibited a total cost of 4.1 million US dollars, 0.009, 3.7, 3.7, LPSP, and 356 h per year. The overall cost is 5.26 million units of currency with a 0.5% Loss of Power Supply Probability (LPSP), which directly impacts system performance and dependability. The improved Al-Biruni algorithm can efficiently optimize the system, reduce costs, and increase load supply, contributing to the growth of renewable energy sources and the application of advanced meta-heuristic techniques in complex energy systems.
  5. Abiri R, Rizan N, Balasundram SK, Shahbazi AB, Abdul-Hamid H
    Heliyon, 2023 Dec;9(12):e22601.
    PMID: 38125472 DOI: 10.1016/j.heliyon.2023.e22601
    Over the decades, agri-food security has become one of the most critical concerns in the world. Sustainable agri-food production technologies have been reliable in mitigating poverty caused by high demands for food. Recently, the applications of agri-food system technologies have been meaningfully changing the worldwide scene due to both external strengths and internal forces. Digital agriculture (DA) is a pioneering technology helping to meet the growing global demand for sustainable food production. Integrating different sub-branches of DA technologies such as artificial intelligence, automation and robotics, sensors, Internet of Things (IoT) and data analytics into agriculture practices to reduce waste, optimize farming inputs and enhance crop production. This can help shift from tedious operations to continuously automated processes, resulting in increasing agricultural production by enabling the traceability of products and processes. The application of DA provides agri-food producers with accurate and real-time observations regarding different features influencing their productivity, such as plant health, soil quality, weather conditions, and pest and disease pressure. Analyzing the results achieved by DA can help agricultural producers and scholars make better decisions to increase yields, improve efficiency, reduce costs, and manage resources. The core focus of the current work is to clarify the benefits of some sub-branches of DA in increasing agricultural production efficiency, discuss the challenges of practical DA in the field, and highlight the future perspectives of DA. This review paper can open new directions to speed up the DA application on the farm and link traditional agriculture with modern farming technologies.
  6. Shela V, Ramayah T, Aravindan KL, Ahmad NH, Alzahrani AI
    Heliyon, 2023 Dec;9(12):e22476.
    PMID: 38125546 DOI: 10.1016/j.heliyon.2023.e22476
    Partial least squares structural equation modelling (PLS-SEM) is emerging as a prominent methodological tool in strategic management research. Although it offers various advancements to stay relevant with growing research needs, the pace of PLS-SEM adoption may differ in different parts of the world. In this paper, we conducted a systematic review using the PRISMA framework and extracted from the top-ranking strategic management journals 120 articles published between 2011 and 2022 that presented a microscopic view on developing nations. Our findings reveal that despite the astounding methodological solutions offered by PLS-SEM, the studies from developing nations are still trailing behind developed nations in terms of fully exploiting the advancements of PLS-SEM to provide substantial insights to strategic management literature. This review identifies discrepancies in the current application of the method, discusses the most recent advancements and provides the best practices, standard guidelines and recommendations for the best use of PLS-SEM in strategic management research.
  7. Mohammad Faizal NDF, Ramli NA, Mat Rani NNI, Shaibie NA, Aarti, Poonsawas P, et al.
    Asian J Pharm Sci, 2023 Nov;18(6):100855.
    PMID: 38125653 DOI: 10.1016/j.ajps.2023.100855
    The global COVID-19 pandemic arising from SARS-CoV-2 has impacted many lives, gaining interest worldwide ever since it was first identified in December 2019. Till 2023, 752 million cumulative cases and 6.8 million deaths were documented globally. COVID-19 has been rapidly evolving, affecting virus transmissibility and properties and contributing to increased disease severity. The Omicron is the most circulating variant of concern. Although success in its treatment has indicated progress in tackling the virus, limitations in delivering the current antiviral agents in battling emerging variants remain remarkable. With the latest advancements in nanotechnology for controlling infectious diseases, liposomes have the potential to counteract SARS-CoV-2 because of their ability to employ different targeting strategies, incorporating monoclonal antibodies for the active and passive targeting of infected patients. This review will present a concise summary of the possible strategies for utilizing immunoliposomes to improve current treatment against the occurrence of SARS-CoV-2 and its variants.
  8. Barteit S, Colmar D, Nellis S, Thu M, Watterson J, Gouwanda D, et al.
    Front Public Health, 2023;11:1153149.
    PMID: 38125843 DOI: 10.3389/fpubh.2023.1153149
    BACKGROUND: Malaysia is projected to experience an increase in heat, rainfall, rainfall variability, dry spells, thunderstorms, and high winds due to climate change. This may lead to a rise in heat-related mortality, reduced nutritional security, and potential migration due to uninhabitable land. Currently, there is limited data regarding the health implications of climate change on the Malaysian populace, which hinders informed decision-making and interventions.

