Development of the global inflammatory bowel disease visualization of epidemiology studies in the 21st century (GIVES-21)

Mak JWY 1 , Sun Y 2 , Limsrivilai J 3 , Abdullah M 4 , Kaibullayeva J 5 , Balderramo D 6 Show all authors , Vergara BI 7 , Paudel MS 8 , Banerjee R 9 , Hilmi I 10 , Ali RAR 11 , Wei SC 12 , Ng KK 13 , Altuwaijri M 14 , Kelly P 15 , Yamamoto-Furusho JK 16 , Kotze PG 17 , Ahuja V 18 , Chong VH 19 , Dao HV 20 , Abbey Y 21 , Ching JYL 1 , Ho A 1 , Chan AKW 1 , Bernstein CN 22 , Gearry RB 23 , Abreu M 24 , Rubin DT 25 , Dotan I 26 , Hracs L 27 , Kaplan GG 27 , Ng SC 28 , GIVES-21 Consortium

Affiliations 

  • 1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
  • 2 The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China
  • 3 Siriraj Hospital, Bangkok, Thailand
  • 4 University of Indonesia, Depok, Indonesia
  • 5 Research Institute of Cardiology and Internal Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • 6 Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina
  • 7 CASMU, Las Piedras, Uruguay
  • 8 National Academy of Medical Sciences, Kathmandu, Nepal
  • 9 Asian Institute of Gastroenterology, Hyderabad, India
  • 10 University of Malaya, Kuala Lumpur, Malaysia
  • 11 The National University of Malaysia, Bangi, Malaysia
  • 12 National Taiwan University Hospital, Taipei, Taiwan
  • 13 Conde S. Januário Hospital, Macao SAR, China
  • 14 Division of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  • 15 Tropical Gastroenterology & Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia
  • 16 Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirá, Mexico City, Mexico
  • 17 Pontifícia Universidade Católica Do Paraná (PUCPR), Curitiba, Brazil
  • 18 All India Institute of Medical Sciences, Asian Institute of Gastroenterology, Hyderabad, India
  • 19 RIPAS Hospital, Bandar Seri Begawan, Brunei Darussalam
  • 20 Hanoi Medical University, Hanoi, Vietnam
  • 21 Euracare Hospital, Accra, Ghana
  • 22 University of Manitoba IBD Clinical and Research Center, Winnipeg, MB, Canada
  • 23 Department of Medicine, University of Otago, Christchurch, New Zealand
  • 24 Department of Medicine, University of Miami Miller School of Medicine, Florida, USA
  • 25 Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL, USA
  • 26 Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • 27 Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, AB, Canada
  • 28 Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China. siewchienng@cuhk.edu.hk
BMC Med Res Methodol, 2023 May 25;23(1):129.
PMID: 37231405 DOI: 10.1186/s12874-023-01944-2

Abstract

BACKGROUND: There is a rapid increase in the incidence of inflammatory bowel diseases (IBD) in newly industrialized countries, yet epidemiological data is incomplete. We herein report the methodology adopted to study the incidence of IBD in newly industrialized countries and to evaluate the effect of environmental factors including diet on IBD development.

METHODS: Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) is a population-based cohort of newly diagnosed persons with Crohn's disease and ulcerative colitis in Asia, Africa, and Latin America to be followed prospectively for 12 months. New cases were ascertained from multiple sources and were entered into a secured online system. Cases were confirmed using standard diagnostic criteria. In addition, endoscopy, pathology and pharmacy records from each local site were searched to ensure completeness of case capture. Validated environmental and dietary questionnaires were used to determine exposure in incident cases prior to diagnosis.

RESULTS: Through November 2022, 106 hospitals from 24 regions (16 Asia; 6 Latin America; 2 Africa) have joined the GIVES-21 Consortium. To date, over 290 incident cases have been reported. All patients have demographic data, clinical disease characteristics, and disease course data including healthcare utilization, medication history and environmental and dietary exposures data collected. We have established a comprehensive platform and infrastructure required to examine disease incidence, risk factors and disease course of IBD in the real-world setting.

CONCLUSIONS: The GIVES-21 consortium offers a unique opportunity to investigate the epidemiology of IBD and explores new clinical research questions on the association between environmental and dietary factors and IBD development in newly industrialized countries.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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