Eco-friendly fabrication of nonenzymatic electrochemical sensor based on cobalt/polymelamine/nitrogen-doped graphitic-porous carbon nanohybrid material for glucose monitoring in human blood

Elancheziyan M 1 , Prakasham K 2 , Eswaran M 3 , Duraisamy M 4 , Ganesan S 5 , Lee SL 6 Show all authors , Ponnusamy VK 7

Affiliations 

  • 1 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City-807, Taiwan; Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam-602105, India
  • 2 Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City-807, Taiwan
  • 3 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City-807, Taiwan; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden
  • 4 Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City-807, Taiwan; SSN Research Centre, SSN College of Engineering, Kalavakkam-603110, India
  • 5 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City-807, Taiwan
  • 6 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia; Centre for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia. Electronic address: lsling@utm.my
  • 7 Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City-807, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City-807, Taiwan; Department of Chemistry, National Sun Yat-sen University, Kaohsiung City-804, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital (KMUH), Kaohsiung City-807, Taiwan. Electronic address: kumar@kmu.edu.tw
Environ Res, 2023 Apr 15;223:115403.
PMID: 36754108 DOI: 10.1016/j.envres.2023.115403

Abstract

The design and development of eco-friendly fabrication of cost-effective electrochemical nonenzymatic biosensors with enhanced sensitivity and selectivity are one of the emerging area in nanomaterial and analytical chemistry. In this aspect, we developed a facile fabrication of tertiary nanocomposite material based on cobalt and polymelamine/nitrogen-doped graphitic porous carbon nanohybrid composite (Co-PM-NDGPC/SPE) for the application as a nonenzymatic electrochemical sensor to quantify glucose in human blood samples. Co-PM-NDGPC/SPE nanocomposite electrode fabrication was achieved using a single-step electrodeposition method under cyclic voltammetry (CV) technique under 1 M NH4Cl solution at 20 constitutive CV cycles (sweep rate 20 mV/s). Notably, the fabricated nonenzymatic electroactive nanocomposite material exhibited excellent electrocatalytic sensing towards the quantification of glucose in 0.1 M NaOH over a wide concentration range from 0.03 to 1.071 mM with a sensitive limit of detection 7.8 μM. Moreover, the Co-PM-NDGPC nanocomposite electrode with low charge transfer resistance (Rct∼81 Ω) and high ionic diffusion indicates excellent stability, reproducibility, and high sensitivity. The fabricated nanocomposite materials exhibit a commendable sensing response toward glucose molecules present in the blood serum samples recommends its usage in real-time applications.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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