    OBJECTIVE: This study aims to assess the feasibility and reliability of using sensor-based devices to enhance climate change and health research within the SEACO health and demographic surveillance site (HDSS) in Malaysia. We will particularly focus on the effects of climate-sensitive diseases, emphasizing lung conditions like chronic obstructive pulmonary disease (COPD) and asthma.

    METHODS: In our mixed-methods approach, 120 participants (>18 years) from the SEACO HDSS in Segamat, Malaysia, will be engaged over three cycles, each lasting 3 weeks. Participants will use wearables to monitor heart rate, activity, and sleep. Indoor sensors will measure temperature in indoor living spaces, while 3D-printed weather stations will track indoor temperature and humidity. In each cycle, a minimum of 10 participants at high risk for COPD or asthma will be identified. Through interviews and questionnaires, we will evaluate the devices' reliability, the prevalence of climate-sensitive lung diseases, and their correlation with environmental factors, like heat and humidity.

    RESULTS: We anticipate that the sensor-based measurements will offer a comprehensive understanding of the interplay between climate-sensitive diseases and weather variables. The data is expected to reveal correlations between health impacts and weather exposures like heat. Participant feedback will offer perspectives on the usability and feasibility of these digital tools.

    CONCLUSION: Our study within the SEACO HDSS in Malaysia will evaluate the potential of sensor-based digital technologies in monitoring the interplay between climate change and health, particularly for climate-sensitive diseases like COPD and asthma. The data generated will likely provide details on health profiles in relation to weather exposures. Feedback will indicate the acceptability of these tools for broader health surveillance. As climate change continues to impact global health, evaluating the potential of such digital technologies is crucial to understand its potential to inform policy and intervention strategies in vulnerable regions.

    MeSH terms: Asthma*; Demography; Far East; Humans; Malaysia/epidemiology; Reproducibility of Results; Telemedicine*; Climate Change
  9. Zhou Z, Zhou X, Shen G, Khairani AZ, Saibon J
    Psychol Res Behav Manag, 2023;16:5041-5051.
    PMID: 38116586 DOI: 10.2147/PRBM.S441619
    BACKGROUND AND OBJECTIVE: Bullying is notably prevalent among children and adolescents, especially within the context of physical education (PE) environments. Understanding the underlying factors that trigger bullying behavior is essential in designing strategies to prevent bullying and formulating more effective interventions in PE. There is a lack of integrated findings regarding the wide range of correlates of bullying behavior among children and adolescents within the PE context. Therefore, this systematic review aimed to synthesize the correlates of bullying behavior among children and adolescents within the context of PE.

    METHODS: We conducted a systematic search across four databases (EBSCOhost, PubMed, Scopus, Web of Science) for relevant studies published before August 2023. Two reviewers independently examined the articles, assessed their methodological quality, and performed data extraction.

    RESULTS: A total of 23 articles met the inclusion criteria. It is found that demographic, physical movement, physical appearance, psycho-cognitive, teacher-related, and contextual factors emerged as six prominent influential factors affecting adolescent bullying behavior. Specifically, demographic factors mainly encompassed age and gender; physical movement factors primarily include physical activity, sedentary behavior, physical exercise, and sports competence; physical appearance factors primarily include being overweight, too thin, too tall, or too short; psycho-cognitive factors chiefly involved cognitive empathy, motivation, enjoyment of physical activity; teacher-related factors primarily comprised activity choices, teachers competence, controlling style, autonomy support; and contextual factors primarily cover desolate climate, perceived caring climate, strong sense of competition and winning setting.

    CONCLUSION: The results indicate that bullying is a complex and multifaced behavior primarily determined by demographic, physical movement, physical appearance, psycho-cognitive, teacher-related, and contextual factors. Future studies need to enhance the diversity of research samples and comparative studies on the factors influencing bullying behavior among children and adolescents in different countries. Additionally, a more extensive range of intervention studies addressing bullying behavior among children and adolescents is warranted.

