Affiliations 

  • 1 Department of Dentistry, Islamic Azad University, Tehran, Iran
  • 2 Department of Periodontics, Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • 3 Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Department of Oral and Maxillofacial Surgery, School of Dentistry, Qom University of Medical Sciences, Qom, Iran
  • 5 Department of Prosthodontics, Islamic Azad University, Shiraz, Iran
  • 6 Department of Dentistry, Borujerd University of Medical Science, Borujerd, Iran
  • 7 Student Research Committee, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
  • 8 Department of Prosthodontics, Dental Materials Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. amir_alty@yahoo.com
Clin Transl Oncol, 2023 Oct;25(10):2801-2811.
PMID: 37036595 DOI: 10.1007/s12094-023-03162-0

Abstract

Periodontitis is a polymicrobial disorder caused by dysbiosis. Porphyromonas gingivalis (P.gingivalis) and Fusobacterium nucleatum (F.nucleatum) are pathobiont related to periodontitis pathogenesis and were found to be abundant in the intestinal mucosa of inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. Besides, periodontal infections have been found in a variety of tissues and organs, indicating that periodontitis is not just an inflammation limited to the oral cavity. Considering the possible translocation of pathobiont from the oral cavity to the gastrointestinal (GI) tract, this study aimed to review the published articles in this field to provide a comprehensive view of the existing knowledge about the relationship between periodontitis and GI malignancies by focusing on the oral/gut axis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.