Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis

Che Mat CMH 1 , Md Shukri N 2 , Mohamad S 1 , Tuan Sharif SE 3 , Ramli R 4 , Jais MH 5 Show all authors , Mat Jaeb MZ 6 , Yaacob NM 7 , Yusoff MY 8 , Husna SMN 9 , Abdullah B 1

Affiliations 

  • 1 Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 2 Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. asnieda@usm.my
  • 3 Department of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 4 Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia
  • 5 Department of Pathology, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia
  • 6 Department of Respiratory, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia
  • 7 Department of Biostatistics and Research Methodology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  • 8 Department of Clinical Research Centre, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia
  • 9 Department of Immunology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Eur Arch Otorhinolaryngol, 2023 May;280(5):2283-2291.
PMID: 36401099 DOI: 10.1007/s00405-022-07746-4

Abstract

BACKGROUND: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases of sinonasal mucosa. Asthma among CRS patients is often underdiagnosed which makes the management of CRS more challenging. Therefore, using serum and tissue eosinophil as an indicator and predictor of asthma in CRS patients is vital for further preventing recurrent and increasing the effectiveness of treatment for CRS.

OBJECTIVE: To determine the association and diagnostic ability of serum and tissue eosinophils in the diagnosis of asthma among CRS patients.

METHODS: A cross-sectional study was conducted involving 24 CRS patients with asthma and without asthma, respectively, from the Otorhinolaryngology clinic of two tertiary hospitals located on the East Coast of Peninsular Malaysia. Serum and tissue eosinophils (obtained from nasal polyp) levels between both groups were compared. Association between serum and tissue eosinophils with asthma was evaluated using logistic regression analysis, adjusting for important sociodemographic characteristics. The diagnostic ability of serum and tissue eosinophil was then evaluated by assessing the receiver operating characteristic curve.

RESULTS: A total of 48 CRS patients with a mean [SD] age of 47.50 [14.99] years were included. Patients with asthma had significantly higher serum [0.48 vs 0.35 × 109/L] and tissue eosinophil [100 vs 8.5 per HPF] levels. Tissue eosinophils were found to be an independent predictor of asthma with adjusted OR 1.05, p  0.375 × 109/L and tissue eosinophil > 58 per HPF.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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