  10. Sababathy M, Ramanathan G, Abd Rahaman NY, Ramasamy R, Biau FJ, Qi Hao DL, et al.
    Regen Med, 2023 Dec;18(12):913-934.
    PMID: 38111999 DOI: 10.2217/rme-2023-0193
    This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology and pathophysiology, along with current treatment trends and challenges. The lipopolysaccharides (LPS) role in ARDS and its association between non-communicable diseases and COVID-19 are discussed. The review highlights the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory effects. This review also underlines how T2DM exacerbates ARDS pathophysiology and discusses the potential of hUC-MSCs in modulating immune responses. In conclusion, the review highlights the multidisciplinary approach to managing ARDS and T2DM, focusing on inflammation, oxidative stress and potential therapy of hUC-MSCs in the future.
    MeSH terms: Humans; Inflammation; Umbilical Cord; Mesenchymal Stem Cell Transplantation*; Mesenchymal Stromal Cells*
  11. Vaishnav M, Javed A, Gupta S, Kumar V, Vaishnav P, Kumar A, et al.
    Indian J Psychiatry, 2023 Oct;65(10):995-1011.
    PMID: 38108051 DOI: 10.4103/indianjpsychiatry.indianjpsychiatry_667_23
    BACKGROUND: Stigma related to mental illness (and its treatment) is prevalent worldwide. This stigma could be at the structural or organizational level, societal level (interpersonal stigma), and the individual level (internalized stigma). Vulnerable populations, for example, gender minorities, children, adolescents, and geriatric populations, are more prone to stigma. The magnitude of stigma and its negative influence is determined by socio-cultural factors and macro (mental health policies, programs) or micro-level factors (societal views, health sectors, or individuals' attitudes towards mentally ill persons). Mental health stigma is associated with more serious psychological problems among the victims, reduced access to mental health care, poor adherence to treatment, and unfavorable outcomes. Although various nationwide and well-established anti-stigma interventions/campaigns exist in high-income countries (HICs) with favorable outcomes, a comprehensive synthesis of literature from the Low- and Middle-Income Countries (LMICs), more so from the Asian continent is lacking. The lack of such literature impedes growth in stigma-related research, including developing anti-stigma interventions.

    AIM: To synthesize the available mental health stigma literature from Asia and LMICs and compare them on the mental health stigma, anti-stigma interventions, and the effectiveness of such interventions from HICs.

    MATERIALS AND METHODS: PubMed and Google Scholar databases were screened using the following search terms: stigma, prejudice, discrimination, stereotype, perceived stigma, associate stigma (for Stigma), mental health, mental illness, mental disorder psychiatric* (for mental health), and low-and-middle-income countries, LMICs, High-income countries, and Asia, South Asian Association for Regional Cooperation/SAARC (for countries of interest). Bibliographic and grey literature were also performed to obtain the relevant records.

    RESULTS: The anti-stigma interventions in Asia nations and LMICs are generalized (vs. disorder specific), population-based (vs. specific groups, such as patients, caregivers, and health professionals), mostly educative (vs. contact-based or attitude and behavioral-based programs), and lacking in long-term effectiveness data. Government, international/national bodies, professional organizations, and mental health professionals can play a crucial in addressing mental health stigma.

    CONCLUSION: There is a need for a multi-modal intervention and multi-sectoral coordination to mitigate the mental health stigma. Greater research (nationwide surveys, cultural determinants of stigma, culture-specific anti-stigma interventions) in this area is required.

