Displaying publications 1 - 20 of 866 in total

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  1. Mallhi TH, Khan AH, Sarriff A, Adnan AS, Khan YH
    J Coll Physicians Surg Pak, 2016 Mar;26(3):238-9.
    PMID: 26975963 DOI: 03.2016/JCPSP.238239
    Matched MeSH terms: Dengue*
  2. Arima Y, Matsui T
    PMID: 23908882 DOI: 10.5365/WPSAR.2011.2.2.005
    Dengue is an emerging vectorborne infectious disease that is a major public health concern in the Asia Pacific region. Official dengue surveillance data for 2010 provided by ministries of health were summarized as part of routine activities of the World Health Organization Regional Office for the Western Pacific. Based on reported data, dengue has continued to show an increasing trend in the Western Pacific Region. In 2010, countries and areas reported a total of 353 907 dengue cases, of which 1073 died, for a case fatality ratio of 0.30%. More than 1000 cases were reported each from Australia (North Queensland), Cambodia, the Lao People's Democratic Republic, Malaysia, the Philippines, Singapore and Viet Nam. With the exception of Australia, the number of reported cases in 2010 was greater than that reported in 2009 for these countries. The elevated number of cases reported in 2010 in some countries, such as the Philippines, is likely due to several factors, such as enhanced reporting and continued epidemic activity. However, increases in reported number of cases in other areas, such as Singapore and Malaysia, appear to indicate sustained epidemic activity in those countries. The continued epidemic dengue activity in the Region highlights the need for timely and routine regional sharing of information.
    Matched MeSH terms: Dengue*
  3. Abu Bakar S, Wong PF
    Med J Malaysia, 2002 Jun;57(2):242-3.
    PMID: 24326663
    Matched MeSH terms: Dengue*; Dengue Virus*
  4. Chin KS
    Family Practitioner, 1974;1(4):14.
    Matched MeSH terms: Dengue
  5. Matched MeSH terms: Dengue
  6. Pang EL, Loh HS
    Asian Pac J Trop Med, 2016 Apr;9(4):395-401.
    PMID: 27086160 DOI: 10.1016/j.apjtm.2016.03.004
    Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per annum. Urban encroachment, ecological disruption and poor sanitation are all contributory factors of increased epidemiology. Complication however arises from the fact that dengue virus inherently exists as four different serotypes. Secondary infection is often manifested in the more severe form, such that antibody-dependent enhancement (ADE) could aggravate ailment by allowing pre-existing antibodies to form complexes with infecting viruses as means of intrusion. Consequently, increased viraemic titter and suppression of antiviral response are observed. Deep concerns are thus expressed in regards to escalating trend of hospitalisation and mortality rates. In Malaysia, situation is exacerbated by improper clinical management and pending vector control operations. As a preparedness strategy against the potential deadly dengue pandemic, the call for development of a durable and cost-effective dengue vaccine against all infecting serotypes is intensified. Even though several vaccine candidates are currently being evaluated in clinical trials, uncertainties in regards to serotypes interference, incomplete protection and dose adequacy have been raised. Instead of sole reliance on outsourcing, production of local vaccine should be considered in coherent to government's efforts to combat against dengue.
    Matched MeSH terms: Dengue*
  7. Pang T
    Immunol. Today, 1983 Dec;4(12):331-4.
    PMID: 25290926 DOI: 10.1016/0167-5699(83)90163-9
    It is now nearly 20 years since a strong correlation was noted in Thailand between secondary immune responses and severe dengue syndromes. It is currently thought that 'enhancing' antibodies, in an individual undergoing a second infection with a different serotype of dengue virus, promotes viral replication in monocytes which then become the targets of an immune elimination response (possibly T-cell mediated). The monocytes then release various chemical mediators which produce the symptoms of shock and haemorrhage seen in dengue haemorrhagic fever (DHF). Much new knowledge has been gained in recent years especially from immunoepidemiological and immunological studies, and these were discussed at a recent meeting.
    Matched MeSH terms: Dengue/immunology*
  8. Ng SC
    Family Physician, 1992;4:27-28.
