Comparative phytochemical composition, oleuropein quantification, antioxidant and cytotoxic properties of Olea europaea L. leaves

Anwar S 1 , Saleem H 2 , Khurshid U 3 , Ansari SY 4 , Alghamdi S 5 , Al-Khulaidi AWA 6 Show all authors , Malik JA 7 , Ahemad N 8 , Awadh Ali NA 9

Affiliations 

  • 1 Department of Pharmaceutical Chemistry, Pharmacology Unit, Faculty of Clinical Pharmacy, Al Baha University, Al Baha, Kingdom of Saudi Arabia
  • 2 Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences (UVAS), Lahore, Pakistan
  • 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
  • 4 Chemical Engineering Department, Pharmaceutical unit, University of Messina, Messina, Italy
  • 5 Department of Clinical Pharmacy, Faculty of Clinical Pharmacy, Al Baha University, Al Baha, Kingdom of Saudi Arabia
  • 6 Departments of Biology, Faculty of Science and Art, Al Baha University, Baljurashi, Kingdom of Saudi Arabia
  • 7 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Research, Guwahati, India
  • 8 School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway Selangor, Malaysia
  • 9 Department of Pharmacognosy and Herbal medicine, Faculty of Clinical Pharmacy, Al Baha University, Al Baha, Kingdom of Saudi Arabia
Nat Prod Res, 2023 Mar;37(6):1023-1029.
PMID: 35815778 DOI: 10.1080/14786419.2022.2097230

Abstract

In the present research, oleuropein (OLE) contents from two Saudi Arabian wild olive trees (Olea europaea L.) leaves (O1 and O2), were collected from two nearby geographical sites differing in altitudes, and were determined via UHPLC-MS analysis. Moreover, total bioactive contents, antioxidant, and cytotoxicity (against MCF-7 and MDA-MB-231 cells) potential were also evaluated. The sample (O2) was found to contain significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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