  12. Hazdi SN, Phang HC, Ng ZQ, Chew YL, Uddin AH, Sarker ZI, et al.
    Int J Pharm Compd, 2023;27(6):522-527.
    PMID: 38100670
    Orally disintegrating tablets, which were originally developed in the pharmaceutical field to improve the compliance of patients who had difficulty swallowing tablets, have become a preferable choice in solid dosage forms since it brings advantages to the patients and consumers in the healthcare system. Among the advantages of this novel dosage form are a faster onset of action, improved bioavailability, and the ease of administration as it can be taken without water. However, there are still some limitations of orally disintegrating tablets that need to be overcome, including a lack of mechanical strength, an unpleasant taste of the drug in the mouth, and a stability issue due to its hygroscopicity nature. This objective of this study was to identify the composition of co-processed excipients comprising of mannitol, microcrystalline cellulose, xylitol, and crospovidone or croscarmellose sodium in order to formulate orally disintegrating tablets containing memantine hydrochloride. This study was carried out in two stages. Firstly, orally disintegrating tablets containing memantine hydrochloride with 6 different formulations, which differed in the percentage of crospovidone or croscarmellose sodium, were formulated and manufactured. Secondly, the orally disintegrating tablets obtained were evaluated through pre- and post-compression tests based on the standard for orally disintegrating tablets. Formulation 3, which consisted of 10% xylitol, 10% mannitol, 72% microcrystalline cellulose, and 8% crospovidone, was chosen as the optimum formulation for the co-processed excipient since it was the fastest disintegration process among all the formulations in the study. In addition, Formulation 3 also showed the acceptable and satisfying results in other evaluation tests such as - weight variation test, hardness test, and friability test. The co-processed excipient comprising of 10% xylitol, 10% mannitol, 72% microcrystalline cellulose, and 8% crospovidone, which is characterized by improved functionalities such as a fast disintegration process, plays a crucial role in the application of orally disintegrating tablets.
  13. Shi J, Zhao J, Zhang Y, Wang Y, Tan CP, Xu YJ, et al.
    Anal Chem, 2023 Dec 26;95(51):18793-18802.
    PMID: 38095040 DOI: 10.1021/acs.analchem.3c03785
    Metabolomics and proteomics offer significant advantages in understanding biological mechanisms at two hierarchical levels. However, conventional single omics analysis faces challenges due to the high demand for specimens and the complexity of intrinsic associations. To obtain comprehensive and accurate system biological information, we developed a multiomics analytical method called Windows Scanning Multiomics (WSM). In this method, we performed simultaneous extraction of metabolites and proteins from the same sample, resulting in a 10% increase in the coverage of the identified biomolecules. Both metabolomics and proteomics analyses were conducted by using ultrahigh-performance liquid chromatography mass spectrometry (UPLC-MS), eliminating the need for instrument conversions. Additionally, we designed an R-based program (WSM.R) to integrate mathematical and biological correlations between metabolites and proteins into a correlation network. The network created from simultaneously extracted biomolecules was more focused and comprehensive compared to those from separate extractions. Notably, we excluded six pairs of false-positive relationships between metabolites and proteins in the network established using simultaneously extracted biomolecules. In conclusion, this study introduces a novel approach for multiomics analysis and data processing that greatly aids in bioinformation mining from multiomics results. This method is poised to play an indispensable role in systems biology research.
    MeSH terms: Chromatography, Liquid; Tandem Mass Spectrometry; Metabolomics/methods
  14. Zulhisham M, Suhaimi H, Shatriah I
    Korean J Ophthalmol, 2023 Dec;37(6):462-467.
    PMID: 37899288 DOI: 10.3341/kjo.2023.0040
    PURPOSE: The aim of this study is to determine the mean central corneal thickness (CCT) and mean intraocular pressure (IOP) in children with type 1 diabetes mellitus (T1DM) and to determine the relationship between CCT and IOP on the one hand and age, sex, retinopathy hemoglobin A1c (HbA1c), and duration of diabetes on the other.

    METHODS: This is a case-control, hospital-based study conducted at Hospital Universiti Sains Malaysia between January and November 2022. Thirty-eight children with T1DM were recruited as cases, and 38 healthy children were recruited as controls. The cases and controls then underwent ophthalmic examination, IOP measurement, and CCT measurement using optical coherence tomography (OCT) of the right eye. The IOP measurements were adjusted for CCT for further analysis.

    RESULTS: The means of CCT and IOP values were significantly higher in the T1DM group than in the control group (all p = 0.02). The mean CCT was 542.18 ± 20.40 μm in the T1DM group, and 529.52 ± 26.17 μm in the control group. The mean IOP was 14.68 ± 1.98 mmHg in the T1DM group, and 13.52 ± 1.66 mmHg in the control group. The mean HbA1c was 10.68% ± 2.49% in the T1DM group. Age and duration of DM were found to have a significant association with CCT in children with T1DM. The duration of DM was also found to be significantly associated with the IOP. Sex and HbA1c levels were found to have no significant relationship with either CCT or IOP.

    CONCLUSIONS: Children with T1DM have significantly higher CCT and IOP than the average child. The duration of DM is a significant factor that impacts both CCT and IOP. In addition, age is another factor that affects CCT in children with T1DM.

