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Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19

Yong YK 1 , Wong WF 2 , Vignesh R 3 , Chattopadhyay I 4 , Velu V 5 , Tan HY 6 Show all authors , Zhang Y 7 , Larsson M 8 , Shankar EM 9

Affiliations 

  • 1 Laboratory Centre, Xiamen University Malaysia, Sepang, Malaysia
  • 2 Department of Medical Microbiology, Faculty Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Preclinical Department, Royal College of Medicine Perak (UniKL RCMP), Universiti Kuala Lumpur, Ipoh, Malaysia
  • 4 Cancer and Microbiome Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India
  • 5 Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States
  • 6 School of Traditional Chinese Medicine, Xiamen University Malaysia, Sepang, Malaysia
  • 7 Chemical Engineering, Xiamen University Malaysia, Sepang, Malaysia
  • 8 Molecular Medicine and Virology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
  • 9 Infection Biology, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India
Front Immunol, 2022;13:889196.
PMID: 35874775 DOI: 10.3389/fimmu.2022.889196

Abstract

The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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