Affiliations 

  • 1 Division of Infection Biology, Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India
  • 2 Department of Medicine, Government Theni Medical College & Hospital, Theni, India
  • 3 Laboratory Center, Department of Preclinical, Xiamen University Malaysia, Sepang, Malaysia
  • 4 Department of Paraclinical Medicine, University of Kuala Lumpur Royal College of Medicine, Perak, Ipoh, Malaysia
  • 5 Department of Microbiology, University of Madras, Taramani Campus, Chennai, India
  • 6 Division of Blood and Vascular Biology, Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur, India
Viral Immunol, 2019 09 18;33(1):54-60.
PMID: 31532346 DOI: 10.1089/vim.2019.0100

Abstract

Dengue virus (DENV) infection has become an increasingly common concern in tropical and subtropical regions. It has protean manifestations ranging from febrile phase to severe life-threatening illness. In this study, we estimated Th1 and Th2 cytokines and correlated the levels with dengue severity along with certain hematological and biochemical parameters. We also studied the seroprevalence of dengue between October and December 2017 at the Government Theni Medical College, India. Individuals with dengue fever (DF) were positive for either IgM or IgG, or both. The biochemical and hematological parameters along with plasma tumor necrosis factor alpha (TNF-α), interferon-gamma (IFN-γ), granulocyte monocyte-colony stimulating factor (GM-CSF), interleukin (IL)-13, IL-12p70, IL-10, IL-5, IL-4, and IL-2 cytokines were estimated. The prevalence of DF was 42.9% during the study period. IL-2, TNF-α, IL-4, and IL-10 levels were significantly elevated (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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