  15. Chaturvedi R, Biswas S, Bisht K, Sharma A
    Parasitology, 2023 Nov;150(13):1167-1177.
    PMID: 37929579 DOI: 10.1017/S003118202300077X
    Of the 5 human malarial parasites, Plasmodium falciparum and Plasmodium vivax are the most prevalent species globally, while Plasmodium malariae, Plasmodium ovale curtisi and Plasmodium ovale wallikeri are less prevalent and typically occur as mixed-infections. Plasmodium knowlesi, previously considered a non-human primate (NHP) infecting species, is now a cause of human malaria in Malaysia. The other NHP Plasmodium species, Plasmodium cynomolgi, Plasmodium brasilianum, Plasmodium inui, Plasmodium simium, Plasmodium coatneyi and Plasmodium fieldi cause malaria in primates, which are mainly reported in southeast Asia and South America. The non-knowlesi NHP Plasmodium species also emerged and were found to cross-transmit from their natural hosts (NHP) – to human hosts in natural settings. Here we have reviewed and collated data from the literature on the NHPs-to-human-transmitting non-knowlesi Plasmodium species. It was observed that the natural transmission of these NHP parasites to humans had been reported from 2010 onwards. This study shows that: (1) the majority of the non-knowlesi NHP Plasmodium mixed species infecting human cases were from Yala province of Thailand; (2) mono/mixed P. cynomolgi infections with other human-infecting Plasmodium species were prevalent in Malaysia and Thailand and (3) P. brasilianum and P. simium were found in Central and South America.
    MeSH terms: Animals; Asia, Southeastern; Humans; Plasmodium vivax; Primates; Plasmodium knowlesi*
  16. Khan MN, Jan AA, Asif M, Lai FW, Shad MK, Shadab S
    Heliyon, 2023 Dec;9(12):e22848.
    PMID: 38076083 DOI: 10.1016/j.heliyon.2023.e22848
    PURPOSE: Innovation activities have gained much importance due to their pivotal role in achieving economic growth - directly by increasing productivity and - indirectly by increasing the degree of trade openness. This study aims to focus on the indirect channel, a rarely explored area of research, especially in the context of emerging economies.

    METHODOLOGY: To achieve the aim of the study, four proxies of innovation (resident patent applications, nonresident patent applications, scientific and technical journal articles, and research and development expenditures) are used to establish a robust relationship between innovation activities and trade openness in BRICS economies. Panel data from 2000 to 2020 is obtained from World Development Indicators and Penn World Tables. Econometric techniques of panel data such as fixed effect and generalized least squares are employed to extract results from the specified models.

    FINDINGS: The findings of the study revealed that three proxies of innovation (i.e., resident patent applications, nonresident patent applications, scientific and technical journal articles) have a significant positive role in improving trade openness in the BRICS economies. However, the fourth proxy of innovation i.e., research and development expenditures had a negative impact on the degree of trade openness. Besides, innovation activities such as inflation rate and foreign direct investment have also influenced the degree of trade openness positively and significantly. Conversely, GDP per capita had a negative relationship with trade openness. Moreover, domestic investments showed a positive influence on the degree of trade openness while employment had a negative and insignificant influence on the degree of trade openness. Finally, the causality analysis revealed a one-way relationship running from innovations to trade openness.

    IMPLICATIONS: In view of the results obtained, the policymakers of the BRICS economies might focus on encouraging innovation activities to enhance the degree of trade openness. Increased trade openness will consequently contribute to economic growth enormously and thus the attainment of sustainable development goals (SDG-8). Policymakers are also suggested to encourage FDI inflows and further ensure a moderate inflation rate to improve the degree of trade openness and hence accelerate economic growth.

    ORIGINALITY: This study focused on examining the nexus between innovation activities and trade openness in emerging economies, which is indeed an interesting but rarely explored area of research. The findings of the study might help the policymakers of the BRICS economies in formulating policies regarding trade openness and innovation activities.