    Matched MeSH terms: Dengue; Severe Dengue
  9. Skae FM
    Br Med J, 1902 Nov 15;2(2185):1581-2.
    PMID: 20760524
    Matched MeSH terms: Dengue*
  10. Lushington CF
    J Trop Med Hyg, 1922;25:137-8.
    Matched MeSH terms: Dengue
  11. Singham KT
    Family Physician, 2000;11:14-15.
    Matched MeSH terms: Dengue
  12. Lim TW
    Family Practitioner, 1984;7:29-30.
    Matched MeSH terms: Dengue
  13. Lum LCS, Ng CJ, Khoo EM
    Malays Fam Physician, 2014;9(2):2-10.
    PMID: 25893065 MyJurnal
    Dengue is a common cause of illness seen in primary care in the tropical and subtropical countries. An understanding of the course of disease progression, risk factors, recognition of the warning signs and look out for clinical problems during the different phases of the disease will enable primary care physicians to manage dengue fever in an appropriate and timely manner to reduce morbidity and mortality.
    Matched MeSH terms: Dengue*
  14. Cardosa MJ
    Curr. Opin. Infect. Dis., 2000 Oct;13(5):471-475.
    PMID: 11964816 DOI: 10.1097/00001432-200010000-00007
    The year under review has seen a remarkable proliferation of papers on dengue. Four prospective studies have been carried out across the dengue belt, many groups have been pushing at the question of pathogenesis of dengue haemorrhagic fever, and a breakthrough has been achieved in the development of a mouse model for human dengue haemorrhagic fever.
    Matched MeSH terms: Dengue/physiopathology*
  15. Pang T, Lam KS
    Immunol. Today, 1983 Feb;4(2):46-9.
    PMID: 25291069 DOI: 10.1016/0167-5699(83)90110-X
    Over the past 20 years, dengue haemorrhagic fever (DHF) has been the subject of intensive epidemiological, clinical, virological and immunological investigations. Considerable debate and controversy have surrounded its causation and the probable role of immunological mechanisms in its pathogenesis. The exact cause of DHF is still uncertain and this article reviews current thinking about the problem.
    Matched MeSH terms: Severe Dengue/physiopathology*
  16. Diong KI
    Family Practitioner, 1981;4(2):31-34.
    Matched MeSH terms: Dengue; Severe Dengue
  17. George R
    Family Practitioner, 1988;11:39-47.
    Matched MeSH terms: Dengue; Severe Dengue
  18. George R
    Family Practitioner, 1988;11:79-80.
    The first report of dengue haemorrhagic fever was in 1962 in Penang. Subsequently several outbreaks had been reported. A high index of suspicion is needed for early recognition.
    Matched MeSH terms: Dengue; Severe Dengue
  19. Preeyaa SU, Murugesan A, Sopnajothi S, Yong YK, Tan HY, Larsson M, et al.
    Viral Immunol, 2020 11;33(9):610-615.
    PMID: 32996843 DOI: 10.1089/vim.2020.0149
    Peripheral follicular helper T (pTfh) cells represent specialized CD4+ T cells that help B cells to secrete antibodies. Dengue infection appears to cause immune activation in a wide array of immune cells. Herein, we investigated the signatures of immune activation of circulating Tfh cells and mucosal-associated invariant T (MAIT) cells in adult subjects with confirmed acute clinical dengue virus (DENV) infection by multiparametric flow cytometry. The acute DENV infection induced a significant expansion of highly activated pTfh cells and circulating MAIT cells during acute febrile infection. We found a higher frequency of activated PD-1+ Tfh cells and CD38+ pTfh cells in clinical DENV infection. We also found similar activated and expanding phenotypes of MAIT cells in the patients tested. The total counts of activated pTfh cells and circulating MAIT cells were higher in dengue patients relative to healthy controls. We concluded that pTfh cells and circulating MAIT cells represent activated phenotypes in acute DENV infection.
    Matched MeSH terms: Dengue/immunology*
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