  17. Lam WS, Lam WH, Lee PF, Jaaman SH
    Heliyon, 2023 Dec;9(12):e23011.
    PMID: 38076099 DOI: 10.1016/j.heliyon.2023.e23011
    Biophotonics procures wide practicability in life sciences and medicines. The contribution of biophotonics is well recognized in various Nobel Prizes. Therefore, this paper aims to conduct a bibliometric analysis of biophotonics publications. The scientific database used is the Web of Science database. Harzing's Publish or Perish and VOSviewer are the bibliometric tools used in this analysis. This study found an increasing trend in the number of publications in recent years as the number of publications peaked at 347 publications in 2020. Most of the documents are articles (3361 publications) and proceeding papers (1632 publications). The top three subject areas are Optics (3206 publications), Engineering (1706 publications) and Radiology, Nuclear Medicine, and Medical Imaging (1346 publications). The United States has the highest number of publications (2041 publications) and citation impact (38.07 citations per publication; h-index: 125). The top three publication titles are Proceedings of SPIE (920 publications), Journal of Biomedical Optics (599 publications), and Proceedings of the Society of Photo Optical Instrumentation Engineers SPIE (245 publications). The potential areas for future research include to overcome the optical penetration depth issue and to develop publicly available biosensors for the detection of common diseases.
  18. AlObaid L, Rajan R, Al Jarallah M, Dashti R, Bulbanat B, Ridha M, et al.
    Heliyon, 2023 Dec;9(12):e22175.
    PMID: 38076138 DOI: 10.1016/j.heliyon.2023.e22175
    This study aimed to evaluate the clinical outcomes of patients with acute heart failure (AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf CARE registry were identified from 47 hospitals in seven Arabian Gulf countries (Yemen, Oman, Kuwait, Qatar, Bahrain, the United Arab Emirates, and Saudi Arabia) from February to November 2012. The cohort was stratified into two groups based on the presence of MR. Univariable and multivariable statistical analyses were performed. The population cohort included 5005 consecutive patients presenting with AHF, of whom 1491 (29.8 %) had concomitant MR. The mean age of patients with AHF and concomitant MR was 59.2 ± 14.9 years, and 63.1 % (n = 2886) were male. A total of 58.6 % (n = 2683) had heart failure (HF) with reduced ejection fraction (EF) (HFrEF), 21.0 % (n = 961) had HF with mildly reduced EF (HFmrEF), and 20.4 % (n = 932) had HF with preserved EF (HFpEF). Patients with MR had a lower haemoglobin (Hb) level (12.4 vs. 12.7 g/dL; p 
  19. Rehman A, Khun MC, Salleh Z, Khan W, Albely MS, Jan R, et al.
    Heliyon, 2023 Dec;9(12):e22491.
    PMID: 38076163 DOI: 10.1016/j.heliyon.2023.e22491
    The main goal of this research is to present the concept of enhancing heat transfer within emerging technology. To achieve this, tiny metal and nonmetal particles ranging from 1 to 100 nm in size are introduced into base liquids. These nanoscale particles are utilized to improve the thermal performance of the liquids, leading to what are termed nanofluids. The utilization of these fluids and the examination of the flow of thin films have valuable implications across various sectors such as engineering, technology, and industries. This research focuses on analyzing the convective flow behavior of nanofluids, specifically, graphene oxide-ethylene glycol (GO-EG) and graphene oxide-water (GO-W) on a moving surface. The study investigates the impacts of magnetic fields and varying viscosity. By making use of the thermophysical characteristics of the base fluid and the nanofluid, as well as implementing a similarity transformation within the fundamental equations that govern energy and momentum, we formulate a 5th order nonlinear ordinary differential equation (NODE) to describe the velocity profile. This is combined with a second-order NODE that describes the distribution of temperature. To solve this derived NODE, we employ a method known as the Homotopy Analysis Method (HAM) for analytical solution. The impact of the relevant factors, Prandtl number, including magnetic field parameter, thickness of the liquid, couple stress parameter, temperature distribution, dynamic viscosity, and Eckert number, on the skin friction, velocity profile, and Nusselt's number are interrogated through graphical representation. The velocity field exhibits a decline as the couple stress parameter, magnetic field parameter, liquid thickness, and dynamic viscosity experience an increase. Conversely, the temperature field displays a rise as the Eckert number and dynamic viscosity experience an increase. To ensure the convergence of the issue, dual solutions of the problem are employed, and this is verified through the utilization graphs and tables. Due to the considerable challenge encountered in heat transfer applications for cooling diverse equipment and devices across industries like automotive, microelectronics, defense, and manufacturing, there is a strong expectation that this theoretical methodology could make a favorable contribution towards enhancing heat transfer efficiency. This improvement is sought to meet the requirements of the manufacturing and engineering sectors.
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